Therapeutic outcomes of colorectal cancer(CRC)are influenced by intestinal microbiota and metabolites.To leverage the tumor-tropism and microbiota-regulating properties of bacteria,we developed oncolytic magne-totacti...Therapeutic outcomes of colorectal cancer(CRC)are influenced by intestinal microbiota and metabolites.To leverage the tumor-tropism and microbiota-regulating properties of bacteria,we developed oncolytic magne-totactic bacteria(MSR-CPT/APPs)loaded with camptothecin(CPT)and anti-PD-L1 peptide(APP)for targeted chemo-magnetothermal immunotherapy of CRC.To further achieve oral delivery,MSR-CPT/APPs were coated with mulberry leaf lipids and Pluronic F127(LPs).When exposed to an alternating magnetic field,MSR-CPT/APP@LPs penetrated colonic mucus and reached deep-seated tumors.They elevated proinflammatory cyto-kine secretion,prolonged T cell recruitment,and reduced immunosuppressive cell proportions by activating the cGAS-STING pathway,inducing immunogenic cell death,and facilitating macrophage polarization to M1 phenotype.Oral MSR-CPT/APP@LPs increased the relative abundances of crucial commensal microorganisms(e.g.,Lachnospiraceae family and Alistipes)and influenced their metabolites,like elevating beneficial metabolites(short-chain fatty acids and citrulline)levels and decreasing harmful metabolites(L-glutamine and kynurenic acid)amounts,thereby remodeling the tumor immune microenvironment.Overall,MSR-CPT/APP@LPs foster a supportive intestinal environment and mitigate immunosuppression,achieving the eradication of both primary and distant colorectal tumors.展开更多
Global public health faces substantial challenges from malignant tumors and infectious diseases.Vaccination provides an approach for treating and preventing these diseases.Oral vaccinations are particularly advantageo...Global public health faces substantial challenges from malignant tumors and infectious diseases.Vaccination provides an approach for treating and preventing these diseases.Oral vaccinations are particularly advantageous in disease treatment and prevention due to their non-invasive nature,high patient compliance,convenience,cost-effectiveness,and capacity to stimulate comprehensive and adaptive immune responses.However,the overwhelming majority of oral vaccines remain in experimental development,struggling with clinical and commercial translation due to their suboptimal efficacy.Thus,enhancing scientists’understanding of the interaction between vaccines and gastrointestinal immune system,creating antigen delivery systems suitable for the gut mucosal environment,developing more potent antigenic epitopes,and using personalized combination therapies are critical for advancing the next generation of oral vaccines.This article explores the fundamental principles and applications of current oral anti-tumor and anti-infective vaccines and discusses considerations necessary for designing future oral vaccines.展开更多
Constructing an artificial intelligence interactive system is still challenging due to the lack of an integrated artificial sensing and processing system with high performance.In this work,an artificial tactile percep...Constructing an artificial intelligence interactive system is still challenging due to the lack of an integrated artificial sensing and processing system with high performance.In this work,an artificial tactile perception system with integrated sensing,storage,and computing functions is designed based on silk fibroin composite memristors and piezoresistive pressure sensors.The sensors based on polydimethylsiloxane/silver nanowires can sense the external pressure stimulation with fast response speed.In addition,the composite memristor based on silk fibroin possesses good cyclic stability and synaptic plasticity simulation and acts as an artificial synapse to process tactile information.As a result,the integrated tactile perception system realizes the perception,storage,and processing of pressure information,demonstrating the possibility to simulate the biological tactile perception nervous system.This type of system may promote potential applications in artificial intelligence,such as autonomous driving,wearable,flexible electronic devices,and bionic robots.展开更多
The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota imbalance.While traditional medications mainly focus on mitigating inflammation,it remains chall...The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota imbalance.While traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple symptoms.Here,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO_(2) nanospheres with Cu_(2)O nanoblocks.The resulting CaO_(2)–Cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size distribution.It could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 phenotype.This nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen bubbles.Rectal administration of CaO_(2)–Cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and anti-inflammation.Impressively,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven CaO_(2)–Cu_(2)O offers a promising therapeutic platform for robust treatment of UC via the rectal route.展开更多
The authors regret that there are errors in the author information and author contributions.The name of the corresponding author,Zhenghua Zhu,should be corrected to Zhenhua Zhu.The modification does not affect the res...The authors regret that there are errors in the author information and author contributions.The name of the corresponding author,Zhenghua Zhu,should be corrected to Zhenhua Zhu.The modification does not affect the results of the article.The authors apologize for any inconvenience caused to the journal and readers.展开更多
The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment...The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment.Herein,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MLNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.展开更多
基金supported by the Sichuan Science and Technology Program(2025ZNSFSC1036 and 2024YFFK0345)the Fundamental Research Funds for the Central Universities(SWU-KQ22075 and SWUXDPY22006)+3 种基金the Chongqing Natural Science Foundation(CSTB2023NSCQ-MSX0422)the National Natural Science Foundation of China(82472132,82072060,32401170)the Distinguished Young Scholars of Chongqing(2022NSCQ-JQX5279)the Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202300223).
文摘Therapeutic outcomes of colorectal cancer(CRC)are influenced by intestinal microbiota and metabolites.To leverage the tumor-tropism and microbiota-regulating properties of bacteria,we developed oncolytic magne-totactic bacteria(MSR-CPT/APPs)loaded with camptothecin(CPT)and anti-PD-L1 peptide(APP)for targeted chemo-magnetothermal immunotherapy of CRC.To further achieve oral delivery,MSR-CPT/APPs were coated with mulberry leaf lipids and Pluronic F127(LPs).When exposed to an alternating magnetic field,MSR-CPT/APP@LPs penetrated colonic mucus and reached deep-seated tumors.They elevated proinflammatory cyto-kine secretion,prolonged T cell recruitment,and reduced immunosuppressive cell proportions by activating the cGAS-STING pathway,inducing immunogenic cell death,and facilitating macrophage polarization to M1 phenotype.Oral MSR-CPT/APP@LPs increased the relative abundances of crucial commensal microorganisms(e.g.,Lachnospiraceae family and Alistipes)and influenced their metabolites,like elevating beneficial metabolites(short-chain fatty acids and citrulline)levels and decreasing harmful metabolites(L-glutamine and kynurenic acid)amounts,thereby remodeling the tumor immune microenvironment.Overall,MSR-CPT/APP@LPs foster a supportive intestinal environment and mitigate immunosuppression,achieving the eradication of both primary and distant colorectal tumors.
基金supported by the National Natural Science Foundation of China(82472132 and 82072060)the Fundamental Research Funds for the Central Universities(SWU-XDPY22006 and SWU-KQ22075,China)+2 种基金the Venture&Innovation Support Program for Chongqing Overseas Returnees(2205012980212766,China)the Distinguished Young Scholars of Chongqing(2022NSCQ-JQX5279,China)the Natural Science Foundation of Chongqing(cstc2021jcyj-cxtt0005,China).
文摘Global public health faces substantial challenges from malignant tumors and infectious diseases.Vaccination provides an approach for treating and preventing these diseases.Oral vaccinations are particularly advantageous in disease treatment and prevention due to their non-invasive nature,high patient compliance,convenience,cost-effectiveness,and capacity to stimulate comprehensive and adaptive immune responses.However,the overwhelming majority of oral vaccines remain in experimental development,struggling with clinical and commercial translation due to their suboptimal efficacy.Thus,enhancing scientists’understanding of the interaction between vaccines and gastrointestinal immune system,creating antigen delivery systems suitable for the gut mucosal environment,developing more potent antigenic epitopes,and using personalized combination therapies are critical for advancing the next generation of oral vaccines.This article explores the fundamental principles and applications of current oral anti-tumor and anti-infective vaccines and discusses considerations necessary for designing future oral vaccines.
基金supported by Shanghai Rising-Star Program(22QA1400400)the Basic Research Project of the Science and Technology Commission of Shanghai Municipality(21JC1400100)+1 种基金the National Natural Science Foundation of China(52173031)the Oriental Talent Plan(Leading Talent Program,152)。
文摘Constructing an artificial intelligence interactive system is still challenging due to the lack of an integrated artificial sensing and processing system with high performance.In this work,an artificial tactile perception system with integrated sensing,storage,and computing functions is designed based on silk fibroin composite memristors and piezoresistive pressure sensors.The sensors based on polydimethylsiloxane/silver nanowires can sense the external pressure stimulation with fast response speed.In addition,the composite memristor based on silk fibroin possesses good cyclic stability and synaptic plasticity simulation and acts as an artificial synapse to process tactile information.As a result,the integrated tactile perception system realizes the perception,storage,and processing of pressure information,demonstrating the possibility to simulate the biological tactile perception nervous system.This type of system may promote potential applications in artificial intelligence,such as autonomous driving,wearable,flexible electronic devices,and bionic robots.
基金supported by the National Natural Science Foundation of China(82072060,82360110,and 22008201)the Fundamental Research Funds for the Central Universities(SWU-XDPY22006,China)+2 种基金the Venture&Innovation Support Program for Chongqing Overseas Returnees(2205012980212766,China)the Distinguished Young Scholars of Chongqing(2022NSCQ-JQX5279,China)the Science and Technology Department of Jiangxi Province(20212BDH81019 and 20224BAB206073,China).
文摘The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota imbalance.While traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple symptoms.Here,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO_(2) nanospheres with Cu_(2)O nanoblocks.The resulting CaO_(2)–Cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size distribution.It could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 phenotype.This nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen bubbles.Rectal administration of CaO_(2)–Cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and anti-inflammation.Impressively,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven CaO_(2)–Cu_(2)O offers a promising therapeutic platform for robust treatment of UC via the rectal route.
文摘The authors regret that there are errors in the author information and author contributions.The name of the corresponding author,Zhenghua Zhu,should be corrected to Zhenhua Zhu.The modification does not affect the results of the article.The authors apologize for any inconvenience caused to the journal and readers.
基金the National Natural Science Foundation of China(82072060 and 22008201)the Fundamental Research Funds for the Central Universities(SWU-XDPY22006)+2 种基金the Venture&Innovation Support Program for Chongqing Overseas Returnees(2205012980212766)the Natural Science Foundation Project of Chongqing(cstc2020jcyj-msxmX0292)the Natural Science Foundation Project of Chongqing for Distinguished Young Scholar.
文摘The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory microenvironment.Herein,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MLNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.
