Solar chimneys are renewable energy systems designed to enhance natural ventilation,improving thermal comfort in buildings.As passive systems,solar chimneys contribute to energy efficiency in a sustainable and environ...Solar chimneys are renewable energy systems designed to enhance natural ventilation,improving thermal comfort in buildings.As passive systems,solar chimneys contribute to energy efficiency in a sustainable and environmentally friendly way.The effectiveness of a solar chimney depends on its design and orientation relative to the cardinal directions,both of which are critical for optimal performance.This article presents a supervised learning approach using artificial neural networks to forecast the performance indicators of solar chimneys.Thedataset includes information from 2784 solar chimney configurations,which encompasses various factors such as chimney height,channel thickness,glass thickness,paint,wall material,measurement date,and orientation.The case study examines the four cardinal orientations and weather data from Mexico City,covering the period from 01 January to 31 December 2024.The main results indicate that the proposed artificial neural network models achieved higher coefficient of determination values(0.905-0.990)than the baseline method across performance indicators of the solar chimney system,demonstrating greater accuracy and improved generalization.The proposed approach highlights the potential of using artificial neural networks as a decision-making tool in the design stage of solar chimneys in sustainable architecture.展开更多
Objective: To record the human cases of dengue fever(DF) and investigate the Aedes mosquito species circulating during the Hanoi 2011 DF epidemics. Methods: 24 different outbreak points were recorded in 8 districts be...Objective: To record the human cases of dengue fever(DF) and investigate the Aedes mosquito species circulating during the Hanoi 2011 DF epidemics. Methods: 24 different outbreak points were recorded in 8 districts between August and December 2011. Results: 140 patients were hospitalized following dengue diagnostic with a predominance of males(59.3%) and the 15-34 age class. Only DENV-1(11.27%) and DENV-2(88.73%) serotypes were detected in human samples. Mosquito sampling performed in and around patients households revealed the predominance of Aedes aegypti(95.15%) versus Aedes albopictus(4.85%). There is a positive correlation between the population density of Aedes aegypti and the number of human cases and duration of outbreaks. Conclusions: This was not observed for Aedes albopictus. 3 pools of Aedes aegypti were positive with dengue virus, two with DENV-1 and one with DENV-2.展开更多
In mammals, myeloid progenitors infiltrate the developing central nervous system (CNS), through the immature blood-brain barrier (BBB), the ventricular layer or the pial surface migrate and give rise to resident micro...In mammals, myeloid progenitors infiltrate the developing central nervous system (CNS), through the immature blood-brain barrier (BBB), the ventricular layer or the pial surface migrate and give rise to resident microglia. In the mature brain, however, the BBB hampers such recruitment from the blood-stream and long-term establishment of blood borne myeloid cells in the CNS thus appears at best limited. Hematopoietic stem cell-derived microglia, nevertheless, represents a promising tool for the correction of genetic deficits in the brain. We thus investigated the fate of primary human monocytes, and monocyte-derived macrophages, following transplantation into the adult mouse brain overpassing the BBB. Furthermore, we documented the ability of such cells to deliver a lysosomal enzyme into the brain following genetic modification with a recombinant adenoviral vector carrying the human β-glucuronidase cDNA. When implanted into the mouse striatum, the engineered primary cells survived and expressed the transgene for as much as 8 months. Moreover, the donor cells could migrate out of the grafting site and settle along blood vessels or myelin tracts although at limited distance. Migrating donor cells down-regulated the expression of CD14 andHLA DR, suggesting the adoption of a deactivated microglia-like phenotype. Our observations establish the ability of circulating mononuclear phagocytes to integrate into the brain after transplantation and express a transgene on the long term. These cells might thus be employed for autologous transplantation for the delivery of secreted therapeutic proteins in the context of a wide range of brain affections.展开更多
To investigate (1) whether ischemic preconditioning (IPC) could protect immature rabbit hearts against ischemia reperfusion injury and (2) the role of K ATP channel in the mechanism of myocardial protection ...To investigate (1) whether ischemic preconditioning (IPC) could protect immature rabbit hearts against ischemia reperfusion injury and (2) the role of K ATP channel in the mechanism of myocardial protection Since cardioplegia is a t raditional and effective cardioprotective measure in clinic, our study is also d esigned to probe the compatibility between IPC and cardioplegia Methods New Zealand rabbits aged 14-21 days weighing 220-280 g were used The animals w ere anesthetized and heparinized The chest was opened and the heart was quickl y removed for connection of the aorta via Langendorff's method within 30 s after excision All hearts were perfused with Krebs Henseleit buffer balanced with gas mixture (O 2∶CO 2=95%∶5%) at 60 cm H 2O (perfusion pressure) IPC cons isted of 5 min global ischemia plus 10 min reperfusion Glibenclamide was used as the K ATP channel blocker at a concentration of 10 μmol/L before IPC Cardiac arrest was induced with 4℃ St Thomas cardioplegic solution, at which point the heart was made globally ischemic by withholding perfusion for 45 min f ollowed by 40 min reperfusion Thirty immature rabbit hearts were randomly divi ded into four groups: CON (n=9) was subjected to ischemia reperfusion only; IPC ( n=9) underwent IPC and ischemia reperfusion; Gli (n=6) was given glibenclamide and ischemia reperfusion; and Gli+IPC (n=6) underwent glibenclamide, IPC and is chemia reperfusion Coronary flow (CF), HR, left ventricle developed pressure (LVDP), and ±dp/dt max were monitored at equilibration (baseline value) an d 5, 1 0, 20, 30 and 40 min after reperfusion The values resulting from reperfusion w ere expressed as a percentage of their baseline values Arrhythmia quantificati on, myocardial enzyme in the coronary effluent and myocardial energy metaboli sm were also determined Results The recovery of CF, HR, LVDP and ±dp/dt max in preconditioned hearts was b est am ong the four groups The incidence of arrhythmia was low and less CK MB leaked out in the IPC group Myocardial ATP content was better preserved by IPC Pre treatment with glibenclamide completely abolished the myocardial protection prov ided by IPC, but did not affect ischemia reperfusion injury Conclusions While applying cardioplegia, IPC provides significant cardioprotective effects Activation of K ATP channels is involved in the mechanism of IPC produced cardioprotection展开更多
Background Pediatric acute fulminant myocarditis(AFM)is a very dangerous disease that may lead to acute heart failure or even sudden death.Previous reports have identified some prognostic factors in adult AFM;however,...Background Pediatric acute fulminant myocarditis(AFM)is a very dangerous disease that may lead to acute heart failure or even sudden death.Previous reports have identified some prognostic factors in adult AFM;however,there is no such research on children with AFM on venoarterial extracorporeal membrane oxygenation(VA-ECMO).This study aimed to find relevant prognostic factors for predicting adverse clinical outcomes.Methods A retrospective analysis was performed in an affiliated university children’s hospital with consecutive patients receiving VA-ECMO for AFM from July 2010 to November 2020.These children were classified into a survivor group(n=33)and a non-survivor group(n=8).Patient demographics,clinical events,laboratory findings,and electrocardiographic and echocardiographic parameters were analyzed.Results Peak serum creatinine(SCr)and peak creatine kinase isoenzyme MB during ECMO had joint predictive value for in-hospital mortality(p=0.011,AUC=0.962).Based on multivariable logistic regression analysis,peak SCr level during ECMO support was an independent predictor of in-hospital mortality(OR=1.035,95%CI 1.006 to 1.064,p=0.017,AUC=0.936,with optimal cut-off value of 78μmol/L).Conclusion Tissue hypoperfusion and consequent end-organ damage ultimately hampered the outcomes.The need for left atrial decompression indicated a sicker patient on ECMO and introduced additional risk for complications.Earlier and more cautious deployment would likely be associated with decreased risk of complications and mortality.展开更多
Magnesium alloys have attracted attention due to their biocompatibility and biodegradability.In this work,composite coatings are developed to potentially improve the corrosion resistance of AZ91D Mg alloy in simulated...Magnesium alloys have attracted attention due to their biocompatibility and biodegradability.In this work,composite coatings are developed to potentially improve the corrosion resistance of AZ91D Mg alloy in simulated physiological fluid.Cerium-based/stearic acid coatings were prepared by electrodeposition combined with a simple immersion method.The effect of stearic acid bath concentration on the contact angle and corrosion resistance of the composite coatings was evaluated.The results showed that the stearic acid treatment increased the hydrophobicity of the surfaces of the cerium-based simple coatings.The use of an appropriate stearic acid concentration is a key for the fabrication of hydrophobic surfaces.The duplex coatings were demonstrated to protect the substrate from corrosion in Ringer solution.展开更多
Objective: To investigate the effect of Shen-Fu (SF) injection on gastrointestinal tract injury and its potential mechanism.Methods: Thirty-eight patients undergoing elective open heart surgery were assigned to Group ...Objective: To investigate the effect of Shen-Fu (SF) injection on gastrointestinal tract injury and its potential mechanism.Methods: Thirty-eight patients undergoing elective open heart surgery were assigned to Group C (control group, n = 18) and Group SF (n = 20) randomly. In Group SF, the patients received intravenous injection of SF (0.5 ml/kg) at the beginning of the surgery followed by a continuous infusion of 100 ml SF (1.0 ml/kg) solution diluted by saline at a rate of 0.004 ml · Kg-1 · min-1 with a Grasby pump. The control group was injected with normal saline in the same volume. Gastric intramucosal pH (pHi), activity of blood diamine oxidase ( DAO ), and concentrations of blood LPS and IL-6 were measured before CPB ( S0) and 1 h ( S1 ) and 2 h ( S2) after aortic declamping, respectively.Results: In Group C, pHi value was significantly lower at S1 and S2 than at S0 ( mean P <0.01) and blood DAO and concentrations of LPS and IL-6 were significantly higher at S1 and S2 than at S0 ( meanP < 0.01). In Group SF, pHi was obviously lower at S1 and S2 than at S0(P< 0.05) but LPS and IL-6 levels and DAO were higher at S, (mean P<0.05). Blood DAO and LPS level demonstrated significant negative correlations with pHi ( mean P < 0.01) while LPS concentration showed a positive correlation with blood DAO (P < 0.01) and IL-6 concentration (P < 0.05). At S1 and S2 after aortic declamping, the levels of pHi were higher in Group SF than in Group C (mean P <0.01 ) but DAO and LPS and IL-6 levels were significantly lower in Group SF than in Group C ( P <0.01).Conclusions: SF has a protective effect on gastrointestinal tract and can reduce inflammatory actions.展开更多
文摘Solar chimneys are renewable energy systems designed to enhance natural ventilation,improving thermal comfort in buildings.As passive systems,solar chimneys contribute to energy efficiency in a sustainable and environmentally friendly way.The effectiveness of a solar chimney depends on its design and orientation relative to the cardinal directions,both of which are critical for optimal performance.This article presents a supervised learning approach using artificial neural networks to forecast the performance indicators of solar chimneys.Thedataset includes information from 2784 solar chimney configurations,which encompasses various factors such as chimney height,channel thickness,glass thickness,paint,wall material,measurement date,and orientation.The case study examines the four cardinal orientations and weather data from Mexico City,covering the period from 01 January to 31 December 2024.The main results indicate that the proposed artificial neural network models achieved higher coefficient of determination values(0.905-0.990)than the baseline method across performance indicators of the solar chimney system,demonstrating greater accuracy and improved generalization.The proposed approach highlights the potential of using artificial neural networks as a decision-making tool in the design stage of solar chimneys in sustainable architecture.
基金supported in part by the Erasmus Mundus project MAHEVAthe CNRS-UM1-UM2 PEPS project MoD yCAsupported by the Entomology department, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
文摘Objective: To record the human cases of dengue fever(DF) and investigate the Aedes mosquito species circulating during the Hanoi 2011 DF epidemics. Methods: 24 different outbreak points were recorded in 8 districts between August and December 2011. Results: 140 patients were hospitalized following dengue diagnostic with a predominance of males(59.3%) and the 15-34 age class. Only DENV-1(11.27%) and DENV-2(88.73%) serotypes were detected in human samples. Mosquito sampling performed in and around patients households revealed the predominance of Aedes aegypti(95.15%) versus Aedes albopictus(4.85%). There is a positive correlation between the population density of Aedes aegypti and the number of human cases and duration of outbreaks. Conclusions: This was not observed for Aedes albopictus. 3 pools of Aedes aegypti were positive with dengue virus, two with DENV-1 and one with DENV-2.
基金funded by the CNRS,The INSERM and Vaincre les Maladie Lysosomiales(vml-asso.org).
文摘In mammals, myeloid progenitors infiltrate the developing central nervous system (CNS), through the immature blood-brain barrier (BBB), the ventricular layer or the pial surface migrate and give rise to resident microglia. In the mature brain, however, the BBB hampers such recruitment from the blood-stream and long-term establishment of blood borne myeloid cells in the CNS thus appears at best limited. Hematopoietic stem cell-derived microglia, nevertheless, represents a promising tool for the correction of genetic deficits in the brain. We thus investigated the fate of primary human monocytes, and monocyte-derived macrophages, following transplantation into the adult mouse brain overpassing the BBB. Furthermore, we documented the ability of such cells to deliver a lysosomal enzyme into the brain following genetic modification with a recombinant adenoviral vector carrying the human β-glucuronidase cDNA. When implanted into the mouse striatum, the engineered primary cells survived and expressed the transgene for as much as 8 months. Moreover, the donor cells could migrate out of the grafting site and settle along blood vessels or myelin tracts although at limited distance. Migrating donor cells down-regulated the expression of CD14 andHLA DR, suggesting the adoption of a deactivated microglia-like phenotype. Our observations establish the ability of circulating mononuclear phagocytes to integrate into the brain after transplantation and express a transgene on the long term. These cells might thus be employed for autologous transplantation for the delivery of secreted therapeutic proteins in the context of a wide range of brain affections.
文摘To investigate (1) whether ischemic preconditioning (IPC) could protect immature rabbit hearts against ischemia reperfusion injury and (2) the role of K ATP channel in the mechanism of myocardial protection Since cardioplegia is a t raditional and effective cardioprotective measure in clinic, our study is also d esigned to probe the compatibility between IPC and cardioplegia Methods New Zealand rabbits aged 14-21 days weighing 220-280 g were used The animals w ere anesthetized and heparinized The chest was opened and the heart was quickl y removed for connection of the aorta via Langendorff's method within 30 s after excision All hearts were perfused with Krebs Henseleit buffer balanced with gas mixture (O 2∶CO 2=95%∶5%) at 60 cm H 2O (perfusion pressure) IPC cons isted of 5 min global ischemia plus 10 min reperfusion Glibenclamide was used as the K ATP channel blocker at a concentration of 10 μmol/L before IPC Cardiac arrest was induced with 4℃ St Thomas cardioplegic solution, at which point the heart was made globally ischemic by withholding perfusion for 45 min f ollowed by 40 min reperfusion Thirty immature rabbit hearts were randomly divi ded into four groups: CON (n=9) was subjected to ischemia reperfusion only; IPC ( n=9) underwent IPC and ischemia reperfusion; Gli (n=6) was given glibenclamide and ischemia reperfusion; and Gli+IPC (n=6) underwent glibenclamide, IPC and is chemia reperfusion Coronary flow (CF), HR, left ventricle developed pressure (LVDP), and ±dp/dt max were monitored at equilibration (baseline value) an d 5, 1 0, 20, 30 and 40 min after reperfusion The values resulting from reperfusion w ere expressed as a percentage of their baseline values Arrhythmia quantificati on, myocardial enzyme in the coronary effluent and myocardial energy metaboli sm were also determined Results The recovery of CF, HR, LVDP and ±dp/dt max in preconditioned hearts was b est am ong the four groups The incidence of arrhythmia was low and less CK MB leaked out in the IPC group Myocardial ATP content was better preserved by IPC Pre treatment with glibenclamide completely abolished the myocardial protection prov ided by IPC, but did not affect ischemia reperfusion injury Conclusions While applying cardioplegia, IPC provides significant cardioprotective effects Activation of K ATP channels is involved in the mechanism of IPC produced cardioprotection
基金This work was financially support by the Scientific Research Program of Shanghai Maternal and Child Health Association(ZGMF-B 201908).
文摘Background Pediatric acute fulminant myocarditis(AFM)is a very dangerous disease that may lead to acute heart failure or even sudden death.Previous reports have identified some prognostic factors in adult AFM;however,there is no such research on children with AFM on venoarterial extracorporeal membrane oxygenation(VA-ECMO).This study aimed to find relevant prognostic factors for predicting adverse clinical outcomes.Methods A retrospective analysis was performed in an affiliated university children’s hospital with consecutive patients receiving VA-ECMO for AFM from July 2010 to November 2020.These children were classified into a survivor group(n=33)and a non-survivor group(n=8).Patient demographics,clinical events,laboratory findings,and electrocardiographic and echocardiographic parameters were analyzed.Results Peak serum creatinine(SCr)and peak creatine kinase isoenzyme MB during ECMO had joint predictive value for in-hospital mortality(p=0.011,AUC=0.962).Based on multivariable logistic regression analysis,peak SCr level during ECMO support was an independent predictor of in-hospital mortality(OR=1.035,95%CI 1.006 to 1.064,p=0.017,AUC=0.936,with optimal cut-off value of 78μmol/L).Conclusion Tissue hypoperfusion and consequent end-organ damage ultimately hampered the outcomes.The need for left atrial decompression indicated a sicker patient on ECMO and introduced additional risk for complications.Earlier and more cautious deployment would likely be associated with decreased risk of complications and mortality.
基金financially supported by CONICET(No.PIP11220200102064CO)ANPCYT(No.PICT 2019–02758)+1 种基金Universidad Nacional del Sur(No.PGI 24/M159)Bahía Blanca,Argentina
文摘Magnesium alloys have attracted attention due to their biocompatibility and biodegradability.In this work,composite coatings are developed to potentially improve the corrosion resistance of AZ91D Mg alloy in simulated physiological fluid.Cerium-based/stearic acid coatings were prepared by electrodeposition combined with a simple immersion method.The effect of stearic acid bath concentration on the contact angle and corrosion resistance of the composite coatings was evaluated.The results showed that the stearic acid treatment increased the hydrophobicity of the surfaces of the cerium-based simple coatings.The use of an appropriate stearic acid concentration is a key for the fabrication of hydrophobic surfaces.The duplex coatings were demonstrated to protect the substrate from corrosion in Ringer solution.
文摘Objective: To investigate the effect of Shen-Fu (SF) injection on gastrointestinal tract injury and its potential mechanism.Methods: Thirty-eight patients undergoing elective open heart surgery were assigned to Group C (control group, n = 18) and Group SF (n = 20) randomly. In Group SF, the patients received intravenous injection of SF (0.5 ml/kg) at the beginning of the surgery followed by a continuous infusion of 100 ml SF (1.0 ml/kg) solution diluted by saline at a rate of 0.004 ml · Kg-1 · min-1 with a Grasby pump. The control group was injected with normal saline in the same volume. Gastric intramucosal pH (pHi), activity of blood diamine oxidase ( DAO ), and concentrations of blood LPS and IL-6 were measured before CPB ( S0) and 1 h ( S1 ) and 2 h ( S2) after aortic declamping, respectively.Results: In Group C, pHi value was significantly lower at S1 and S2 than at S0 ( mean P <0.01) and blood DAO and concentrations of LPS and IL-6 were significantly higher at S1 and S2 than at S0 ( meanP < 0.01). In Group SF, pHi was obviously lower at S1 and S2 than at S0(P< 0.05) but LPS and IL-6 levels and DAO were higher at S, (mean P<0.05). Blood DAO and LPS level demonstrated significant negative correlations with pHi ( mean P < 0.01) while LPS concentration showed a positive correlation with blood DAO (P < 0.01) and IL-6 concentration (P < 0.05). At S1 and S2 after aortic declamping, the levels of pHi were higher in Group SF than in Group C (mean P <0.01 ) but DAO and LPS and IL-6 levels were significantly lower in Group SF than in Group C ( P <0.01).Conclusions: SF has a protective effect on gastrointestinal tract and can reduce inflammatory actions.
