Objective: This study aimed to demonstrate the feasibility of laparoscopic-resection of the abdominal cystic lymphangiomas in Pediatric Surgery and describe the morbidity associated to this management in Queen fabiola...Objective: This study aimed to demonstrate the feasibility of laparoscopic-resection of the abdominal cystic lymphangiomas in Pediatric Surgery and describe the morbidity associated to this management in Queen fabiola children’s university hospital (HUDERF) in Brussels. Methods: We retrospectively conducted a study at the Pediatric Surgery Department of HUDERF, Brussels. The studied period was from January 1, 2014, to January 1, 2024;a span of 10 years. All patients with a confirmed diagnosis of cystic lymphangiomas and who underwent laparoscopic surgery were included in our study. Those who have been operated exclusively by open surgery have been excluded. The technique involved either total laparoscopic resection or laparoscopic-assisted with extra-abdominal resection of the tumor. Parameters that were studied included age, sex, weight, symptoms, preoperative diagnosis, imaging assessment, location, size of the tumor, type of mass, surgical procedure, duration of the surgery, conversion to open surgery, morbidity, and histopathology. Data were analyzed using Microsoft Office Excel 2010 and SPSS. Results: We retrieved 10 files of patients presenting with abdominal cystic lymphangiomas within two patients underwent exclusive open surgery and have excluded from our study. Then our sample was constituted with 8 patients. The mean age of the patients was 6.4 years (standard deviation: 3.6 years, range: 1 to 11 years). Male patients were predominant. The mean weight was 26.7 kg (standard deviation: 14.7 kg, range: 10 to 55 kg). The most common symptom was abdominal pain. Preoperative diagnosis of abdominal cystic lymphangioma was made in 8 cases. Abdominal ultrasound was performed in all patients. MRI was done in 5 patients, and CT scan in 2 patients. All patients presented a multicystic mass. Pure laparoscopic resection of the cyst was done in 2 cases. Laparoscopic-assisted resection in 4 cases (with extra-peritoneal with small bowel resection and mesenteric detorsion in 1 case), and conversion in 2 cases due to the complex location of the cyst. After a follow-up period of 5 years, morbidity was noted in one patient (Patient 3) who developed postoperative bowel obstruction 1 month post-surgery. This patient was re-operated on with a favorable clinical outcome following conventional small bowel resection and anastomosis. The other patients (1, 2, 4, 5, 6, 7 and 8) had a simple clinical course, and no recurrence was observed in our series. Conclusion: Laparoscopic-resection of the abdominal cystic lymphangiomas is feasible in Pediatric Surgery. As minimally invasive surgery it gives many advantages even for complex abdominal cystic lymphangiomas with less morbidity as shown in our series.展开更多
The predictability of a coupled system composed of a coupled reduced-order extratropical ocean-atmosphere model forced by a low-order three-variable tropical recharge-discharge model is explored with emphasis on its l...The predictability of a coupled system composed of a coupled reduced-order extratropical ocean-atmosphere model forced by a low-order three-variable tropical recharge-discharge model is explored with emphasis on its long-term forecasting capabilities.Highly idealized ensemble forecasts are produced taking into account the uncertainties in the initial states of the system,with specific attention to the structure of the initial errors in the tropical model.Three main types of experiments are explored:with random perturbations along the three Lyapunov vectors of the tropical model;along the two dominant Lyapunov vectors;and along the first Lyapunov vector only.When perturbations are introduced along all vectors,forecasting biases develop even if in a perfect model framework and with known initial uncertainty properties.Theses biases are considerably reduced only when the perturbations are introduced along the dominant Lyapunov vector.Furthermore,this perturbation strategy allows a reduced mean square error to be obtained at long lead times of a few years,as well as reliable ensemble forecasts across the whole time range.These very counterintuitive findings further underline the importance of appropriately controlling the initial error structure in the tropics through data assimilation.展开更多
Cities often have a substantial green infrastructure,which provides local ecosystem services that improve the quality of life of urban residents.These services should be explicitly addressed in urban development polic...Cities often have a substantial green infrastructure,which provides local ecosystem services that improve the quality of life of urban residents.These services should be explicitly addressed in urban development policies,and areas with insufficient vegetation and limited access to public green spaces should be identified.This paper presents two spatially explicit urban green indicators that are derived using remote sensing imagery,freely available map data and spatial analysis tools from open source geospatial libraries and commercial software.The first indicator represents proportional green cover(public as well as private)in the vicinity of each building within a city.The second indicator quantifies the proximity of public green spaces as walking distances from buildings to actual park entrances.A dasymetric mapping approach was used to take spatial variations in population density into account.This allows representing the indicators from the perspective of citizens instead of buildings,which may be more meaningful for deriving statistics at city level or at the level of neighbourhoods or administrative zones.The potential use of these indicators in a planning context is discussed on a case study carried out for the city of Brussels,Belgium.展开更多
In order to find closed form solutions of nonintegrable nonlinear ordinary differential equations,numerous tricks have been proposed.The goal of this short review is to explain how a theorem of Eremenko on meromorphic...In order to find closed form solutions of nonintegrable nonlinear ordinary differential equations,numerous tricks have been proposed.The goal of this short review is to explain how a theorem of Eremenko on meromorphic solutions of some nonlinear ODEs together with some classical,19th-century results,can be turned into algorithms(thus avoiding ad hoc assumptions)which provide all(as opposed to some)solutions in a precise class.To illustrate these methods,we present some new such exact solutions,physically relevant.展开更多
The development of innovative surgical techniques has been a constant and fundamental aspect in liver transplantation(LT)to address chronic organ shortage.Domino liver transplantation(DLT),initially performed by Furta...The development of innovative surgical techniques has been a constant and fundamental aspect in liver transplantation(LT)to address chronic organ shortage.Domino liver transplantation(DLT),initially performed by Furtado et al.in Lisbon in 1995,is an innovative technique in which a liver from a patient with a metabolic disorder is transplanted into a recipient with end-stage liver disease[1].展开更多
Portal hypertension and cirrhosis are associated with severe hemodynamic changes in hepatic and systemic circulation in the adult population.During cirrhosis progression,circulation becomes hyperdynamic,with cardiac,p...Portal hypertension and cirrhosis are associated with severe hemodynamic changes in hepatic and systemic circulation in the adult population.During cirrhosis progression,circulation becomes hyperdynamic,with cardiac,pulmonary and renal consequences.Cirrhotic adults also present with cirrhotic cardiomyopathy,with systolic and diastolic dysfunction and electrophysiological abnormalities.This article provides an update on normal liver hemodynamics,a brief reminder of the liver and systemic hemodynamics in cirrhotic adults,and a description of liver and systemic hemodynamics in cirrhotic children.This review attempts to clarify whether liver and systemic hemodynamics are altered in cirrhotic children like they are in adults.The characterization of these hemodynamic disturbances could contribute to a better understanding of hepatic and systemic physiopathology in pediatric cirrhosis.展开更多
Hepatic arterial infusion(HAI)chemotherapy,first introduced in the 1980s,has gained recognition as an effective locoregional treatment for colorectal liver metastasis(CRLM).Initially used for unresectable liver metast...Hepatic arterial infusion(HAI)chemotherapy,first introduced in the 1980s,has gained recognition as an effective locoregional treatment for colorectal liver metastasis(CRLM).Initially used for unresectable liver metastases,HAI’s app-lication has expanded to the adjuvant setting following hepatic resection,with early studies indicating improved hepatic disease-free survival.Recent research demonstrates that combining HAI with modern systemic therapies enhances conversion to resectability and prolongs both recurrence-free and overall survival,even in heavily pretreated patients with diverse RAS mutational statuses.Person-alization through approaches like microsatellite instability status and dose mo-difications further optimize outcomes.However,the complexity of HAI requires expertise across multidisciplinary teams,limiting its widespread adoption to specialized centers.Ongoing clinical trials continue to investigate HAI’s role in CRLM management,highlighting its potential to become a cornerstone of liver-directed therapy.We explore how HAI chemotherapy,in combination with personalized medicine,can advance treatment strategies for metastatic colorectal cancer.展开更多
Azoospermia is characterized by the absence of sperm in the ejaculate and is categorized into obstructive azoospermia(OA)and nonobstructive azoospermia(NOA).For men with NOA,testicular sperm extraction(TESE)is the onl...Azoospermia is characterized by the absence of sperm in the ejaculate and is categorized into obstructive azoospermia(OA)and nonobstructive azoospermia(NOA).For men with NOA,testicular sperm extraction(TESE)is the only method to obtain sperm for assisted reproductive technology(ART).Given the rarity of these sperm and the unpredictable success of subsequent retrieval attempts,cryopreservation of microdissection-TESE-obtained sperm is essential.Effective cryopreservation prevents the need for repeated surgical procedures and supports future ART attempts.After first delving into the physiological and molecular aspects of sperm cryopreservation,this review aims to examine the current methods and devices for preserving small numbers of sperm.It presents conventional freezing and vitrification techniques,evaluating their respective strengths and limitations in effectively preserving rare sperm,and compares the efficacy of using fresh versus cryopreserved testicular sperm.展开更多
The first liver transplantation(LT)in humans was performed by Thomas Starzl on March 1,1963[1,2](Fig.1).During the period 1963-1983,this challenging procedure was performed in four centers only,one in the USA and thre...The first liver transplantation(LT)in humans was performed by Thomas Starzl on March 1,1963[1,2](Fig.1).During the period 1963-1983,this challenging procedure was performed in four centers only,one in the USA and three in Western Europe:Denver,Cambridge,Hannover and Groningen.Their collected experience including only 540 cases(meaning 27(!)cases yearly)was the basis of the 1983 National Institutes of Health(NIH)development consensus conference leading to the conclusion that LT could become“a promising alternative to the current therapy in the management of the late phase of several forms of serious liver disease…candidates are those who exhausted alternative medical and surgical treatments…and are approaching the terminal phase of their illness”.Patients presenting liver tumors and inherited,liver based,metabolic diseases could also be considered for LT[3].This conference put forward ten absolute and five relative contraindications restricting thereby the access to LT to a minority of very well selected liver diseased patients.展开更多
Acute rheumatic fever(ARF)and its sequela,rheumatic heart disease(RHD),remain major causes of morbidity and mortality in low-and middle-income countries,particularly in sub-Saharan Africa.In Cameroon,RHD accounts for ...Acute rheumatic fever(ARF)and its sequela,rheumatic heart disease(RHD),remain major causes of morbidity and mortality in low-and middle-income countries,particularly in sub-Saharan Africa.In Cameroon,RHD accounts for a considerable share of pediatric and adolescent heart disease.Severe valvular involvement often requires surgical intervention,but access to cardiac surgery is critically constrained.Since the 1980s,cardiac surgery in Cameroon has evolved from sporadic humanitarian missions to structured initiatives at the Douala and YaoundéGeneral Hospital and also the Shisong Cardiac Center.This article sheds light on the historical development and current state of cardiac surgery in Cameroon,emphasizing RHD as the leading surgical indication.It highlights both achievements and persistent gaps,and outlines perspectives for sustainability,including national training pathways,diaspora engagement,research and innovation,public-private partnerships,and South-South collaboration.Strengthening local capacity,securing sustainable financing mechanisms such as universal health coverage,and fostering regional cooperation are essential to build autonomous,resilient cardiac surgery programs in Cameroon.Addressing these priorities will be critical to improving access to timely surgical care and reducing preventable mortality from rheumatic heart disease.展开更多
Purpose:We aimed to measure the variation in researchers’knowledge and attitudes towards bibliometric indicators.The focus is on mapping the heterogeneity of this metric-wiseness within and between disciplines.Design...Purpose:We aimed to measure the variation in researchers’knowledge and attitudes towards bibliometric indicators.The focus is on mapping the heterogeneity of this metric-wiseness within and between disciplines.Design/methodology/approach:An exploratory survey is administered to researchers at the Sapienza University of Rome,one of Europe’s oldest and largest generalist universities.To measure metric-wiseness,we use attitude statements that are evaluated by a 5-point Likert scale.Moreover,we analyze documents of recent initiatives on assessment reform to shed light on how researchers’heterogeneous attitudes regarding and knowledge of bibliometric indicators are taken into account.Findings:We found great heterogeneity in researchers’metric-wiseness across scientific disciplines.In addition,within each discipline,we observed both supporters and critics of bibliometric indicators.From the document analysis,we found no reference to individual heterogeneity concerning researchers’metric wiseness.Research limitations:We used a self-selected sample of researchers from one Italian university as an exploratory case.Further research is needed to check the generalizability of our findings.Practical implications:To gain sufficient support for research evaluation practices,it is key to consider researchers’diverse attitudes towards indicators.Originality/value:We contribute to the current debate on reforming research assessment by providing a novel empirical measurement of researchers’knowledge and attitudes towards bibliometric indicators and discussing the importance of the obtained results for improving current research evaluation systems.展开更多
Rare earth elements(REEs)play a crucial role in many technologies from daily appliances in cell phones to more advanced wind turbines and electric cars.Permanent magnets account for a quarter of total global REEs prod...Rare earth elements(REEs)play a crucial role in many technologies from daily appliances in cell phones to more advanced wind turbines and electric cars.Permanent magnets account for a quarter of total global REEs production and have high recycling value.In this study,smelting process was used to selectively oxidize REEs in the permanent magnets by adding Fe_(2)O_(3).This separates REEs into a slag phase from an iron-rich metallic phase.B_(2)O_(3) was also added to the system as a flux to lower the slag melting temperature.This minimizes REEs loss to the metallic phase and allows a more efficient phase separation.The effect of flux and oxidizing agent addition was investigated on both regular and cerium-rich NdFeB(NdCeFeB)magnets.At 1350℃and for 1 h,the slag phase was successfully separated from the metallic phase with the addition of 0.8 stoichiometric amount of Fe_(2)O_(3) and 40 wt%of B_(2)O_(3).Scanning electron microscopy-energy dispersive X-ray spectroscopy(SEM-EDX)analysis reveals that REEs in the magnet do not migrate to the metal phase while the REE-rich slag phase contains almost no iron.After the selective removal of iron into the metallic phase,REEs are recovered from the slag phase through an acid leaching process allowing>99%of REEs recovery.Boron in the magnet can also be recovered as useful boric acid by evaporation and crystallisation technique.The proposed process in this study is reagent and energy-efficient with almost complete valorisation of both NdCeFeB and NdFeB magnets.展开更多
Membrane technology has thus far played an essential role in promoting environmental sustainability through improving the quality of water.Taking into account the current growth rate of membrane products along with th...Membrane technology has thus far played an essential role in promoting environmental sustainability through improving the quality of water.Taking into account the current growth rate of membrane products along with the market capacity,a tremendous rise in the amount of end-of-life(EoL)membranes is inevitable.In 2022,the global records of EoL membranes reached 35,000 tons.Recycling and resource utilization of EoL membranes is a viable option and hold significant promises for energy conservation and carbon neutralization.The present work provides an extensive overview of the latest progress in the field in relation with the prominent application cases.Furthermore,the avenues for the contributions of membrane recycling treatment technology within the framework of“carbon neutrality”are discussed with emphasis on permeability,pollutant interception capacity,and other relevant factors associated with the recycled membranes.This review strives to summarize the recycling and efficient utilization of EoL membranes,aiming at providing technical support to reduce operational costs and promote the low-carbon development of membrane technology.展开更多
A substantial body of research has been conducted with the objective of enhancing the understanding of Non-Timber Forest Products (NTFP) in Central Africa. A significant proportion of the studies focus on medicinal pl...A substantial body of research has been conducted with the objective of enhancing the understanding of Non-Timber Forest Products (NTFP) in Central Africa. A significant proportion of the studies focus on medicinal plants, in contrast to those that examine food products. Nevertheless, studies on edible wild mushrooms as NTFPs and cultivated mushrooms, on their economic potential and value chains in the Great Lakes Region, remain scarce and largely absent for some NTFPs. In light of the aforementioned considerations, the present study aims to examine the economic potential and value chain of the production sector of wild edible mushrooms (WEM) and cultivated mushrooms (CM) within the Virunga National Park (PNVi) and its surrounding areas in North Kivu, Democratic Republic of the Congo (DRC). To this end, a sample of 432 respondents was selected, distributed equitably among the actors of the Goma-Kitshanga-Mweso value chain, the Goma-Rutshuru chain, the Beni-Mutwanga chain, and the Beni-Mangina chain. A digital questionnaire consisting of open and closed questions was administered, and observations were carried out concurrently. The quantities of mushrooms sold were weighed and photographed. The results demonstrated that, when the eight-month fruiting period of wild and cultivated mushrooms was considered as a single year for all actors within the value chain, a picker could sell 6.1 kg at $2 and earn $12. A seller could sell 16 kg at $4 and earn $64, while a grower could sell 502 kg at $3 and earn $1506. Consequently, the CM grower generates a significantly higher profit than other participants in the value chain, despite the expenses he incurs. Ultimately, the domestication of WEM, highly prized by the local population of the Virunga National Park, has the potential to enhance their household incomes, as evidenced by the findings of this study.展开更多
Objective:Drawbacks of human papillomavirus(HPV)primary screening,including high referral rates and low specificity,highlight the necessity for triage strategies to balance the screening benefits with potential harms....Objective:Drawbacks of human papillomavirus(HPV)primary screening,including high referral rates and low specificity,highlight the necessity for triage strategies to balance the screening benefits with potential harms.Methods:A cross-sectional,population-based diagnostic study was conducted in rural Xinjiang,China involving 8,638 women≥25 years of age who participated in organized cervical cancer screening between 2023 and 2024.The study evaluated the accuracy and efficiency of multiple HPV-based"screen-triage"strategies.Histologically confirmed cervical intraepithelial neoplasia grade 2 or worse(CIN2+and CIN3+)served as disease outcomes.Results:Among single-step triage strategies,only extended genotyping for the seven most carcinogenic HPV types(HPV16/18/31/33/45/52/58)maintained sensitivity for CIN2+comparable to HPV screening without triage(90.0%vs.92.5%,P=0.50)but significantly improved specificity(94.7%vs.90.8%,P<0.001).This approach led to a 38%reduction in colposcopy referrals(relative rate,0.62;95%CI:0.59±0.65).Two-step triage algorithms(HPV16/18 with reflex ASC-US+or methylation)showed slightly lower but non-significant sensitivity(87.5%,P=0.13/89.6%,P=0.50)than HPV primary screening without triage,yet achieved significantly increased specificity(>95%,P<0.001)and reduced colposcopy referral by~50%(relative rate,0.5;P<0.001).If negative for cytology or methylation,women positive for 12 high-risk HPV types(excluding HPV16/18)had a<2%risk of CIN2+(CIN3+risk<1%),indicating delayed follow-up.Conclusions:Focusing on the seven high-risk HPV types within a one-step"screen-triage"framework effectively balances minimal sensitivity loss with significant gains in specificity,reducing unnecessary referrals and treatments,especially valuable in resourcelimited settings.Integrating HPV genotyping with methylation results improves the accurate identification of women requiring immediate referral,which is advisable when resources allow.展开更多
Background:Gastric Cancer(GC)is the 5th most prevalent and 4th most deadly neoplasm globally.Immunotherapy has emerged as a promising treatment approach in GC,potentially improving positive clinical outcomes while add...Background:Gastric Cancer(GC)is the 5th most prevalent and 4th most deadly neoplasm globally.Immunotherapy has emerged as a promising treatment approach in GC,potentially improving positive clinical outcomes while addressing the limitations of conventional therapies.GC immunotherapy modalities consist of adoptive cell therapy(ACT),cancer vaccines,and immune checkpoint inhibitors(ICI).Objectives:This systematic review aims to provide an overview of the advances in immune-based therapeutic approaches in GC,highlighting the potential of this therapy as a strategy for GC treatment.Methods:Key studies investigating several immunotherapeutic agents and combination therapies were searched in PUBMED and included in this study.Specific cancer outcomes related to disease progression or survival were analyzed.Results:After screening 236 studies,the results revealed that immunotherapy,particularly the ICI pembrolizumab,demonstrated promising efficacy in the treatment of GC,as several studies reported improved OS,PFS,and objective response rate with the use of pembrolizumab alone or in combination with other treatment modalities.Conclusion:Safety analysis showed that immunotherapy was mostly well-tolerated,with manageable adverse events and relatively good safety profiles.Nonetheless,further research is required to understand the mechanisms of tumor resistance better and identify predictive biomarkers that can direct treatment optimization.展开更多
The Hyperspectral Infrared Atmospheric Sounder-II(HIRAS-II)onboard China’s FungYun(FY)-3F meteorological satellite was launched in August 2023.This study presents the first attempt to retrieve the global carbon monox...The Hyperspectral Infrared Atmospheric Sounder-II(HIRAS-II)onboard China’s FungYun(FY)-3F meteorological satellite was launched in August 2023.This study presents the first attempt to retrieve the global carbon monoxide(CO)column from HIRAS-II/FY-3F spectra based on a newly established full-physics algorithm.The CO global columns derived from the HIRAS-II/FY-3F satellite are compared to measurements from the Infrared Atmospheric Sounding Interferometer(IASI)onboard Europe’s MetopB satellite,as both satellites have the same spectral range with a similar overpass time.The correlation coefficient between the IASI/Metop-B and HIRAS-II/FY-3F CO retrievals is about 0.8.The HIRAS-II/FY-3F satellite can capture well the regions with high CO values,e.g.,Africa,North America,and East Asia.The relative difference in the CO global column between HIRAS-II and IASI is 1.2±13.7(1)%,which is within their combined retrieval uncertainty.The CO plumes from the fire emissions in North America between 18 and 23 July 2024 were observed by the HIRAS-II/FY-3F satellite and consistent with the CAMS(Copernicus Atmosphere Monitoring Service)model simulations.Our results show that the HIRAS-II/FY-3F spectra are of good enough quality to provide quantitative observations of global CO column remote sensing observations.展开更多
Droughts pose significant threats to forest ecosystems globally.Effective forest management strategies,adapted to local conditions,are needed to mitigate negative drought impacts.One proposed strategy is competition r...Droughts pose significant threats to forest ecosystems globally.Effective forest management strategies,adapted to local conditions,are needed to mitigate negative drought impacts.One proposed strategy is competition reduction to increase water availability and,as a result,alleviate drought stress.This study investigates the effect of competition intensity on drought stress and tree growth in European beech(Fagus sylvatica)and pedunculate oak(Quercus robur).We deployed 72 point dendrometers,placed along a competition intensity gradient,in National Park Brabantse Wouden(Belgium),to measure daily minimum tree water deficit(TWD_(min))as a drought stress proxy and daily radial growth at tree level.Our results revealed species-dependent effects of competition intensity(CI).For European beech,competition reductions positively influenced growth and alleviated(1<CI<2)or aggravated(CI<0.5)drought stress.For pedunculate oak,competition intensity did not affect drought stress or growth along the investigated gradient.Environmental variables consistently affected TWDmin and growth of both species.Precipitation reduced TWDmin and increased growth,while vapor pressure deficit led to opposite trends.Thus,environmental conditions and competition can play a critical role in forest dynamics,especially in light of climate change.However,reducing competition through increased management efforts does not seem to be a one-size-fits-all solution to alleviating drought stress.Additionally,there seems to be a trade-off between reducing drought stress and improving tree growth in European beech:tree growth continuously benefited from competition reductions,while under low competition(CI<0.5)drought stress increased.Revisiting or reviving long-term thinning intensity trials encompassing various regions,species,and soil types will be needed to gain comprehensive insights into mitigating drought stress through management interventions under different local stand conditions.展开更多
Ozone production sensitivity is widely used to reveal the chemical dominant precursors of urban ozone rise.Here,we diagnose the impact of the decline in global human production activities level caused by the COVID-19 ...Ozone production sensitivity is widely used to reveal the chemical dominant precursors of urban ozone rise.Here,we diagnose the impact of the decline in global human production activities level caused by the COVID-19 on ozone sensitivity through the ratio of formaldehyde(HCHO)and NO_(2)(FNR=HCHO/NO_(2))observations from the TROPOspheric Monitoring Instrument.We use a relative uncertainty threshold to clean the satellite FNR,and our satellite FNR present a good correlation(R=0.6248)with U.S.Environmental Protection Agency observations.We found that the outbreak of the COVID-19 did not change the pattern of global ozone sensitivity,while the global regimes was transforming or strengthening to VOC-limited regimes due to the significant decline of human production activities levels.During the COVID-19,ozone sensitivity in Eastern China and East Africa continued to shift to VOC-limited regimes,while India,Western Europe and North America first moved to NOx-limited regimes,and then changed to VOC-limited regimes with the resumption of production and the increase in travel.The clustering results tell that urban ozone sensitivity tends to shift towards NOx-limited regimes as economic growing.The ozone formation in cities with lower FNR and per capita gross domestic product(GDP)are more sensitive to changes in VOCs,while cities with higher FNR and per capita GDP are more sensitive to variations in NOx.Cities with intermediate FNR and GDP are good evidence of the existence of transitional regimes.Our study identifies the driving role of urban economics in orienting the evolution of ozone sensitivity regimes.展开更多
BACKGROUND There is a lack of study on vitamin D and calcium levels in epileptic patients receiving therapy,despite the growing recognition of the importance of bone health in individuals with epilepsy.Associations on...BACKGROUND There is a lack of study on vitamin D and calcium levels in epileptic patients receiving therapy,despite the growing recognition of the importance of bone health in individuals with epilepsy.Associations one statistical method for finding correlations between variables in big datasets is called association rule mining(ARM).This technique finds patterns of common items or events in the data set,including associations.Through the analysis of patient data,including demographics,genetic information,and reactions with previous treatments,ARM can identify harmful drug reactions,possible novel combinations of medicines,and trends which connect particular individual features to treatment outcomes.AIM To investigate the evidence on the effects of anti-epileptic drugs(AEDs)on calcium metabolism and supplementing with vitamin D to help lower the likelihood of bone-related issues using ARM technique.METHODS ARM technique was used to analyze patients’behavior on calcium metabolism,vitamin D and anti-epileptic medicines.Epileptic sufferers of both sexes who attended neurological outpatient and in patient department clinics were recruited for the study.There were three patient groups:Group 1 received one AED,group 2 received two AEDs,and group 3 received more than two AEDs.The researchers analyzed the alkaline phosphatase,ionized calcium,total calcium,phosphorus,vitamin D levels,or parathyroid hormone values.RESULTS A total of 150 patients,aged 12 years to 60 years,were studied,with 50 in each group(1,2,and 3).60%were men,this gender imbalance may affect the study’s findings,as women have different bone metabolism dynamics influenced by hormonal variations,including menopause.The results may not fully capture the distinct effects of AEDs on female patients.A greater equal distribution of women should be the goal of future studies in order to offer a complete comprehension of the metabolic alterations brought on by AEDs.86 patients had generalized epilepsy,64 partial.42%of patients had AEDs for>5 years.Polytherapy reduced calcium and vitamin D levels compared to mono and dual therapy.Polytherapy elevated alkaline phosphatase and phosphorus levels.CONCLUSION ARM revealed the possible effects of variables like age,gender,and polytherapy on parathyroid hormone levels in individuals taking antiepileptic medication.展开更多
文摘Objective: This study aimed to demonstrate the feasibility of laparoscopic-resection of the abdominal cystic lymphangiomas in Pediatric Surgery and describe the morbidity associated to this management in Queen fabiola children’s university hospital (HUDERF) in Brussels. Methods: We retrospectively conducted a study at the Pediatric Surgery Department of HUDERF, Brussels. The studied period was from January 1, 2014, to January 1, 2024;a span of 10 years. All patients with a confirmed diagnosis of cystic lymphangiomas and who underwent laparoscopic surgery were included in our study. Those who have been operated exclusively by open surgery have been excluded. The technique involved either total laparoscopic resection or laparoscopic-assisted with extra-abdominal resection of the tumor. Parameters that were studied included age, sex, weight, symptoms, preoperative diagnosis, imaging assessment, location, size of the tumor, type of mass, surgical procedure, duration of the surgery, conversion to open surgery, morbidity, and histopathology. Data were analyzed using Microsoft Office Excel 2010 and SPSS. Results: We retrieved 10 files of patients presenting with abdominal cystic lymphangiomas within two patients underwent exclusive open surgery and have excluded from our study. Then our sample was constituted with 8 patients. The mean age of the patients was 6.4 years (standard deviation: 3.6 years, range: 1 to 11 years). Male patients were predominant. The mean weight was 26.7 kg (standard deviation: 14.7 kg, range: 10 to 55 kg). The most common symptom was abdominal pain. Preoperative diagnosis of abdominal cystic lymphangioma was made in 8 cases. Abdominal ultrasound was performed in all patients. MRI was done in 5 patients, and CT scan in 2 patients. All patients presented a multicystic mass. Pure laparoscopic resection of the cyst was done in 2 cases. Laparoscopic-assisted resection in 4 cases (with extra-peritoneal with small bowel resection and mesenteric detorsion in 1 case), and conversion in 2 cases due to the complex location of the cyst. After a follow-up period of 5 years, morbidity was noted in one patient (Patient 3) who developed postoperative bowel obstruction 1 month post-surgery. This patient was re-operated on with a favorable clinical outcome following conventional small bowel resection and anastomosis. The other patients (1, 2, 4, 5, 6, 7 and 8) had a simple clinical course, and no recurrence was observed in our series. Conclusion: Laparoscopic-resection of the abdominal cystic lymphangiomas is feasible in Pediatric Surgery. As minimally invasive surgery it gives many advantages even for complex abdominal cystic lymphangiomas with less morbidity as shown in our series.
基金supported by the National Key R&D Program of China(Grant No.2023YFF0805100)。
文摘The predictability of a coupled system composed of a coupled reduced-order extratropical ocean-atmosphere model forced by a low-order three-variable tropical recharge-discharge model is explored with emphasis on its long-term forecasting capabilities.Highly idealized ensemble forecasts are produced taking into account the uncertainties in the initial states of the system,with specific attention to the structure of the initial errors in the tropical model.Three main types of experiments are explored:with random perturbations along the three Lyapunov vectors of the tropical model;along the two dominant Lyapunov vectors;and along the first Lyapunov vector only.When perturbations are introduced along all vectors,forecasting biases develop even if in a perfect model framework and with known initial uncertainty properties.Theses biases are considerably reduced only when the perturbations are introduced along the dominant Lyapunov vector.Furthermore,this perturbation strategy allows a reduced mean square error to be obtained at long lead times of a few years,as well as reliable ensemble forecasts across the whole time range.These very counterintuitive findings further underline the importance of appropriately controlling the initial error structure in the tropics through data assimilation.
文摘Cities often have a substantial green infrastructure,which provides local ecosystem services that improve the quality of life of urban residents.These services should be explicitly addressed in urban development policies,and areas with insufficient vegetation and limited access to public green spaces should be identified.This paper presents two spatially explicit urban green indicators that are derived using remote sensing imagery,freely available map data and spatial analysis tools from open source geospatial libraries and commercial software.The first indicator represents proportional green cover(public as well as private)in the vicinity of each building within a city.The second indicator quantifies the proximity of public green spaces as walking distances from buildings to actual park entrances.A dasymetric mapping approach was used to take spatial variations in population density into account.This allows representing the indicators from the perspective of citizens instead of buildings,which may be more meaningful for deriving statistics at city level or at the level of neighbourhoods or administrative zones.The potential use of these indicators in a planning context is discussed on a case study carried out for the city of Brussels,Belgium.
基金partially supported by RGC(No.17307420)supported by NSFC(No.12471077)。
文摘In order to find closed form solutions of nonintegrable nonlinear ordinary differential equations,numerous tricks have been proposed.The goal of this short review is to explain how a theorem of Eremenko on meromorphic solutions of some nonlinear ODEs together with some classical,19th-century results,can be turned into algorithms(thus avoiding ad hoc assumptions)which provide all(as opposed to some)solutions in a precise class.To illustrate these methods,we present some new such exact solutions,physically relevant.
文摘The development of innovative surgical techniques has been a constant and fundamental aspect in liver transplantation(LT)to address chronic organ shortage.Domino liver transplantation(DLT),initially performed by Furtado et al.in Lisbon in 1995,is an innovative technique in which a liver from a patient with a metabolic disorder is transplanted into a recipient with end-stage liver disease[1].
文摘Portal hypertension and cirrhosis are associated with severe hemodynamic changes in hepatic and systemic circulation in the adult population.During cirrhosis progression,circulation becomes hyperdynamic,with cardiac,pulmonary and renal consequences.Cirrhotic adults also present with cirrhotic cardiomyopathy,with systolic and diastolic dysfunction and electrophysiological abnormalities.This article provides an update on normal liver hemodynamics,a brief reminder of the liver and systemic hemodynamics in cirrhotic adults,and a description of liver and systemic hemodynamics in cirrhotic children.This review attempts to clarify whether liver and systemic hemodynamics are altered in cirrhotic children like they are in adults.The characterization of these hemodynamic disturbances could contribute to a better understanding of hepatic and systemic physiopathology in pediatric cirrhosis.
文摘Hepatic arterial infusion(HAI)chemotherapy,first introduced in the 1980s,has gained recognition as an effective locoregional treatment for colorectal liver metastasis(CRLM).Initially used for unresectable liver metastases,HAI’s app-lication has expanded to the adjuvant setting following hepatic resection,with early studies indicating improved hepatic disease-free survival.Recent research demonstrates that combining HAI with modern systemic therapies enhances conversion to resectability and prolongs both recurrence-free and overall survival,even in heavily pretreated patients with diverse RAS mutational statuses.Person-alization through approaches like microsatellite instability status and dose mo-difications further optimize outcomes.However,the complexity of HAI requires expertise across multidisciplinary teams,limiting its widespread adoption to specialized centers.Ongoing clinical trials continue to investigate HAI’s role in CRLM management,highlighting its potential to become a cornerstone of liver-directed therapy.We explore how HAI chemotherapy,in combination with personalized medicine,can advance treatment strategies for metastatic colorectal cancer.
文摘Azoospermia is characterized by the absence of sperm in the ejaculate and is categorized into obstructive azoospermia(OA)and nonobstructive azoospermia(NOA).For men with NOA,testicular sperm extraction(TESE)is the only method to obtain sperm for assisted reproductive technology(ART).Given the rarity of these sperm and the unpredictable success of subsequent retrieval attempts,cryopreservation of microdissection-TESE-obtained sperm is essential.Effective cryopreservation prevents the need for repeated surgical procedures and supports future ART attempts.After first delving into the physiological and molecular aspects of sperm cryopreservation,this review aims to examine the current methods and devices for preserving small numbers of sperm.It presents conventional freezing and vitrification techniques,evaluating their respective strengths and limitations in effectively preserving rare sperm,and compares the efficacy of using fresh versus cryopreserved testicular sperm.
文摘The first liver transplantation(LT)in humans was performed by Thomas Starzl on March 1,1963[1,2](Fig.1).During the period 1963-1983,this challenging procedure was performed in four centers only,one in the USA and three in Western Europe:Denver,Cambridge,Hannover and Groningen.Their collected experience including only 540 cases(meaning 27(!)cases yearly)was the basis of the 1983 National Institutes of Health(NIH)development consensus conference leading to the conclusion that LT could become“a promising alternative to the current therapy in the management of the late phase of several forms of serious liver disease…candidates are those who exhausted alternative medical and surgical treatments…and are approaching the terminal phase of their illness”.Patients presenting liver tumors and inherited,liver based,metabolic diseases could also be considered for LT[3].This conference put forward ten absolute and five relative contraindications restricting thereby the access to LT to a minority of very well selected liver diseased patients.
文摘Acute rheumatic fever(ARF)and its sequela,rheumatic heart disease(RHD),remain major causes of morbidity and mortality in low-and middle-income countries,particularly in sub-Saharan Africa.In Cameroon,RHD accounts for a considerable share of pediatric and adolescent heart disease.Severe valvular involvement often requires surgical intervention,but access to cardiac surgery is critically constrained.Since the 1980s,cardiac surgery in Cameroon has evolved from sporadic humanitarian missions to structured initiatives at the Douala and YaoundéGeneral Hospital and also the Shisong Cardiac Center.This article sheds light on the historical development and current state of cardiac surgery in Cameroon,emphasizing RHD as the leading surgical indication.It highlights both achievements and persistent gaps,and outlines perspectives for sustainability,including national training pathways,diaspora engagement,research and innovation,public-private partnerships,and South-South collaboration.Strengthening local capacity,securing sustainable financing mechanisms such as universal health coverage,and fostering regional cooperation are essential to build autonomous,resilient cardiac surgery programs in Cameroon.Addressing these priorities will be critical to improving access to timely surgical care and reducing preventable mortality from rheumatic heart disease.
基金supported by the Sapienza Universitàdi Roma Sapienza Awards no.6H15XNFS.
文摘Purpose:We aimed to measure the variation in researchers’knowledge and attitudes towards bibliometric indicators.The focus is on mapping the heterogeneity of this metric-wiseness within and between disciplines.Design/methodology/approach:An exploratory survey is administered to researchers at the Sapienza University of Rome,one of Europe’s oldest and largest generalist universities.To measure metric-wiseness,we use attitude statements that are evaluated by a 5-point Likert scale.Moreover,we analyze documents of recent initiatives on assessment reform to shed light on how researchers’heterogeneous attitudes regarding and knowledge of bibliometric indicators are taken into account.Findings:We found great heterogeneity in researchers’metric-wiseness across scientific disciplines.In addition,within each discipline,we observed both supporters and critics of bibliometric indicators.From the document analysis,we found no reference to individual heterogeneity concerning researchers’metric wiseness.Research limitations:We used a self-selected sample of researchers from one Italian university as an exploratory case.Further research is needed to check the generalizability of our findings.Practical implications:To gain sufficient support for research evaluation practices,it is key to consider researchers’diverse attitudes towards indicators.Originality/value:We contribute to the current debate on reforming research assessment by providing a novel empirical measurement of researchers’knowledge and attitudes towards bibliometric indicators and discussing the importance of the obtained results for improving current research evaluation systems.
基金Project supported by the Science and Engineering Research Board of India(SRG/2020/002096)。
文摘Rare earth elements(REEs)play a crucial role in many technologies from daily appliances in cell phones to more advanced wind turbines and electric cars.Permanent magnets account for a quarter of total global REEs production and have high recycling value.In this study,smelting process was used to selectively oxidize REEs in the permanent magnets by adding Fe_(2)O_(3).This separates REEs into a slag phase from an iron-rich metallic phase.B_(2)O_(3) was also added to the system as a flux to lower the slag melting temperature.This minimizes REEs loss to the metallic phase and allows a more efficient phase separation.The effect of flux and oxidizing agent addition was investigated on both regular and cerium-rich NdFeB(NdCeFeB)magnets.At 1350℃and for 1 h,the slag phase was successfully separated from the metallic phase with the addition of 0.8 stoichiometric amount of Fe_(2)O_(3) and 40 wt%of B_(2)O_(3).Scanning electron microscopy-energy dispersive X-ray spectroscopy(SEM-EDX)analysis reveals that REEs in the magnet do not migrate to the metal phase while the REE-rich slag phase contains almost no iron.After the selective removal of iron into the metallic phase,REEs are recovered from the slag phase through an acid leaching process allowing>99%of REEs recovery.Boron in the magnet can also be recovered as useful boric acid by evaporation and crystallisation technique.The proposed process in this study is reagent and energy-efficient with almost complete valorisation of both NdCeFeB and NdFeB magnets.
基金supported by the National Natural Science Foundation of China(Nos.52322001,52070183,and 52330001)the National Key R&D Program of China(No.2023YFE0113800)the Excellent Member of the Youth Innovation Promotion Association,Chinese Academy of Sciences(No.Y2023010).
文摘Membrane technology has thus far played an essential role in promoting environmental sustainability through improving the quality of water.Taking into account the current growth rate of membrane products along with the market capacity,a tremendous rise in the amount of end-of-life(EoL)membranes is inevitable.In 2022,the global records of EoL membranes reached 35,000 tons.Recycling and resource utilization of EoL membranes is a viable option and hold significant promises for energy conservation and carbon neutralization.The present work provides an extensive overview of the latest progress in the field in relation with the prominent application cases.Furthermore,the avenues for the contributions of membrane recycling treatment technology within the framework of“carbon neutrality”are discussed with emphasis on permeability,pollutant interception capacity,and other relevant factors associated with the recycled membranes.This review strives to summarize the recycling and efficient utilization of EoL membranes,aiming at providing technical support to reduce operational costs and promote the low-carbon development of membrane technology.
文摘A substantial body of research has been conducted with the objective of enhancing the understanding of Non-Timber Forest Products (NTFP) in Central Africa. A significant proportion of the studies focus on medicinal plants, in contrast to those that examine food products. Nevertheless, studies on edible wild mushrooms as NTFPs and cultivated mushrooms, on their economic potential and value chains in the Great Lakes Region, remain scarce and largely absent for some NTFPs. In light of the aforementioned considerations, the present study aims to examine the economic potential and value chain of the production sector of wild edible mushrooms (WEM) and cultivated mushrooms (CM) within the Virunga National Park (PNVi) and its surrounding areas in North Kivu, Democratic Republic of the Congo (DRC). To this end, a sample of 432 respondents was selected, distributed equitably among the actors of the Goma-Kitshanga-Mweso value chain, the Goma-Rutshuru chain, the Beni-Mutwanga chain, and the Beni-Mangina chain. A digital questionnaire consisting of open and closed questions was administered, and observations were carried out concurrently. The quantities of mushrooms sold were weighed and photographed. The results demonstrated that, when the eight-month fruiting period of wild and cultivated mushrooms was considered as a single year for all actors within the value chain, a picker could sell 6.1 kg at $2 and earn $12. A seller could sell 16 kg at $4 and earn $64, while a grower could sell 502 kg at $3 and earn $1506. Consequently, the CM grower generates a significantly higher profit than other participants in the value chain, despite the expenses he incurs. Ultimately, the domestication of WEM, highly prized by the local population of the Virunga National Park, has the potential to enhance their household incomes, as evidenced by the findings of this study.
基金supported by grants from The Key Research and Development Program of Xinjiang Uygur Autonomous Region of China(Grant No.2022B03019-2)the National Natural Science Foundation of China(Grant Nos.82260660 and 72264038)the CAMS Innovation Fund for Medical Sciences(Grant No.CAMS 2021-I2M-1-004)。
文摘Objective:Drawbacks of human papillomavirus(HPV)primary screening,including high referral rates and low specificity,highlight the necessity for triage strategies to balance the screening benefits with potential harms.Methods:A cross-sectional,population-based diagnostic study was conducted in rural Xinjiang,China involving 8,638 women≥25 years of age who participated in organized cervical cancer screening between 2023 and 2024.The study evaluated the accuracy and efficiency of multiple HPV-based"screen-triage"strategies.Histologically confirmed cervical intraepithelial neoplasia grade 2 or worse(CIN2+and CIN3+)served as disease outcomes.Results:Among single-step triage strategies,only extended genotyping for the seven most carcinogenic HPV types(HPV16/18/31/33/45/52/58)maintained sensitivity for CIN2+comparable to HPV screening without triage(90.0%vs.92.5%,P=0.50)but significantly improved specificity(94.7%vs.90.8%,P<0.001).This approach led to a 38%reduction in colposcopy referrals(relative rate,0.62;95%CI:0.59±0.65).Two-step triage algorithms(HPV16/18 with reflex ASC-US+or methylation)showed slightly lower but non-significant sensitivity(87.5%,P=0.13/89.6%,P=0.50)than HPV primary screening without triage,yet achieved significantly increased specificity(>95%,P<0.001)and reduced colposcopy referral by~50%(relative rate,0.5;P<0.001).If negative for cytology or methylation,women positive for 12 high-risk HPV types(excluding HPV16/18)had a<2%risk of CIN2+(CIN3+risk<1%),indicating delayed follow-up.Conclusions:Focusing on the seven high-risk HPV types within a one-step"screen-triage"framework effectively balances minimal sensitivity loss with significant gains in specificity,reducing unnecessary referrals and treatments,especially valuable in resourcelimited settings.Integrating HPV genotyping with methylation results improves the accurate identification of women requiring immediate referral,which is advisable when resources allow.
文摘Background:Gastric Cancer(GC)is the 5th most prevalent and 4th most deadly neoplasm globally.Immunotherapy has emerged as a promising treatment approach in GC,potentially improving positive clinical outcomes while addressing the limitations of conventional therapies.GC immunotherapy modalities consist of adoptive cell therapy(ACT),cancer vaccines,and immune checkpoint inhibitors(ICI).Objectives:This systematic review aims to provide an overview of the advances in immune-based therapeutic approaches in GC,highlighting the potential of this therapy as a strategy for GC treatment.Methods:Key studies investigating several immunotherapeutic agents and combination therapies were searched in PUBMED and included in this study.Specific cancer outcomes related to disease progression or survival were analyzed.Results:After screening 236 studies,the results revealed that immunotherapy,particularly the ICI pembrolizumab,demonstrated promising efficacy in the treatment of GC,as several studies reported improved OS,PFS,and objective response rate with the use of pembrolizumab alone or in combination with other treatment modalities.Conclusion:Safety analysis showed that immunotherapy was mostly well-tolerated,with manageable adverse events and relatively good safety profiles.Nonetheless,further research is required to understand the mechanisms of tumor resistance better and identify predictive biomarkers that can direct treatment optimization.
基金supported by the FengYun Application Pioneering Project (Grant No. FY-APP-2022.0502)the National Natural Science Foundation of China (42205140)the State Key Laboratory of Atmospheric Environment end Extreme Meteorology (Grant No. 2024QN04)
文摘The Hyperspectral Infrared Atmospheric Sounder-II(HIRAS-II)onboard China’s FungYun(FY)-3F meteorological satellite was launched in August 2023.This study presents the first attempt to retrieve the global carbon monoxide(CO)column from HIRAS-II/FY-3F spectra based on a newly established full-physics algorithm.The CO global columns derived from the HIRAS-II/FY-3F satellite are compared to measurements from the Infrared Atmospheric Sounding Interferometer(IASI)onboard Europe’s MetopB satellite,as both satellites have the same spectral range with a similar overpass time.The correlation coefficient between the IASI/Metop-B and HIRAS-II/FY-3F CO retrievals is about 0.8.The HIRAS-II/FY-3F satellite can capture well the regions with high CO values,e.g.,Africa,North America,and East Asia.The relative difference in the CO global column between HIRAS-II and IASI is 1.2±13.7(1)%,which is within their combined retrieval uncertainty.The CO plumes from the fire emissions in North America between 18 and 23 July 2024 were observed by the HIRAS-II/FY-3F satellite and consistent with the CAMS(Copernicus Atmosphere Monitoring Service)model simulations.Our results show that the HIRAS-II/FY-3F spectra are of good enough quality to provide quantitative observations of global CO column remote sensing observations.
基金supported by the Fonds Wetenschappelijk Onderzoek(FWO)[grant number 1S16824N]the Cost Action CLEANFOREST[E-COST-GRANT-CA21138-c4968ca1].
文摘Droughts pose significant threats to forest ecosystems globally.Effective forest management strategies,adapted to local conditions,are needed to mitigate negative drought impacts.One proposed strategy is competition reduction to increase water availability and,as a result,alleviate drought stress.This study investigates the effect of competition intensity on drought stress and tree growth in European beech(Fagus sylvatica)and pedunculate oak(Quercus robur).We deployed 72 point dendrometers,placed along a competition intensity gradient,in National Park Brabantse Wouden(Belgium),to measure daily minimum tree water deficit(TWD_(min))as a drought stress proxy and daily radial growth at tree level.Our results revealed species-dependent effects of competition intensity(CI).For European beech,competition reductions positively influenced growth and alleviated(1<CI<2)or aggravated(CI<0.5)drought stress.For pedunculate oak,competition intensity did not affect drought stress or growth along the investigated gradient.Environmental variables consistently affected TWDmin and growth of both species.Precipitation reduced TWDmin and increased growth,while vapor pressure deficit led to opposite trends.Thus,environmental conditions and competition can play a critical role in forest dynamics,especially in light of climate change.However,reducing competition through increased management efforts does not seem to be a one-size-fits-all solution to alleviating drought stress.Additionally,there seems to be a trade-off between reducing drought stress and improving tree growth in European beech:tree growth continuously benefited from competition reductions,while under low competition(CI<0.5)drought stress increased.Revisiting or reviving long-term thinning intensity trials encompassing various regions,species,and soil types will be needed to gain comprehensive insights into mitigating drought stress through management interventions under different local stand conditions.
基金supported by the National Key R&D Program(No.2021YFE0117300)the National Natural Science Foundation of China(No.42375090)+6 种基金Shenzhen Key Laboratory of Precision Measurement and Early Warning Technology for Urban Environmental Health Risks(No.ZDSYS20220606100604008)Guangdong Basic and Applied Basic Research Foundation(No.2021A1515110713)Guangdong University Research Project Science Team(No.2021KCXTD004)the Major Talent Project of Guangdong Province(No.2021QN020924)Shandong Provincial Natural Science Foundation,China(No.ZR2020QD012)Shenzhen Science and Technology Program(Nos.KQTD20210811090048025,JCYJ20210324104604012 and JCYJ20220530115404009)supported by the Center for Computational Science and Engineering at Southern University of Science and Technology.
文摘Ozone production sensitivity is widely used to reveal the chemical dominant precursors of urban ozone rise.Here,we diagnose the impact of the decline in global human production activities level caused by the COVID-19 on ozone sensitivity through the ratio of formaldehyde(HCHO)and NO_(2)(FNR=HCHO/NO_(2))observations from the TROPOspheric Monitoring Instrument.We use a relative uncertainty threshold to clean the satellite FNR,and our satellite FNR present a good correlation(R=0.6248)with U.S.Environmental Protection Agency observations.We found that the outbreak of the COVID-19 did not change the pattern of global ozone sensitivity,while the global regimes was transforming or strengthening to VOC-limited regimes due to the significant decline of human production activities levels.During the COVID-19,ozone sensitivity in Eastern China and East Africa continued to shift to VOC-limited regimes,while India,Western Europe and North America first moved to NOx-limited regimes,and then changed to VOC-limited regimes with the resumption of production and the increase in travel.The clustering results tell that urban ozone sensitivity tends to shift towards NOx-limited regimes as economic growing.The ozone formation in cities with lower FNR and per capita gross domestic product(GDP)are more sensitive to changes in VOCs,while cities with higher FNR and per capita GDP are more sensitive to variations in NOx.Cities with intermediate FNR and GDP are good evidence of the existence of transitional regimes.Our study identifies the driving role of urban economics in orienting the evolution of ozone sensitivity regimes.
文摘BACKGROUND There is a lack of study on vitamin D and calcium levels in epileptic patients receiving therapy,despite the growing recognition of the importance of bone health in individuals with epilepsy.Associations one statistical method for finding correlations between variables in big datasets is called association rule mining(ARM).This technique finds patterns of common items or events in the data set,including associations.Through the analysis of patient data,including demographics,genetic information,and reactions with previous treatments,ARM can identify harmful drug reactions,possible novel combinations of medicines,and trends which connect particular individual features to treatment outcomes.AIM To investigate the evidence on the effects of anti-epileptic drugs(AEDs)on calcium metabolism and supplementing with vitamin D to help lower the likelihood of bone-related issues using ARM technique.METHODS ARM technique was used to analyze patients’behavior on calcium metabolism,vitamin D and anti-epileptic medicines.Epileptic sufferers of both sexes who attended neurological outpatient and in patient department clinics were recruited for the study.There were three patient groups:Group 1 received one AED,group 2 received two AEDs,and group 3 received more than two AEDs.The researchers analyzed the alkaline phosphatase,ionized calcium,total calcium,phosphorus,vitamin D levels,or parathyroid hormone values.RESULTS A total of 150 patients,aged 12 years to 60 years,were studied,with 50 in each group(1,2,and 3).60%were men,this gender imbalance may affect the study’s findings,as women have different bone metabolism dynamics influenced by hormonal variations,including menopause.The results may not fully capture the distinct effects of AEDs on female patients.A greater equal distribution of women should be the goal of future studies in order to offer a complete comprehension of the metabolic alterations brought on by AEDs.86 patients had generalized epilepsy,64 partial.42%of patients had AEDs for>5 years.Polytherapy reduced calcium and vitamin D levels compared to mono and dual therapy.Polytherapy elevated alkaline phosphatase and phosphorus levels.CONCLUSION ARM revealed the possible effects of variables like age,gender,and polytherapy on parathyroid hormone levels in individuals taking antiepileptic medication.
