Objective: To review the long-term outcomes for 155 women with a vulvar dystrophy (VD) who attended the Royal Brisbane Hospital Vulvar Clinic between 1976 and 1988. Methods: VD data from Vulvar Diseases Clinic were re...Objective: To review the long-term outcomes for 155 women with a vulvar dystrophy (VD) who attended the Royal Brisbane Hospital Vulvar Clinic between 1976 and 1988. Methods: VD data from Vulvar Diseases Clinic were reviewed and analysed using the computer software Statistical package for the Social Sciences (SPSS) 11.0. Results: Of 155 patients 94 had Lichen Sclerosus (LS), 41 Lichen Simplex Chronicus (LSC) and 20 Mixed Dystrophy (MD). Three patients developed squamous cell carcinomas of the vulva between 10 and 26 years after presentation with a VD. To date only one of these three patients remains alive following treatment. Conclusion: The need for long term follow up is stressed and any of the three types of VD may become malignant. Time from diagnosis to malignant change is not predictive. VD treatments seem to go through phases with the application of potent steroid creams having stood the test of time.展开更多
AIM: To evaluate the ability of the McGill Brisbane Symptom Score (MBSS) to predict survival in resectable pancreatic head adenocarcinoma (PHA) patients.
Object: To determine if vulvar melanosis progressed to melanoma over a period of 20 years or more. Methods: In 2010 the hospital records from the Royal Brisbane Hospital Vulvar Clinic between 1976 and 1988 were review...Object: To determine if vulvar melanosis progressed to melanoma over a period of 20 years or more. Methods: In 2010 the hospital records from the Royal Brisbane Hospital Vulvar Clinic between 1976 and 1988 were reviewed and cross checked with the state wide Queensland Centre for Gynaecological Cancer (QCGC) data base to determine if any patient had been lost to follow up and subsequently developed a vulvar melanoma. Data collected were stored and analysed using the computer software Statistical Package for the Social Sciences (SPSS) 11.0. Results: None of the 12 patients developed vulval melanoma in the years up to 2010. Conclusion: In this small group, followed for more than 20 years, melanosis was not a precursor of melanoma. One patient, who attended the Vulvar Clinic but was not included in this melanosis study, was found to have co-existing melanosis well away from her melanoma in situ and malignant melanoma at presentation. It was not possible to determine if these findings represented a progression of the benign to malignant. Biopsy of abnormal hyper pigmented vulvar skin is recommended. Current knowledge suggests that vulvar melanosis is a benign condition but to be on the safe side follow up of all hyper pigmented vulval lesions to detect early malignant change is recommended.展开更多
Objectives: To describe thoracic endovascular aortic repair (TEVAR) outcomes at the Royal Brisbane and Women’s Hospital between 2001-2010. Design: Prospective cohort study. Results: We successfully treated 95 of 97 p...Objectives: To describe thoracic endovascular aortic repair (TEVAR) outcomes at the Royal Brisbane and Women’s Hospital between 2001-2010. Design: Prospective cohort study. Results: We successfully treated 95 of 97 patients for a 98% procedural success rate. Of the treated patients, 68 (72%) were males and mean age was 61 ± 17 years. Average follow up was 3.6 ± 2.0 years. Pathologies treated were: dissection (n = 35), aneurysmal disease (n = 32), traumatic disease (n = 19), coarctation (n = 5) and miscellaneous (n = 4). There was one peri-procedural myocardial infarction. Renal complications occurred in 7 patients (3 with doubling creatinine and 4 requiring temporary renal replacement therapy). Stroke occurred in 2 patients and paresis in 2 patients (permanent in one). Six patients died during index hospitalization and 17 deaths occurred during follow-up, 2 of which were confirmed secondary to aortic pathology. Age (HR 1.08 per year, p < 0.01) and ASA class (HR 2.2 per class, p = 0.02) were independently associated with mortality. There were 25 re-interventions in 22 patients. Eighteen of these re-interventions in 16 patients were related to the management of complications of TEVAR of which 13 were for endoleaks;eight type I, four type II, one type III. Conclusion: TEVAR can be used to treat thoracic aortic pathology but questions remain regarding long-term durability.展开更多
Background:Heatwaves have a significant impact on population health including both morbidity and mortality.In this study we examined the association between heatwaves and emergency hospital admissions(EHAs)for renal d...Background:Heatwaves have a significant impact on population health including both morbidity and mortality.In this study we examined the association between heatwaves and emergency hospital admissions(EHAs)for renal diseases in children(aged 0-14 years)in Brisbane,Australia.Methods:Daily data on EHAs for renal diseases in children and exposure to temperature and air pollution were obtained for Brisbane city from January 1,1996 to December 31,2005.A time-stratified case-crossover design was used to compare the risks for renal diseases between heatwave and non-heatwave periods.Results:There were 1565 EHAs for renal diseases in children during the study period.Heatwaves exhibited a signifi cant impact on EHAs for renal diseases in children after adjusting for confounding factors(odds ratio:3.6;95%confidence interval:1.4-9.5).The risk estimates differed with lags and the use of different heatwave defi nitions.Conclusions:There was a significant increase in EHAs for renal diseases in children during heatwaves in Brisbane,a subtropical city where people are well accustomed to warm weather.This finding may have significant implications for pediatric renal care,particularly in subtropical and tropical regions.展开更多
Aim:Laparoscopic liver resection for hepatocellular carcinoma(HCC)is increasingly common around the world.There may be significant advantages over open resections.However,due to technical difficulties,they are perform...Aim:Laparoscopic liver resection for hepatocellular carcinoma(HCC)is increasingly common around the world.There may be significant advantages over open resections.However,due to technical difficulties,they are performed in few centers with expertise in liver and advanced laparoscopic surgery.In this study the authors summarize the experience to date.Methods:A retrospective analysis of consecutive patients undergoing laparoscopic liver resection for HCC in 2 tertiary academic hepatobiliary units in Brisbane,Australia,between 1999 and 2015 was performed.Operative characteristics,perioperative morbidity,and pathological data were described.Patients with and without cirrhosis were analyzed and compared.Results:F ifty-two p atients u nderwent r esection of 79 H CCs.Sixty-five percent of patients had cirrhosis.Fourteen percent of patients underwent a major hepatectomy.There was a trend towards more parenchyma-sparing resections for cirrhotic patients.Blood loss was higher in cirrhotics.Conversion to an open procedure occurred in 9%.There was one 90-day mortality due to liver failure(1.9%),and 7 patients(13%)experienced a complication.R0 resection was achieved in 92%.Overall survival at 1,3,and 5 years was 88%,81%,and 61%,respectively.Conclusion:Laparoscopic liver resection for HCC,particularly in cirrhotic patients,is technically challenging.It can be performed with acceptable morbidity and adequate surgical margins.展开更多
Background Broiler chickens are most vulnerable immediately after hatching due to their immature immune systems,making them susceptible to infectious diseases.The yolk plays an important role in early immune defence b...Background Broiler chickens are most vulnerable immediately after hatching due to their immature immune systems,making them susceptible to infectious diseases.The yolk plays an important role in early immune defence by showing relevant antioxidant and passive immunity capabilities during broiler embryonic development.The immunomodulatory effects of phytogenic compound carvacrol have been widely reported.After in ovo delivery in the amniotic fluid during embryonic development carvacrol is known to migrate to the yolk sac.However,it is unknown whether carvacrol in the yolk could enhance defence responsiveness in the yolk sac.Therefore,the aim of this study was to improve early immune function in chicken embryos,and it was hypothesized that in ovo delivery of carvacrol would result in immunomodulatory effects in the yolk sac,potentially improving post-hatch resilience.Methods On embryonic day(E)17.5,either a saline(control)or carvacrol solution was injected into the amniotic fluid.Yolk sac tissue samples were collected at E19.5,and transcriptomic analyses using RNA sequencing were performed,following functional enrichment analyses comparing the control(saline)and carvacrol-injected groups.Results The results showed that 268 genes were upregulated and 174 downregulated in the carvacrol group compared to the control(P<0.05;logFC<-0.5 or log FC>0.5).Functional analyses of these differentially expressed genes,using KEGG,REACTOME,and Gene Ontology databases,showed enrichment of several immune-related pathways.This included the pathways‘Antimicrobial peptides’(P=0.001)and‘Chemoattractant activity’(P=0.004),amongst others.Moreover,the‘NOD-like receptor signaling’pathway was enriched(P=0.002).Antimicrobial peptides are part of the innate immune defence and are amongst the molecules produced after the nucleotide oligomeriza-tion domain(NOD)-like receptor pathway activation.While these responses may be associated with an inflammatory reaction to an exogenous threat,they could also indicate that in ovo delivery of carvacrol could prepare the newly hatched chick against bacterial pathogens by potentially promoting antimicrobial peptide production through acti-vation of NOD-like receptor signaling in the yolk sac.Conclusion In conclusion,these findings suggest that in ovo delivery of carvacrol has the potential to enhance anti-pathogenic and pro-inflammatory responses in the yolk sac via upregulation of antimicrobial peptides,and NOD-like receptor pathways.展开更多
This review focuses on the diagnostic algorithm for nonobstructive azoospermia(NOA),a significant male factor contributing to infertility.NOA,characterized by the absence of sperm in the ejaculate,requires a systemati...This review focuses on the diagnostic algorithm for nonobstructive azoospermia(NOA),a significant male factor contributing to infertility.NOA,characterized by the absence of sperm in the ejaculate,requires a systematic diagnostic approach to identify reversible conditions,genetic factors,and prognosis for achieving pregnancy.The diagnostic pathway involves semen analysis and a comprehensive evaluation for hormonal deficiencies,anatomical abnormalities,and genetic factors.The importance of medical history,physical examination,endocrine evaluation,imaging,and genetic testing is emphasized.This review highlights the significance of differentiating NOA from obstructive azoospermia(OA)and outlines key considerations for effective management,including surgical sperm retrieval and assisted reproductive techniques.Testicular biopsy is discussed as a definitive method to distinguish obstructive cases from nonobstructive cases,providing valuable prognostic information.Overall,a thorough and systematic diagnostic approach is essential for the effective management of men suspected with NOA,offering insights into potential treatment options and reproductive outcomes.展开更多
Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) hom...Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.展开更多
Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion...Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium storage.With enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal decomposition.This review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these materials.Based on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.展开更多
Induced brain oscillations in the gamma range have recently garnered attention due to their reported neuroprotective effects in the treatment of Alzheimer’s disease.This method differs from pharmacological approaches...Induced brain oscillations in the gamma range have recently garnered attention due to their reported neuroprotective effects in the treatment of Alzheimer’s disease.This method differs from pharmacological approaches by tapping into the neuronal population dynamics that underlie the homeostatic processes in the brain that are crucial for the recovery of function.Recently,induced gamma-range oscillations have been used to improve cerebral blood flow,motor function,and synaptic plasticity in a mouse model of focal stroke,highlighting the broad potential of recruiting intrinsic recovery processes for the treatment of neurological conditions.Addressing open questions,such as the frequency specificity of the benefits,will shed light on the intrinsic processes involved and allow clinicians to optimize recovery after stroke.展开更多
Because of the recent widespread usage of antibiotics,the acquisition and dissemination of antibiotic-resistance genes(ARGs)were prevalent in the majority of habitats.Generally,the biological wastewater treatment proc...Because of the recent widespread usage of antibiotics,the acquisition and dissemination of antibiotic-resistance genes(ARGs)were prevalent in the majority of habitats.Generally,the biological wastewater treatment processes used in wastewater treatment plants have a limited efficiencies of antibiotics resistant bacteria(ARB)disinfection and ARGs degradation and even promote the proliferation of ARGs.Problematically,ARB and ARGs in effluent pose potential risks if they are not further treated.Photocatalytic oxidation is considered a promising disinfection technology,where the photocatalytic process generates many free radicals that enhance the interaction between light and deoxyribonucleic acid(DNA)for ARB elimination and subsequent degradation of ARGs.This reviewaims to illustrate the progress of photocatalytic oxidation technology for removing antibiotics resistant(AR)from wastewater in recent years.We discuss the sources and transfer of ARGs in wastewater.The overall removal efficiencies of ultraviolet radiation(UV)/chlorination,UV/ozone,UV/H_(2)O_(2),and UV/sulfate-radical based system for ARB and ARGs,as well as the experimental parameters and removal mechanisms,are systematically discussed.The contribution of photocatalytic materials based on TiO_(2) and g-C_(3)N_(4) to the inactivation of ARB and degradation of ARGs is highlighted,producingmany free radicals to attack ARB and ARGs while effectively limiting the horizontal gene transfer(HGT)in wastewater.Finally,based on the reviewed studies,future research directions are proposed to realize specific photocatalytic oxidation technology applications and overcome current challenges.展开更多
BACKGROUND In the context of hepatobiliary and liver transplant surgery,ischemia-reperfusion(I/R)injury can occur due to temporary interruption of blood flow to the organ followed by a potentially damaging inflammator...BACKGROUND In the context of hepatobiliary and liver transplant surgery,ischemia-reperfusion(I/R)injury can occur due to temporary interruption of blood flow to the organ followed by a potentially damaging inflammatory response to reperfusion.Ma-crophages can drive inflammation in response to injury,but they can also pro-mote liver growth and resolution of chronic liver injury and fibrosis.In chronic liver injury models in mice,macrophage colony stimulating factor(CSF)1 stimu-lates pro-regenerative macrophages.AIM To determine whether stimulation of macrophages with macrophage CSF could promote liver repair after I/R injury.METHODS We investigated the impact of perisurgical treatment with a long-circulating CSF1-Fc conjugate on liver injury and hepatocyte proliferation after 70%ischemia for 60 minutes at 6 hours,48 hours and 7 days post reperfusion in rats.Circulating and liver tissue monocyte and macrophage subsets in the ischaemic and oxyge-nated lobes were assessed using quantitative PCR and flow cytometry.RESULTS CSF1-Fc treatment did not affect the extent of hepatocellular injury post-reperfu-sion,as indicated by serum transaminases.Liver I/R injury,especially necrotic area,was reduced in CSF1-Fc-treated rats 48 h post-surgery.This was associated with increased accumulation of macrophages in both the oxygenated and ischemic lobes(ILs),and peri-necrotic zone localization in the IL.CSF1-Fc treatment also promoted liver growth,associated with increased parenchymal and non-parenchymal cell proliferation.CSF1-Fc increased the abundance of CD43+non-classical monocytes,consistent with the role of CSF1 signaling in monocyte maturation,and increased CD163 expression on mature macrophages.CONCLUSION This study suggests CSF1 stimulation drives monocytes/macrophages towards a pro-regenerative response and perisurgical CSF1 treatment might augment liver regeneration in patients undergoing liver resection.展开更多
Against the backdrop of the rapid development of digitalization today,the platform economy,as an emerging economic form,is profoundly changing the operation mode and resource allocation methods of the labor market.The...Against the backdrop of the rapid development of digitalization today,the platform economy,as an emerging economic form,is profoundly changing the operation mode and resource allocation methods of the labor market.The efficiency of labor resource allocation is an important indicator to measure the vitality and potential of economic development in a country or region.It is not only related to the welfare level of workers but also directly affects the productivity level and development quality of the entire society.With the help of modern information technology means such as Internet technology,big data algorithms,and mobile communication devices,the platform economy closely connects originally scattered individual workers with employers,building a large and complex networked trading platform.Based on this,this paper focuses on the impact and role of the platform economy on the efficiency of labor resource allocation,aiming to stabilize the efficient operation of the labor market.展开更多
A new manufactured soil product (Turba) was produced using acidified bauxite residue into which 10% green waste compost had been incorporated. A laboratory/greenhouse experiment was carried out to determine if sand co...A new manufactured soil product (Turba) was produced using acidified bauxite residue into which 10% green waste compost had been incorporated. A laboratory/greenhouse experiment was carried out to determine if sand could be used as an ingredient or an amendment for Turba. Sand was added at rates of 0%, 5%, 10%, 25, 50% and 75% (w/w) in two different ways 1) by incorporating it into the Turba during its manufacture (IN) or 2) by mixing it with Turba aggregates after their manufacture (OUT). Incorporation of sand into Turba aggregates (IN) decreased the percentage of sample present as large aggregates (2 - 4 mm dia.) after crushing and sieving (<4 mm) and also reduced the stability of 2 - 4 mm dia. formed aggregates (to dry/wet sieving) and are therefore not recommended. In a 16-week greenhouse study, ryegrass shoot yields were greater in Turba than in sand [and decreased with increasing sand additions (OUT)] while root dry matter showed the opposite trend. The greater grass growth in Turba than sand was attributed to incipit water stress in plants grown in sand and this may have promoted greater allocation of assimilates to roots resulting in a greater root-to-top mass ratio. The much lower macroporosity in Turba coupled with the solid cemented nature of Turba aggregates resulted in production of thinner roots and therefore greater root length than in sand. Turba (manufactured from bauxite residue and compost added at 10% w/w) is a suitable medium for plant growth and there is no advantage in incorporating sand into, or with, the Turba aggregates.展开更多
In this work,we have applied molybdenum(Mo)and titanium(Ti)co-doping to solve the degradation of Ni-rich cathodes.The modified cathode,i.e.,Li(Ni_(0.89)Co_(0.05)Mn_(0.05)Mo_(0.005)Ti_(0.005))O_(2) holds a stable struc...In this work,we have applied molybdenum(Mo)and titanium(Ti)co-doping to solve the degradation of Ni-rich cathodes.The modified cathode,i.e.,Li(Ni_(0.89)Co_(0.05)Mn_(0.05)Mo_(0.005)Ti_(0.005))O_(2) holds a stable structure with expanded crystal lattice distance which improves Li ion diffusion kinetics.The dopants have suppressed the growth of primary particles,formed a coating on the surface,and promoted the elongated morphology.Moreover,the mechanical strength of these particles has increased,as confirmed by the nanoindentation test,which can help suppress particle cracking.The detrimental H2-H3 phase transition has been postponed by 90 mV allowing the cathode to operate at a higher voltage.A better cycling stability over 100 cycles with 69%capacity retention has been observed.We believe this work points out a way to improve the cycling performance,Coulombic efficiency and capacity retention in Ni-rich cathodes.展开更多
The primary clinical manifestation of osteoarthritis (OA) is pain, yet considerable variability exists in the pain experience among OA patients. This narrative review aims to explore the mechanisms driving OA pain het...The primary clinical manifestation of osteoarthritis (OA) is pain, yet considerable variability exists in the pain experience among OA patients. This narrative review aims to explore the mechanisms driving OA pain heterogeneity to inform the development of targeted interventions that improve treatment efficacy and patient outcomes. A comprehensive literature search was conducted across multiple databases (PubMed, Scopus, and Google Scholar) for papers published between January 1, 2020, and December 31, 2024. Inclusion criteria focused on studies addressing pain mechanisms and therapeutic interventions in OA. This review identifies key mechanisms of OA pain, including joint alterations, angiogenesis, nervous system involvement, peripheral and central sensitization, and psychosocial factors. It highlights the underlying distinct mechanisms in OA pain, which contribute to the variability in individuals’ responses to treatment. It was suggested that interactions between neuroimmune and neurovascular systems are key contributors to chronic pain in OA. This narrative review emphasizes the complexity of OA pain, highlighting the importance of thoroughly understanding the underlying mechanisms for developing personalized and effective pain management strategies. Additional research is required to refine treatment approaches and explore long-term effects.展开更多
1 Plant SecondaryMetabolism and Functional Biology Progress Plants have long been recognized as biochemical powerhouses,producing a vast array of compounds through their secondary metabolic pathways[1].Although histor...1 Plant SecondaryMetabolism and Functional Biology Progress Plants have long been recognized as biochemical powerhouses,producing a vast array of compounds through their secondary metabolic pathways[1].Although historically referred to as‘secondary’due to their perceived non-essential role in basic plant survival,it is now understood that these metabolites are integral to plant growth,development and adaptation to environmental challenges.Secondary metabolites,such as alkaloids,terpenoids,phenolics and flavonoids,serve as critical mediators of plant-environment interactions,conferring resistance to biotic and abiotic stressors[2].Beyond their ecological functions,these compounds are invaluable to humans,supporting industries ranging from pharmaceuticals and nutrition to agrochemicals and chemical additives.展开更多
At the end of the Cretaceous period,66 million years ago,the 7−19 km diameter Chicxulub asteroid hit the Yucatan Peninsula in Mexico,triggering global catastrophic environmental changes and mass extinction.The contrib...At the end of the Cretaceous period,66 million years ago,the 7−19 km diameter Chicxulub asteroid hit the Yucatan Peninsula in Mexico,triggering global catastrophic environmental changes and mass extinction.The contributions of this event towards changes in plate and plume geodynamics are not fully understood.Here we present a range of geological observations indicating that the impact marked a tectonic turning point in the behavior of mantle plume and plate motion in the Caribbean region and worldwide.At a regional scale,the impact coincides with the termination of seafloor spreading in the Caribbean Ridge.Shortly after the Cretaceous-Paleogene transition,magmatism associated with the Caribbean Large Igneous Province waned,and intensive Paleogene volcanism was initiated.These events happened synchronously with anomalously high mid-ocean ridge magmatism worldwide and an abrupt change in the relative motion of the South American and North American tectonic plates.The evidence for such abrupt changes in plate kinematics and plume behavior raises the possibility that the Chicxulub impact triggered a chain of effects that modified melt reservoirs,subducting plates,mantle flows,and lithospheric deformation.To explain how an asteroid impact could modify tectonic behavior,we discuss two end-member mechanisms:quasi-static and dynamic triggering mechanisms.We designed a numerical model to investigate the strain field and the relative plate motion before and after the impact.The model predicts an enhanced deformation associated with the impact,which surficially tapers off∼500 km from the crater.The impact modifies the subjacent mantle flow field,contributing to long-term mantle-driven dynamic changes.Additionally,deformation associated with seismic effects may have contributed to far-field effects and global changes.We conclude that large asteroid impacts,such as the Chicxulub collision,could trigger cascading effects sufficient to disrupt and significantly modify plate geodynamics.展开更多
文摘Objective: To review the long-term outcomes for 155 women with a vulvar dystrophy (VD) who attended the Royal Brisbane Hospital Vulvar Clinic between 1976 and 1988. Methods: VD data from Vulvar Diseases Clinic were reviewed and analysed using the computer software Statistical package for the Social Sciences (SPSS) 11.0. Results: Of 155 patients 94 had Lichen Sclerosus (LS), 41 Lichen Simplex Chronicus (LSC) and 20 Mixed Dystrophy (MD). Three patients developed squamous cell carcinomas of the vulva between 10 and 26 years after presentation with a VD. To date only one of these three patients remains alive following treatment. Conclusion: The need for long term follow up is stressed and any of the three types of VD may become malignant. Time from diagnosis to malignant change is not predictive. VD treatments seem to go through phases with the application of potent steroid creams having stood the test of time.
文摘AIM: To evaluate the ability of the McGill Brisbane Symptom Score (MBSS) to predict survival in resectable pancreatic head adenocarcinoma (PHA) patients.
文摘Object: To determine if vulvar melanosis progressed to melanoma over a period of 20 years or more. Methods: In 2010 the hospital records from the Royal Brisbane Hospital Vulvar Clinic between 1976 and 1988 were reviewed and cross checked with the state wide Queensland Centre for Gynaecological Cancer (QCGC) data base to determine if any patient had been lost to follow up and subsequently developed a vulvar melanoma. Data collected were stored and analysed using the computer software Statistical Package for the Social Sciences (SPSS) 11.0. Results: None of the 12 patients developed vulval melanoma in the years up to 2010. Conclusion: In this small group, followed for more than 20 years, melanosis was not a precursor of melanoma. One patient, who attended the Vulvar Clinic but was not included in this melanosis study, was found to have co-existing melanosis well away from her melanoma in situ and malignant melanoma at presentation. It was not possible to determine if these findings represented a progression of the benign to malignant. Biopsy of abnormal hyper pigmented vulvar skin is recommended. Current knowledge suggests that vulvar melanosis is a benign condition but to be on the safe side follow up of all hyper pigmented vulval lesions to detect early malignant change is recommended.
文摘Objectives: To describe thoracic endovascular aortic repair (TEVAR) outcomes at the Royal Brisbane and Women’s Hospital between 2001-2010. Design: Prospective cohort study. Results: We successfully treated 95 of 97 patients for a 98% procedural success rate. Of the treated patients, 68 (72%) were males and mean age was 61 ± 17 years. Average follow up was 3.6 ± 2.0 years. Pathologies treated were: dissection (n = 35), aneurysmal disease (n = 32), traumatic disease (n = 19), coarctation (n = 5) and miscellaneous (n = 4). There was one peri-procedural myocardial infarction. Renal complications occurred in 7 patients (3 with doubling creatinine and 4 requiring temporary renal replacement therapy). Stroke occurred in 2 patients and paresis in 2 patients (permanent in one). Six patients died during index hospitalization and 17 deaths occurred during follow-up, 2 of which were confirmed secondary to aortic pathology. Age (HR 1.08 per year, p < 0.01) and ASA class (HR 2.2 per class, p = 0.02) were independently associated with mortality. There were 25 re-interventions in 22 patients. Eighteen of these re-interventions in 16 patients were related to the management of complications of TEVAR of which 13 were for endoleaks;eight type I, four type II, one type III. Conclusion: TEVAR can be used to treat thoracic aortic pathology but questions remain regarding long-term durability.
基金funded by Australian Research Council(DP0559655),Queensland Departments of Environment and Resources,Community Safety,Queensland Health,and Environmental Protection Agencysupported by an NHMRC research fellowship(#553043).
文摘Background:Heatwaves have a significant impact on population health including both morbidity and mortality.In this study we examined the association between heatwaves and emergency hospital admissions(EHAs)for renal diseases in children(aged 0-14 years)in Brisbane,Australia.Methods:Daily data on EHAs for renal diseases in children and exposure to temperature and air pollution were obtained for Brisbane city from January 1,1996 to December 31,2005.A time-stratified case-crossover design was used to compare the risks for renal diseases between heatwave and non-heatwave periods.Results:There were 1565 EHAs for renal diseases in children during the study period.Heatwaves exhibited a signifi cant impact on EHAs for renal diseases in children after adjusting for confounding factors(odds ratio:3.6;95%confidence interval:1.4-9.5).The risk estimates differed with lags and the use of different heatwave defi nitions.Conclusions:There was a significant increase in EHAs for renal diseases in children during heatwaves in Brisbane,a subtropical city where people are well accustomed to warm weather.This finding may have significant implications for pediatric renal care,particularly in subtropical and tropical regions.
文摘Aim:Laparoscopic liver resection for hepatocellular carcinoma(HCC)is increasingly common around the world.There may be significant advantages over open resections.However,due to technical difficulties,they are performed in few centers with expertise in liver and advanced laparoscopic surgery.In this study the authors summarize the experience to date.Methods:A retrospective analysis of consecutive patients undergoing laparoscopic liver resection for HCC in 2 tertiary academic hepatobiliary units in Brisbane,Australia,between 1999 and 2015 was performed.Operative characteristics,perioperative morbidity,and pathological data were described.Patients with and without cirrhosis were analyzed and compared.Results:F ifty-two p atients u nderwent r esection of 79 H CCs.Sixty-five percent of patients had cirrhosis.Fourteen percent of patients underwent a major hepatectomy.There was a trend towards more parenchyma-sparing resections for cirrhotic patients.Blood loss was higher in cirrhotics.Conversion to an open procedure occurred in 9%.There was one 90-day mortality due to liver failure(1.9%),and 7 patients(13%)experienced a complication.R0 resection was achieved in 92%.Overall survival at 1,3,and 5 years was 88%,81%,and 61%,respectively.Conclusion:Laparoscopic liver resection for HCC,particularly in cirrhotic patients,is technically challenging.It can be performed with acceptable morbidity and adequate surgical margins.
基金support by AgriFutures Australia’s Chicken Meat Program[grant number PRJ-011584]is gratefully acknowledged.
文摘Background Broiler chickens are most vulnerable immediately after hatching due to their immature immune systems,making them susceptible to infectious diseases.The yolk plays an important role in early immune defence by showing relevant antioxidant and passive immunity capabilities during broiler embryonic development.The immunomodulatory effects of phytogenic compound carvacrol have been widely reported.After in ovo delivery in the amniotic fluid during embryonic development carvacrol is known to migrate to the yolk sac.However,it is unknown whether carvacrol in the yolk could enhance defence responsiveness in the yolk sac.Therefore,the aim of this study was to improve early immune function in chicken embryos,and it was hypothesized that in ovo delivery of carvacrol would result in immunomodulatory effects in the yolk sac,potentially improving post-hatch resilience.Methods On embryonic day(E)17.5,either a saline(control)or carvacrol solution was injected into the amniotic fluid.Yolk sac tissue samples were collected at E19.5,and transcriptomic analyses using RNA sequencing were performed,following functional enrichment analyses comparing the control(saline)and carvacrol-injected groups.Results The results showed that 268 genes were upregulated and 174 downregulated in the carvacrol group compared to the control(P<0.05;logFC<-0.5 or log FC>0.5).Functional analyses of these differentially expressed genes,using KEGG,REACTOME,and Gene Ontology databases,showed enrichment of several immune-related pathways.This included the pathways‘Antimicrobial peptides’(P=0.001)and‘Chemoattractant activity’(P=0.004),amongst others.Moreover,the‘NOD-like receptor signaling’pathway was enriched(P=0.002).Antimicrobial peptides are part of the innate immune defence and are amongst the molecules produced after the nucleotide oligomeriza-tion domain(NOD)-like receptor pathway activation.While these responses may be associated with an inflammatory reaction to an exogenous threat,they could also indicate that in ovo delivery of carvacrol could prepare the newly hatched chick against bacterial pathogens by potentially promoting antimicrobial peptide production through acti-vation of NOD-like receptor signaling in the yolk sac.Conclusion In conclusion,these findings suggest that in ovo delivery of carvacrol has the potential to enhance anti-pathogenic and pro-inflammatory responses in the yolk sac via upregulation of antimicrobial peptides,and NOD-like receptor pathways.
文摘This review focuses on the diagnostic algorithm for nonobstructive azoospermia(NOA),a significant male factor contributing to infertility.NOA,characterized by the absence of sperm in the ejaculate,requires a systematic diagnostic approach to identify reversible conditions,genetic factors,and prognosis for achieving pregnancy.The diagnostic pathway involves semen analysis and a comprehensive evaluation for hormonal deficiencies,anatomical abnormalities,and genetic factors.The importance of medical history,physical examination,endocrine evaluation,imaging,and genetic testing is emphasized.This review highlights the significance of differentiating NOA from obstructive azoospermia(OA)and outlines key considerations for effective management,including surgical sperm retrieval and assisted reproductive techniques.Testicular biopsy is discussed as a definitive method to distinguish obstructive cases from nonobstructive cases,providing valuable prognostic information.Overall,a thorough and systematic diagnostic approach is essential for the effective management of men suspected with NOA,offering insights into potential treatment options and reproductive outcomes.
文摘Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.
基金financial support from the Special Funds for the Cultivation of Guangdong College Students’Scientific and Technological Innovation(“Climbing Program”Special Funds,pdjh2023b0145)the Scientific Research Innovation Project of Graduate School of South China Normal University(2024KYLX047)financial support from the Australian Research Council,Centre for Materials Science,Queensland University of Technology.
文摘Lithium-ion batteries(LIBs)have dominated the portable electronic and electrochemical energy markets since their commercialisation,whose high cost and lithium scarcity have prompted the development of other alkali-ion batteries(AIBs)including sodium-ion batteries(SIBs)and potassium-ion batteries(PIBs).Owing to larger ion sizes of Na^(+)and K^(+)compared with Li^(+),nanocomposites with excellent crystallinity orientation and well-developed porosity show unprecedented potential for advanced lithium/sodium/potassium storage.With enticing open rigid framework structures,Prussian blue analogues(PBAs)remain promising self-sacrificial templates for the preparation of various nanocomposites,whose appeal originates from the well-retained porous structures and exceptional electrochemical activities after thermal decomposition.This review focuses on the recent progress of PBA-derived nanocomposites from their fabrication,lithium/sodium/potassium storage mechanism,and applications in AIBs(LIBs,SIBs,and PIBs).To distinguish various PBA derivatives,the working mechanism and applications of PBA-templated metal oxides,metal chalcogenides,metal phosphides,and other nanocomposites are systematically evaluated,facilitating the establishment of a structure–activity correlation for these materials.Based on the fruitful achievements of PBA-derived nanocomposites,perspectives for their future development are envisioned,aiming to narrow down the gap between laboratory study and industrial reality.
基金supported by the Brazil Family Program for Neurology(to MB),Alastair Rushworth Research Fund(to MS),Australian Government Research Training Program Scholarship(to MS),the National Natural Science Foundation of China(82202787)(to CW).
文摘Induced brain oscillations in the gamma range have recently garnered attention due to their reported neuroprotective effects in the treatment of Alzheimer’s disease.This method differs from pharmacological approaches by tapping into the neuronal population dynamics that underlie the homeostatic processes in the brain that are crucial for the recovery of function.Recently,induced gamma-range oscillations have been used to improve cerebral blood flow,motor function,and synaptic plasticity in a mouse model of focal stroke,highlighting the broad potential of recruiting intrinsic recovery processes for the treatment of neurological conditions.Addressing open questions,such as the frequency specificity of the benefits,will shed light on the intrinsic processes involved and allow clinicians to optimize recovery after stroke.
基金supported by the National Natural Science Foundation of China (Nos.52100182 and 52300204)the the Science and Technology Innovation Program of Hunan Province (No.2023RC3122).
文摘Because of the recent widespread usage of antibiotics,the acquisition and dissemination of antibiotic-resistance genes(ARGs)were prevalent in the majority of habitats.Generally,the biological wastewater treatment processes used in wastewater treatment plants have a limited efficiencies of antibiotics resistant bacteria(ARB)disinfection and ARGs degradation and even promote the proliferation of ARGs.Problematically,ARB and ARGs in effluent pose potential risks if they are not further treated.Photocatalytic oxidation is considered a promising disinfection technology,where the photocatalytic process generates many free radicals that enhance the interaction between light and deoxyribonucleic acid(DNA)for ARB elimination and subsequent degradation of ARGs.This reviewaims to illustrate the progress of photocatalytic oxidation technology for removing antibiotics resistant(AR)from wastewater in recent years.We discuss the sources and transfer of ARGs in wastewater.The overall removal efficiencies of ultraviolet radiation(UV)/chlorination,UV/ozone,UV/H_(2)O_(2),and UV/sulfate-radical based system for ARB and ARGs,as well as the experimental parameters and removal mechanisms,are systematically discussed.The contribution of photocatalytic materials based on TiO_(2) and g-C_(3)N_(4) to the inactivation of ARB and degradation of ARGs is highlighted,producingmany free radicals to attack ARB and ARGs while effectively limiting the horizontal gene transfer(HGT)in wastewater.Finally,based on the reviewed studies,future research directions are proposed to realize specific photocatalytic oxidation technology applications and overcome current challenges.
基金Supported by the German Research Foundation(Deutsche Forschungsgemeinschaft)and the Australian National Health and Medical Research Council and the Mater Foundation.
文摘BACKGROUND In the context of hepatobiliary and liver transplant surgery,ischemia-reperfusion(I/R)injury can occur due to temporary interruption of blood flow to the organ followed by a potentially damaging inflammatory response to reperfusion.Ma-crophages can drive inflammation in response to injury,but they can also pro-mote liver growth and resolution of chronic liver injury and fibrosis.In chronic liver injury models in mice,macrophage colony stimulating factor(CSF)1 stimu-lates pro-regenerative macrophages.AIM To determine whether stimulation of macrophages with macrophage CSF could promote liver repair after I/R injury.METHODS We investigated the impact of perisurgical treatment with a long-circulating CSF1-Fc conjugate on liver injury and hepatocyte proliferation after 70%ischemia for 60 minutes at 6 hours,48 hours and 7 days post reperfusion in rats.Circulating and liver tissue monocyte and macrophage subsets in the ischaemic and oxyge-nated lobes were assessed using quantitative PCR and flow cytometry.RESULTS CSF1-Fc treatment did not affect the extent of hepatocellular injury post-reperfu-sion,as indicated by serum transaminases.Liver I/R injury,especially necrotic area,was reduced in CSF1-Fc-treated rats 48 h post-surgery.This was associated with increased accumulation of macrophages in both the oxygenated and ischemic lobes(ILs),and peri-necrotic zone localization in the IL.CSF1-Fc treatment also promoted liver growth,associated with increased parenchymal and non-parenchymal cell proliferation.CSF1-Fc increased the abundance of CD43+non-classical monocytes,consistent with the role of CSF1 signaling in monocyte maturation,and increased CD163 expression on mature macrophages.CONCLUSION This study suggests CSF1 stimulation drives monocytes/macrophages towards a pro-regenerative response and perisurgical CSF1 treatment might augment liver regeneration in patients undergoing liver resection.
文摘Against the backdrop of the rapid development of digitalization today,the platform economy,as an emerging economic form,is profoundly changing the operation mode and resource allocation methods of the labor market.The efficiency of labor resource allocation is an important indicator to measure the vitality and potential of economic development in a country or region.It is not only related to the welfare level of workers but also directly affects the productivity level and development quality of the entire society.With the help of modern information technology means such as Internet technology,big data algorithms,and mobile communication devices,the platform economy closely connects originally scattered individual workers with employers,building a large and complex networked trading platform.Based on this,this paper focuses on the impact and role of the platform economy on the efficiency of labor resource allocation,aiming to stabilize the efficient operation of the labor market.
文摘A new manufactured soil product (Turba) was produced using acidified bauxite residue into which 10% green waste compost had been incorporated. A laboratory/greenhouse experiment was carried out to determine if sand could be used as an ingredient or an amendment for Turba. Sand was added at rates of 0%, 5%, 10%, 25, 50% and 75% (w/w) in two different ways 1) by incorporating it into the Turba during its manufacture (IN) or 2) by mixing it with Turba aggregates after their manufacture (OUT). Incorporation of sand into Turba aggregates (IN) decreased the percentage of sample present as large aggregates (2 - 4 mm dia.) after crushing and sieving (<4 mm) and also reduced the stability of 2 - 4 mm dia. formed aggregates (to dry/wet sieving) and are therefore not recommended. In a 16-week greenhouse study, ryegrass shoot yields were greater in Turba than in sand [and decreased with increasing sand additions (OUT)] while root dry matter showed the opposite trend. The greater grass growth in Turba than sand was attributed to incipit water stress in plants grown in sand and this may have promoted greater allocation of assimilates to roots resulting in a greater root-to-top mass ratio. The much lower macroporosity in Turba coupled with the solid cemented nature of Turba aggregates resulted in production of thinner roots and therefore greater root length than in sand. Turba (manufactured from bauxite residue and compost added at 10% w/w) is a suitable medium for plant growth and there is no advantage in incorporating sand into, or with, the Turba aggregates.
基金support from Queensland University of Technology,Brisbane,Queensland,Australiafinancial support from ARC Discovery Project(DP210103266).
文摘In this work,we have applied molybdenum(Mo)and titanium(Ti)co-doping to solve the degradation of Ni-rich cathodes.The modified cathode,i.e.,Li(Ni_(0.89)Co_(0.05)Mn_(0.05)Mo_(0.005)Ti_(0.005))O_(2) holds a stable structure with expanded crystal lattice distance which improves Li ion diffusion kinetics.The dopants have suppressed the growth of primary particles,formed a coating on the surface,and promoted the elongated morphology.Moreover,the mechanical strength of these particles has increased,as confirmed by the nanoindentation test,which can help suppress particle cracking.The detrimental H2-H3 phase transition has been postponed by 90 mV allowing the cathode to operate at a higher voltage.A better cycling stability over 100 cycles with 69%capacity retention has been observed.We believe this work points out a way to improve the cycling performance,Coulombic efficiency and capacity retention in Ni-rich cathodes.
基金supported by the National Health and Medical Research Council of Australia(No.APP1176298).
文摘The primary clinical manifestation of osteoarthritis (OA) is pain, yet considerable variability exists in the pain experience among OA patients. This narrative review aims to explore the mechanisms driving OA pain heterogeneity to inform the development of targeted interventions that improve treatment efficacy and patient outcomes. A comprehensive literature search was conducted across multiple databases (PubMed, Scopus, and Google Scholar) for papers published between January 1, 2020, and December 31, 2024. Inclusion criteria focused on studies addressing pain mechanisms and therapeutic interventions in OA. This review identifies key mechanisms of OA pain, including joint alterations, angiogenesis, nervous system involvement, peripheral and central sensitization, and psychosocial factors. It highlights the underlying distinct mechanisms in OA pain, which contribute to the variability in individuals’ responses to treatment. It was suggested that interactions between neuroimmune and neurovascular systems are key contributors to chronic pain in OA. This narrative review emphasizes the complexity of OA pain, highlighting the importance of thoroughly understanding the underlying mechanisms for developing personalized and effective pain management strategies. Additional research is required to refine treatment approaches and explore long-term effects.
基金supported by High Level Talents Research Initiation Fund of West Anhui University(WGKQ2022025)Quality Engineering Project of Anhui Province(2024zybj032)+1 种基金Quality Engineering Project of West Anhui University(wxxy2024011)Development of Big Data Integration and Analysis Platform for Traditional Chinese Medicine Genomics(0045025050).
文摘1 Plant SecondaryMetabolism and Functional Biology Progress Plants have long been recognized as biochemical powerhouses,producing a vast array of compounds through their secondary metabolic pathways[1].Although historically referred to as‘secondary’due to their perceived non-essential role in basic plant survival,it is now understood that these metabolites are integral to plant growth,development and adaptation to environmental challenges.Secondary metabolites,such as alkaloids,terpenoids,phenolics and flavonoids,serve as critical mediators of plant-environment interactions,conferring resistance to biotic and abiotic stressors[2].Beyond their ecological functions,these compounds are invaluable to humans,supporting industries ranging from pharmaceuticals and nutrition to agrochemicals and chemical additives.
文摘At the end of the Cretaceous period,66 million years ago,the 7−19 km diameter Chicxulub asteroid hit the Yucatan Peninsula in Mexico,triggering global catastrophic environmental changes and mass extinction.The contributions of this event towards changes in plate and plume geodynamics are not fully understood.Here we present a range of geological observations indicating that the impact marked a tectonic turning point in the behavior of mantle plume and plate motion in the Caribbean region and worldwide.At a regional scale,the impact coincides with the termination of seafloor spreading in the Caribbean Ridge.Shortly after the Cretaceous-Paleogene transition,magmatism associated with the Caribbean Large Igneous Province waned,and intensive Paleogene volcanism was initiated.These events happened synchronously with anomalously high mid-ocean ridge magmatism worldwide and an abrupt change in the relative motion of the South American and North American tectonic plates.The evidence for such abrupt changes in plate kinematics and plume behavior raises the possibility that the Chicxulub impact triggered a chain of effects that modified melt reservoirs,subducting plates,mantle flows,and lithospheric deformation.To explain how an asteroid impact could modify tectonic behavior,we discuss two end-member mechanisms:quasi-static and dynamic triggering mechanisms.We designed a numerical model to investigate the strain field and the relative plate motion before and after the impact.The model predicts an enhanced deformation associated with the impact,which surficially tapers off∼500 km from the crater.The impact modifies the subjacent mantle flow field,contributing to long-term mantle-driven dynamic changes.Additionally,deformation associated with seismic effects may have contributed to far-field effects and global changes.We conclude that large asteroid impacts,such as the Chicxulub collision,could trigger cascading effects sufficient to disrupt and significantly modify plate geodynamics.
