Phenacoccus solenopsis has been recognized as an aggressively invasive species on cotton plants in different countries.This study was conducted to investigate the effect of green synthesized Cu/Zn-nanoparticles using ...Phenacoccus solenopsis has been recognized as an aggressively invasive species on cotton plants in different countries.This study was conducted to investigate the effect of green synthesized Cu/Zn-nanoparticles using aqueous leaf extract of Prosopis juliflora(mezquite)against P.solenopsis.The scanning electron microscope(SEM)showed bimetallic nanoparticles of Cu/Zn-NPs with spherical shape with varying size of 74.33 nm to 59.46 nm.More than 30%mortality of P.solenopsis was observed with Cu/Zn-nanoparticles(100 ppm)at 96 hours after treatment.Negligible mortality of P.solenopsis was recorded with Cu/Zn solution(100 ppm)and aqueous P.juliflora extracts.The results of the viability test for Cu/Zn-nanoparticles of P.juliflora showed a significant reduction of the cell viability by 50%in insect exposed to Cu/Zn-nanoparticles-P.juliflora.Therefore studies about nanotoxicity of Cu/Zn-NPs of P.juliflora are needed to reveal the mechanism of toxicity this phytonanoparticles in P.solenopsis.展开更多
In present study invasion of Parthenium hysterophorus L. and its impacts on agriculture fields will be done in different cultivated crops in Bilaspur. The present work deals with diversity and distribution of weeds sp...In present study invasion of Parthenium hysterophorus L. and its impacts on agriculture fields will be done in different cultivated crops in Bilaspur. The present work deals with diversity and distribution of weeds species in cultivated fields of Bilaspur C.G. A total number of 28 species under 27 genera and 16 families was distributed in three study sites (Koni, Sakri & Kota) of cultivated fields in Bilaspur C.G. These study sites were located in different altitudinal zones responding different conditions in the this study. The number of species per sites ranged from 13 to 24. In the Sakri, number of species was ranged from 17 to 27, and the relative density of plant species ranged between 0.77 (Heteropogon contortus, Solanum surratense, Vernonia cinneria and Leucas aspera) and 22.92 (Parthenium hysterophorus). In the Kota, number of species was ranged from 14 to 28, and the relative density of plant species ranged between 0.85 (Ageratum conyzoides, Heteropogon contortus, Triticum aestivum) and 29.06 (Zea mays) and 30.91 (Parthenium hysterophorus). In the Agriculture field, number of species was ranged from 15 to 28, and the relative density of plant species ranged between 0.58 (Leucas aspera) and 26.23 (Triticum aestivum). Present work will give the information that weeds are harmful to herbs, crops and medicinal plants. Parthenium weed can suppress and crowd out other weed species, and could form a single dominant population in the invasion area, causing serious threat to plant community biological diversity.展开更多
There has been an increase of community studies that incorporate the use of functional diversity indices. The incorporation of these indices in the analysis of marine communities is recent, however, could contribute w...There has been an increase of community studies that incorporate the use of functional diversity indices. The incorporation of these indices in the analysis of marine communities is recent, however, could contribute with relevant information about the health of those communities. The lagoon of La Paz is a body of water located in La Paz, B.C.S., México. Despite its regional importance, there are not recent studies about its fish communities. Therefore, the aim of the present study was to analyze the temporal and spatial structure of the functional diversity of fish communities associated to soft bottoms, from August 2016 to July 2017, as well as important environmental variables. Functional diversity indices showed significant differences between months. Spatial analysis did not show significant differences perhaps due to low variability of the type of substrate. Temperature showed temporal differences as well. Therefore, temperature may be a limiting environmental variable for many fish species inhabiting coastal lagoons.展开更多
An analysis of the variation of the density and biomass of the fish communities of the lagoon of La Paz, Mexico was carried out from November 2016 to September 2017. A total of 2763 organisms were collected with a tot...An analysis of the variation of the density and biomass of the fish communities of the lagoon of La Paz, Mexico was carried out from November 2016 to September 2017. A total of 2763 organisms were collected with a total biomass of 211,422.93 g in an area of 5022 m<sup>2</sup>, a density and biomass of 0.550 lnd/m<sup>2</sup> and 44.091 g/m<sup>2</sup>. The site with the largest biomass was recorded in Zacatecas (11.179 g/m<sup>2</sup>) located north of the lagoon, while Grand Plaza recorded the lowest biomass (2.732 g/m<sup>2</sup>). Regarding the density, the maximum value was recorded in the site Yate Hundido, located northwest of the lagoon (0.129 lnd/m<sup>2</sup>) and the lowest was Las Palmas (0.036 lnd/m<sup>2</sup>) located north of the lagoon. The most abundant species was Diapterus peruvianus with 683 individuals and a biomass of 37,507.57 g. The physicochemical variables showed two seasons with significant change where we can observe higher temperatures in the summer (average of 27.45<span style="white-space:normal;"><span style="font-family:;" "=""><span style="white-space:nowrap;">°C) and minimum in winter (average of 22.49<span style="white-space:nowrap;">°C). The Shannon-Weaver diversity index showed a difference (p = 0.050) between months, with the highest value recorded in April (H<span style="white-space:normal;"><span style="font-family:;" "="">'<span style="white-space:normal;"><span style="font-family:;" "=""> = 2.133 bits/ind) and the lowest in June (H<span style="white-space:normal;"><span style="font-family:;" "="">'<span style="white-space:normal;"><span style="font-family:;" "=""> = 1.041 bits/ind). The biomass and density values recorded in the lagoon were found to be associated with the spatio-temporal variation of temperature of the lagoon, as well as the resident and transitory species located in the area of study. In addition, the body sizes recorded corresponded to juvenile and young adult individuals.展开更多
In C?te d’Ivoire, ginger (Zingiber officinale Rosc.), generally used to make a drink called “Gnamankoudji”, has become an important source of agricultural income diversification. In order to assess the agromorpholo...In C?te d’Ivoire, ginger (Zingiber officinale Rosc.), generally used to make a drink called “Gnamankoudji”, has become an important source of agricultural income diversification. In order to assess the agromorphological diversity of a ginger collection from different regions of C?te d’Ivoire, a survey collection of accessions was carried out in the different production zones of the country. One hundred and eighty-eight ginger accessions were collected in 15 regions and one autonomous district of C?te d’Ivoire. Analysis of variance revealed that all the variables used in this study discriminated between the ginger accessions collected. Principal component analysis revealed morphological variability of 45.931% for the first two components. Ascending Hierarchical Classification was used to classify these accessions into three groups based on fourteen quantitative characters. These three groups were formed independently of collection areas and are characterized by moderate morphological variability. This variability has been structured into three distinct agromorphological groups, with thallus (rhizome) length and width, finger width, secondary finger length and yield in tons per hectare as distinctive characters. This revealed genetic diversity could be exploited in ginger breeding and improvement programs in C?te d’Ivoire.展开更多
Abnormal levels of plasma lipid have been linked to atherosclerosis, strokes and heart conditions. Variations in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels are considered as ri...Abnormal levels of plasma lipid have been linked to atherosclerosis, strokes and heart conditions. Variations in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels are considered as risk factors for coronary artery disease (CAD). Furthermore, triglycerides are a leading cause of cardiovascular disease. Therefore, measurement of plasma lipid levels is an important mortality predictor. Several factors were associated with irregularity in plasma lipids such as genetic alterations. Recent researches have linked single nucleotides polymorphism (SNP) in ApoA5 gene with these deviations. In this study, we reported the effects of the genetic variant c.553G>T in ApoA5 on the levels of plasma lipids. To explore these effects, a case-control study including 280 male and female subjects (44 of them were assigned as CAD cases while the remaining subjects were categorized as control) was established. All patients in the study were recruited from the western region in KSA. The results have detected minor variations in LDL, HDL and cholesterol levels between CAD patients carrying T allele and CAD patients carrying the WT allele. However, there were no significant effects due to these variations. TG levels in the wild type carriers reached up to 291 mg/dl while T allele carriers, the cases, presented lower levels of TG (170 mg/dl and 71 mg/dl). Although, T allele showed no effects on plasma lipids with the exception of TG levels. We suggest by this study that T allele in this SNP might be considered as a valuable tool in the diagnosis of CAD.展开更多
The issue of resistance reduction through hull ventilation is of particular interest in contemporary research.This paper presents multiphase computational fluid dynamics(CFD)simulations with 2-DOF motion of a planing ...The issue of resistance reduction through hull ventilation is of particular interest in contemporary research.This paper presents multiphase computational fluid dynamics(CFD)simulations with 2-DOF motion of a planing hull.The original hull was modified by introducing a step to allow air ventilation.Following an assessment of the hull performance,a simulation campaign in calm water was conducted to characterize the hull at various forward speeds and air insufflation rates for a defined single step geometry.Geometric analysis of the air layer thickness beneath the hull for each simulated condition was performed using a novel method for visualizing local air thickness.Additionally,two new parameters were introduced to understand the influence of spray rails on the air volume beneath the hull and to indicate the primary direction of ventilated air escape.A validation campaign and an assessment of uncertainty of the simulation has been conducted.The features offered by the CFD methodology include the evaluation of the air layer thickness as a function of hull velocity and injection flow rate and the air volume distribution beneath the hull.The air injection velocity can be adjusted across various operating conditions,thereby preventing performance or efficiency loss during navigation.Based on these findings,the study highlights the benefits of air insufflation in reducing hull resistance for high-speed planing vessels.This work lays a robust foundation for future research and new promising topics,as the exploration of air insufflation continues to be a topic of contemporary interest within naval architecture and hydrodynamics.展开更多
Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs:the integrated stress response(ISR)and the senescence-associated secretory phenotype(SASP)...Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs:the integrated stress response(ISR)and the senescence-associated secretory phenotype(SASP).These pathways act as a Yin-Yang system,balancing beneficial and detrimental outcomes across development,tissue homeostasis,and disease.On the yin(protective)side,transient ISR activation and acute SASP signaling foster adaptation,embryonic patterning,wound healing,and regeneration.On the yang(maladaptive)side,chronic ISR signaling and unresolved SASP output drive stem cell exhaustion,fibrosis,inflammation,and tumorigenesis.This duality highlights their roles as both guardians and disruptors of stem cell integrity.Mechanistically,ISR regulates translational control via eukaryotic initiation factor 2 alpha(eIF2α)phosphorylation and activating transcription factor 4(ATF4)-dependent transcription,while SASP reprograms the extracellular milieu through cytokines,growth factors,and proteases.Their crosstalk creates feedback loops that shape tissue niches and long-termstemcell potential.Framing ISR-SASP interactions through a Yin-Yang lens underscores the balance between resilience and decline,to offer new insights into regenerative medicine,anti-aging interventions,and cancer therapeutics.展开更多
Background:Low-dose rate(LDR)prostate brachytherapy is a recommended treatment of localized prostate cancer in current guidelines.The study aimed to determine biochemical relapse-free survival(BRFS)in patients treated...Background:Low-dose rate(LDR)prostate brachytherapy is a recommended treatment of localized prostate cancer in current guidelines.The study aimed to determine biochemical relapse-free survival(BRFS)in patients treated with dynamic real-time low-dose rate(LDR)brachytherapy using Iodine 125(I^(125)).Methods:We retrospectively reviewed 499 patients with localized prostate cancer treated with I^(125) LDR realtime brachytherapy between 2003 and 2021.The mean patient age was 65 years(range:45–84 years).Based on the National Comprehensive Cancer Network(NCCN)risk classification,230 patients(46.1%)were categorized as low risk,235(47.1%)as intermediate risk,and 34(6.8%)as high risk.Gleason scores were distributed as follows:3+3 in 283 cases(56.7%),3+4 in 157 cases(31.5%),4+3 in 46 cases(9.2%),and 4+4 in 13 cases(2.6%).The mean follow-up was 70.5 months.Results:Tumor relapse was observed in 47 patients(9.4%)over a mean follow-up period of 6.26 years(SD 4.16).Local recurrence within the prostate occurred in 20 cases(4%).Patients with nadir PSA<0.2 ng/mL at 5 years of follow-up had a significantly lower incidence of tumor recurrence(3%)compared to those with a nadir PSA>0.2 ng/mL(21.9%)(p=0.0001).Biochemical relapse-free(BRFS)rates at 5,10 and 15 years were 96%,91.5% and 88.9%,respectively.When stratified by NCCCN risk groups,5-year BRFS was 96% in low risk,98% in intermediate risk and 85% in high risk patients(p=0.003).Inmultivariate analysis,only age at the time of brachytherapy(p=0.009),initial PSA(p=0.007)and Gleason grade(p=0.007)were significantly associated with tumor recurrence.Cancer-specific survival and overall survival were 99.8% and 98.0%,respectively.Conclusions:LDR with I^(125) has excellent longterm oncological outcomes for patients with low and intermediate-risk prostate cancer,in particular,patients achieving a nadir PSA<0.2 ng/mL at 5 years post-treatment.展开更多
Curtain wall systems have evolved from aesthetic facade elements into multifunctional building envelopes that actively contribute to energy efficiency and climate responsiveness.This reviewpresents a comprehensive exa...Curtain wall systems have evolved from aesthetic facade elements into multifunctional building envelopes that actively contribute to energy efficiency and climate responsiveness.This reviewpresents a comprehensive examination of curtain walls from an energy-engineering perspective,highlighting their structural typologies(Stick and Unitized),material configurations,and integration with smart technologies such as electrochromic glazing,parametric design algorithms,and Building Management Systems(BMS).Thestudy explores the thermal,acoustic,and solar performance of curtain walls across various climatic zones,supported by comparative analyses and iconic case studies including Apple Park,Burj Khalifa,and Milad Tower.Key challenges—including installation complexity,high maintenance costs,and climate sensitivity—are critically assessed alongside proposed solutions.A central innovation of this work lies in framing curtain walls not only as passive architectural elements but as dynamic interfaces that modulate energy flows,reduce HVAC loads,and enhance occupant comfort.The reviewed data indicate that optimized curtain wall configurations—especially those integrating electrochromic glazing and BIPV modules—can achieve annual energy consumption reductions ranging fromapproximately 5%to 27%,depending on climate,control strategy,and facade typology.The findings offer a valuable reference for architects,energy engineers,and decision-makers seeking to integrate high-performance facades into future-ready building designs.展开更多
Mexican oregano(Lippia graveolens Kunth)is an aromatic species of high culinary and medicinal relevance.In Mexico,more than 40 taxa with characteristic aroma and flavor are commercially recognized as oregano,with L.gr...Mexican oregano(Lippia graveolens Kunth)is an aromatic species of high culinary and medicinal relevance.In Mexico,more than 40 taxa with characteristic aroma and flavor are commercially recognized as oregano,with L.graveolens being the most widely distributed and economically important.Despite its relevance,few domesticated or semi-domesticated cultivars exist,and wild populations remain the main source of raw material,raising concerns regarding sustainability and quality standardization.The essential oil and oleoresins of L.graveolens possess recognized bioactivity,including antioxidant,antifungal,antibacterial,and anti-inflammatory properties,largely attributed to phenolic compounds such as thymol and carvacrol.Given the increasing global demand for natural bioactives and functional foods,optimizing cultivation practices is essential to enhance both the yield and phytochemical quality of this species.This study evaluated the effect of organic fertilization(0,5,10,and 15 t ha^(−1)of vermicompost)on the phenolic profile,flavonoid content,and antioxidant capacity of oregano oleoresin obtained from a semi-domesticated population across three harvests.The highest phenolic concentration(≈500 mg GAE g^(−1)extract)and greatest antioxidant activity(ABTS>3.5×10^(5)μmol TE g^(−1)extract)were observed at the 5 t ha^(−1)dose during the second harvest.Flavonoid content peaked in the third harvest(480-620 mg QE g^(−1)extract),whereas the unfertilized control exhibited the highest DPPH activity in the first harvest.Overall,the results indicate that vermicompost dosage and harvest timing substantially influence the functional quality of L.graveolens.Moderate organic fertilization,particularly 5 t ha^(−1),enhances the biosynthesis of bioactive secondary metabolites,underscoring its potential for sustainable production systems.展开更多
Ascorbate(Asc),commonly known as vitamin C,is a vital molecule for plant growth,development,and stress resilience.It is also known to play a crucial role in various physiological processes,including photosynthesis,cel...Ascorbate(Asc),commonly known as vitamin C,is a vital molecule for plant growth,development,and stress resilience.It is also known to play a crucial role in various physiological processes,including photosynthesis,cell division,and differentiation.This article thoroughly explores the processes governing the metabolism of Asc in plants and its roles in physiological functions.It lays down a robust theoretical groundwork for delving into Asc production,transportation,functions,and its potential applications in stress alleviation and horticulture.Furthermore,recent studies indicate that Asc plays a role in regulating fruit development and affecting postharvest storage characteristics,thereby influencing fruit ripening and resilience to stress.Hence,there is a growing importance in studying the synthesis and utilization of Asc in plants.Although the critical role of Asc in controlling plant redox signals has been extensively studied,the precise mechanisms by which it manages cellular redox homeostasis to maintain the equilibrium between reactive oxygen scavenging and cell redox signaling remain elusive.This gap in knowledge presents fresh opportunities to explore how the production of Asc in plants is regulated and how plants react to environmental stressors.Furthermore,this article delves into the potential for a comprehensive investigation into the essential function of Asc in fruits,the development of Asc-rich fruits,and the enhancement of postharvest storage properties.展开更多
文摘Phenacoccus solenopsis has been recognized as an aggressively invasive species on cotton plants in different countries.This study was conducted to investigate the effect of green synthesized Cu/Zn-nanoparticles using aqueous leaf extract of Prosopis juliflora(mezquite)against P.solenopsis.The scanning electron microscope(SEM)showed bimetallic nanoparticles of Cu/Zn-NPs with spherical shape with varying size of 74.33 nm to 59.46 nm.More than 30%mortality of P.solenopsis was observed with Cu/Zn-nanoparticles(100 ppm)at 96 hours after treatment.Negligible mortality of P.solenopsis was recorded with Cu/Zn solution(100 ppm)and aqueous P.juliflora extracts.The results of the viability test for Cu/Zn-nanoparticles of P.juliflora showed a significant reduction of the cell viability by 50%in insect exposed to Cu/Zn-nanoparticles-P.juliflora.Therefore studies about nanotoxicity of Cu/Zn-NPs of P.juliflora are needed to reveal the mechanism of toxicity this phytonanoparticles in P.solenopsis.
文摘In present study invasion of Parthenium hysterophorus L. and its impacts on agriculture fields will be done in different cultivated crops in Bilaspur. The present work deals with diversity and distribution of weeds species in cultivated fields of Bilaspur C.G. A total number of 28 species under 27 genera and 16 families was distributed in three study sites (Koni, Sakri & Kota) of cultivated fields in Bilaspur C.G. These study sites were located in different altitudinal zones responding different conditions in the this study. The number of species per sites ranged from 13 to 24. In the Sakri, number of species was ranged from 17 to 27, and the relative density of plant species ranged between 0.77 (Heteropogon contortus, Solanum surratense, Vernonia cinneria and Leucas aspera) and 22.92 (Parthenium hysterophorus). In the Kota, number of species was ranged from 14 to 28, and the relative density of plant species ranged between 0.85 (Ageratum conyzoides, Heteropogon contortus, Triticum aestivum) and 29.06 (Zea mays) and 30.91 (Parthenium hysterophorus). In the Agriculture field, number of species was ranged from 15 to 28, and the relative density of plant species ranged between 0.58 (Leucas aspera) and 26.23 (Triticum aestivum). Present work will give the information that weeds are harmful to herbs, crops and medicinal plants. Parthenium weed can suppress and crowd out other weed species, and could form a single dominant population in the invasion area, causing serious threat to plant community biological diversity.
文摘There has been an increase of community studies that incorporate the use of functional diversity indices. The incorporation of these indices in the analysis of marine communities is recent, however, could contribute with relevant information about the health of those communities. The lagoon of La Paz is a body of water located in La Paz, B.C.S., México. Despite its regional importance, there are not recent studies about its fish communities. Therefore, the aim of the present study was to analyze the temporal and spatial structure of the functional diversity of fish communities associated to soft bottoms, from August 2016 to July 2017, as well as important environmental variables. Functional diversity indices showed significant differences between months. Spatial analysis did not show significant differences perhaps due to low variability of the type of substrate. Temperature showed temporal differences as well. Therefore, temperature may be a limiting environmental variable for many fish species inhabiting coastal lagoons.
文摘An analysis of the variation of the density and biomass of the fish communities of the lagoon of La Paz, Mexico was carried out from November 2016 to September 2017. A total of 2763 organisms were collected with a total biomass of 211,422.93 g in an area of 5022 m<sup>2</sup>, a density and biomass of 0.550 lnd/m<sup>2</sup> and 44.091 g/m<sup>2</sup>. The site with the largest biomass was recorded in Zacatecas (11.179 g/m<sup>2</sup>) located north of the lagoon, while Grand Plaza recorded the lowest biomass (2.732 g/m<sup>2</sup>). Regarding the density, the maximum value was recorded in the site Yate Hundido, located northwest of the lagoon (0.129 lnd/m<sup>2</sup>) and the lowest was Las Palmas (0.036 lnd/m<sup>2</sup>) located north of the lagoon. The most abundant species was Diapterus peruvianus with 683 individuals and a biomass of 37,507.57 g. The physicochemical variables showed two seasons with significant change where we can observe higher temperatures in the summer (average of 27.45<span style="white-space:normal;"><span style="font-family:;" "=""><span style="white-space:nowrap;">°C) and minimum in winter (average of 22.49<span style="white-space:nowrap;">°C). The Shannon-Weaver diversity index showed a difference (p = 0.050) between months, with the highest value recorded in April (H<span style="white-space:normal;"><span style="font-family:;" "="">'<span style="white-space:normal;"><span style="font-family:;" "=""> = 2.133 bits/ind) and the lowest in June (H<span style="white-space:normal;"><span style="font-family:;" "="">'<span style="white-space:normal;"><span style="font-family:;" "=""> = 1.041 bits/ind). The biomass and density values recorded in the lagoon were found to be associated with the spatio-temporal variation of temperature of the lagoon, as well as the resident and transitory species located in the area of study. In addition, the body sizes recorded corresponded to juvenile and young adult individuals.
文摘In C?te d’Ivoire, ginger (Zingiber officinale Rosc.), generally used to make a drink called “Gnamankoudji”, has become an important source of agricultural income diversification. In order to assess the agromorphological diversity of a ginger collection from different regions of C?te d’Ivoire, a survey collection of accessions was carried out in the different production zones of the country. One hundred and eighty-eight ginger accessions were collected in 15 regions and one autonomous district of C?te d’Ivoire. Analysis of variance revealed that all the variables used in this study discriminated between the ginger accessions collected. Principal component analysis revealed morphological variability of 45.931% for the first two components. Ascending Hierarchical Classification was used to classify these accessions into three groups based on fourteen quantitative characters. These three groups were formed independently of collection areas and are characterized by moderate morphological variability. This variability has been structured into three distinct agromorphological groups, with thallus (rhizome) length and width, finger width, secondary finger length and yield in tons per hectare as distinctive characters. This revealed genetic diversity could be exploited in ginger breeding and improvement programs in C?te d’Ivoire.
文摘Abnormal levels of plasma lipid have been linked to atherosclerosis, strokes and heart conditions. Variations in high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol levels are considered as risk factors for coronary artery disease (CAD). Furthermore, triglycerides are a leading cause of cardiovascular disease. Therefore, measurement of plasma lipid levels is an important mortality predictor. Several factors were associated with irregularity in plasma lipids such as genetic alterations. Recent researches have linked single nucleotides polymorphism (SNP) in ApoA5 gene with these deviations. In this study, we reported the effects of the genetic variant c.553G>T in ApoA5 on the levels of plasma lipids. To explore these effects, a case-control study including 280 male and female subjects (44 of them were assigned as CAD cases while the remaining subjects were categorized as control) was established. All patients in the study were recruited from the western region in KSA. The results have detected minor variations in LDL, HDL and cholesterol levels between CAD patients carrying T allele and CAD patients carrying the WT allele. However, there were no significant effects due to these variations. TG levels in the wild type carriers reached up to 291 mg/dl while T allele carriers, the cases, presented lower levels of TG (170 mg/dl and 71 mg/dl). Although, T allele showed no effects on plasma lipids with the exception of TG levels. We suggest by this study that T allele in this SNP might be considered as a valuable tool in the diagnosis of CAD.
基金supported by European Union funding(PON“Ricerca e Innovazione”2014‒2020).
文摘The issue of resistance reduction through hull ventilation is of particular interest in contemporary research.This paper presents multiphase computational fluid dynamics(CFD)simulations with 2-DOF motion of a planing hull.The original hull was modified by introducing a step to allow air ventilation.Following an assessment of the hull performance,a simulation campaign in calm water was conducted to characterize the hull at various forward speeds and air insufflation rates for a defined single step geometry.Geometric analysis of the air layer thickness beneath the hull for each simulated condition was performed using a novel method for visualizing local air thickness.Additionally,two new parameters were introduced to understand the influence of spray rails on the air volume beneath the hull and to indicate the primary direction of ventilated air escape.A validation campaign and an assessment of uncertainty of the simulation has been conducted.The features offered by the CFD methodology include the evaluation of the air layer thickness as a function of hull velocity and injection flow rate and the air volume distribution beneath the hull.The air injection velocity can be adjusted across various operating conditions,thereby preventing performance or efficiency loss during navigation.Based on these findings,the study highlights the benefits of air insufflation in reducing hull resistance for high-speed planing vessels.This work lays a robust foundation for future research and new promising topics,as the exploration of air insufflation continues to be a topic of contemporary interest within naval architecture and hydrodynamics.
基金funded by the National Institutes of Health,grant numbers UG3OD023285,P42ES030991,and P30ES036084.
文摘Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs:the integrated stress response(ISR)and the senescence-associated secretory phenotype(SASP).These pathways act as a Yin-Yang system,balancing beneficial and detrimental outcomes across development,tissue homeostasis,and disease.On the yin(protective)side,transient ISR activation and acute SASP signaling foster adaptation,embryonic patterning,wound healing,and regeneration.On the yang(maladaptive)side,chronic ISR signaling and unresolved SASP output drive stem cell exhaustion,fibrosis,inflammation,and tumorigenesis.This duality highlights their roles as both guardians and disruptors of stem cell integrity.Mechanistically,ISR regulates translational control via eukaryotic initiation factor 2 alpha(eIF2α)phosphorylation and activating transcription factor 4(ATF4)-dependent transcription,while SASP reprograms the extracellular milieu through cytokines,growth factors,and proteases.Their crosstalk creates feedback loops that shape tissue niches and long-termstemcell potential.Framing ISR-SASP interactions through a Yin-Yang lens underscores the balance between resilience and decline,to offer new insights into regenerative medicine,anti-aging interventions,and cancer therapeutics.
文摘Background:Low-dose rate(LDR)prostate brachytherapy is a recommended treatment of localized prostate cancer in current guidelines.The study aimed to determine biochemical relapse-free survival(BRFS)in patients treated with dynamic real-time low-dose rate(LDR)brachytherapy using Iodine 125(I^(125)).Methods:We retrospectively reviewed 499 patients with localized prostate cancer treated with I^(125) LDR realtime brachytherapy between 2003 and 2021.The mean patient age was 65 years(range:45–84 years).Based on the National Comprehensive Cancer Network(NCCN)risk classification,230 patients(46.1%)were categorized as low risk,235(47.1%)as intermediate risk,and 34(6.8%)as high risk.Gleason scores were distributed as follows:3+3 in 283 cases(56.7%),3+4 in 157 cases(31.5%),4+3 in 46 cases(9.2%),and 4+4 in 13 cases(2.6%).The mean follow-up was 70.5 months.Results:Tumor relapse was observed in 47 patients(9.4%)over a mean follow-up period of 6.26 years(SD 4.16).Local recurrence within the prostate occurred in 20 cases(4%).Patients with nadir PSA<0.2 ng/mL at 5 years of follow-up had a significantly lower incidence of tumor recurrence(3%)compared to those with a nadir PSA>0.2 ng/mL(21.9%)(p=0.0001).Biochemical relapse-free(BRFS)rates at 5,10 and 15 years were 96%,91.5% and 88.9%,respectively.When stratified by NCCCN risk groups,5-year BRFS was 96% in low risk,98% in intermediate risk and 85% in high risk patients(p=0.003).Inmultivariate analysis,only age at the time of brachytherapy(p=0.009),initial PSA(p=0.007)and Gleason grade(p=0.007)were significantly associated with tumor recurrence.Cancer-specific survival and overall survival were 99.8% and 98.0%,respectively.Conclusions:LDR with I^(125) has excellent longterm oncological outcomes for patients with low and intermediate-risk prostate cancer,in particular,patients achieving a nadir PSA<0.2 ng/mL at 5 years post-treatment.
文摘Curtain wall systems have evolved from aesthetic facade elements into multifunctional building envelopes that actively contribute to energy efficiency and climate responsiveness.This reviewpresents a comprehensive examination of curtain walls from an energy-engineering perspective,highlighting their structural typologies(Stick and Unitized),material configurations,and integration with smart technologies such as electrochromic glazing,parametric design algorithms,and Building Management Systems(BMS).Thestudy explores the thermal,acoustic,and solar performance of curtain walls across various climatic zones,supported by comparative analyses and iconic case studies including Apple Park,Burj Khalifa,and Milad Tower.Key challenges—including installation complexity,high maintenance costs,and climate sensitivity—are critically assessed alongside proposed solutions.A central innovation of this work lies in framing curtain walls not only as passive architectural elements but as dynamic interfaces that modulate energy flows,reduce HVAC loads,and enhance occupant comfort.The reviewed data indicate that optimized curtain wall configurations—especially those integrating electrochromic glazing and BIPV modules—can achieve annual energy consumption reductions ranging fromapproximately 5%to 27%,depending on climate,control strategy,and facade typology.The findings offer a valuable reference for architects,energy engineers,and decision-makers seeking to integrate high-performance facades into future-ready building designs.
文摘Mexican oregano(Lippia graveolens Kunth)is an aromatic species of high culinary and medicinal relevance.In Mexico,more than 40 taxa with characteristic aroma and flavor are commercially recognized as oregano,with L.graveolens being the most widely distributed and economically important.Despite its relevance,few domesticated or semi-domesticated cultivars exist,and wild populations remain the main source of raw material,raising concerns regarding sustainability and quality standardization.The essential oil and oleoresins of L.graveolens possess recognized bioactivity,including antioxidant,antifungal,antibacterial,and anti-inflammatory properties,largely attributed to phenolic compounds such as thymol and carvacrol.Given the increasing global demand for natural bioactives and functional foods,optimizing cultivation practices is essential to enhance both the yield and phytochemical quality of this species.This study evaluated the effect of organic fertilization(0,5,10,and 15 t ha^(−1)of vermicompost)on the phenolic profile,flavonoid content,and antioxidant capacity of oregano oleoresin obtained from a semi-domesticated population across three harvests.The highest phenolic concentration(≈500 mg GAE g^(−1)extract)and greatest antioxidant activity(ABTS>3.5×10^(5)μmol TE g^(−1)extract)were observed at the 5 t ha^(−1)dose during the second harvest.Flavonoid content peaked in the third harvest(480-620 mg QE g^(−1)extract),whereas the unfertilized control exhibited the highest DPPH activity in the first harvest.Overall,the results indicate that vermicompost dosage and harvest timing substantially influence the functional quality of L.graveolens.Moderate organic fertilization,particularly 5 t ha^(−1),enhances the biosynthesis of bioactive secondary metabolites,underscoring its potential for sustainable production systems.
基金supported by the Lendület/Momentum Programme of the Hungarian Academy of Sciencesthe National Research, Development, and Innovation Office, Hungary (Grant Nos. LP2024/21 and K146791)+2 种基金Bayers fellowship program MEDHA and Department of Botany, University of Calicutthe financial assistance provided in the form of Junior Research Fellowship from the University Grants Commission (UGC), Indiathe financial assistance provided by the Council for Scientific and Industrial Research(CSIR), India
文摘Ascorbate(Asc),commonly known as vitamin C,is a vital molecule for plant growth,development,and stress resilience.It is also known to play a crucial role in various physiological processes,including photosynthesis,cell division,and differentiation.This article thoroughly explores the processes governing the metabolism of Asc in plants and its roles in physiological functions.It lays down a robust theoretical groundwork for delving into Asc production,transportation,functions,and its potential applications in stress alleviation and horticulture.Furthermore,recent studies indicate that Asc plays a role in regulating fruit development and affecting postharvest storage characteristics,thereby influencing fruit ripening and resilience to stress.Hence,there is a growing importance in studying the synthesis and utilization of Asc in plants.Although the critical role of Asc in controlling plant redox signals has been extensively studied,the precise mechanisms by which it manages cellular redox homeostasis to maintain the equilibrium between reactive oxygen scavenging and cell redox signaling remain elusive.This gap in knowledge presents fresh opportunities to explore how the production of Asc in plants is regulated and how plants react to environmental stressors.Furthermore,this article delves into the potential for a comprehensive investigation into the essential function of Asc in fruits,the development of Asc-rich fruits,and the enhancement of postharvest storage properties.
