Background Myopia control interventions,such as defocus incorporated multiple segments(DIMS)spectacle lenses,have been adopted in school-aged children to reduce the prevalence of myopia and its complications.This stud...Background Myopia control interventions,such as defocus incorporated multiple segments(DIMS)spectacle lenses,have been adopted in school-aged children to reduce the prevalence of myopia and its complications.This study aimed to investigate the effect of DIMS spectacle lenses on subfoveal choroidal thickness(SfChT)over a period of two years,as the choroidal response to myopic control is a crucial factor in exploring its potential effect on predict-ingmyopiaprogression.Methods This study involved a secondary analysis of our previous randomized clinical trial.Myopic school-aged children aged 8-13 years were recruited in a two-year study investigating the effect of DIMS spectacle lenses on myo-pia progression.The treated group received DIMS spectacle lenses(n=78),while the control group was treated with a pair of single vision(SV)spectacle lenses(n=80).SfChT was monitored at 1 week,1,3,6,12,18 and 24 months post lens wear using spectral-domain optical coherence tomography and a custom made auto-segmentation algo-rithm utilizing convolutional neural networks.Results SfChT increased significantly after 1 week of DIMS spectacle lens wear compared to those wearing SV spectacle lenses(adjusted mean change relative to baseline±SEM at 1 week;DIMS vs.SV,6.75±1.52μum vs.-3.17±1.48μm;P<0.0001,general linear model).The thickness of choroid increased to 13.64±2.62μm after 12 months of DiMS lens wear while the choroid thinned in SV group(-9.46±2.55μm).Choroidal changes demonstrated a significant negative association with axial elongation over two years in both the DIMS and SV groups.Choroidal change at 3 months significantly predicted the changes in AL at 12 months after controlling the effect of age and gender.Conclusions Our study demonstrated a significant choroidal thickening in response to myopic defocus incorpo-rated in a spectacle lens after 1 week of lens wear,sustained over the two-year study period.The results suggested that choroidal changes at 3 months may help predict changes in axial length after one year.展开更多
基金support as the collabora-tive research(PolyU Grant No.H-ZG3B and 1-87LK)the spectacles and lenses for the study+4 种基金supported by other PolyU Grants(Grant Nos.BD90,ZVS5,ZVN1)Research Impact Fund(Grant No.R5032-18)Research Center for SHARP Vision(Grant No.1-BBCO)Henry G.Leong Endowed Professorship in Elderly Vision Health(Grant No.8-847)The Hong Kong Special Administrative Region Government(InnoHK initiative).
文摘Background Myopia control interventions,such as defocus incorporated multiple segments(DIMS)spectacle lenses,have been adopted in school-aged children to reduce the prevalence of myopia and its complications.This study aimed to investigate the effect of DIMS spectacle lenses on subfoveal choroidal thickness(SfChT)over a period of two years,as the choroidal response to myopic control is a crucial factor in exploring its potential effect on predict-ingmyopiaprogression.Methods This study involved a secondary analysis of our previous randomized clinical trial.Myopic school-aged children aged 8-13 years were recruited in a two-year study investigating the effect of DIMS spectacle lenses on myo-pia progression.The treated group received DIMS spectacle lenses(n=78),while the control group was treated with a pair of single vision(SV)spectacle lenses(n=80).SfChT was monitored at 1 week,1,3,6,12,18 and 24 months post lens wear using spectral-domain optical coherence tomography and a custom made auto-segmentation algo-rithm utilizing convolutional neural networks.Results SfChT increased significantly after 1 week of DIMS spectacle lens wear compared to those wearing SV spectacle lenses(adjusted mean change relative to baseline±SEM at 1 week;DIMS vs.SV,6.75±1.52μum vs.-3.17±1.48μm;P<0.0001,general linear model).The thickness of choroid increased to 13.64±2.62μm after 12 months of DiMS lens wear while the choroid thinned in SV group(-9.46±2.55μm).Choroidal changes demonstrated a significant negative association with axial elongation over two years in both the DIMS and SV groups.Choroidal change at 3 months significantly predicted the changes in AL at 12 months after controlling the effect of age and gender.Conclusions Our study demonstrated a significant choroidal thickening in response to myopic defocus incorpo-rated in a spectacle lens after 1 week of lens wear,sustained over the two-year study period.The results suggested that choroidal changes at 3 months may help predict changes in axial length after one year.
