There are data about the positive effect of rehabilitation with postural training in traumatic brain injury (TBI) patients. Brain mechanisms of functional recovery have been investigated insufficiently. In this study,...There are data about the positive effect of rehabilitation with postural training in traumatic brain injury (TBI) patients. Brain mechanisms of functional recovery have been investigated insufficiently. In this study, functional recovery was examined in TBI patients with primary motor (20 patients) or higher mental impairment (10 patients)—post-traumatic Korsakov syndrome compared to healthy volunteers (n = 20). Integral clinical, stabilographic, and EEG approach was used as a tool for estimation of functional deficit in TBI patients before and after rehabilitation course. Specific alterations of stabilographic and EEG parameters were observed in TBI patients with primary motor or mental deficit before rehabilitation. Rehabilitation course with postural training improved recovery of all functions in both patient groups. To understand brain mechanisms of rehabilitation, we examined EEG findings during standing and postural task performance in healthy volunteers (n = 10). EEG coherence increase was marked for different spectral bands predominantly in the right hemisphere and more in alpha-2 and beta bands during postural task performance. These EEG findings were discussed in relation to rehabilitation effect on TBI patients and proved that postural training with visual feedback may provoke primary activation of the right hemisphere and can serve as a trigger for integration of cortical and subcortical structures and for recovery of motor and higher mental function in TBI patients.展开更多
Current study presents an advanced method for improving the visualization of subsurface blood vessels using laser speckle contrast imaging (LSCI), enhanced through principal component analysis (PCA) filtering. By comb...Current study presents an advanced method for improving the visualization of subsurface blood vessels using laser speckle contrast imaging (LSCI), enhanced through principal component analysis (PCA) filtering. By combining LSCI and laser speckle entropy imaging with PCA filtering, the method effectively separates static and dynamic components of the speckle signal, significantly improving the accuracy of blood flow assessments, even in the presence of static scattering layers located above and below the vessel. Experiments conducted on optical phantoms, with the vessel depths ranging from 0.6 to 2 mm, and in vivo studies on a laboratory mouse ear demonstrate substantial improvements in image contrast and resolution. The method’s sensitivity to blood flow velocity within the physiologic range (0.98-19.66 mm/s) is significantly enhanced, while its sensitivity to vessel depth is minimized. These results highlight the method’s ability to assess blood flow velocity independently of vessel depth, overcoming a major limitation of conventional LSCI techniques. The proposed approach holds great potential for non-invasive biomedical imaging, offering improved diagnostic accuracy and contrast in vascular imaging. These findings may be particularly valuable for advancing the use of LSCI in clinical diagnostics and biomedical research, where high precision in blood flow monitoring is essential.展开更多
Posterior circulation intracranial aneurysm(IA)treatment remains challenging,due to the anatomy of the area and the high rupture possibility.Endovascular treatment seems to be more suitable for these aneurysms,but stu...Posterior circulation intracranial aneurysm(IA)treatment remains challenging,due to the anatomy of the area and the high rupture possibility.Endovascular treatment seems to be more suitable for these aneurysms,but studies focused on endovascular treatment demonstrate a high rate of re-intervention needing.A meta-analysis might offer a clearer view,being useful in a more effective treatment planning.Methods:A systematic search was performed,using the PubMed database platform.The final article pool contained 20 articles.Studied parameters were operative mortality,late mortality,permanent neurologic deficit(PND),and the need for re-intervention(Re-int).We divided patients into two subgroups,those with ruptured and those with unruptured aneurysm.Statistical analysis was performed using appropriate software.Results:In the total population(645 patients),there was a superiority of coiling over clipping in terms of PND and of coiling in terms of Re-int.As regards mortality,there was no clear superiority of one method over the other.Conclusions:The current study came to the conclusion that there is a superiority of coiling over clipping in terms of PND.On the other hand,clipping seems to be superior to coiling in terms of the need for re-intervention.As regards mortality(both operative and late),there is no clear superiority of one method over the other.Studying subgroups of patients(ruptured and unruptured posterior circulation IAs),in terms of PND,there is no superiority of one method over the other.The same goes for Op-Mo on ruptured aneurysms.展开更多
文摘There are data about the positive effect of rehabilitation with postural training in traumatic brain injury (TBI) patients. Brain mechanisms of functional recovery have been investigated insufficiently. In this study, functional recovery was examined in TBI patients with primary motor (20 patients) or higher mental impairment (10 patients)—post-traumatic Korsakov syndrome compared to healthy volunteers (n = 20). Integral clinical, stabilographic, and EEG approach was used as a tool for estimation of functional deficit in TBI patients before and after rehabilitation course. Specific alterations of stabilographic and EEG parameters were observed in TBI patients with primary motor or mental deficit before rehabilitation. Rehabilitation course with postural training improved recovery of all functions in both patient groups. To understand brain mechanisms of rehabilitation, we examined EEG findings during standing and postural task performance in healthy volunteers (n = 10). EEG coherence increase was marked for different spectral bands predominantly in the right hemisphere and more in alpha-2 and beta bands during postural task performance. These EEG findings were discussed in relation to rehabilitation effect on TBI patients and proved that postural training with visual feedback may provoke primary activation of the right hemisphere and can serve as a trigger for integration of cortical and subcortical structures and for recovery of motor and higher mental function in TBI patients.
基金The work was financially supported by a grant from the Russian Science Foundation No.22-65-00096.
文摘Current study presents an advanced method for improving the visualization of subsurface blood vessels using laser speckle contrast imaging (LSCI), enhanced through principal component analysis (PCA) filtering. By combining LSCI and laser speckle entropy imaging with PCA filtering, the method effectively separates static and dynamic components of the speckle signal, significantly improving the accuracy of blood flow assessments, even in the presence of static scattering layers located above and below the vessel. Experiments conducted on optical phantoms, with the vessel depths ranging from 0.6 to 2 mm, and in vivo studies on a laboratory mouse ear demonstrate substantial improvements in image contrast and resolution. The method’s sensitivity to blood flow velocity within the physiologic range (0.98-19.66 mm/s) is significantly enhanced, while its sensitivity to vessel depth is minimized. These results highlight the method’s ability to assess blood flow velocity independently of vessel depth, overcoming a major limitation of conventional LSCI techniques. The proposed approach holds great potential for non-invasive biomedical imaging, offering improved diagnostic accuracy and contrast in vascular imaging. These findings may be particularly valuable for advancing the use of LSCI in clinical diagnostics and biomedical research, where high precision in blood flow monitoring is essential.
文摘Posterior circulation intracranial aneurysm(IA)treatment remains challenging,due to the anatomy of the area and the high rupture possibility.Endovascular treatment seems to be more suitable for these aneurysms,but studies focused on endovascular treatment demonstrate a high rate of re-intervention needing.A meta-analysis might offer a clearer view,being useful in a more effective treatment planning.Methods:A systematic search was performed,using the PubMed database platform.The final article pool contained 20 articles.Studied parameters were operative mortality,late mortality,permanent neurologic deficit(PND),and the need for re-intervention(Re-int).We divided patients into two subgroups,those with ruptured and those with unruptured aneurysm.Statistical analysis was performed using appropriate software.Results:In the total population(645 patients),there was a superiority of coiling over clipping in terms of PND and of coiling in terms of Re-int.As regards mortality,there was no clear superiority of one method over the other.Conclusions:The current study came to the conclusion that there is a superiority of coiling over clipping in terms of PND.On the other hand,clipping seems to be superior to coiling in terms of the need for re-intervention.As regards mortality(both operative and late),there is no clear superiority of one method over the other.Studying subgroups of patients(ruptured and unruptured posterior circulation IAs),in terms of PND,there is no superiority of one method over the other.The same goes for Op-Mo on ruptured aneurysms.
