Still common in developing countries, acute rheumatic fever (ARF) is not only a disease of children and adolescents, but can also occur in adults. At this age, the diagnosis of rheumatic flare-ups can be difficult due...Still common in developing countries, acute rheumatic fever (ARF) is not only a disease of children and adolescents, but can also occur in adults. At this age, the diagnosis of rheumatic flare-ups can be difficult due to the frequency of other types of joint diseases and the existence of degenerative and dystrophic valve disease. In adults, the initial rheumatic attack is marked by the predominance of joint damage over cardiac damage. However, it is often at this age that rheumatic valve disease is discovered. The revised Jones criteria also find their place in the diagnosis of AAR in adults. Objective: To study the demographic, clinical, and biological characteristics of acute rheumatic fever (ARF) in the General Medicine Department of the Siguiri Prefectural Hospital. Materials and Methods: This descriptive observational study examined the demographic, clinical and biological characteristics of acute rheumatic fever (ARF) at the Siguiri Prefectural Hospital, Guinea, between April 1 and September 31, 2021 according to Jones criteria. The data were collected on a form containing sociodemographic variables (age, sex, profession), rheumatological, cardiac, pulmonary and neurological clinical signs, biological variables and treatment. Results: Figure 1 shows the flow of the hospital frequency of the RAA in the General Medicine Department of the Prefectural Hospital of Siguiri. During the study period, 420 patients were hospitalized, of whom 161 patients had AAR, a frequency of 38.33%. Table 1 shows the distribution of patients diagnosed with ARB, by sociodemographic characteristics. The average age was 44.7 ± 19.78 years and the extremes of 14 and 90 years, the female sex dominated with a ratio of 0.75. The informal sector was in the majority in 45.34% of cases and most were illiterate, i.e. 53.42%. In our study, the incidence was lower during the dry season than during the rainy season, a hot season with high rainfall and humidity, the rainy period was a provider with a peak in August and September. The lifestyle was characterized by overcrowding in 87.58% of patients. The main complaint was fever, i.e. 88.82%. Rheumatological manifestations such as arthritis were 98.14%, chest pain was 37.89% (61 cases). The diagnosis was confirmed by ASLO titration in 85.71% of patients and 98.55% (136 cases) had a titration greater than 400 U/ml. Conclusion: The results obtained from our study show a high prevalence of acute rheumatic fever, which makes it a worrying health problem in the Siguiri health district. Young female adult patients, married with an informal profession and not in school residing in Siguiri were the most encountered in our study. The main functional signs mentioned by the patients were fever, cough and abdominal pain;osteoarticular pain and chest pain dominated the clinical picture. Almost all of our patients had an ASLO titer greater than 400 U/ml and a positive C-reactive protein. Our results show a high risk of spread of acute rheumatic fever within the population of Siguiri. Due to the serious complications caused by acute rheumatic fever, particular attention must be paid to it by carrying out other, much larger studies in order to identify the problem of RAA.展开更多
Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to ...Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to produce satisfa ctory effects.Therefore,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of ORM.In this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s disease.Furthermore,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM deficits.These findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s disease.Therefore,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.展开更多
BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an epiphenomenon.This study aimed to investigate the clinical and analytical features and the APOE genotypes in ...BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an epiphenomenon.This study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe hypertriglyceridemia.METHODS:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum triglycerides.The APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being taken.The patients’ progression,etiological diagnosis,hospital stay and clinical and radiological severity were all recorded.RESULTS:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) origin.Compared with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes mellitus.They usually consumed alcohol or consumed it excessively on the days before admission.Also,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption.展开更多
Surface modification is often performed using grit or shot blasting treatment for improving the performances of biomedical implants. The effects of blasting treatments using steel slag balls and spherical shots on the...Surface modification is often performed using grit or shot blasting treatment for improving the performances of biomedical implants. The effects of blasting treatments using steel slag balls and spherical shots on the surface and subsurface of titanium were studied in this paper. The treatments were conducted for 60-300 s using 2-5 mm steel slag bails and 3.18 mm spherical shots. The surface morphology, roughness, and elemental composition of titanium specimens were examined prior to and after the treatments. Irregular and rough titanium surfaces were formed after the treatment with the steel slag balls instead of the spherical shots. The former treatment also introduced some bioactive elements on the titanium surface, but the latter one yielded a harder surface layer. In conclusion, both steel slag ball and shot blasting treatment have their own specialization in modifying the surface of metallic biomaterials. Steel slag ball blasting is potential for improving the osseointegration quality of implants; but the shot blasting is more appropriate for improving the mechanical properties of temporary and load bearing implants, such as osteosynthesis plates.展开更多
The aim of this work is to investigate the effect of cold working and sandblasting on the microhardness, tensile strength and corro-sion rate of AISI 316L stainless steel. The specimens were deformed from 17% to 47% a...The aim of this work is to investigate the effect of cold working and sandblasting on the microhardness, tensile strength and corro-sion rate of AISI 316L stainless steel. The specimens were deformed from 17% to 47% and sandblasted for 20 min using SiC particles with a diameter of 500-700 μm and an air flow with 0.6-0.7 MPa pressure. The microhardness distribution and tensile test were conducted and a measurement on the corrosion current density was done to determine the corrosion rate of the specimens. The result shows that the cold working enhances the bulk microhardness, tensile and yield strength of the specimen by the degree of deformation applied in the treatment. The sandblasting treatment increases the microhardness only at the surface of the specimen without or with a low degree of deformation. In addition, the sandblasting enhances the surface roughness. The corrosion resistance is improved by cold working, especially for the highly deformed specimen. However the follow-up sandblasting treatment reduces the corrosion resistance. In conclusion, the cold working is prominent to be used for improving the mechanical properties and corrosion resistance of AISI 316L stainless steel. Meanwhile, the sandblasting subjected to the cold worked steel is only useful for surface texturing instead of improving the mechanical properties and corrosion resistance.展开更多
Intact memory function is critical for carrying out daily life activities,such as managing finances,remembering to take medications,driving in familiar environments,remembering a grandchild’s birthday,and learning to...Intact memory function is critical for carrying out daily life activities,such as managing finances,remembering to take medications,driving in familiar environments,remembering a grandchild’s birthday,and learning to use a new computer.However,memory deficits not only accompany normal aging but are also comorbid with many psychiatric,neurological,and neurodegenerative diseases.Intellectual disability,autism,attention deficit disorder,learning disability,schizophrenia,and depression all have memory deficit components,as do Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and other neurodegenerative diseases(Khan et al.,2014).Therefore,a large proportion of the human population is affected by this brain disorder.展开更多
The aim of our work was to establish the diagnostic difficulty of isolated nonspecific retroperitoneal congestive adenitis on medical imaging. Patient: This is a 27-year-old patient from a district located 660 km from...The aim of our work was to establish the diagnostic difficulty of isolated nonspecific retroperitoneal congestive adenitis on medical imaging. Patient: This is a 27-year-old patient from a district located 660 km from Bamako with no known medical history or notion of travel. The onset of the disease dates back to 3 years marked by pain in the right hypochondrium and the epigastrium radiating to the back in the form of torsion, of medium intensity associated with periodic vomiting and jaundice. She was referred to the medical imaging department for pain in the right hypochondrium and cholestatic jaundice. The abdominal CT scan with and without contrast injection showed an oval retroperitoneal mass, with regular contours sitting behind the head of the pancreas and in front of the right kidney with its hypo-dense center of density equal to 23 HU measuring 44 × 28 mm, with a thick wall enhanced after injection of contrast product. It was associated with a distended gallbladder with a thin wall and hypo-dense content and a moderate dilation of the intrahepatic bile ducts. Following these examinations, the diagnostic hypothesis of cystic dilation of the common bile duct was retained. Surgery made it possible to cure the retroperitoneal lesion, discectomy of the gallbladder and biopsy of the lesions. The histological examination made it possible to make the diagnosis of isolated nonspecific reactive congestive adenitis. Conclusion: Isolated nonspecific congestive retropancreatic adenitis with a necrotic center poses a diagnostic problem for imaging in our environment because of its similarity to the bile duct cyst. This study, which is a very illustrative case, showed us a diagnostic discrepancy between the result of cross-sectional imaging and that of surgery and pathology.展开更多
Two populations of the kentrurostylid ciliate Pseudokeronopsis erythrina Chen et al.,2011 were isolated from a brackish wastewater treatment plant,Pisa,Italy and from a nutrient-rich freshwater body,the East Lake,Wuha...Two populations of the kentrurostylid ciliate Pseudokeronopsis erythrina Chen et al.,2011 were isolated from a brackish wastewater treatment plant,Pisa,Italy and from a nutrient-rich freshwater body,the East Lake,Wuhan,China.The populations were thoroughly investigated for their morphology,focusing on cell body plasticity.The study was supplemented with 18S rDNA phylogenetic analysis and mitogenome sequencing,following the integrative taxonomy approach.The Italian population possesses a great variation in terms of the frontal area,and the numbers of left marginal rows,and dorsal kineties.Additionally,the number of left marginal anlagen and dorsal kineties anlagen varied.For instance,additional small anlagen appeared in the left marginal rows,and two dorsal kineties anlagen derived from a single dorsal kinety.The Wuhan population resembled the type population(originally isolated from Guangzhou,China),differing only by the presence of an extra dorsal kinety.The existence of giant individuals characterized both new populations of P.erythrina although with some differences in their respective frequency and features.The 18S rDNA sequences of the Italian,Wuhan,and type populations were identical.Phylogenetic analyses showed that these three populations formed a distinct cluster within the clade containing P.songi,P.parasongi,and P.flava.The structure of the P.erythrina mitochondrial genome is also provided.The content of this genome closely resembled Pseudourostyla cristata,except for the absence of genes nadh3 and nadh6.Our findings suggest that the Wuhan population represents an intermediate form between the type and Italian populations.The greater morphological plasticity observed in the Italian population underscores the importance of molecular data and integrative analyses in species identification.展开更多
High-quality and large-scale growth of monolayer molybdenum disulfide(MoS2)has caught intensive attention because of its potential in many applications due to unique electronic properties.Here,we report the wafer-scal...High-quality and large-scale growth of monolayer molybdenum disulfide(MoS2)has caught intensive attention because of its potential in many applications due to unique electronic properties.Here,we report the wafer-scale growth of high-quality mono layer MoS2 on singlecrystalline sapphire and also on SiO2 substrates by a facile metal-organic chemical vapor deposit!on(MOCVD)method.Prior to growth,an aqueous solution of sodium molybdate(Na2MoO4)is spun onto the substrates as the molybdenum precursor and diethyl sulfide((C2H5)2S)is used as the sulfur precursor duri ng the growth.The grown MoS2 films exhibit crystal I i nity,good electrical performa nee(electro n mobility of 22 cm2·V^-1·s^-1)and structural continuity maintained over the entire wafer.The sapphire substrates are reusable for subsequent growth.The same method is applied for the synthesis of tungsten disulfide(WS2).Our work provides a facile,reproducible and cost-efficient method for the scalable fabricati on of high-quality mono layer MoS2 for versatile applicati ons,such as electro nic and optoelectr onic devices as well as the membranes for desalination and power generation.展开更多
Carbon micro-and nanoelectrodes fabricated by carbon microelectromechanical systems(carbon MEMS)are increasingly used in various biosensors and supercapacitor applications.Surface modification of as-produced carbon el...Carbon micro-and nanoelectrodes fabricated by carbon microelectromechanical systems(carbon MEMS)are increasingly used in various biosensors and supercapacitor applications.Surface modification of as-produced carbon electrodes with oxygen functional groups is sometimes necessary for biofunctionalization or to improve electrochemical properties.However,conventional surface treatment methods have a limited ability for selective targeting of parts of a surface area for surface modification without using complex photoresist masks.Here,we report microplasma direct writing as a simple,low-cost,and low-power technique for site-selective plasma patterning of carbon MEMS electrodes with oxygen functionalities.In microplasma direct writing,a high-voltage source generates a microplasma discharge between a microelectrode tip and a target surface held at atmospheric pressure.In our setup,water vapor acts as an ionic precursor for the carboxylation and hydroxylation of carbon surface atoms.Plasma direct writing increases the oxygen content of an SU-8-derived pyrolytic carbon surface from~3 to 27%while reducing the carbon-to-oxygen ratio from 35 to 2.75.Specifically,a microplasma treatment increases the number of carbonyl,carboxylic,and hydroxyl functional groups with the largest increase observed for carboxylic functionalities.Furthermore,water microplasma direct writing improves the hydrophilicity and the electrochemical performance of carbon electrodes with a contact-angle change from~90°to~20°,a reduction in the anodic peak to cathodic peak separation from 0.5 V to 0.17 V,and a 5-fold increase in specific capacitance from 8.82 mF∙cm−2 to 46.64 mF∙cm^(−2).The plasma direct-writing technology provides an efficient and easy-to-implement method for the selective surface functionalization of carbon MEMS electrodes for electrochemical and biosensor applications.展开更多
文摘Still common in developing countries, acute rheumatic fever (ARF) is not only a disease of children and adolescents, but can also occur in adults. At this age, the diagnosis of rheumatic flare-ups can be difficult due to the frequency of other types of joint diseases and the existence of degenerative and dystrophic valve disease. In adults, the initial rheumatic attack is marked by the predominance of joint damage over cardiac damage. However, it is often at this age that rheumatic valve disease is discovered. The revised Jones criteria also find their place in the diagnosis of AAR in adults. Objective: To study the demographic, clinical, and biological characteristics of acute rheumatic fever (ARF) in the General Medicine Department of the Siguiri Prefectural Hospital. Materials and Methods: This descriptive observational study examined the demographic, clinical and biological characteristics of acute rheumatic fever (ARF) at the Siguiri Prefectural Hospital, Guinea, between April 1 and September 31, 2021 according to Jones criteria. The data were collected on a form containing sociodemographic variables (age, sex, profession), rheumatological, cardiac, pulmonary and neurological clinical signs, biological variables and treatment. Results: Figure 1 shows the flow of the hospital frequency of the RAA in the General Medicine Department of the Prefectural Hospital of Siguiri. During the study period, 420 patients were hospitalized, of whom 161 patients had AAR, a frequency of 38.33%. Table 1 shows the distribution of patients diagnosed with ARB, by sociodemographic characteristics. The average age was 44.7 ± 19.78 years and the extremes of 14 and 90 years, the female sex dominated with a ratio of 0.75. The informal sector was in the majority in 45.34% of cases and most were illiterate, i.e. 53.42%. In our study, the incidence was lower during the dry season than during the rainy season, a hot season with high rainfall and humidity, the rainy period was a provider with a peak in August and September. The lifestyle was characterized by overcrowding in 87.58% of patients. The main complaint was fever, i.e. 88.82%. Rheumatological manifestations such as arthritis were 98.14%, chest pain was 37.89% (61 cases). The diagnosis was confirmed by ASLO titration in 85.71% of patients and 98.55% (136 cases) had a titration greater than 400 U/ml. Conclusion: The results obtained from our study show a high prevalence of acute rheumatic fever, which makes it a worrying health problem in the Siguiri health district. Young female adult patients, married with an informal profession and not in school residing in Siguiri were the most encountered in our study. The main functional signs mentioned by the patients were fever, cough and abdominal pain;osteoarticular pain and chest pain dominated the clinical picture. Almost all of our patients had an ASLO titer greater than 400 U/ml and a positive C-reactive protein. Our results show a high risk of spread of acute rheumatic fever within the population of Siguiri. Due to the serious complications caused by acute rheumatic fever, particular attention must be paid to it by carrying out other, much larger studies in order to identify the problem of RAA.
基金supported by grants from the Ministerio de Economia y Competitividad(BFU2013-43458-R)Junta de Andalucia(P12-CTS-1694 and Proyexcel-00422)to ZUK。
文摘Memory deficit,which is often associated with aging and many psychiatric,neurological,and neurodegenerative diseases,has been a challenging issue for treatment.Up till now,all potential drug candidates have failed to produce satisfa ctory effects.Therefore,in the search for a solution,we found that a treatment with the gene corresponding to the RGS14414protein in visual area V2,a brain area connected with brain circuits of the ventral stream and the medial temporal lobe,which is crucial for object recognition memory(ORM),can induce enhancement of ORM.In this study,we demonstrated that the same treatment with RGS14414in visual area V2,which is relatively unaffected in neurodegenerative diseases such as Alzheimer s disease,produced longlasting enhancement of ORM in young animals and prevent ORM deficits in rodent models of aging and Alzheimer’s disease.Furthermore,we found that the prevention of memory deficits was mediated through the upregulation of neuronal arbo rization and spine density,as well as an increase in brain-derived neurotrophic factor(BDNF).A knockdown of BDNF gene in RGS14414-treated aging rats and Alzheimer s disease model mice caused complete loss in the upregulation of neuronal structural plasticity and in the prevention of ORM deficits.These findings suggest that BDNF-mediated neuronal structural plasticity in area V2 is crucial in the prevention of memory deficits in RGS14414-treated rodent models of aging and Alzheimer’s disease.Therefore,our findings of RGS14414gene-mediated activation of neuronal circuits in visual area V2 have therapeutic relevance in the treatment of memory deficits.
基金supported by a grant from Grupos de Investigacion y Desarrollo Tecnologico de la Junta de Andalucía(Grupo consolidado CTS-159)
文摘BACKGROUND:Hypertriglyceridemia is an unusual cause of acute pancreatitis and sometimes considered to be an epiphenomenon.This study aimed to investigate the clinical and analytical features and the APOE genotypes in patients with acute pancreatitis and severe hypertriglyceridemia.METHODS:We undertook a one-year,prospective study of patients with acute pancreatitis whose first laboratory analysis on admission to the emergency department included measurement of serum triglycerides.The APOE genotype was determined and the patients answered an established questionnaire within the first 24 hours concerning their alcohol consumption,the presence of co-morbidities and any medications being taken.The patients’ progression,etiological diagnosis,hospital stay and clinical and radiological severity were all recorded.RESULTS:Hypertriglyceridemia was responsible for 7 of 133 cases of pancreatitis (5%);the remaining cases were of biliary (53%),idiopathic (26%),alcoholic (11%) or other (5%) origin.Compared with these remaining cases,the patients with hypertriglyceridemia were significantly younger,had more relapses,and more often had diabetes mellitus.They usually consumed alcohol or consumed it excessively on the days before admission.Also,the ε4 allele of the APOE gene was more common in this group (P<0.05).CONCLUSION:One of 20 episodes of acute pancreatitis is caused by hypertriglyceridemia and it is linked to genetic (ε4 allele) and comorbid factors such as diabetes and,especially,alcohol consumption.
基金financially funded by the Institute for Research and Community Service,Gadjah Mada University,Indonesia,through Research Grant for Junior Lecturer 2012 (Grant No. LPPM-UGM/315/BID.I/2012)
文摘Surface modification is often performed using grit or shot blasting treatment for improving the performances of biomedical implants. The effects of blasting treatments using steel slag balls and spherical shots on the surface and subsurface of titanium were studied in this paper. The treatments were conducted for 60-300 s using 2-5 mm steel slag bails and 3.18 mm spherical shots. The surface morphology, roughness, and elemental composition of titanium specimens were examined prior to and after the treatments. Irregular and rough titanium surfaces were formed after the treatment with the steel slag balls instead of the spherical shots. The former treatment also introduced some bioactive elements on the titanium surface, but the latter one yielded a harder surface layer. In conclusion, both steel slag ball and shot blasting treatment have their own specialization in modifying the surface of metallic biomaterials. Steel slag ball blasting is potential for improving the osseointegration quality of implants; but the shot blasting is more appropriate for improving the mechanical properties of temporary and load bearing implants, such as osteosynthesis plates.
文摘The aim of this work is to investigate the effect of cold working and sandblasting on the microhardness, tensile strength and corro-sion rate of AISI 316L stainless steel. The specimens were deformed from 17% to 47% and sandblasted for 20 min using SiC particles with a diameter of 500-700 μm and an air flow with 0.6-0.7 MPa pressure. The microhardness distribution and tensile test were conducted and a measurement on the corrosion current density was done to determine the corrosion rate of the specimens. The result shows that the cold working enhances the bulk microhardness, tensile and yield strength of the specimen by the degree of deformation applied in the treatment. The sandblasting treatment increases the microhardness only at the surface of the specimen without or with a low degree of deformation. In addition, the sandblasting enhances the surface roughness. The corrosion resistance is improved by cold working, especially for the highly deformed specimen. However the follow-up sandblasting treatment reduces the corrosion resistance. In conclusion, the cold working is prominent to be used for improving the mechanical properties and corrosion resistance of AISI 316L stainless steel. Meanwhile, the sandblasting subjected to the cold worked steel is only useful for surface texturing instead of improving the mechanical properties and corrosion resistance.
基金supported by grants from the Ministerio de Economía y Competitividad(BFU2013-43458-R)Junta de Andalucía(P12-CTS-1694, PI-0542-2013 and CTS-586)to ZUK
文摘Intact memory function is critical for carrying out daily life activities,such as managing finances,remembering to take medications,driving in familiar environments,remembering a grandchild’s birthday,and learning to use a new computer.However,memory deficits not only accompany normal aging but are also comorbid with many psychiatric,neurological,and neurodegenerative diseases.Intellectual disability,autism,attention deficit disorder,learning disability,schizophrenia,and depression all have memory deficit components,as do Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and other neurodegenerative diseases(Khan et al.,2014).Therefore,a large proportion of the human population is affected by this brain disorder.
文摘The aim of our work was to establish the diagnostic difficulty of isolated nonspecific retroperitoneal congestive adenitis on medical imaging. Patient: This is a 27-year-old patient from a district located 660 km from Bamako with no known medical history or notion of travel. The onset of the disease dates back to 3 years marked by pain in the right hypochondrium and the epigastrium radiating to the back in the form of torsion, of medium intensity associated with periodic vomiting and jaundice. She was referred to the medical imaging department for pain in the right hypochondrium and cholestatic jaundice. The abdominal CT scan with and without contrast injection showed an oval retroperitoneal mass, with regular contours sitting behind the head of the pancreas and in front of the right kidney with its hypo-dense center of density equal to 23 HU measuring 44 × 28 mm, with a thick wall enhanced after injection of contrast product. It was associated with a distended gallbladder with a thin wall and hypo-dense content and a moderate dilation of the intrahepatic bile ducts. Following these examinations, the diagnostic hypothesis of cystic dilation of the common bile duct was retained. Surgery made it possible to cure the retroperitoneal lesion, discectomy of the gallbladder and biopsy of the lesions. The histological examination made it possible to make the diagnosis of isolated nonspecific reactive congestive adenitis. Conclusion: Isolated nonspecific congestive retropancreatic adenitis with a necrotic center poses a diagnostic problem for imaging in our environment because of its similarity to the bile duct cyst. This study, which is a very illustrative case, showed us a diagnostic discrepancy between the result of cross-sectional imaging and that of surgery and pathology.
基金supported by the European Commission H2020-MSCA-RISE 2019(872767)the National Natural Science Foundation of China(32370475)+1 种基金the Biological taxonomist,Chinese Academy of Sciences(CAS-TAX-24-037)by the University of Pisa,PRA_2018_63 project.
文摘Two populations of the kentrurostylid ciliate Pseudokeronopsis erythrina Chen et al.,2011 were isolated from a brackish wastewater treatment plant,Pisa,Italy and from a nutrient-rich freshwater body,the East Lake,Wuhan,China.The populations were thoroughly investigated for their morphology,focusing on cell body plasticity.The study was supplemented with 18S rDNA phylogenetic analysis and mitogenome sequencing,following the integrative taxonomy approach.The Italian population possesses a great variation in terms of the frontal area,and the numbers of left marginal rows,and dorsal kineties.Additionally,the number of left marginal anlagen and dorsal kineties anlagen varied.For instance,additional small anlagen appeared in the left marginal rows,and two dorsal kineties anlagen derived from a single dorsal kinety.The Wuhan population resembled the type population(originally isolated from Guangzhou,China),differing only by the presence of an extra dorsal kinety.The existence of giant individuals characterized both new populations of P.erythrina although with some differences in their respective frequency and features.The 18S rDNA sequences of the Italian,Wuhan,and type populations were identical.Phylogenetic analyses showed that these three populations formed a distinct cluster within the clade containing P.songi,P.parasongi,and P.flava.The structure of the P.erythrina mitochondrial genome is also provided.The content of this genome closely resembled Pseudourostyla cristata,except for the absence of genes nadh3 and nadh6.Our findings suggest that the Wuhan population represents an intermediate form between the type and Italian populations.The greater morphological plasticity observed in the Italian population underscores the importance of molecular data and integrative analyses in species identification.
文摘High-quality and large-scale growth of monolayer molybdenum disulfide(MoS2)has caught intensive attention because of its potential in many applications due to unique electronic properties.Here,we report the wafer-scale growth of high-quality mono layer MoS2 on singlecrystalline sapphire and also on SiO2 substrates by a facile metal-organic chemical vapor deposit!on(MOCVD)method.Prior to growth,an aqueous solution of sodium molybdate(Na2MoO4)is spun onto the substrates as the molybdenum precursor and diethyl sulfide((C2H5)2S)is used as the sulfur precursor duri ng the growth.The grown MoS2 films exhibit crystal I i nity,good electrical performa nee(electro n mobility of 22 cm2·V^-1·s^-1)and structural continuity maintained over the entire wafer.The sapphire substrates are reusable for subsequent growth.The same method is applied for the synthesis of tungsten disulfide(WS2).Our work provides a facile,reproducible and cost-efficient method for the scalable fabricati on of high-quality mono layer MoS2 for versatile applicati ons,such as electro nic and optoelectr onic devices as well as the membranes for desalination and power generation.
基金This research is supported by the Transdisciplinary Research Grant Scheme(TR002A-2014B)University of Malaya Flagship Grant(FL001A-14AET),and Faculty of Engineering Research Grant(GPF041A-2018)。
文摘Carbon micro-and nanoelectrodes fabricated by carbon microelectromechanical systems(carbon MEMS)are increasingly used in various biosensors and supercapacitor applications.Surface modification of as-produced carbon electrodes with oxygen functional groups is sometimes necessary for biofunctionalization or to improve electrochemical properties.However,conventional surface treatment methods have a limited ability for selective targeting of parts of a surface area for surface modification without using complex photoresist masks.Here,we report microplasma direct writing as a simple,low-cost,and low-power technique for site-selective plasma patterning of carbon MEMS electrodes with oxygen functionalities.In microplasma direct writing,a high-voltage source generates a microplasma discharge between a microelectrode tip and a target surface held at atmospheric pressure.In our setup,water vapor acts as an ionic precursor for the carboxylation and hydroxylation of carbon surface atoms.Plasma direct writing increases the oxygen content of an SU-8-derived pyrolytic carbon surface from~3 to 27%while reducing the carbon-to-oxygen ratio from 35 to 2.75.Specifically,a microplasma treatment increases the number of carbonyl,carboxylic,and hydroxyl functional groups with the largest increase observed for carboxylic functionalities.Furthermore,water microplasma direct writing improves the hydrophilicity and the electrochemical performance of carbon electrodes with a contact-angle change from~90°to~20°,a reduction in the anodic peak to cathodic peak separation from 0.5 V to 0.17 V,and a 5-fold increase in specific capacitance from 8.82 mF∙cm−2 to 46.64 mF∙cm^(−2).The plasma direct-writing technology provides an efficient and easy-to-implement method for the selective surface functionalization of carbon MEMS electrodes for electrochemical and biosensor applications.
