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人乳头瘤病毒6b L1 VLPs免疫治疗生殖道尖锐湿疣的初步研究 被引量:1
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作者 张丽芳 周健 +1 位作者 陈韶 蔡莲莲 《温州医学院学报》 CAS 2007年第5期415-418,共4页
目的:研究人乳头瘤病毒(HPV)6b型L1蛋白形成的病毒样颗粒(VLPs)对女性生殖道复发性尖锐湿疣(CA)的免疫治疗作用。方法:采用HPV6bL1VLPs1μg、5μg、10μg3组剂量经0w、4w、8w免疫18例CA复发患者。分别用ELISA法和迟发性超敏反应(DTH)检... 目的:研究人乳头瘤病毒(HPV)6b型L1蛋白形成的病毒样颗粒(VLPs)对女性生殖道复发性尖锐湿疣(CA)的免疫治疗作用。方法:采用HPV6bL1VLPs1μg、5μg、10μg3组剂量经0w、4w、8w免疫18例CA复发患者。分别用ELISA法和迟发性超敏反应(DTH)检测血清特异性抗体和细胞免疫效应,同时每周随访观察CA病变情况直到20w。结果:所有研究对象均能在免疫后的血清中检测到特异性抗体。各剂量组免疫前后比较,血清抗体均值间差异均有统计学意义(均P<0.05);所有患者DTH试验均呈阳性反应。经免疫治疗后20w的观察,77.8%(14/18)的患者CA完全消退,61.1%(11/18)的患者CA于9w之内完全消退,14例CA完全消退对象随访1年未见复发。生殖道CA消退与机体DTH反应有相关性(rs=-0.746,P=0.000)。结论:HPV6bL1VLPs可用于生殖道复发性CA的免疫治疗研究。 展开更多
关键词 人乳头瘤病毒 病毒样颗粒 尖锐湿疣 免疫
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Prospecting microbial biofilms as climate smart strategies for improving plant and soil health: A review 被引量:2
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作者 Kulandaivelu VELMOUROUGANE Shobit THAPA Radha PRASANNA 《Pedosphere》 SCIE CAS CSCD 2023年第1期129-152,共24页
Microbes and their products play key roles in complementing chemical fertilizers and plant protection chemicals by eliciting defence mechanisms in crop plants,thereby providing immunity and resistance against diverse ... Microbes and their products play key roles in complementing chemical fertilizers and plant protection chemicals by eliciting defence mechanisms in crop plants,thereby providing immunity and resistance against diverse stresses.Among the different environmental technologies used to mitigate climate change,several microbiological interventions are promising,among which biofilms,both naturally-existing and laboratory-developed,and their application have gained momentum recently.Microbial biofilms are aggregations of microbial cells in a self-generated polymeric matrix,which are produced by several genera of bacteria,yeasts,cyanobacteria,and fungi as a mode of reproductive fitness,thereby advantageous in successful proliferation,even in extreme environments.The propensity of microbial biofilms to grow in diverse niches and adapt to biotic and abiotic stresses illustrates their immense potential as biofertilizers and disease suppression options in various crops across diverse ecologies.In the inhospitable habitats of deserts and denudated land,biofilms play an important role in preventing soil erosion and sustaining vegetation,microflora,and fauna.Biofilms represent a mode of growth for several microbes with plant growth-promoting and biocontrol potential,which are important in seed establishment and the facilitation of exchanging nutrients and metabolites from the environment.In this review,we discuss the prospects of microbial biofilms as a green option in agriculture in general and,more specifically,their potential in mitigating climate change. 展开更多
关键词 BIOCONTROL BIOREMEDIATION climate change environmental stress nutrient sequestration plant growth promotion
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Development of Permanent Mapping Populations RILs in Diploid A Genome
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作者 WAGHMARE VIJAY N DONGRE A B GOTMARE Vinita PATIL P G DESHPANDE L A KHADI B M 《棉花学报》 CSCD 北大核心 2008年第S1期99-,共1页
Recombinant inbred lines(RILs) serve as powerful tools for genetic mapping.RILs are obtained by crossing two inbred lines followed by repeated selfing or sib-mating to create a set of new
关键词 QTLS LENGTH Development of Permanent Mapping Populations RILs in Diploid A Genome
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Gossypium herbaceum Negative Mutant for Fiber Elongation a Useful Isoline for Identification of Genes for Fiber Elongation
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作者 KATAGERI I S KHADI B M ANANDKUMA P REDDY V S VAMADEVAAH H M 《棉花学报》 CSCD 北大核心 2008年第S1期83-,共1页
Actin cytoskeleton plays an important role in cell morphogenesis in plants as demonstrated by pharmacological,biochemical,and genetic studies.The actin cytoskeleton may be involved in
关键词 Gossypium herbaceum Negative Mutant for Fiber Elongation a Useful Isoline for Identification of Genes for Fiber Elongation GENE
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Comparative Transmission Genetics of Introgressed Chromatin in Gossypium Species
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作者 WAGHMARE Vijay N ROGERS Carl J +1 位作者 BOWERS John E PATERSON Andrew H 《棉花学报》 CSCD 北大核心 2008年第S1期117-,共1页
Wild relatives and un-adapted germplasm of crop species harbors several adaptive traits.Introgression of genes for economic and adaptive traits brings in novel genetic variation into the gene
关键词 Comparative Transmission Genetics of Introgressed Chromatin in Gossypium Species
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Plague risk in vulnerable community:assessment of Xenopsylla cheopis susceptibility to insecticides in Malagasy prisons 被引量:1
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作者 Adelaide Miarinjara Jean Vergain +2 位作者 Jean Marcel Kavaruganda Minoarisoa Rajerison Sebastien Boyer 《Infectious Diseases of Poverty》 SCIE 2017年第1期1255-1261,共7页
Background:Prisons in Madagascar are at high risk of plague outbreak.Occurrence of plague epidemic in prisons can cause significant episode of urban plague through the movement of potentially infected humans,rodents a... Background:Prisons in Madagascar are at high risk of plague outbreak.Occurrence of plague epidemic in prisons can cause significant episode of urban plague through the movement of potentially infected humans,rodents and fleas.Rodent and flea controls are essential in plague prevention,by reducing human contact with plague reservoirs and vectors.Insecticide treatment is the key step available for the control of rat fleas which transmit the disease from infected rodents to human.The implementation of an adapted flea control strategy should rely on the insecticide susceptibility status of the targeted population.For the purpose of plague prevention campaign in prisons,we conducted insecticide resistance survey on Xenopsylla cheopis,the rat flea.Methods:Fleas were collected on rats caught in six prisons of Madagascar.They were exposed to insecticide treated filter papers and mortality was recorded following World Health Organization protocol.Results:The fleas collected in the prisons had different resistance patterns,while a high level of resistance to insecticides tested was described in the Antanimora prison,located in the heart of Antananarivo,the capital of Madagascar.Conclusions:This finding is alarming in the context of public health,knowing that the effectiveness of flea control could be jeopardized by insecticide resistance.In order to establish more accurate rat fleas control in prisons,the main recommendations are based on continuous monitoring insecticide susceptibility of flea,insecticide rotation,and the development of a new method for flea control. 展开更多
关键词 PLAGUE PRISON FLEA INSECTICIDE Madagascar
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