AIM:To investigate the effect of intraocular pressure(IOP)fluctuations on the visual performance in steroid responders after laser in situ keratomileusis(LASIK).METHODS:Fifteen post-LASIK patients who underwent steroi...AIM:To investigate the effect of intraocular pressure(IOP)fluctuations on the visual performance in steroid responders after laser in situ keratomileusis(LASIK).METHODS:Fifteen post-LASIK patients who underwent steroid-induced IOP fluctuations were enrolled as study group.And all received effective therapy when identified.Another 15 matched post-LASIK patients who used topical steroids for the same duration without developing hypertension were selected as control group.During the follow-up visits,uncorrected distant visual acuity(UDVA),photopic contrast sensitivity,wavefront aberrations,and corneal topography,were measured.These aimed at comparing the differences in postoperative changes between the groups.RESULTS:In study group,comparison of preoperative and postoperative IOP,the amplitude of abnormal IOP fluctuations reached 10.6±4.4mmHg(ranged from 21.3 to 32.9mmHg).Compared with postoperative ocular hypertension,statistics demonstrated significant changes such as UDVA,photopic contrast sensitivity,and wavefront aberrations,and corneal topography under the condition of normal tension.1)UDVA:a significant difference was seen in UDVA between ocular hypertension and normal tension(P〈0.001);2)Contrast sensitivity:results showed significant differences in 3,6,12,and 18 cycles/degree of photopic contrast sensitivity(all P〈0.05);3)Wavefront aberrations:statistics indicated significant differences in higher order aberrations(HOA),trefoil and spherical aberration(P〈0.05 for all);4)Corneal topography parameters such as Q-value,difference value(Diff-value)between the posterior corneal surface and the best fit sphere in the central region(Ф=6mm),and central corneal thickness(CCT)showed significant differences(P〈0.01 for all).However,in control group,except for the increased CCT with time,no other significant changes were observed during the follow-up visits.CONCLUSION:Transient abnormal IOP fluctuations might induce remarkable optical and visual changes,and limiting the IOP fluctuations might improve the visual performance in steroid responders after LASIK.展开更多
文摘AIM:To investigate the effect of intraocular pressure(IOP)fluctuations on the visual performance in steroid responders after laser in situ keratomileusis(LASIK).METHODS:Fifteen post-LASIK patients who underwent steroid-induced IOP fluctuations were enrolled as study group.And all received effective therapy when identified.Another 15 matched post-LASIK patients who used topical steroids for the same duration without developing hypertension were selected as control group.During the follow-up visits,uncorrected distant visual acuity(UDVA),photopic contrast sensitivity,wavefront aberrations,and corneal topography,were measured.These aimed at comparing the differences in postoperative changes between the groups.RESULTS:In study group,comparison of preoperative and postoperative IOP,the amplitude of abnormal IOP fluctuations reached 10.6±4.4mmHg(ranged from 21.3 to 32.9mmHg).Compared with postoperative ocular hypertension,statistics demonstrated significant changes such as UDVA,photopic contrast sensitivity,and wavefront aberrations,and corneal topography under the condition of normal tension.1)UDVA:a significant difference was seen in UDVA between ocular hypertension and normal tension(P〈0.001);2)Contrast sensitivity:results showed significant differences in 3,6,12,and 18 cycles/degree of photopic contrast sensitivity(all P〈0.05);3)Wavefront aberrations:statistics indicated significant differences in higher order aberrations(HOA),trefoil and spherical aberration(P〈0.05 for all);4)Corneal topography parameters such as Q-value,difference value(Diff-value)between the posterior corneal surface and the best fit sphere in the central region(Ф=6mm),and central corneal thickness(CCT)showed significant differences(P〈0.01 for all).However,in control group,except for the increased CCT with time,no other significant changes were observed during the follow-up visits.CONCLUSION:Transient abnormal IOP fluctuations might induce remarkable optical and visual changes,and limiting the IOP fluctuations might improve the visual performance in steroid responders after LASIK.
