This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase(PDP)in malignant tumors and its potential mechanisms.Recent research on tumor metabolic mechanisms has shown that...This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase(PDP)in malignant tumors and its potential mechanisms.Recent research on tumor metabolic mechanisms has shown that PDP dysregulation is closely linked to metabolic reprogramming in tumor cells,and potentially promotes tumor.Research has comprehensively explored the structural-functional characteristics of PDP,its metabolic regulatory mechanisms,and its role in various types of malignant tumors.Nevertheless,several questions still exist regarding its potential mechanisms within acetylation,phosphorylation,hypoxia,immune infiltration,mitochondrial metabolism,drug resistance,oxidative phosphorylation,and tumor prognosis.This article intends to summarize the latest research,examine PDP’s potential as a therapeutic target,and propose future research directions to enhance cancer treatment strategies.展开更多
Feng Fengyi , Zhang Pin , He Youjian 1, Li Yuhong1 , Zhou Meizhen2 , Chen Gang2 and Li Lin2 The Cancer Hospital of the CAMS & PUMC, Beijing 1000211 The Cancer Hospital of Sun Yat Sen University of Medical Science...Feng Fengyi , Zhang Pin , He Youjian 1, Li Yuhong1 , Zhou Meizhen2 , Chen Gang2 and Li Lin2 The Cancer Hospital of the CAMS & PUMC, Beijing 1000211 The Cancer Hospital of Sun Yat Sen University of Medical Sciences, Guangzhou 5100602Beijing Hospital of the Ministry of Health, Beijing 100730展开更多
Purpose:To investigate the correlation between acceptance of disability and the quality of social relations of patients with colostomies.Methods:A total of 111 patients with permanent colostomies were recruited by con...Purpose:To investigate the correlation between acceptance of disability and the quality of social relations of patients with colostomies.Methods:A total of 111 patients with permanent colostomies were recruited by convenience sampling.They were asked to complete a general information questionnaire and assessed according to the Acceptance of Disability Scale and Social Relational Quality Scale.Results:Overall,the patients’acceptance of disability was moderate.The total score and factor scores of acceptance of disability were significantly correlated with the total score of social relational quality and the factor scores of family commitment and friendship(p<0.05).Conclusion:There is a positive correlation between acceptance of disability and social relational quality in patients with colostomy.These results will help improve patients’social relational quality of life and provide psychological intervention to promote their acceptance of disability.展开更多
Objective: To evaluate the feasibility and safety of the non-placement of a drainage tube in transvestibular endoscopic thyroid papillary carcinoma surgery by applying the concept of rapid rehabilitation surgery. Meth...Objective: To evaluate the feasibility and safety of the non-placement of a drainage tube in transvestibular endoscopic thyroid papillary carcinoma surgery by applying the concept of rapid rehabilitation surgery. Methods: 106 patients with papillary thyroid carcinoma in the Department of Head and Neck of Affiliated Cancer Hospital of Sun Yat-sen University were retrospectively analyzed, and the observation group (n = 43) 1 who underwent endoscopic surgery without negative pressure drainage tube in the hospital from January 2019 to March 2023 were selected. The control group (n = 63) underwent the same operation at the same time and placed the negative pressure drainage tube. Postoperative hematoma, incision infection, subcutaneous effusion, and use of painkillers were compared between the two groups. Results: There were no statistically significant differences in operation time, intraoperative blood loss, postoperative hospital stay, and number of lymph node dissection between the two groups (P > 0.05). No postoperative hematoma or incision infection occurred between the two groups. There were no statistically significant differences in the incidence of subcutaneous effusion and the use rate of painkillers between the two groups (P > 0.05). Conclusion: No drainage tube in patients undergoing endoscopic thyroid surgery through oral vestibular approach will not increase the probability of complications such as postoperative hematoma, incision infection, subcutaneous effusion, and the use of painkillers, but can improve the comfort of patients in the concept of rapid rehabilitation.展开更多
Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective inve...Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival.展开更多
基金funded by National Social Science Foundation if Gansu Province(24JRRA694)Scientific and Technological Development Guiding Plan Project of Lanzhou City(2023-ZD-62,2024-9-52)GanSu Health Industry Planning Project(GSWSKY2024-51).
文摘This review focuses on the metabolic issues related to mitochondrial pyruvate dehydrogenase phosphatase(PDP)in malignant tumors and its potential mechanisms.Recent research on tumor metabolic mechanisms has shown that PDP dysregulation is closely linked to metabolic reprogramming in tumor cells,and potentially promotes tumor.Research has comprehensively explored the structural-functional characteristics of PDP,its metabolic regulatory mechanisms,and its role in various types of malignant tumors.Nevertheless,several questions still exist regarding its potential mechanisms within acetylation,phosphorylation,hypoxia,immune infiltration,mitochondrial metabolism,drug resistance,oxidative phosphorylation,and tumor prognosis.This article intends to summarize the latest research,examine PDP’s potential as a therapeutic target,and propose future research directions to enhance cancer treatment strategies.
文摘Feng Fengyi , Zhang Pin , He Youjian 1, Li Yuhong1 , Zhou Meizhen2 , Chen Gang2 and Li Lin2 The Cancer Hospital of the CAMS & PUMC, Beijing 1000211 The Cancer Hospital of Sun Yat Sen University of Medical Sciences, Guangzhou 5100602Beijing Hospital of the Ministry of Health, Beijing 100730
基金supported by Guangdong Provincial Science and Technology Plan Fund,social development projects(2012B031800062)。
文摘Purpose:To investigate the correlation between acceptance of disability and the quality of social relations of patients with colostomies.Methods:A total of 111 patients with permanent colostomies were recruited by convenience sampling.They were asked to complete a general information questionnaire and assessed according to the Acceptance of Disability Scale and Social Relational Quality Scale.Results:Overall,the patients’acceptance of disability was moderate.The total score and factor scores of acceptance of disability were significantly correlated with the total score of social relational quality and the factor scores of family commitment and friendship(p<0.05).Conclusion:There is a positive correlation between acceptance of disability and social relational quality in patients with colostomy.These results will help improve patients’social relational quality of life and provide psychological intervention to promote their acceptance of disability.
文摘Objective: To evaluate the feasibility and safety of the non-placement of a drainage tube in transvestibular endoscopic thyroid papillary carcinoma surgery by applying the concept of rapid rehabilitation surgery. Methods: 106 patients with papillary thyroid carcinoma in the Department of Head and Neck of Affiliated Cancer Hospital of Sun Yat-sen University were retrospectively analyzed, and the observation group (n = 43) 1 who underwent endoscopic surgery without negative pressure drainage tube in the hospital from January 2019 to March 2023 were selected. The control group (n = 63) underwent the same operation at the same time and placed the negative pressure drainage tube. Postoperative hematoma, incision infection, subcutaneous effusion, and use of painkillers were compared between the two groups. Results: There were no statistically significant differences in operation time, intraoperative blood loss, postoperative hospital stay, and number of lymph node dissection between the two groups (P > 0.05). No postoperative hematoma or incision infection occurred between the two groups. There were no statistically significant differences in the incidence of subcutaneous effusion and the use rate of painkillers between the two groups (P > 0.05). Conclusion: No drainage tube in patients undergoing endoscopic thyroid surgery through oral vestibular approach will not increase the probability of complications such as postoperative hematoma, incision infection, subcutaneous effusion, and the use of painkillers, but can improve the comfort of patients in the concept of rapid rehabilitation.
基金supported by the State Key Project on Inflectional Disease of China(2012ZX10002016-004,2012ZX 10002010-001-004)the Chinese Ministry of Public Health for Key Clinical Projects(439,2010)to Prof.Xiaoping Chenthe National Natural Science Foundation of China(81502524)to Dr.Binhao Zhang
文摘Hepatectomy is currently routinely performed in most hospitals in China. China owns the largest population of liver diseases and the biggest number of liver resection cases. A nationwide multicenter retrospective investigation involving 112 hospitals was performed, and focused on liver resection for patients with hepatocellular carcinoma(HCC). 42,573 cases of hepatectomy were enrolled, and 18,275 valid cases of liver resection for HCC patients were selected for statistical analysis. The epidemiology of HCC, distribution of hepatectomy, postoperative complications and prognosis were finally analyzed. In the 18,275 HCC patients,81% had hepatitis B virus infection and 10% had hepatitis C virus infection. 38% of the HCC patients had normal Alphafetoprotein(AFP) level, and other 35% had an AFP level lower than 400 ng mL^(-1). In the study period, 97% of the hepatectomy for HCC were treated with open surgery, and 23.81% had vascular exclusion techniques. The operation time was(191.7±105.6) min,the blood loss was(546.0±562.8) m L, and blood transfusion was(543.0±1,035.2) m L. The median survival for HCC patients was 631 days, with 1-, 3-, and 5-year overall survival of 73.2%, 28.8% and 19.6%, respectively. Liver cirrhosis, multiple nodules,tumor thrombosis and high AFP level were risk factors that affect postoperative survival.
