Objective To investigate the cardiovascular magnetic resonance(CMR)imaging characteristics and influence factors of aortic insufficiency(AI)patients with myocardial fibrosis.Methods This retrospective study included 5...Objective To investigate the cardiovascular magnetic resonance(CMR)imaging characteristics and influence factors of aortic insufficiency(AI)patients with myocardial fibrosis.Methods This retrospective study included 59 AI patients who received CMR and transthoracic echocardiography(TTE)examinations from June 2011 to February 2015.AI patients were divided into 2 groups:bicuspid aortic valve(BAV)group(n=30)and non-BAV group(n=29).Patients were also divided into late gadolinium enhancement(LGE)group(n=27)and non-LGE group(n=32).The baseline clinical characteristics were collected through electronic medical records.Hemodynamic parameters such as grade of AI,cardiac functional parameters and LGE mass fraction(LGE%)were measured by CMR post-processing analysis.Kappa test was used to assess the consistency of AI severity between CMR and TTE.展开更多
Objective To explore the relationship between low density lipoprotein cholesterol(LDL-C)/high density lipoprotein cholesterol(HDL-C)ratio with the severity of coronary artery disease and 2-yeat outcome in patients wit...Objective To explore the relationship between low density lipoprotein cholesterol(LDL-C)/high density lipoprotein cholesterol(HDL-C)ratio with the severity of coronary artery disease and 2-yeat outcome in patients with premature coronary heart disease.Methods This prospective,multicenter,observational cohort study was originated from the PROMISE study.展开更多
Objective To evaluate the incidence and case fatality rate of cardiovascular disease(CVD)among populations in urban and rural communities in eastern,central and western regions of China.Methods The present study was b...Objective To evaluate the incidence and case fatality rate of cardiovascular disease(CVD)among populations in urban and rural communities in eastern,central and western regions of China.Methods The present study was based on the data of the Prospective Urban and Rural Epidemiology(PURE)-China cohort,which enrolled participants who had at least one followup visit and complete information on age and sex.Information on baseline demographics,cardiovascular risk factors,and prevention and treatment for CVD were collected.CVD and mortality events were documented using the standardized case report form of the PURE Global Study to assess the incidence and case fatality rate ofCVD among populations in urban and rural communities in eastern,central and western China.Results This study included a total of 47262 communitydwelling participants(age:(51.1±9.6)years;female,n=27529,58.2%)from 115 urban and rural communities in 12 provinces across the eastern,central,and western regions of China.Over a follow-up period of 11.9(9.5,12.6)years,2686 deaths and 5873 cardiovascular events were documented.The incidence of CVD was 11.90(95%CI:11.60-12.21)/1000 person-years.A significant difference in CVD incidence was observed across regions(Prend<0.001).展开更多
Objective To evaluate the value of myocardial scar burden for predicting cardiovascular events in patients with myocardial infarction and cardiac dysfunction after coronary artery bypass graft(CABG).Methods Consecutiv...Objective To evaluate the value of myocardial scar burden for predicting cardiovascular events in patients with myocardial infarction and cardiac dysfunction after coronary artery bypass graft(CABG).Methods Consecutive patients with myocardial infarction and cardiac dysfunction evidenced by late gadolinium enhancement cardiovascular magnetic resonance imaging(LGE-CMR)before CABG from April 2010 to April 2013 were enrolled.展开更多
Objective To investigate the association between estimated cumulative low-density lipoprotein cholesterol(LDL-C)exposure and the severity of coronary artery disease and long-term adverse cardiovascularrand cerebrovasc...Objective To investigate the association between estimated cumulative low-density lipoprotein cholesterol(LDL-C)exposure and the severity of coronary artery disease and long-term adverse cardiovascularrand cerebrovascular events(MACCE)in patients with acute coronary syndrome(ACS).Methods The subjects were from the PROMISE study.This study was a prospective cohort study led by Fuwai Hospital,Chinese Academy of Medical Sciences,with participation from eight regional tertiary hospitals as sub-centers,and enrolled 18701 patients with confirmed coronary heart disease between January 2015 and May 2019.Among them,8429 patients with ACS were included in this study.The estimated cumulative LDL-C exposure was calculated by multiplying LDL-C by age.Participants were then divided into four groups based on quartiles.Baseline data and coronary angiography data were collected,and participants were followed for 2 years.The primary endpoint was MACCE,which was composed of all-cause death,cardiac death,myocardial infarction,revascularization,and stroke.Spearman correlation analysis was used to estimate the correlation between cumulative LDL-C exposure and the severity of coronary artery disease.The differences in MACCE among the four groups were compared,and mulivariate Cox regression was used to divide the estimated cumulative exposure LDL-C into two groups,three groups,and four groups to analyze its relationship with MACCE.Results The 8429 ACS patients included in the study had an age of(60.9±11.4)years,with 1951(23.1%)females.Spearman correlation analysis revealed that estimated cumulative LDL-C exposurewas positively associated with the preoperative SYNTAX score,three-vessel lesions disease,left main disease,and the number of target lesions(correlation coefficients r=0.14,0.10,0.04 and 0.03,respectively,with all P<0.05).The 2-year follow-up results indicated that the incidence rates of MACCE,all-cause death,cardiac death,myocardial infarction,and stroke in ACS patients grouped by different levels of estimated cumulative LDL-C exposure were statistically significant(all P<0.05).The results of the Cox multivariate regression analysis showed that when the estimated cumulative LDL-C exposurewas treated as a continuous variable and analyzed in two,three,and four groups,with the lowest group as the reference,the risk of MACCE occurrence in the highvalue group increased by 21%(95%CI 1.08-1.37,P=0.002),24%(95%CI 1.07-1.43,P=0.004),and 21%(95%CI 1.02-1.43,P=0.025)respectively.Conclusion A positive correlation is found between estimated cumulative LDL-C exposure and severity of coronary artery disease.High estimated cumulative LDLC exposure level is a risk factor for MACCE in ACS patients within 2 years.展开更多
Objective To explore the feasibility of a coronary angiography-based method developed with artificial intelligence which was able to automatically and quickly calculate coronary volumetric blood flow and coronary flow...Objective To explore the feasibility of a coronary angiography-based method developed with artificial intelligence which was able to automatically and quickly calculate coronary volumetric blood flow and coronary flow reserve (CFR),and explore the differences in CFR after injection of different vasodilators.展开更多
Objective To explore the value of cardiac magnetic resonance imaging (CMR) derived left ventricular late gadolinium enhancement (LV LGE) for the primary prevention of malignant ventricular arrhythmias in arrhythmogeni...Objective To explore the value of cardiac magnetic resonance imaging (CMR) derived left ventricular late gadolinium enhancement (LV LGE) for the primary prevention of malignant ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy (ARVC)patients.展开更多
Objective To evaluate the predictive value of postoperative cardiac troponin Ⅰ(cTnI) level on new onset myocardial infarction(MI) and thirty-day mortality after coronary artery bypass grafting(CABG).
Objective To explore the predictive value of N-terminalpro-B-type natriuretic peptide ( NT-proBNP) onadmission on left ventricular ejection fraction ( LVEF)and the in-hospital major adverse cardiac and cerebrovascular...Objective To explore the predictive value of N-terminalpro-B-type natriuretic peptide ( NT-proBNP) onadmission on left ventricular ejection fraction ( LVEF)and the in-hospital major adverse cardiac and cerebrovascularevents (MACCE) in hospitalized patients with unstableangina (UA). Methods Data of 2 972 consecutivehospitalized patients with UA in Beijing Friendship Hospitalfrom January 2013 to September 2017 were retrospectivelyanalyzed. Patients were divided into 4 groupsaccording to the level of NT-proBNP on admission: 733cases with NT-proBNP lower than 61 ng /L,749 caseswith NT-proBNP between 61 and 133 ng /L,747 caseswith NT-proBNP between 133 and 326 ng /L,and 743cases with NT-proBNP higher than 326 ng /L. LVEF andin-hospital MACCE were compared among the 4 groupsand the predictive value of NT-proBNP on admission onLVEF and in-hospital MACCE was determined by multiple logistical regression analysis.展开更多
Objective To observe the safety and impact of shortterm anticoagulant therapy on prognosis after selective percutaneous coronary intervention (PCI) in patients with coronary artery disease. Methods From January2013 to...Objective To observe the safety and impact of shortterm anticoagulant therapy on prognosis after selective percutaneous coronary intervention (PCI) in patients with coronary artery disease. Methods From January2013 to December 2013,9 769 consecutive patients underwent selective PCI in Fuwai Hospital were retrospectively included in this study.展开更多
Objective CHADS2and CHA2DS2-VASc scores are two widely used systems for evaluating the risk of stroke in patients with atrial fibrillation(AF).The Quality of life(Qo L)after a single radiofrequency ablation(RFA)in AF ...Objective CHADS2and CHA2DS2-VASc scores are two widely used systems for evaluating the risk of stroke in patients with atrial fibrillation(AF).The Quality of life(Qo L)after a single radiofrequency ablation(RFA)in AF patients with low CHADS2score has been established.This study was designed to further explore the association between the Qo L and AF patients with展开更多
Objective To investigate the distribution pattern of late gadolinium enhancement (LGE) in left ventricular free wall of patients with dilated cardiomyopathy(DCM).Methods A total of 130 consecutive DCM patients who wer...Objective To investigate the distribution pattern of late gadolinium enhancement (LGE) in left ventricular free wall of patients with dilated cardiomyopathy(DCM).Methods A total of 130 consecutive DCM patients who were hospitalized in our hospital,underwent both CMR and CTA examinations and met the inclusion and exclusion criteria including negative results of coronary angiography or coronary CTA,were retrospectively included in this study.展开更多
Objective To explore the relationship between weight status in early adulthood and body weight change in middle age in adults and type 2 diabetes mellitus(T2DM).Methods The data of 14 population samples from China Mul...Objective To explore the relationship between weight status in early adulthood and body weight change in middle age in adults and type 2 diabetes mellitus(T2DM).Methods The data of 14 population samples from China Multicenter Collaborative Study of Cardiovascular Epidemiology conducted in 1998 were used.Ap-展开更多
<正>Objective To investigate the plasma osteoprotegerin(OPG)measurement for assessing the prognosis of intermediate coronary lesions in elderly patients.Methods We retrospectively analyzed patients meeting the i...<正>Objective To investigate the plasma osteoprotegerin(OPG)measurement for assessing the prognosis of intermediate coronary lesions in elderly patients.Methods We retrospectively analyzed patients meeting the inclusion criteria of suspicious chest pain or confirmed coronary artery disease(CHD),and intermediate stenosis lesions(20%~70%)in 3 main coronary arteries展开更多
Objective To explore the feasibility and value of a new categorization of double outlet right ventricular(DORV)in guiding the optimal choices of surgical approaches.Methods Five hundred and twenty one
Objective To investigate the relationship between thrombolysis in myocardial infarction risk index (TRI) and the severity of coronary artery lesions and long-term outcome in acute myocardial infarction (AMI) patients ...Objective To investigate the relationship between thrombolysis in myocardial infarction risk index (TRI) and the severity of coronary artery lesions and long-term outcome in acute myocardial infarction (AMI) patients undergoing percutaneous coronary in tervention (PCI).展开更多
Objective To investigate the impact of poly vascular disease(PVD)on long-term outcomes in coronary artery disease(CAD)patients undergoing percutaneous coronary intervention(PCI).Methods A total of 10287 consecutive pa...Objective To investigate the impact of poly vascular disease(PVD)on long-term outcomes in coronary artery disease(CAD)patients undergoing percutaneous coronary intervention(PCI).Methods A total of 10287 consecutive patients undergoing PCI in Beijing Fuwai Hospital from January 2013 to December 2013 were enrolled.According to the history of PVD.展开更多
Objective To compare the impact of ticagrelor or clopidogrel on serum uric acid levels among patients with ST-segment elevation myocardial infarction (STEMI)who underwent primary percutaneous coronary intervention(PCI...Objective To compare the impact of ticagrelor or clopidogrel on serum uric acid levels among patients with ST-segment elevation myocardial infarction (STEMI)who underwent primary percutaneous coronary intervention(PCI) and further evaluate the effects of variation of serum uric acid levels on platelet reactivity.展开更多
Objective To compare trends in congenital heart disease(CHD)mortality between China and North America from 1990 to 2017.Methods Using the data from the Global Burden Of Disease(GBD)study 2017,we analyzed the related i...Objective To compare trends in congenital heart disease(CHD)mortality between China and North America from 1990 to 2017.Methods Using the data from the Global Burden Of Disease(GBD)study 2017,we analyzed the related indicators of CHD mortality in China and North America from 1990 to 2017,including standardized mortality.展开更多
Objective To investigate the influence of uric acid on coronary artery calcification in the natural population in Beijing.Methods From April to July 2012,903 subjects from the natural population (aged 37—76 years for...Objective To investigate the influence of uric acid on coronary artery calcification in the natural population in Beijing.Methods From April to July 2012,903 subjects from the natural population (aged 37—76 years for men,aged 42—76 years for women) in展开更多
文摘Objective To investigate the cardiovascular magnetic resonance(CMR)imaging characteristics and influence factors of aortic insufficiency(AI)patients with myocardial fibrosis.Methods This retrospective study included 59 AI patients who received CMR and transthoracic echocardiography(TTE)examinations from June 2011 to February 2015.AI patients were divided into 2 groups:bicuspid aortic valve(BAV)group(n=30)and non-BAV group(n=29).Patients were also divided into late gadolinium enhancement(LGE)group(n=27)and non-LGE group(n=32).The baseline clinical characteristics were collected through electronic medical records.Hemodynamic parameters such as grade of AI,cardiac functional parameters and LGE mass fraction(LGE%)were measured by CMR post-processing analysis.Kappa test was used to assess the consistency of AI severity between CMR and TTE.
文摘Objective To explore the relationship between low density lipoprotein cholesterol(LDL-C)/high density lipoprotein cholesterol(HDL-C)ratio with the severity of coronary artery disease and 2-yeat outcome in patients with premature coronary heart disease.Methods This prospective,multicenter,observational cohort study was originated from the PROMISE study.
文摘Objective To evaluate the incidence and case fatality rate of cardiovascular disease(CVD)among populations in urban and rural communities in eastern,central and western regions of China.Methods The present study was based on the data of the Prospective Urban and Rural Epidemiology(PURE)-China cohort,which enrolled participants who had at least one followup visit and complete information on age and sex.Information on baseline demographics,cardiovascular risk factors,and prevention and treatment for CVD were collected.CVD and mortality events were documented using the standardized case report form of the PURE Global Study to assess the incidence and case fatality rate ofCVD among populations in urban and rural communities in eastern,central and western China.Results This study included a total of 47262 communitydwelling participants(age:(51.1±9.6)years;female,n=27529,58.2%)from 115 urban and rural communities in 12 provinces across the eastern,central,and western regions of China.Over a follow-up period of 11.9(9.5,12.6)years,2686 deaths and 5873 cardiovascular events were documented.The incidence of CVD was 11.90(95%CI:11.60-12.21)/1000 person-years.A significant difference in CVD incidence was observed across regions(Prend<0.001).
文摘Objective To evaluate the value of myocardial scar burden for predicting cardiovascular events in patients with myocardial infarction and cardiac dysfunction after coronary artery bypass graft(CABG).Methods Consecutive patients with myocardial infarction and cardiac dysfunction evidenced by late gadolinium enhancement cardiovascular magnetic resonance imaging(LGE-CMR)before CABG from April 2010 to April 2013 were enrolled.
文摘Objective To investigate the association between estimated cumulative low-density lipoprotein cholesterol(LDL-C)exposure and the severity of coronary artery disease and long-term adverse cardiovascularrand cerebrovascular events(MACCE)in patients with acute coronary syndrome(ACS).Methods The subjects were from the PROMISE study.This study was a prospective cohort study led by Fuwai Hospital,Chinese Academy of Medical Sciences,with participation from eight regional tertiary hospitals as sub-centers,and enrolled 18701 patients with confirmed coronary heart disease between January 2015 and May 2019.Among them,8429 patients with ACS were included in this study.The estimated cumulative LDL-C exposure was calculated by multiplying LDL-C by age.Participants were then divided into four groups based on quartiles.Baseline data and coronary angiography data were collected,and participants were followed for 2 years.The primary endpoint was MACCE,which was composed of all-cause death,cardiac death,myocardial infarction,revascularization,and stroke.Spearman correlation analysis was used to estimate the correlation between cumulative LDL-C exposure and the severity of coronary artery disease.The differences in MACCE among the four groups were compared,and mulivariate Cox regression was used to divide the estimated cumulative exposure LDL-C into two groups,three groups,and four groups to analyze its relationship with MACCE.Results The 8429 ACS patients included in the study had an age of(60.9±11.4)years,with 1951(23.1%)females.Spearman correlation analysis revealed that estimated cumulative LDL-C exposurewas positively associated with the preoperative SYNTAX score,three-vessel lesions disease,left main disease,and the number of target lesions(correlation coefficients r=0.14,0.10,0.04 and 0.03,respectively,with all P<0.05).The 2-year follow-up results indicated that the incidence rates of MACCE,all-cause death,cardiac death,myocardial infarction,and stroke in ACS patients grouped by different levels of estimated cumulative LDL-C exposure were statistically significant(all P<0.05).The results of the Cox multivariate regression analysis showed that when the estimated cumulative LDL-C exposurewas treated as a continuous variable and analyzed in two,three,and four groups,with the lowest group as the reference,the risk of MACCE occurrence in the highvalue group increased by 21%(95%CI 1.08-1.37,P=0.002),24%(95%CI 1.07-1.43,P=0.004),and 21%(95%CI 1.02-1.43,P=0.025)respectively.Conclusion A positive correlation is found between estimated cumulative LDL-C exposure and severity of coronary artery disease.High estimated cumulative LDLC exposure level is a risk factor for MACCE in ACS patients within 2 years.
文摘Objective To explore the feasibility of a coronary angiography-based method developed with artificial intelligence which was able to automatically and quickly calculate coronary volumetric blood flow and coronary flow reserve (CFR),and explore the differences in CFR after injection of different vasodilators.
文摘Objective To explore the value of cardiac magnetic resonance imaging (CMR) derived left ventricular late gadolinium enhancement (LV LGE) for the primary prevention of malignant ventricular arrhythmias in arrhythmogenic right ventricular cardiomyopathy (ARVC)patients.
文摘Objective To evaluate the predictive value of postoperative cardiac troponin Ⅰ(cTnI) level on new onset myocardial infarction(MI) and thirty-day mortality after coronary artery bypass grafting(CABG).
文摘Objective To explore the predictive value of N-terminalpro-B-type natriuretic peptide ( NT-proBNP) onadmission on left ventricular ejection fraction ( LVEF)and the in-hospital major adverse cardiac and cerebrovascularevents (MACCE) in hospitalized patients with unstableangina (UA). Methods Data of 2 972 consecutivehospitalized patients with UA in Beijing Friendship Hospitalfrom January 2013 to September 2017 were retrospectivelyanalyzed. Patients were divided into 4 groupsaccording to the level of NT-proBNP on admission: 733cases with NT-proBNP lower than 61 ng /L,749 caseswith NT-proBNP between 61 and 133 ng /L,747 caseswith NT-proBNP between 133 and 326 ng /L,and 743cases with NT-proBNP higher than 326 ng /L. LVEF andin-hospital MACCE were compared among the 4 groupsand the predictive value of NT-proBNP on admission onLVEF and in-hospital MACCE was determined by multiple logistical regression analysis.
文摘Objective To observe the safety and impact of shortterm anticoagulant therapy on prognosis after selective percutaneous coronary intervention (PCI) in patients with coronary artery disease. Methods From January2013 to December 2013,9 769 consecutive patients underwent selective PCI in Fuwai Hospital were retrospectively included in this study.
文摘Objective CHADS2and CHA2DS2-VASc scores are two widely used systems for evaluating the risk of stroke in patients with atrial fibrillation(AF).The Quality of life(Qo L)after a single radiofrequency ablation(RFA)in AF patients with low CHADS2score has been established.This study was designed to further explore the association between the Qo L and AF patients with
文摘Objective To investigate the distribution pattern of late gadolinium enhancement (LGE) in left ventricular free wall of patients with dilated cardiomyopathy(DCM).Methods A total of 130 consecutive DCM patients who were hospitalized in our hospital,underwent both CMR and CTA examinations and met the inclusion and exclusion criteria including negative results of coronary angiography or coronary CTA,were retrospectively included in this study.
文摘Objective To explore the relationship between weight status in early adulthood and body weight change in middle age in adults and type 2 diabetes mellitus(T2DM).Methods The data of 14 population samples from China Multicenter Collaborative Study of Cardiovascular Epidemiology conducted in 1998 were used.Ap-
文摘<正>Objective To investigate the plasma osteoprotegerin(OPG)measurement for assessing the prognosis of intermediate coronary lesions in elderly patients.Methods We retrospectively analyzed patients meeting the inclusion criteria of suspicious chest pain or confirmed coronary artery disease(CHD),and intermediate stenosis lesions(20%~70%)in 3 main coronary arteries
文摘Objective To explore the feasibility and value of a new categorization of double outlet right ventricular(DORV)in guiding the optimal choices of surgical approaches.Methods Five hundred and twenty one
文摘Objective To investigate the relationship between thrombolysis in myocardial infarction risk index (TRI) and the severity of coronary artery lesions and long-term outcome in acute myocardial infarction (AMI) patients undergoing percutaneous coronary in tervention (PCI).
文摘Objective To investigate the impact of poly vascular disease(PVD)on long-term outcomes in coronary artery disease(CAD)patients undergoing percutaneous coronary intervention(PCI).Methods A total of 10287 consecutive patients undergoing PCI in Beijing Fuwai Hospital from January 2013 to December 2013 were enrolled.According to the history of PVD.
文摘Objective To compare the impact of ticagrelor or clopidogrel on serum uric acid levels among patients with ST-segment elevation myocardial infarction (STEMI)who underwent primary percutaneous coronary intervention(PCI) and further evaluate the effects of variation of serum uric acid levels on platelet reactivity.
文摘Objective To compare trends in congenital heart disease(CHD)mortality between China and North America from 1990 to 2017.Methods Using the data from the Global Burden Of Disease(GBD)study 2017,we analyzed the related indicators of CHD mortality in China and North America from 1990 to 2017,including standardized mortality.
文摘Objective To investigate the influence of uric acid on coronary artery calcification in the natural population in Beijing.Methods From April to July 2012,903 subjects from the natural population (aged 37—76 years for men,aged 42—76 years for women) in
