Peripheral immunity forms the foundation of tumor immunity,while tumor immunity represents a more refined adaptation of peripheral immune responses.The tumor microenvironment(TME),a localized niche surrounding tumor c...Peripheral immunity forms the foundation of tumor immunity,while tumor immunity represents a more refined adaptation of peripheral immune responses.The tumor microenvironment(TME),a localized niche surrounding tumor cells,is inherently immunosuppressive(1,2).Effective tumor therapy necessitates the dismantling of this microenvironment,aiming to eradicate tumors from the host system.展开更多
The challenge in searching for fundamental symmetry violation.Neutrinoless double-beta(0νββ)decay represents one of the most profound tests of fundamental symmetries in nature.This hypothetical nuclear process,in w...The challenge in searching for fundamental symmetry violation.Neutrinoless double-beta(0νββ)decay represents one of the most profound tests of fundamental symmetries in nature.This hypothetical nuclear process,in which two neutrons simultaneously decay into two protons with the emission of two electrons but no neutrinos,would demonstrate that lepton number is not conserved and confirm that neutrinos are their own antiparticles(Majorana particles).The observation of 0νββdecay would provide crucial insights into the absolute neutrino mass scale and could illuminate the origin of matter-antimatter asymmetry in the universe.展开更多
Objective To determine the impact of planned preoperative phenazopyridine administration on operative times and costs compared with as-needed intravenous agent use during routine cystoscopy following minimally invasiv...Objective To determine the impact of planned preoperative phenazopyridine administration on operative times and costs compared with as-needed intravenous agent use during routine cystoscopy following minimally invasive hysterectomy for benign indications.Method This prospective cohort study examined patients who underwent laparoscopic or robotic-assisted total or supracervical hysterectomy for benign indications between January 27,2023 and March 11,2024,with one of our minimally invasive gynecologic surgeons at Stony Brook University Hospital.Patients were assigned to the non-phenazopyridine group or the phenazopyridine group.The time needed to visualize the ureteral jets during cystoscopy and the total surgery duration were recorded.A cost analysis was then performed.Results In total,106 patients were included,with 53 patients in each group.Compared with the non-phenazopyridine group,the phenazopyridine group had significantly shorter times from the start of cystoscopy to visualization of the first ureteral jet(31 s vs.42 s,p<0.05).However,there were no significant differences observed for visualization of the second jet,total jet time,or surgery duration.Two patients in the non-phenazopyridine group required the administration of intravenous agents intraoperatively.Routine phenazopyridine was found to be more cost-efficient when medication costs and operative times were examined.Conclusion Routine phenazopyridine use does not significantly shorten overall cystoscopy times,but it is the more cost-efficient option given increased rates of costly intravenous medication use in the non-phenazopyridine group.展开更多
Autosamplers are indispensable key equipment in modern laboratories,playing a pivotal role in fields such as biomedicine,environmental monitoring,food safety,and materials science.However,domestic autosampler enterpri...Autosamplers are indispensable key equipment in modern laboratories,playing a pivotal role in fields such as biomedicine,environmental monitoring,food safety,and materials science.However,domestic autosampler enterprises are facing formidable challenges,confronted by the technological barriers and brand dominance of international giants,as well as increasingly fierce homogeneous competition in the domestic market.This article aims to thoroughly analyze the current market landscape and,based on seven key dimensions—strategic positioning,product technology,sales channels,brand building,service and support,supply chain optimization,and talent development—propose a series of effective market-winning strategies.This will provide theoretical guidance and practical reference for domestic autosampler enterprises to achieve breakthroughs and sustainable development amidst fierce market competition.展开更多
Background Isoacids are the product of branched-chain amino acid fermentation and are naturally producedin the hindgut by microbial fermentation. In ruminants, supplementation of isoacids as a feed additive improvesfi...Background Isoacids are the product of branched-chain amino acid fermentation and are naturally producedin the hindgut by microbial fermentation. In ruminants, supplementation of isoacids as a feed additive improvesfiber utilization, with a positive impact on animal productivity. However, information on how isoacids impact nutrientdigestibility in swine is limited. The objective of this experiment was to determine the optimal inclusion levelof an isoacid blend product based on apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD)of nutrients and fermentation products in the ileal digesta and feces of growing pigs fed a corn-soybean meal diet.Methods Twelve ileal cannulated pigs (20.9 ± 0.6 kg) were used in a 5-period crossover design with 6 diets and 2replicate pigs in each period. Dietary treatments consisted of increasing levels (0%, 0.5%, 0.75%, 1%, 1.25%, and 1.5%)of an isoacid blend (isobutyrate, isovalerate, and 2-methyl butyrate, 1:1:1) added to a corn-soybean meal basal diet.Each experimental period consisted of 14 d: 10 d for acclimatization to the diets, 2 d for fecal collection, and 2 dfor digesta collection.Results Isoacids supplementation quadratically improved the AID of hemicellulose (P < 0.05) and tended to improvethe AID of crude fiber (P < 0.1). The AID of most indispensable amino acids (except Met + Cys, Trp, and Val) as wellas the ATTD of crude protein, gross energy, neutral detergent fiber, and hemicellulose improved or tended to improvelinear or quadratically (P < 0.05 or P < 0.1). In addition, the ATTD values of Arg, His, Ile, Leu, Met + Cys, Phe, Thr, and Valincreased quadratically (P < 0.05). Collectively, 1% of isoacids inclusion resulted in the greatest response. Furthermore,isoacids supplementation tended to increase (P = 0.071, quadratically) the concentration of ammonia and decreased(P < 0.05) the concentrations of acetic acid and total volatile fatty acids with a tendency to decrease (P = 0.064) isovalericacid in the ileal digesta. In fecal samples, the proportion of acetic acid decreased (P < 0.05) quadratically, whereas the proportionsof propionic, valeric, and caproic acids tended to increase linearly and/or quadratically (P < 0.1).Conclusions Isoacids supplementation at 1% in swine diets can improve nutrient digestibility, particularly aminoacids and fiber at the ileal level and ATTD of crude protein, gross energy, and hemicellulose.展开更多
Modern shipboard microgrids(SMGs)incorporating distributed energy resources(DERs)enhance energy resilience and reduce carbon emissions.However,the hierarchical control schemes of DERs bring challenges to the tradition...Modern shipboard microgrids(SMGs)incorporating distributed energy resources(DERs)enhance energy resilience and reduce carbon emissions.However,the hierarchical control schemes of DERs bring challenges to the traditional power flow methods.This paper devises a generalized three-phase power flow approach for SMGs that integrate hierarchically controlled DERs.The main contributions include:(1)a droop-controlled three-phase Newton power flow algorithm that automatically incorporates the droop characteristics of DERs;(2)a secondary-controlled three-phase power flow method for power sharing and voltage regulation;and(3)modified Jacobian matrices to incorporate various hierarchical control modes.Numerical results demonstrate the effectiveness of the devised approach in both balanced and unbalanced three-phase hierarchically controlled SMG systems with arbitrary config-urations.展开更多
We present a novel method for scale-invariant 3D face recognition by integrating computer-generated holography with the Mellin transform.This approach leverages the scale-invariance property of the Mellin transform to...We present a novel method for scale-invariant 3D face recognition by integrating computer-generated holography with the Mellin transform.This approach leverages the scale-invariance property of the Mellin transform to address challenges related to variations in 3D facial sizes during recognition.By applying the Mellin transform to computer-generated holograms and performing correlation between them,which,to the best of our knowledge,is being done for the first time,we have developed a robust recognition framework capable of managing significant scale variations without compromising recognition accuracy.Digital holograms of 3D faces are generated from a face database,and the Mellin transform is employed to enable robust recognition across scale factors ranging from 0.4 to 2.0.Within this range,the method achieves 100%recognition accuracy,as confirmed by both simulation-based and hybrid optical/digital experimental validations.Numerical calculations demonstrate that our method significantly enhances the accuracy and reliability of 3D face recognition,as evidenced by the sharp correlation peaks and higher peak-to-noise ratio(PNR)values than that of using conventional holograms without the Mellin transform.Additionally,the hybrid optical/digital joint transform correlation hardware further validates the method's effectiveness,demonstrating its capability to accurately identify and distinguish 3D faces at various scales.This work provides a promising solution for advanced biometric systems,especially for those which require 3D scale-invariant recognition.展开更多
We generalize the convex duality symmetry in Gibbs' statistical ensemble formulation, between the Gibbs entropy φ_(V,N)(E) as a function of mean internal energy E and Massieu's free entropy Ψ_(V,N)(β) as a ...We generalize the convex duality symmetry in Gibbs' statistical ensemble formulation, between the Gibbs entropy φ_(V,N)(E) as a function of mean internal energy E and Massieu's free entropy Ψ_(V,N)(β) as a function of inverse temperature β. The duality in terms of Legendre–Fenchel transform tells us that Gibbs' thermodynamic entropy is to the law of large numbers(LLN) for arithmetic sample mean values what Shannon's information entropy is to the LLN for empirical counting frequencies in independent and identically distributed data. Proceeding with the same mathematical logic, we identify the energy of the state {ui} as the conjugate variable to the counting of statistical occurrence {mi} and find a Hamilton–Jacobi equation for the Shannon entropy analogous to an equation of state in thermodynamics. An eigenvalue problem that is reminiscent of certain features in quantum mechanics arises in the entropy theory of statistical counting frequencies of Markov correlated data.展开更多
Objectives:Physical activity(PA)levels in young people with cerebral palsy(YPwCP)remain consistently low.Previous research suggests that fitness parameters such as muscular strength and cardiovascular capacity are int...Objectives:Physical activity(PA)levels in young people with cerebral palsy(YPwCP)remain consistently low.Previous research suggests that fitness parameters such as muscular strength and cardiovascular capacity are interrelated with mobility and PA levels in YPwCP.This study aimed to(1)describe fitness parameters and PA levels in YPwCP,(2)explore associations between fitness parameters and PA,and(3)evaluate the reliability of accelerometer-based PA measurement.Methods:A cross-sectional study was conducted with an embedded test–retest reliability assessment of accelerometermeasured PA over a one-month interval.Participants included 36 YPwCP(19 males,17 females;mean age 15.5±0.7 years),classified within GMFCS levels I–III.Cardiorespiratory endurance(VO2max)was assessed using an incremental cycle ergometer test,and leg power was measured using the FiveTimes Sit-to-Stand(5xSTS).PA was measured via self-report using the Physical Activity Questionnaire for Adolescents(PAQ-A)and via device-measured data using a wrist-worn accelerometer over seven consecutive days.Results:We found low levels of PA.The 5xSTS completion time showed moderate to strong correlations with selfreported PA(ρ=−0.384,p≤0.01)and device-measured vigorous PA(ρ=−0.566,p≤0.01).VO2max was positively but not significantly associated with total PA(ρ=0.173)and moderate-to-vigorous PA(ρ=0.115).Accelerometry demonstrated good reliability(ICC=0.796).Conclusions:These findings suggest that accelerometer has good reliability in YPwCP but highlight low levels of PA measured by self-report and accelerometer.Higher lowerlimb power,assessed by faster 5xSTS test,was associated with greater PA.展开更多
In clinical specialties focusing on neurological disorders,there is a need for comprehensive and integrated non-invasive,sensitive,and specific testing methods.Both Parkinson's disease and multiple system atrophy ...In clinical specialties focusing on neurological disorders,there is a need for comprehensive and integrated non-invasive,sensitive,and specific testing methods.Both Parkinson's disease and multiple system atrophy are classified asα-synucleinopathies,characterized by abnormal accumulation ofα-synuclein protein,which provides a shared pathological background for their comparative study.In addition,both Parkinson's disease and multiple system atrophy involve neuronal death,a process that may release circulating cell–free DNA(cfDNA)into the bloodstream,leading to specific alterations.This premise formed the basis for investigating cell–free DNA as a potential biomarker.Cellfree DNA has garnered attention for its potential pathological significance,yet its characteristics in the context of Parkinson's disease and multiple system atrophy are not fully understood.This study investigated the total concentration,nonapoptotic level,integrity,and cellfree DNA relative telomere length of cell-free DNA in the peripheral blood of 171 participants,comprising 76 normal controls,62 patients with Parkinson's disease,and 33 patients with multiple system atrophy.In our cohort,75.8%of patients with Parkinson's disease(stage 1–2 of Hoehn&Yahr)and 60.6%of patients with multiple system atrophy(disease duration less than 3 years)were in the early stages.The diagnostic potential of the cell-free DNA parameters was evaluated using receiver operating characteristic(ROC)analysis,and their association with disease prevalence was examined through logistic regression models,adjusting for confounders such as age,sex,body mass index,and education level.The results showed that cell-free DNA integrity was significantly elevated in both Parkinson's disease and multiple system atrophy patients compared with normal controls(P<0.001 for both groups),whereas cell-free DNA relative telomere length was markedly shorter(P=0.003 for Parkinson's disease and P=0.010 for multiple system atrophy).Receiver operating characteristic analysis indicated that both cell-free DNA integrity and cell-free DNA relative telomere length possessed good diagnostic accuracy for differentiating Parkinson's disease and multiple system atrophy from normal controls.Specifically,higher cell-free DNA integrity was associated with increased risk of Parkinson's disease(odds ratio[OR]:5.72;95%confidence interval[CI]:1.54–24.19)and multiple system atrophy(OR:10.10;95%CI:1.55–122.98).Conversely,longer cell-free DNA relative telomere length was linked to reduced risk of Parkinson's disease(OR:0.16;95%CI:0.04–0.54)and multiple system atrophy(OR:0.10;95%CI:0.01–0.57).These findings suggest that cell-free DNA integrity and cellfree DNA relative telomere length may serve as promising biomarkers for the early diagnosis of Parkinson's disease and multiple system atrophy,potentially reflecting specific underlying pathophysiological processes of these neurodegenerative disorders.展开更多
Chemical hydrogen storage technology is crucial for the widespread use of hydrogen,with significant research progress being made in hydrazine hydrate(N_(2)H_(4)·H_(2)O).However,the efficient decomposition of N_(2...Chemical hydrogen storage technology is crucial for the widespread use of hydrogen,with significant research progress being made in hydrazine hydrate(N_(2)H_(4)·H_(2)O).However,the efficient decomposition of N_(2)H_(4)·H_(2)O remains a major challenge,hindered by dynamic constraints.To address this,we prepared NiPt nanoparticles deposited onto urchin-like TiO_(2)(u-TiO_(2))using the impregnation-reduction method,resulting in the NiPt/u-TiO_(2)catalyst.Remarkably,the Ni0.5Pt0.5/u-TiO_(2)catalyst demonstrated 100%H_(2)selectivity,ultrahigh catalytic activity and remarkable durability for N_(2)H_(4)·H_(2)O dehydrogenation,with a turnover frequency(TOF)of115.8 min^(-1),surpassing that of the corresponding NiPt/commercial TiO_(2)(c-TiO_(2)).Characterization and experimental findings suggest that the remarkable activity may originate from the unique urchin-like structure of the catalyst,along with the synergistic interaction between NiPt metals and the support.This research opens new avenues for designing nanomaterials with morphology advantages for hydrogen evolution reaction.展开更多
Electrocatalysis for nitrate(NO_(3^(–)))removal from wastewater faces the challenge of merging efficient reduction and high selectivity to nitrogen(N2)with economic viability in a durable catalyst.In this study,bimet...Electrocatalysis for nitrate(NO_(3^(–)))removal from wastewater faces the challenge of merging efficient reduction and high selectivity to nitrogen(N2)with economic viability in a durable catalyst.In this study,bimetallic PdCu/TiO_(x)composite catalysts were synthesized with varying Pd and Cu ratios through electrochemical deposition on defective TiOxnanotube arrays.Denitrification experiments demonstrated that the Pd_(1)Cu_(1)/TiO_(x)catalyst exhibited the highest(NO_(3^(–)))removal rate(81.2%)and N_(2)selectivity(67.2%)among all tested catalysts.Leveraging the exceptional light-responsive property of TiO_(x),the introduction of light energy as an assisting factor in electrocatalysis further augmented the(NO_(3^(–)))treatment rate,resulting in a higher(NO_(3^(–)))removal rate of 95.1%and N_(2)selectivity of approximately 90%.Compared to individual electrocatalysis and photocatalysis systems,the overpotential for the catalytic interface active*H formation in the photo-assisted electrocatalysis system was remarkably reduced,thus accelerating electron migration and promoting(NO_(3^(–)))reduction kinetics.Economic analysis revealed an energy consumption of 2.74 k Wh/mol and a corresponding energy consumption per order(EEO)of 0.79 k Wh/m^(3)for the Pd_(1)Cu_(1)/TiOxcatalyst to reduce 25.2 mg/L of(NO_(3^(–)))-N in water to N_(2),showcasing remarkable competitiveness and economic advantages over other water treatment technologies.This study developed the PdCu/TiOxelectrocatalysts with high(NO_(3^(–)))removal rates and N_(2)selectivity,particularly when combined with light energy,the efficiency and selectivity were significantly enhanced,offering a competitive and economically viable solution for wastewater treatment.展开更多
Decision Support Tool(DST)enables farmers to make site-specific crop management decisions;however,comprehensive calibration can be both costly and time-consuming.This study assessed the production and economic benefit...Decision Support Tool(DST)enables farmers to make site-specific crop management decisions;however,comprehensive calibration can be both costly and time-consuming.This study assessed the production and economic benefits of two calibrations of the Nutrient Expert(NE)tool for rice in Sri Lanka’s Alfisols:the basic calibration(Nutrient Expert Sri Lanka 1,NESL1)and the comprehensive calibration(Nutrient Expert Sri Lanka 2,NESL2).NESL1 was developed by adapting the South Indian version of NE to local conditions,while NESL2 was an updated version,using three years of data from 71 farmer fields.展开更多
Background:Schistosomiasis is a parasitic disease.It is caused by a prevalent infection in tropical areas and is transmitted through contaminated water with larvae parasites.Schistosomiasis is the second most parasiti...Background:Schistosomiasis is a parasitic disease.It is caused by a prevalent infection in tropical areas and is transmitted through contaminated water with larvae parasites.Schistosomiasis is the second most parasitic disease globally,so investigating its prevention and treatment is crucial.Methods:This paper aims to suggest a time-fractional model of schistosomiasis disease(T-FMSD)in the sense of the Caputo operator.The T-FMSD considers the dynamics involving susceptible ones not infected with schistosomiasis(S_(h)(t)),those infected with the infection(Ih(t)),those recovering from the disease(R(t)),susceptible snails with and without schistosomiasis infection,respectively shown by I_(v)(t)and S_(v)(t).We use a new basis function,generalized Bernoulli polynomials,for the approximate solution of T-FMSD.The operational matrices are incorporated into the method of Lagrange multipliers so that the fractional problem can be transformed into an algebraic system of equations.Results:The existence and uniqueness of the solution,and the convergence analysis of the model are established.The numerical computations are graphically presented to depict the variations of the compartments with time for varied fractional order derivatives.Conclusions:The proposed method not only provides an accurate solution but also can accurately predict schistosomiasis transmission.The results of this study will assist medical scientists in taking necessary measures during screening and treatment processes.展开更多
We report the magnetic and transport properties of EuBi_(2) single crystal. EuBi_(2) exhibits complex magnetic behavior at low temperatures. In both the in-plane and out-of-plane directions, three antiferromagnetic(AF...We report the magnetic and transport properties of EuBi_(2) single crystal. EuBi_(2) exhibits complex magnetic behavior at low temperatures. In both the in-plane and out-of-plane directions, three antiferromagnetic(AFM) transitions have been observed at T_(N1)~18.9 K, T_(N2)~7.0 K, and T_(N3)~3.1 K. Among them, the transitions at T_(N2) and T_(N3) represent the canted AFM orders with ferromagnetic components. As the magnetic field increases, the transition at T_(N3) is rapidly suppressed to disappearance. However, the transitions at T_(N1) and T_(N2) persist until high fields and their signatures can also be reflected in the resistivity and specific heat. Above the magnetic transition temperature T_(N1), the resistivity of EuBi_(2) increases linearly with temperature, exhibiting the strange-metal behavior. In the magnetically ordered region below T_(N1), EuBi_(2) exhibits the weak antilocalization(WAL) effect and large magnetoresistance(475% at 1.8 K and 14 T). It is suggested that the magnetic ordering significantly enhances the spin–orbital coupling interaction and induces the WAL effect.展开更多
Controllable hydrogen production via the catalytic decomposition of hydrous hydrazine(N_(2)H_(4)·H_(2)O)holds significant promise for mobile and portable applications.However,current catalysts suffer from unsatis...Controllable hydrogen production via the catalytic decomposition of hydrous hydrazine(N_(2)H_(4)·H_(2)O)holds significant promise for mobile and portable applications.However,current catalysts suffer from unsatisfactory reaction activity and hydrogen(H2)selectivity.Based on the unique redox properties of CeO_(2),this article aims to enhance the thermal catalytic performance for the decomposition of N_(2)H_(4)·H_(2)O by improving metal-support interactions between the TiCeO_(2)and NiPt active components.Meanwhile,the sea urchin-like TiCeO_(2)support,which is more conducive to the dispersion of the NiPt nanoparticles and provides more reactive sites for the reaction,was used to immobilize Ni-Pt into the NixPt1-x/TiCeO_(2)sample using the impregnation-reduction method.By modulating Ce doping and the Ni-Pt molar ratio,samples with different Ni-Pt compositions were synthesized.The optimal Ni0.5Pt0.5/TiCeO_(2)(nNi:nPt=1)shows the highest catalytic performance compared with the other samples,with a TOF(turnover frequency)of 212.58 min-1and 100%hydrogen selectivity at 323 K.Furthermore,the hydrogen selectivity remains 100%after six cycles.This remarkable activity and stability provide valuable insights and encouragement for accelerating the practical application of N_(2)H_(4)·H_(2)O as a viable hydrogen carrier.展开更多
BACKGROUND Atrial fibrillation,affecting approximately 33 million people globally,is the most common sustained arrhythmia,increasing risks of stroke,heart failure,and mortality.Pulmonary vein isolation via catheter ab...BACKGROUND Atrial fibrillation,affecting approximately 33 million people globally,is the most common sustained arrhythmia,increasing risks of stroke,heart failure,and mortality.Pulmonary vein isolation via catheter ablation is a key rhythm control strategy,with cryoballoon ablation(CBA)being a standard thermal method but associated with risks like phrenic nerve palsy(5%-10%),esophageal injury,and vein stenosis.Pulsed field ablation(PFA),a non-thermal technique using electrical pulses for selective electroporation,offers potential for shorter procedures and improved safety.Limited direct comparisons between PFA and CBA necessitate a systematic evaluation of their efficacy and safety.AIM To compare the procedural success,safety,and 1-year arrhythmia-free survival of PFA vs CBA for first-time pulmonary vein isolation in adults with paroxysmal or persistent atrial fibrillation.METHODS A Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant systematic review and metaanalysis was conducted,searching PubMed,EMBASE,Web of Science,and other databases up to August 2025 for comparative studies.Pooled mean difference for continuous outcomes and odds ratio(OR)for dichotomous outcomes were calculated using random-effects models.Study quality was assessed with the Newcastle-Ottawa Scale,heterogeneity with I2,and publication bias with funnel plots.RESULTS Seven studies(six cohorts,one randomized controlled trial)were included,with a mean age of approximately 66 years,59%-78%male,and high prevalence of hypertension and diabetes.PFA significantly reduced procedure time(mean difference=-15.24 minutes,95%CI:-16.63 to-13.85,P<0.00001;I2=89%),improved arrhythmia-free survival(OR=1.27,95%CI:1.04-1.55,P=0.02;I2=45%),and lowered phrenic nerve palsy risk(OR=0.17,95%CI:0.04-0.63,P=0.008;I2=0%).No significant differences were found in fluoroscopy time,cardiac tamponade,repeat ablation,or vascular complications.CONCLUSION PFA demonstrates shorter procedure times,reduced phrenic nerve palsy,and better arrhythmia control compared to CBA,with comparable safety profiles.However,evidence is limited by observational study designs,heterogeneity,and potential bias.Large-scale randomized controlled trials with extended follow-up are needed to confirm these findings and guide clinical practice.展开更多
Very few studies have benefited from the synergetic implementation of visible,near-infrared,and shortwave infrared(VNIR-SWIR)spectra and terrain attributes in predicting Pb content in agricultural soils.To fill this g...Very few studies have benefited from the synergetic implementation of visible,near-infrared,and shortwave infrared(VNIR-SWIR)spectra and terrain attributes in predicting Pb content in agricultural soils.To fill this gap,this study aimed to predict lead(Pb)contents in agricultural soils by combining machine learning algorithms(MLAs)with VNIR-SWIR spectra or/and terrain attributes under three distinct approaches.Six MLAs were tested,including artificial neural network(ANN),partial least squares regression,support vector machine(SVM),Gaussian process regression(GPR),extreme gradient boosting(EGB),and Cubist.The VNIR-SWIR spectral data were preprocessed by methods of discrete wavelet transformation,logarithmic transformation-Savitzky Golay smoothing,standard normal variate(SNV),multiplicative scatter correction,first derivative(Fi D),and second derivative.In approach 1,MLAs were combined with the preprocessed VNIR-SWIR spectral data.The Cubist-Fi D combination was the most effective,achieving a coefficient of determination(R2)of 0.63,a concordance correlation coefficient(CCC)of 0.51,a mean absolute error(MAE)of 6.87 mg kg^(-1),and a root mean square error(RMSE)of8.66 mg kg^(-1).In approach 2,MLAs were combined with both preprocessed VNIR-SWIR spectral data and terrain attributes,and the EGB-SNV combination yielded superior results with R2of 0.75,CCC of 0.65,MAE of 5.48 mg kg^(-1),and RMSE of 7.34 mg kg^(-1).Approach 3 combined MLAs and terrain attributes,and Cubist demonstrated the best prediction results,with R^(2) of 0.75,CCC of 0.66,MAE of 6.18 mg kg^(-1),and RMSE of 7.71 mg kg^(-1).The cumulative assessment identified the fusion of terrain properties,SNV-preprocessed VNIR-SWIR spectra,and EGB as the optimal method for estimating Pb content in agricultural soils,yielding the highest R2value and minimal error.Comparatively,GPR,ANN,and SVM techniques achieved higher R2values in approaches 2 and 3 but also exhibited higher estimation errors.In conclusion,the study underscores the significance of using relevant auxiliary datasets and appropriate MLAs for accurate Pb content prediction with minimal error in agricultural soils.The findings contribute valuable insights for developing successful soil management strategies based on predictive modeling.展开更多
Objectives:As the Duchenne Muscular Dystrophy(DMD)is a progressive neuromuscular disorder frequently associated with cardiac dysfunction,this study aimed to evaluate the influence of beta-blocker therapy on cardiac au...Objectives:As the Duchenne Muscular Dystrophy(DMD)is a progressive neuromuscular disorder frequently associated with cardiac dysfunction,this study aimed to evaluate the influence of beta-blocker therapy on cardiac autonomic modulation in adolescents withDMDby analyzing heart rate variability(HRV)indices in patients with and without betablockers.Methods:A cross-sectional study was conducted with 90 participants divided into three groups:(1)participants with DMD receiving beta-blocker therapy(DMDB,n=30),(2)participants with DMD without beta-blocker therapy(GMDM,n=30),and(3)age-and sex-matched typically developing participants(GDT,n=30).HRV was assessed using validated beat-to-beat heart rate monitoring(RS800CX,Polar)under controlled conditions.Linear and non-linear HRV indices(including Detrended Fluctuation Analysis and Symbolic Dynamics)were analysed using Kubios HRV software.Results:DMD patients exhibited autonomic impairment,characterized by decreased HRV,increased sympathetic dominance,and reduced parasympathetic modulation.Betablocker therapy was associated with significantly higher Mean Beat-to-beat interval(RR)and lower Mean Heart Rate(HR)compared to the non-beta-blocker DMD group,with values approaching those observed in typically developing participants.Non-linear indices suggested thatDMDpatients receiving beta-blockers demonstrated increased HRV complexity and fractal properties compared to those not receiving beta-blockers,although differences remained between the DMD and control groups.Conclusions:Autonomic dysfunction in DMD is characterized by reduced HRV and altered sympathovagal balance.In our results,beta-blocker therapy was associated with improved HRV and enhanced autonomic control.These findings highlight the potential cardioprotective role of betablockers in DMD management and emphasize the need for further research into optimizing autonomic function in DMD.展开更多
文摘Peripheral immunity forms the foundation of tumor immunity,while tumor immunity represents a more refined adaptation of peripheral immune responses.The tumor microenvironment(TME),a localized niche surrounding tumor cells,is inherently immunosuppressive(1,2).Effective tumor therapy necessitates the dismantling of this microenvironment,aiming to eradicate tumors from the host system.
文摘The challenge in searching for fundamental symmetry violation.Neutrinoless double-beta(0νββ)decay represents one of the most profound tests of fundamental symmetries in nature.This hypothetical nuclear process,in which two neutrons simultaneously decay into two protons with the emission of two electrons but no neutrinos,would demonstrate that lepton number is not conserved and confirm that neutrinos are their own antiparticles(Majorana particles).The observation of 0νββdecay would provide crucial insights into the absolute neutrino mass scale and could illuminate the origin of matter-antimatter asymmetry in the universe.
文摘Objective To determine the impact of planned preoperative phenazopyridine administration on operative times and costs compared with as-needed intravenous agent use during routine cystoscopy following minimally invasive hysterectomy for benign indications.Method This prospective cohort study examined patients who underwent laparoscopic or robotic-assisted total or supracervical hysterectomy for benign indications between January 27,2023 and March 11,2024,with one of our minimally invasive gynecologic surgeons at Stony Brook University Hospital.Patients were assigned to the non-phenazopyridine group or the phenazopyridine group.The time needed to visualize the ureteral jets during cystoscopy and the total surgery duration were recorded.A cost analysis was then performed.Results In total,106 patients were included,with 53 patients in each group.Compared with the non-phenazopyridine group,the phenazopyridine group had significantly shorter times from the start of cystoscopy to visualization of the first ureteral jet(31 s vs.42 s,p<0.05).However,there were no significant differences observed for visualization of the second jet,total jet time,or surgery duration.Two patients in the non-phenazopyridine group required the administration of intravenous agents intraoperatively.Routine phenazopyridine was found to be more cost-efficient when medication costs and operative times were examined.Conclusion Routine phenazopyridine use does not significantly shorten overall cystoscopy times,but it is the more cost-efficient option given increased rates of costly intravenous medication use in the non-phenazopyridine group.
文摘Autosamplers are indispensable key equipment in modern laboratories,playing a pivotal role in fields such as biomedicine,environmental monitoring,food safety,and materials science.However,domestic autosampler enterprises are facing formidable challenges,confronted by the technological barriers and brand dominance of international giants,as well as increasingly fierce homogeneous competition in the domestic market.This article aims to thoroughly analyze the current market landscape and,based on seven key dimensions—strategic positioning,product technology,sales channels,brand building,service and support,supply chain optimization,and talent development—propose a series of effective market-winning strategies.This will provide theoretical guidance and practical reference for domestic autosampler enterprises to achieve breakthroughs and sustainable development amidst fierce market competition.
基金financially supported by Zinpro Corporation(grant number:SA2300029,2022–2025).
文摘Background Isoacids are the product of branched-chain amino acid fermentation and are naturally producedin the hindgut by microbial fermentation. In ruminants, supplementation of isoacids as a feed additive improvesfiber utilization, with a positive impact on animal productivity. However, information on how isoacids impact nutrientdigestibility in swine is limited. The objective of this experiment was to determine the optimal inclusion levelof an isoacid blend product based on apparent ileal digestibility (AID) and apparent total tract digestibility (ATTD)of nutrients and fermentation products in the ileal digesta and feces of growing pigs fed a corn-soybean meal diet.Methods Twelve ileal cannulated pigs (20.9 ± 0.6 kg) were used in a 5-period crossover design with 6 diets and 2replicate pigs in each period. Dietary treatments consisted of increasing levels (0%, 0.5%, 0.75%, 1%, 1.25%, and 1.5%)of an isoacid blend (isobutyrate, isovalerate, and 2-methyl butyrate, 1:1:1) added to a corn-soybean meal basal diet.Each experimental period consisted of 14 d: 10 d for acclimatization to the diets, 2 d for fecal collection, and 2 dfor digesta collection.Results Isoacids supplementation quadratically improved the AID of hemicellulose (P < 0.05) and tended to improvethe AID of crude fiber (P < 0.1). The AID of most indispensable amino acids (except Met + Cys, Trp, and Val) as wellas the ATTD of crude protein, gross energy, neutral detergent fiber, and hemicellulose improved or tended to improvelinear or quadratically (P < 0.05 or P < 0.1). In addition, the ATTD values of Arg, His, Ile, Leu, Met + Cys, Phe, Thr, and Valincreased quadratically (P < 0.05). Collectively, 1% of isoacids inclusion resulted in the greatest response. Furthermore,isoacids supplementation tended to increase (P = 0.071, quadratically) the concentration of ammonia and decreased(P < 0.05) the concentrations of acetic acid and total volatile fatty acids with a tendency to decrease (P = 0.064) isovalericacid in the ileal digesta. In fecal samples, the proportion of acetic acid decreased (P < 0.05) quadratically, whereas the proportionsof propionic, valeric, and caproic acids tended to increase linearly and/or quadratically (P < 0.1).Conclusions Isoacids supplementation at 1% in swine diets can improve nutrient digestibility, particularly aminoacids and fiber at the ileal level and ATTD of crude protein, gross energy, and hemicellulose.
基金supported in part by the Department of Navy award N00014-24-1-2287 and N00014-23-1-2124。
文摘Modern shipboard microgrids(SMGs)incorporating distributed energy resources(DERs)enhance energy resilience and reduce carbon emissions.However,the hierarchical control schemes of DERs bring challenges to the traditional power flow methods.This paper devises a generalized three-phase power flow approach for SMGs that integrate hierarchically controlled DERs.The main contributions include:(1)a droop-controlled three-phase Newton power flow algorithm that automatically incorporates the droop characteristics of DERs;(2)a secondary-controlled three-phase power flow method for power sharing and voltage regulation;and(3)modified Jacobian matrices to incorporate various hierarchical control modes.Numerical results demonstrate the effectiveness of the devised approach in both balanced and unbalanced three-phase hierarchically controlled SMG systems with arbitrary config-urations.
基金financial supports from the National Natural Science Foundation of China(Grant No.6227511362405124).
文摘We present a novel method for scale-invariant 3D face recognition by integrating computer-generated holography with the Mellin transform.This approach leverages the scale-invariance property of the Mellin transform to address challenges related to variations in 3D facial sizes during recognition.By applying the Mellin transform to computer-generated holograms and performing correlation between them,which,to the best of our knowledge,is being done for the first time,we have developed a robust recognition framework capable of managing significant scale variations without compromising recognition accuracy.Digital holograms of 3D faces are generated from a face database,and the Mellin transform is employed to enable robust recognition across scale factors ranging from 0.4 to 2.0.Within this range,the method achieves 100%recognition accuracy,as confirmed by both simulation-based and hybrid optical/digital experimental validations.Numerical calculations demonstrate that our method significantly enhances the accuracy and reliability of 3D face recognition,as evidenced by the sharp correlation peaks and higher peak-to-noise ratio(PNR)values than that of using conventional holograms without the Mellin transform.Additionally,the hybrid optical/digital joint transform correlation hardware further validates the method's effectiveness,demonstrating its capability to accurately identify and distinguish 3D faces at various scales.This work provides a promising solution for advanced biometric systems,especially for those which require 3D scale-invariant recognition.
文摘We generalize the convex duality symmetry in Gibbs' statistical ensemble formulation, between the Gibbs entropy φ_(V,N)(E) as a function of mean internal energy E and Massieu's free entropy Ψ_(V,N)(β) as a function of inverse temperature β. The duality in terms of Legendre–Fenchel transform tells us that Gibbs' thermodynamic entropy is to the law of large numbers(LLN) for arithmetic sample mean values what Shannon's information entropy is to the LLN for empirical counting frequencies in independent and identically distributed data. Proceeding with the same mathematical logic, we identify the energy of the state {ui} as the conjugate variable to the counting of statistical occurrence {mi} and find a Hamilton–Jacobi equation for the Shannon entropy analogous to an equation of state in thermodynamics. An eigenvalue problem that is reminiscent of certain features in quantum mechanics arises in the entropy theory of statistical counting frequencies of Markov correlated data.
基金supported by the Action Medical Research UK and Chartered Society of Physiotherapy the Charitable Trust。
文摘Objectives:Physical activity(PA)levels in young people with cerebral palsy(YPwCP)remain consistently low.Previous research suggests that fitness parameters such as muscular strength and cardiovascular capacity are interrelated with mobility and PA levels in YPwCP.This study aimed to(1)describe fitness parameters and PA levels in YPwCP,(2)explore associations between fitness parameters and PA,and(3)evaluate the reliability of accelerometer-based PA measurement.Methods:A cross-sectional study was conducted with an embedded test–retest reliability assessment of accelerometermeasured PA over a one-month interval.Participants included 36 YPwCP(19 males,17 females;mean age 15.5±0.7 years),classified within GMFCS levels I–III.Cardiorespiratory endurance(VO2max)was assessed using an incremental cycle ergometer test,and leg power was measured using the FiveTimes Sit-to-Stand(5xSTS).PA was measured via self-report using the Physical Activity Questionnaire for Adolescents(PAQ-A)and via device-measured data using a wrist-worn accelerometer over seven consecutive days.Results:We found low levels of PA.The 5xSTS completion time showed moderate to strong correlations with selfreported PA(ρ=−0.384,p≤0.01)and device-measured vigorous PA(ρ=−0.566,p≤0.01).VO2max was positively but not significantly associated with total PA(ρ=0.173)and moderate-to-vigorous PA(ρ=0.115).Accelerometry demonstrated good reliability(ICC=0.796).Conclusions:These findings suggest that accelerometer has good reliability in YPwCP but highlight low levels of PA measured by self-report and accelerometer.Higher lowerlimb power,assessed by faster 5xSTS test,was associated with greater PA.
基金supported by the National Key Research and Development Program of China,No.2021YFC2501205(to YC)the Science and Technology Innovation 2030 project,No.2021ZD0201101(to YC)+1 种基金the National Natural Science Foundation of China,Nos.82201409(to YL),82201401(to CH)the Xuanwu Youth Development Project,No.QNPY2021011(to CH)。
文摘In clinical specialties focusing on neurological disorders,there is a need for comprehensive and integrated non-invasive,sensitive,and specific testing methods.Both Parkinson's disease and multiple system atrophy are classified asα-synucleinopathies,characterized by abnormal accumulation ofα-synuclein protein,which provides a shared pathological background for their comparative study.In addition,both Parkinson's disease and multiple system atrophy involve neuronal death,a process that may release circulating cell–free DNA(cfDNA)into the bloodstream,leading to specific alterations.This premise formed the basis for investigating cell–free DNA as a potential biomarker.Cellfree DNA has garnered attention for its potential pathological significance,yet its characteristics in the context of Parkinson's disease and multiple system atrophy are not fully understood.This study investigated the total concentration,nonapoptotic level,integrity,and cellfree DNA relative telomere length of cell-free DNA in the peripheral blood of 171 participants,comprising 76 normal controls,62 patients with Parkinson's disease,and 33 patients with multiple system atrophy.In our cohort,75.8%of patients with Parkinson's disease(stage 1–2 of Hoehn&Yahr)and 60.6%of patients with multiple system atrophy(disease duration less than 3 years)were in the early stages.The diagnostic potential of the cell-free DNA parameters was evaluated using receiver operating characteristic(ROC)analysis,and their association with disease prevalence was examined through logistic regression models,adjusting for confounders such as age,sex,body mass index,and education level.The results showed that cell-free DNA integrity was significantly elevated in both Parkinson's disease and multiple system atrophy patients compared with normal controls(P<0.001 for both groups),whereas cell-free DNA relative telomere length was markedly shorter(P=0.003 for Parkinson's disease and P=0.010 for multiple system atrophy).Receiver operating characteristic analysis indicated that both cell-free DNA integrity and cell-free DNA relative telomere length possessed good diagnostic accuracy for differentiating Parkinson's disease and multiple system atrophy from normal controls.Specifically,higher cell-free DNA integrity was associated with increased risk of Parkinson's disease(odds ratio[OR]:5.72;95%confidence interval[CI]:1.54–24.19)and multiple system atrophy(OR:10.10;95%CI:1.55–122.98).Conversely,longer cell-free DNA relative telomere length was linked to reduced risk of Parkinson's disease(OR:0.16;95%CI:0.04–0.54)and multiple system atrophy(OR:0.10;95%CI:0.01–0.57).These findings suggest that cell-free DNA integrity and cellfree DNA relative telomere length may serve as promising biomarkers for the early diagnosis of Parkinson's disease and multiple system atrophy,potentially reflecting specific underlying pathophysiological processes of these neurodegenerative disorders.
基金financially supported by the National Natural Science Foundation of China(Nos.22478001,U22A20408 and 22108238)the Excellent Young Scholars Program of Natural Science Foundation Anhui Province(No.2408085Y005)+3 种基金the Excellent Youth Scholars Program of Higher Education Institutions of Anhui Province(No.2024AH030008)the Open Fund of Shanghai Jiao Tong University Shaoxing Research Institute(No.JDSX2023014)the State Key Laboratory of Clean Energy Utilization(No.ZJUCEU2024017)the Outstanding Scientific Research and Innovation Team Program of Higher Education Institutions of Anhui Province(No.2023AH010015)
文摘Chemical hydrogen storage technology is crucial for the widespread use of hydrogen,with significant research progress being made in hydrazine hydrate(N_(2)H_(4)·H_(2)O).However,the efficient decomposition of N_(2)H_(4)·H_(2)O remains a major challenge,hindered by dynamic constraints.To address this,we prepared NiPt nanoparticles deposited onto urchin-like TiO_(2)(u-TiO_(2))using the impregnation-reduction method,resulting in the NiPt/u-TiO_(2)catalyst.Remarkably,the Ni0.5Pt0.5/u-TiO_(2)catalyst demonstrated 100%H_(2)selectivity,ultrahigh catalytic activity and remarkable durability for N_(2)H_(4)·H_(2)O dehydrogenation,with a turnover frequency(TOF)of115.8 min^(-1),surpassing that of the corresponding NiPt/commercial TiO_(2)(c-TiO_(2)).Characterization and experimental findings suggest that the remarkable activity may originate from the unique urchin-like structure of the catalyst,along with the synergistic interaction between NiPt metals and the support.This research opens new avenues for designing nanomaterials with morphology advantages for hydrogen evolution reaction.
基金the National Natural Science Foundation of China(No.52300084)China Postdoctoral Science Foundation(No.2023M741151)the Fundamental Research Funds for the Central Universities(No.2024MS063)。
文摘Electrocatalysis for nitrate(NO_(3^(–)))removal from wastewater faces the challenge of merging efficient reduction and high selectivity to nitrogen(N2)with economic viability in a durable catalyst.In this study,bimetallic PdCu/TiO_(x)composite catalysts were synthesized with varying Pd and Cu ratios through electrochemical deposition on defective TiOxnanotube arrays.Denitrification experiments demonstrated that the Pd_(1)Cu_(1)/TiO_(x)catalyst exhibited the highest(NO_(3^(–)))removal rate(81.2%)and N_(2)selectivity(67.2%)among all tested catalysts.Leveraging the exceptional light-responsive property of TiO_(x),the introduction of light energy as an assisting factor in electrocatalysis further augmented the(NO_(3^(–)))treatment rate,resulting in a higher(NO_(3^(–)))removal rate of 95.1%and N_(2)selectivity of approximately 90%.Compared to individual electrocatalysis and photocatalysis systems,the overpotential for the catalytic interface active*H formation in the photo-assisted electrocatalysis system was remarkably reduced,thus accelerating electron migration and promoting(NO_(3^(–)))reduction kinetics.Economic analysis revealed an energy consumption of 2.74 k Wh/mol and a corresponding energy consumption per order(EEO)of 0.79 k Wh/m^(3)for the Pd_(1)Cu_(1)/TiOxcatalyst to reduce 25.2 mg/L of(NO_(3^(–)))-N in water to N_(2),showcasing remarkable competitiveness and economic advantages over other water treatment technologies.This study developed the PdCu/TiOxelectrocatalysts with high(NO_(3^(–)))removal rates and N_(2)selectivity,particularly when combined with light energy,the efficiency and selectivity were significantly enhanced,offering a competitive and economically viable solution for wastewater treatment.
基金supported by the National Research Council of Sri Lanka(Grant No.NRC TO 16-07).
文摘Decision Support Tool(DST)enables farmers to make site-specific crop management decisions;however,comprehensive calibration can be both costly and time-consuming.This study assessed the production and economic benefits of two calibrations of the Nutrient Expert(NE)tool for rice in Sri Lanka’s Alfisols:the basic calibration(Nutrient Expert Sri Lanka 1,NESL1)and the comprehensive calibration(Nutrient Expert Sri Lanka 2,NESL2).NESL1 was developed by adapting the South Indian version of NE to local conditions,while NESL2 was an updated version,using three years of data from 71 farmer fields.
文摘Background:Schistosomiasis is a parasitic disease.It is caused by a prevalent infection in tropical areas and is transmitted through contaminated water with larvae parasites.Schistosomiasis is the second most parasitic disease globally,so investigating its prevention and treatment is crucial.Methods:This paper aims to suggest a time-fractional model of schistosomiasis disease(T-FMSD)in the sense of the Caputo operator.The T-FMSD considers the dynamics involving susceptible ones not infected with schistosomiasis(S_(h)(t)),those infected with the infection(Ih(t)),those recovering from the disease(R(t)),susceptible snails with and without schistosomiasis infection,respectively shown by I_(v)(t)and S_(v)(t).We use a new basis function,generalized Bernoulli polynomials,for the approximate solution of T-FMSD.The operational matrices are incorporated into the method of Lagrange multipliers so that the fractional problem can be transformed into an algebraic system of equations.Results:The existence and uniqueness of the solution,and the convergence analysis of the model are established.The numerical computations are graphically presented to depict the variations of the compartments with time for varied fractional order derivatives.Conclusions:The proposed method not only provides an accurate solution but also can accurately predict schistosomiasis transmission.The results of this study will assist medical scientists in taking necessary measures during screening and treatment processes.
基金Project supported by the National Key Research and Development Program of China (Grant No. 2023YFA1406500)the National Natural Science Foundation of China (Grant Nos. 12474098, 12274388, 12174361, 12404191, 52102333, 12404043, and 12204004)the Natural Science Foundation of Anhui Province (Grant No. 2408085QA024)。
文摘We report the magnetic and transport properties of EuBi_(2) single crystal. EuBi_(2) exhibits complex magnetic behavior at low temperatures. In both the in-plane and out-of-plane directions, three antiferromagnetic(AFM) transitions have been observed at T_(N1)~18.9 K, T_(N2)~7.0 K, and T_(N3)~3.1 K. Among them, the transitions at T_(N2) and T_(N3) represent the canted AFM orders with ferromagnetic components. As the magnetic field increases, the transition at T_(N3) is rapidly suppressed to disappearance. However, the transitions at T_(N1) and T_(N2) persist until high fields and their signatures can also be reflected in the resistivity and specific heat. Above the magnetic transition temperature T_(N1), the resistivity of EuBi_(2) increases linearly with temperature, exhibiting the strange-metal behavior. In the magnetically ordered region below T_(N1), EuBi_(2) exhibits the weak antilocalization(WAL) effect and large magnetoresistance(475% at 1.8 K and 14 T). It is suggested that the magnetic ordering significantly enhances the spin–orbital coupling interaction and induces the WAL effect.
基金Project supported by the National Natural Science Foundation of China(22478001,22108238,22108002,U22A20408)Excellent Young Scholars Program of Natural Science Foundation Anhui Province(2408085Y005)+2 种基金Excellent Youth Scholars Program of Higher Education Institutions of Anhui Province(2024AH030008)the Open Fund of Shanghai Jiao Tong University Shaoxing Research Institute(JDSX2023014)the Outstanding Scientific Research and Innovation Team Program of Higher Education Institutions of Anhui Province(2023AH010015)。
文摘Controllable hydrogen production via the catalytic decomposition of hydrous hydrazine(N_(2)H_(4)·H_(2)O)holds significant promise for mobile and portable applications.However,current catalysts suffer from unsatisfactory reaction activity and hydrogen(H2)selectivity.Based on the unique redox properties of CeO_(2),this article aims to enhance the thermal catalytic performance for the decomposition of N_(2)H_(4)·H_(2)O by improving metal-support interactions between the TiCeO_(2)and NiPt active components.Meanwhile,the sea urchin-like TiCeO_(2)support,which is more conducive to the dispersion of the NiPt nanoparticles and provides more reactive sites for the reaction,was used to immobilize Ni-Pt into the NixPt1-x/TiCeO_(2)sample using the impregnation-reduction method.By modulating Ce doping and the Ni-Pt molar ratio,samples with different Ni-Pt compositions were synthesized.The optimal Ni0.5Pt0.5/TiCeO_(2)(nNi:nPt=1)shows the highest catalytic performance compared with the other samples,with a TOF(turnover frequency)of 212.58 min-1and 100%hydrogen selectivity at 323 K.Furthermore,the hydrogen selectivity remains 100%after six cycles.This remarkable activity and stability provide valuable insights and encouragement for accelerating the practical application of N_(2)H_(4)·H_(2)O as a viable hydrogen carrier.
文摘BACKGROUND Atrial fibrillation,affecting approximately 33 million people globally,is the most common sustained arrhythmia,increasing risks of stroke,heart failure,and mortality.Pulmonary vein isolation via catheter ablation is a key rhythm control strategy,with cryoballoon ablation(CBA)being a standard thermal method but associated with risks like phrenic nerve palsy(5%-10%),esophageal injury,and vein stenosis.Pulsed field ablation(PFA),a non-thermal technique using electrical pulses for selective electroporation,offers potential for shorter procedures and improved safety.Limited direct comparisons between PFA and CBA necessitate a systematic evaluation of their efficacy and safety.AIM To compare the procedural success,safety,and 1-year arrhythmia-free survival of PFA vs CBA for first-time pulmonary vein isolation in adults with paroxysmal or persistent atrial fibrillation.METHODS A Preferred Reporting Items for Systematic Reviews and Meta-Analyses-compliant systematic review and metaanalysis was conducted,searching PubMed,EMBASE,Web of Science,and other databases up to August 2025 for comparative studies.Pooled mean difference for continuous outcomes and odds ratio(OR)for dichotomous outcomes were calculated using random-effects models.Study quality was assessed with the Newcastle-Ottawa Scale,heterogeneity with I2,and publication bias with funnel plots.RESULTS Seven studies(six cohorts,one randomized controlled trial)were included,with a mean age of approximately 66 years,59%-78%male,and high prevalence of hypertension and diabetes.PFA significantly reduced procedure time(mean difference=-15.24 minutes,95%CI:-16.63 to-13.85,P<0.00001;I2=89%),improved arrhythmia-free survival(OR=1.27,95%CI:1.04-1.55,P=0.02;I2=45%),and lowered phrenic nerve palsy risk(OR=0.17,95%CI:0.04-0.63,P=0.008;I2=0%).No significant differences were found in fluoroscopy time,cardiac tamponade,repeat ablation,or vascular complications.CONCLUSION PFA demonstrates shorter procedure times,reduced phrenic nerve palsy,and better arrhythmia control compared to CBA,with comparable safety profiles.However,evidence is limited by observational study designs,heterogeneity,and potential bias.Large-scale randomized controlled trials with extended follow-up are needed to confirm these findings and guide clinical practice.
基金supported by an institutional Ph.D.grant(No.21130/1312/3131)from the Faculty of Agrobiology,Food,and Natural Resources at the Czech University of Life Sciences Prague(CZU),Czech Republic。
文摘Very few studies have benefited from the synergetic implementation of visible,near-infrared,and shortwave infrared(VNIR-SWIR)spectra and terrain attributes in predicting Pb content in agricultural soils.To fill this gap,this study aimed to predict lead(Pb)contents in agricultural soils by combining machine learning algorithms(MLAs)with VNIR-SWIR spectra or/and terrain attributes under three distinct approaches.Six MLAs were tested,including artificial neural network(ANN),partial least squares regression,support vector machine(SVM),Gaussian process regression(GPR),extreme gradient boosting(EGB),and Cubist.The VNIR-SWIR spectral data were preprocessed by methods of discrete wavelet transformation,logarithmic transformation-Savitzky Golay smoothing,standard normal variate(SNV),multiplicative scatter correction,first derivative(Fi D),and second derivative.In approach 1,MLAs were combined with the preprocessed VNIR-SWIR spectral data.The Cubist-Fi D combination was the most effective,achieving a coefficient of determination(R2)of 0.63,a concordance correlation coefficient(CCC)of 0.51,a mean absolute error(MAE)of 6.87 mg kg^(-1),and a root mean square error(RMSE)of8.66 mg kg^(-1).In approach 2,MLAs were combined with both preprocessed VNIR-SWIR spectral data and terrain attributes,and the EGB-SNV combination yielded superior results with R2of 0.75,CCC of 0.65,MAE of 5.48 mg kg^(-1),and RMSE of 7.34 mg kg^(-1).Approach 3 combined MLAs and terrain attributes,and Cubist demonstrated the best prediction results,with R^(2) of 0.75,CCC of 0.66,MAE of 6.18 mg kg^(-1),and RMSE of 7.71 mg kg^(-1).The cumulative assessment identified the fusion of terrain properties,SNV-preprocessed VNIR-SWIR spectra,and EGB as the optimal method for estimating Pb content in agricultural soils,yielding the highest R2value and minimal error.Comparatively,GPR,ANN,and SVM techniques achieved higher R2values in approaches 2 and 3 but also exhibited higher estimation errors.In conclusion,the study underscores the significance of using relevant auxiliary datasets and appropriate MLAs for accurate Pb content prediction with minimal error in agricultural soils.The findings contribute valuable insights for developing successful soil management strategies based on predictive modeling.
文摘Objectives:As the Duchenne Muscular Dystrophy(DMD)is a progressive neuromuscular disorder frequently associated with cardiac dysfunction,this study aimed to evaluate the influence of beta-blocker therapy on cardiac autonomic modulation in adolescents withDMDby analyzing heart rate variability(HRV)indices in patients with and without betablockers.Methods:A cross-sectional study was conducted with 90 participants divided into three groups:(1)participants with DMD receiving beta-blocker therapy(DMDB,n=30),(2)participants with DMD without beta-blocker therapy(GMDM,n=30),and(3)age-and sex-matched typically developing participants(GDT,n=30).HRV was assessed using validated beat-to-beat heart rate monitoring(RS800CX,Polar)under controlled conditions.Linear and non-linear HRV indices(including Detrended Fluctuation Analysis and Symbolic Dynamics)were analysed using Kubios HRV software.Results:DMD patients exhibited autonomic impairment,characterized by decreased HRV,increased sympathetic dominance,and reduced parasympathetic modulation.Betablocker therapy was associated with significantly higher Mean Beat-to-beat interval(RR)and lower Mean Heart Rate(HR)compared to the non-beta-blocker DMD group,with values approaching those observed in typically developing participants.Non-linear indices suggested thatDMDpatients receiving beta-blockers demonstrated increased HRV complexity and fractal properties compared to those not receiving beta-blockers,although differences remained between the DMD and control groups.Conclusions:Autonomic dysfunction in DMD is characterized by reduced HRV and altered sympathovagal balance.In our results,beta-blocker therapy was associated with improved HRV and enhanced autonomic control.These findings highlight the potential cardioprotective role of betablockers in DMD management and emphasize the need for further research into optimizing autonomic function in DMD.
