BACKGROUND The global incidence of cirrhosis and luminal gastrointestinal cancers are increasing.It is unknown if cirrhosis itself is a predisposing factor for luminal gastrointestinal cancer.Such an association would...BACKGROUND The global incidence of cirrhosis and luminal gastrointestinal cancers are increasing.It is unknown if cirrhosis itself is a predisposing factor for luminal gastrointestinal cancer.Such an association would have significant clinical implications,particularly for cancer screening prior to liver transplantation.AIM To investigate the incidence of luminal gastrointestinal cancers in patients with underlying cirrhosis.METHODS An electronic search was conducted to study the incidence of luminal gastrointestinal cancers in patients with cirrhosis.Study-specific standardized incidence ratios(SIR)along with corresponding 95%CI for both overall cancer incidence and luminal cancer incidence were analyzed using a random-effects model.Subgroup analysis was performed based on cirrhosis etiology and location of luminal malignancy.RESULTS We identified 5054 articles;4 studies were selected for data extraction.The overall incidence of all cancers was significantly higher in patients with cirrhosis,with an SIR of 2.79(95%CI:2.18–3.57).When stratified by cirrhosis etiology,the incidence of luminal cancers remained significantly elevated for alcohol(SIR=3.13,95%CI:2.24–4.39),Primary Biliary Cholangitis(SIR=1.40,95%CI:1.10–1.79),and unspecified cirrhosis(SIR=3.52,95%CI:1.87–6.65).CONCLUSION The incidence of luminal gastrointestinal cancer is increased amongst patients with cirrhosis.Oral cavity,pharyngeal and esophageal cancer had increased incidence across all cirrhosis etiologies compared to gastric and colorectal cancer.Therefore,increased screening of luminal cancers,and in particular these upper luminal tract subtypes,should be considered in this population.展开更多
A new low noise interface circuit for detecting weak current of micro-sensors is designed.By using the transimpedance amplifier to substitute the charge amplifier,the closed-loop circuit can avoid the phase error of t...A new low noise interface circuit for detecting weak current of micro-sensors is designed.By using the transimpedance amplifier to substitute the charge amplifier,the closed-loop circuit can avoid the phase error of the charge amplifier.Therefore,the phase compensation devices will be cancelled,because there is no phase transformation through the transimpedance amplifier.As well as,by using CCCII devices to implement the high value feedback resistor of the impedance amplifier,the noise of the I-V transformation devices is reduced,comparing with the passive resistor.The floating resistor is easy to be integrated into chips,making the integration of the interface circuit of the intelligent sensors increase.Through the simulation,the phase error of the charge amplifier is almost 9°at 2 kHz and it changes with the working frequency of the micro-sensors making the phase compensation not easy.The value of the floating resistor is 250 kΩ where the bias current is 50 μA.The noise of the active resistor is 0.037 fV2/Hz,comparing with the noise of the passive resistor,which is 4.14 fV2/Hz.展开更多
Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological ...Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the"multiple parallel hits"theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD.展开更多
Objective To investigate the role of revascularization procedures with autologous greater saphenous vein in surgical management of iliac-femoral artery pseudoaneurysm in parenteral drug abusers. Methods Twenty-one pat...Objective To investigate the role of revascularization procedures with autologous greater saphenous vein in surgical management of iliac-femoral artery pseudoaneurysm in parenteral drug abusers. Methods Twenty-one patients with iliac-femoral artery pseudoaneurysm caused by parenteral drug abuse from 2004 to 2007 were enrolled. Among them,15 patients were male and 6 were female; their average age was 31.3 years. The size of pseudoaneurysms ranged from 3.0 cm to 7.5 cm. Common femoral artery and distal external iliac artery were often involved. We performed arterial reconstruction on these patients with autologous greater saphenous vein as a graft after excising iliac-femoral artery pseudoaneurysm through a single curved inguinal incision. All patients were followed up,and the complications were recorded. Results The surgical procedures were finished without intraoperative mortality or perioperative complications. All patients were free of claudication symptoms after the surgery except one case with preoperative popliteal artery stenosis. One case of infection and wound tissue fistula was found later. One case had inguinal incisional hematoma and another complained of numbness in thigh skin. Conclusions The use of autologous greater saphenous venous grafts for arterial reconstruction after pseudoaneurysm excision in drug abusers is safe and effective. This technique offers more advantages than arterial ligation alone without revascularization. An optimal greater saphenous venous graft is a prerequisite for revascularization.展开更多
Extensive USGS data tables and detailed,1 m2 Li DAR surveys are used to determine the optimal power n that relates discharge(Q)to stage(h*)above channel bottom(ho)at 39 gauging stations on small streams in the St.Loui...Extensive USGS data tables and detailed,1 m2 Li DAR surveys are used to determine the optimal power n that relates discharge(Q)to stage(h*)above channel bottom(ho)at 39 gauging stations on small streams in the St.Louis,Missouri area,all of which have catchments of 0.6 to 220 km2.Four different methodologies are employed to determine both n and ho:(1)optimizing linearity in a plot of Q1/n vs.local stage(hL)using USGS field measurements at each site;(2)optimizing linearity in a plot of Q1/n vs.hL using USGS rating tables at each site;(3)a mathematical inverse method applied to the same USGS rating tables;(4)use of Li DAR data on channel geometry to determine the power dependences of channel area A and hydraulic radius H on h*,combined with the Manning and rational equations to predict n.Of these methods,only methods 2 and 3 compare favorably,and these values compare poorly with Method 1 based on field data,and with method 4 based on theoretical and empirical relationships.Because Method 4 is predictive,it provides a useful alternative to methods 1–3 that are based on USGS field measurements,which are heavily weighted toward low discharges.We conclude that the apparent values of n in the USGS rating tables are systematically too low for small streams.展开更多
Climate change is the main factor affecting the country’s vulnerability,meanwhile,it is also a complicated and nonlinear dynamic system.In order to solve this complex problem,this paper first uses the analytic hierar...Climate change is the main factor affecting the country’s vulnerability,meanwhile,it is also a complicated and nonlinear dynamic system.In order to solve this complex problem,this paper first uses the analytic hierarchy process(AHP)and natural breakpoint method(NBM)to implement an AHP-NBM comprehensive evaluation model to assess the national vulnerability.By using ArcGIS,national vulnerability scores are classified and the country’s vulnerability is divided into three levels:fragile,vulnerable,and stable.Then,a BP neural network prediction model which is based on multivariate linear regression is used to predict the critical point of vulnerability.The function of the critical point of vulnerability and time is established through multiple linear regression analysis to obtain the regression equation.And the proportion of each factor in the equation is established by using the partial least-squares regression to select the main factors affecting the country’s vulnerability,and using the neural network algorithm to perform the fitting.Lastly,the BP neural network prediction model is optimized by genetic algorithm to get the chaotic time series BP neural network prediction model.In order to verify the practicability of the model,Cambodia is selected to be an example to analyze the critical point of the national vulnerability index.展开更多
A methodology is proposed to evaluate and rank potential sites for facilities dealing with hazardous materials(HAZMAT).The proposed methodology incorporates HAZMAT route planning into facility siting while considering...A methodology is proposed to evaluate and rank potential sites for facilities dealing with hazardous materials(HAZMAT).The proposed methodology incorporates HAZMAT route planning into facility siting while considering transportation preferences and challenges.The area of interest is divided into smaller zones representing potential sites for a HAZMAT facility.A multimodal transportation network including railways and roads is considered for transportation of HAZMAT.Each zone is evaluated based on its accessibility from a set of selected points of interests(POIs),which are defined as potential origin/destination points for transportation of HAZMAT.The shortest routes between each POI and potential zones are evaluated based on a cost function which can accommodate multiple criteria to determine the associated disutility for each potential zone.Finally,zones are ranked based on their cumulative disutility scores.The proposed analysis method is quantitative,and at the same time it is adequately flexible to allow inclusion of subjective criteria.Application of the proposed methodology is demonstrated for identifying optimal locations for a HAZMAT facility(e.g.,a nuclear facility)using the Canadian province of Saskatchewan as an example.Three scenarios were evaluated including(1)all network segments and POIs were treated equally,(2)network segments were rank ordered based on their functional classification while POIs were treated equally and(3)network segments were rank ordered based on their functional classification with preferences given to specific POI(s).展开更多
Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nat...Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.展开更多
Objective To investigate the application of the retroperitoneal approach in aortic surgery. Methods We collected and analyzed data of 7 patients in Macao who presented with aortic diseases from 2007 to 2008 and were t...Objective To investigate the application of the retroperitoneal approach in aortic surgery. Methods We collected and analyzed data of 7 patients in Macao who presented with aortic diseases from 2007 to 2008 and were treated with aorta repair through retroperitoneal approach. Demographic features as well as intraoperative and postoperative data were analyzed. One case of thoracoabdominal aneurysm and 4 cases of abdominal aneurysm received artificial graft, among which hybrid iliac artery reconstruction with Zenith stent covering the ostium of the left subclavian artery was performed in 2 cases of infrarenal abdominal aneurysm. Aortic-iliac artery bypass was performed in 2 cases of aortoiliac occlusion. Results No operative or early postoperative death was observed. No perioperative intestinal adhesion or ureteral obstruction was found. One case reported delayed paraplegia and graft infection as postoperative complications. The complications were partially removed 3 months later after rehabilitation. Conclusion Retroperitoneal approach is a safe and feasible technique, which associated with a low incidence of postoperative pulmonary complications.展开更多
The Early Paleoproterozoic Monchegorsk Complex is exposed over an area of 550 km;and comprises two layered mafite–ultramafite intrusions:the Monchepluton of ultramafic and mafic rocks and the predominantly gabbroid
With the objective to describe the relationship between T. cruzi infection in humans and sinantropic reservoir and vectors in the rural conditions a study was performed in municipalities of the Yucatan state in Mexico...With the objective to describe the relationship between T. cruzi infection in humans and sinantropic reservoir and vectors in the rural conditions a study was performed in municipalities of the Yucatan state in Mexico. Blood samples from humans, dogs and opossum were taken from the households. Vectors were also collected and the infection and infestation indexes were calculated. Serum samples were evaluated by indirect hemagglutination (IH) and indirect immunofluorescence (IFI) to determine IgG antibodies against Trypanosoma cruzi. The polymerase chain reaction (PCR) was also performed in the samples taken from humans and reservoirs. Blood smears were performed in reservoirs. Sampled humans underwent to an electrocardiographic study to identify functional and conduction alterations of the heart. Household building characteristics were noted. A total of 367 blood samples were collected from people. The presence of IgG antibodies was 16.6% and 71.0% at PCR. Electrocardiographic studies revealed that 31% of patients seropositive to T. cruzi have a medical condition. 20.0% of dogs were seropositive and 68.5 positive to PCR. At the direct detection 13.6% resulted positive. In opossum 29.1% were seropositive and 72.9% positive to PCR. A total of 269 triatomineos were captured and 52.7% were infected with T. cruzi. The infection and infestation index were 52.4% and 60.8% respectively. The presence of adult vectors and their nymph’s were more frequently found in households made with wattle roofs (45.2 and 73.9 % respectively) than other kind of building materials. Electrocardiographic abnormalities found in positive persons were: Incomplete right bundle branch block (55%), tachycardia (35%), old myocardial infarction (5%) and incomplete block of the left bundle (5%). This work highlights the importance of comprehensive studies on the transmission of T. cruzi in the Yucatan where the link between human infection in synanthropic reservoirs and vectors is established. This information is important to design programs for the epidemiological surveillance and control to break the chain of transmission of the disease.展开更多
On December 5,2017,CFDA issued a notice on regulating cosmetics registration and filing application(Decree No.195,2017),in order to ensure that the company information on the new version of Cosmetics Production Licens...On December 5,2017,CFDA issued a notice on regulating cosmetics registration and filing application(Decree No.195,2017),in order to ensure that the company information on the new version of Cosmetics Production License and recorded products is consistent.For approved domestic special use cosmetics,the application for the change of company info is not required when the actual production place has no change,but should apply for the change when applying for展开更多
Great changes happened to Chinese cosmetics regulations in 2017. This article focuses on the latest update of cosmetics regulations in China since 2017 and assesses how those changes will impact the import of cosmetic...Great changes happened to Chinese cosmetics regulations in 2017. This article focuses on the latest update of cosmetics regulations in China since 2017 and assesses how those changes will impact the import of cosmetics to China.Data of registered or recorded cosmetics with CFDA or local FDAs Import cosmetics by展开更多
文摘BACKGROUND The global incidence of cirrhosis and luminal gastrointestinal cancers are increasing.It is unknown if cirrhosis itself is a predisposing factor for luminal gastrointestinal cancer.Such an association would have significant clinical implications,particularly for cancer screening prior to liver transplantation.AIM To investigate the incidence of luminal gastrointestinal cancers in patients with underlying cirrhosis.METHODS An electronic search was conducted to study the incidence of luminal gastrointestinal cancers in patients with cirrhosis.Study-specific standardized incidence ratios(SIR)along with corresponding 95%CI for both overall cancer incidence and luminal cancer incidence were analyzed using a random-effects model.Subgroup analysis was performed based on cirrhosis etiology and location of luminal malignancy.RESULTS We identified 5054 articles;4 studies were selected for data extraction.The overall incidence of all cancers was significantly higher in patients with cirrhosis,with an SIR of 2.79(95%CI:2.18–3.57).When stratified by cirrhosis etiology,the incidence of luminal cancers remained significantly elevated for alcohol(SIR=3.13,95%CI:2.24–4.39),Primary Biliary Cholangitis(SIR=1.40,95%CI:1.10–1.79),and unspecified cirrhosis(SIR=3.52,95%CI:1.87–6.65).CONCLUSION The incidence of luminal gastrointestinal cancer is increased amongst patients with cirrhosis.Oral cavity,pharyngeal and esophageal cancer had increased incidence across all cirrhosis etiologies compared to gastric and colorectal cancer.Therefore,increased screening of luminal cancers,and in particular these upper luminal tract subtypes,should be considered in this population.
基金Sponsored by the National High Technology Research Development Plan of China(Grant No.2008AA042201)
文摘A new low noise interface circuit for detecting weak current of micro-sensors is designed.By using the transimpedance amplifier to substitute the charge amplifier,the closed-loop circuit can avoid the phase error of the charge amplifier.Therefore,the phase compensation devices will be cancelled,because there is no phase transformation through the transimpedance amplifier.As well as,by using CCCII devices to implement the high value feedback resistor of the impedance amplifier,the noise of the I-V transformation devices is reduced,comparing with the passive resistor.The floating resistor is easy to be integrated into chips,making the integration of the interface circuit of the intelligent sensors increase.Through the simulation,the phase error of the charge amplifier is almost 9°at 2 kHz and it changes with the working frequency of the micro-sensors making the phase compensation not easy.The value of the floating resistor is 250 kΩ where the bias current is 50 μA.The noise of the active resistor is 0.037 fV2/Hz,comparing with the noise of the passive resistor,which is 4.14 fV2/Hz.
文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the"multiple parallel hits"theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD.
文摘Objective To investigate the role of revascularization procedures with autologous greater saphenous vein in surgical management of iliac-femoral artery pseudoaneurysm in parenteral drug abusers. Methods Twenty-one patients with iliac-femoral artery pseudoaneurysm caused by parenteral drug abuse from 2004 to 2007 were enrolled. Among them,15 patients were male and 6 were female; their average age was 31.3 years. The size of pseudoaneurysms ranged from 3.0 cm to 7.5 cm. Common femoral artery and distal external iliac artery were often involved. We performed arterial reconstruction on these patients with autologous greater saphenous vein as a graft after excising iliac-femoral artery pseudoaneurysm through a single curved inguinal incision. All patients were followed up,and the complications were recorded. Results The surgical procedures were finished without intraoperative mortality or perioperative complications. All patients were free of claudication symptoms after the surgery except one case with preoperative popliteal artery stenosis. One case of infection and wound tissue fistula was found later. One case had inguinal incisional hematoma and another complained of numbness in thigh skin. Conclusions The use of autologous greater saphenous venous grafts for arterial reconstruction after pseudoaneurysm excision in drug abusers is safe and effective. This technique offers more advantages than arterial ligation alone without revascularization. An optimal greater saphenous venous graft is a prerequisite for revascularization.
基金the Jet Propulsion Laboratory,California Institute of Technology。
文摘Extensive USGS data tables and detailed,1 m2 Li DAR surveys are used to determine the optimal power n that relates discharge(Q)to stage(h*)above channel bottom(ho)at 39 gauging stations on small streams in the St.Louis,Missouri area,all of which have catchments of 0.6 to 220 km2.Four different methodologies are employed to determine both n and ho:(1)optimizing linearity in a plot of Q1/n vs.local stage(hL)using USGS field measurements at each site;(2)optimizing linearity in a plot of Q1/n vs.hL using USGS rating tables at each site;(3)a mathematical inverse method applied to the same USGS rating tables;(4)use of Li DAR data on channel geometry to determine the power dependences of channel area A and hydraulic radius H on h*,combined with the Manning and rational equations to predict n.Of these methods,only methods 2 and 3 compare favorably,and these values compare poorly with Method 1 based on field data,and with method 4 based on theoretical and empirical relationships.Because Method 4 is predictive,it provides a useful alternative to methods 1–3 that are based on USGS field measurements,which are heavily weighted toward low discharges.We conclude that the apparent values of n in the USGS rating tables are systematically too low for small streams.
文摘Climate change is the main factor affecting the country’s vulnerability,meanwhile,it is also a complicated and nonlinear dynamic system.In order to solve this complex problem,this paper first uses the analytic hierarchy process(AHP)and natural breakpoint method(NBM)to implement an AHP-NBM comprehensive evaluation model to assess the national vulnerability.By using ArcGIS,national vulnerability scores are classified and the country’s vulnerability is divided into three levels:fragile,vulnerable,and stable.Then,a BP neural network prediction model which is based on multivariate linear regression is used to predict the critical point of vulnerability.The function of the critical point of vulnerability and time is established through multiple linear regression analysis to obtain the regression equation.And the proportion of each factor in the equation is established by using the partial least-squares regression to select the main factors affecting the country’s vulnerability,and using the neural network algorithm to perform the fitting.Lastly,the BP neural network prediction model is optimized by genetic algorithm to get the chaotic time series BP neural network prediction model.In order to verify the practicability of the model,Cambodia is selected to be an example to analyze the critical point of the national vulnerability index.
基金supported by Sylvia Fedoruk Canadian Centre for Nuclear Innovation
文摘A methodology is proposed to evaluate and rank potential sites for facilities dealing with hazardous materials(HAZMAT).The proposed methodology incorporates HAZMAT route planning into facility siting while considering transportation preferences and challenges.The area of interest is divided into smaller zones representing potential sites for a HAZMAT facility.A multimodal transportation network including railways and roads is considered for transportation of HAZMAT.Each zone is evaluated based on its accessibility from a set of selected points of interests(POIs),which are defined as potential origin/destination points for transportation of HAZMAT.The shortest routes between each POI and potential zones are evaluated based on a cost function which can accommodate multiple criteria to determine the associated disutility for each potential zone.Finally,zones are ranked based on their cumulative disutility scores.The proposed analysis method is quantitative,and at the same time it is adequately flexible to allow inclusion of subjective criteria.Application of the proposed methodology is demonstrated for identifying optimal locations for a HAZMAT facility(e.g.,a nuclear facility)using the Canadian province of Saskatchewan as an example.Three scenarios were evaluated including(1)all network segments and POIs were treated equally,(2)network segments were rank ordered based on their functional classification while POIs were treated equally and(3)network segments were rank ordered based on their functional classification with preferences given to specific POI(s).
文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas.
文摘Objective To investigate the application of the retroperitoneal approach in aortic surgery. Methods We collected and analyzed data of 7 patients in Macao who presented with aortic diseases from 2007 to 2008 and were treated with aorta repair through retroperitoneal approach. Demographic features as well as intraoperative and postoperative data were analyzed. One case of thoracoabdominal aneurysm and 4 cases of abdominal aneurysm received artificial graft, among which hybrid iliac artery reconstruction with Zenith stent covering the ostium of the left subclavian artery was performed in 2 cases of infrarenal abdominal aneurysm. Aortic-iliac artery bypass was performed in 2 cases of aortoiliac occlusion. Results No operative or early postoperative death was observed. No perioperative intestinal adhesion or ureteral obstruction was found. One case reported delayed paraplegia and graft infection as postoperative complications. The complications were partially removed 3 months later after rehabilitation. Conclusion Retroperitoneal approach is a safe and feasible technique, which associated with a low incidence of postoperative pulmonary complications.
文摘The Early Paleoproterozoic Monchegorsk Complex is exposed over an area of 550 km;and comprises two layered mafite–ultramafite intrusions:the Monchepluton of ultramafic and mafic rocks and the predominantly gabbroid
文摘With the objective to describe the relationship between T. cruzi infection in humans and sinantropic reservoir and vectors in the rural conditions a study was performed in municipalities of the Yucatan state in Mexico. Blood samples from humans, dogs and opossum were taken from the households. Vectors were also collected and the infection and infestation indexes were calculated. Serum samples were evaluated by indirect hemagglutination (IH) and indirect immunofluorescence (IFI) to determine IgG antibodies against Trypanosoma cruzi. The polymerase chain reaction (PCR) was also performed in the samples taken from humans and reservoirs. Blood smears were performed in reservoirs. Sampled humans underwent to an electrocardiographic study to identify functional and conduction alterations of the heart. Household building characteristics were noted. A total of 367 blood samples were collected from people. The presence of IgG antibodies was 16.6% and 71.0% at PCR. Electrocardiographic studies revealed that 31% of patients seropositive to T. cruzi have a medical condition. 20.0% of dogs were seropositive and 68.5 positive to PCR. At the direct detection 13.6% resulted positive. In opossum 29.1% were seropositive and 72.9% positive to PCR. A total of 269 triatomineos were captured and 52.7% were infected with T. cruzi. The infection and infestation index were 52.4% and 60.8% respectively. The presence of adult vectors and their nymph’s were more frequently found in households made with wattle roofs (45.2 and 73.9 % respectively) than other kind of building materials. Electrocardiographic abnormalities found in positive persons were: Incomplete right bundle branch block (55%), tachycardia (35%), old myocardial infarction (5%) and incomplete block of the left bundle (5%). This work highlights the importance of comprehensive studies on the transmission of T. cruzi in the Yucatan where the link between human infection in synanthropic reservoirs and vectors is established. This information is important to design programs for the epidemiological surveillance and control to break the chain of transmission of the disease.
文摘On December 5,2017,CFDA issued a notice on regulating cosmetics registration and filing application(Decree No.195,2017),in order to ensure that the company information on the new version of Cosmetics Production License and recorded products is consistent.For approved domestic special use cosmetics,the application for the change of company info is not required when the actual production place has no change,but should apply for the change when applying for
文摘Great changes happened to Chinese cosmetics regulations in 2017. This article focuses on the latest update of cosmetics regulations in China since 2017 and assesses how those changes will impact the import of cosmetics to China.Data of registered or recorded cosmetics with CFDA or local FDAs Import cosmetics by
