White matter(WM)comprises approximately half of the human brain volume and is primarily composed of bundles of axons and glia.The axons conduct nerve impulses between gray matter(GM)to support information transmission...White matter(WM)comprises approximately half of the human brain volume and is primarily composed of bundles of axons and glia.The axons conduct nerve impulses between gray matter(GM)to support information transmission and coordination within brain networks or circuits.Despite the overwhelming emphasis of human brain imaging on GM,few would deny the importance of the functional contributions of WM to human cognition and behavior.For in vivo brain studies,diffusion magnetic resonance imaging(MRI)has been widely used to delineate WM fibers and measure their microstructural properties,but diffusion MRI reveals little about functional activity.For a long time,we have lacked an in vivo way to quantify functional metrics of wM.In contrast to the widespread application of functional MRI(fMRI)based on blood oxygenation-level-dependent(BOLD)signals to assess GM functions[1],BOLD effects in WM have been regarded as noise or nuisance variables in most neuroimaging studies.展开更多
基金supported by the National Natural Science Foundation of China(82371507 and 82090034)Outstanding Youth Fund for Universities in Anhui Province(2024AH020004)+5 种基金the collaborative innovation project between universities and Hefei Comprehensive National Science Center(GXXT-2022-028)the Hefei Comprehensive National Science Center Hefei Brain Project,the 2021 Anhui Province Key R&D Project:Population Health Special Project(202104j07020033)major project of Research Fund of Anhui Institute of Translational Medicine in 2020(2020zhyx A04)the Anhui Province Clinical Medical Research Transformation Special Project(202204295107020006 and 202204295107020028)National Institutes of Health grant(R01 NS113832 and R01 NS129855)National Research and Engineering Council Canada,Discovery Grant。
文摘White matter(WM)comprises approximately half of the human brain volume and is primarily composed of bundles of axons and glia.The axons conduct nerve impulses between gray matter(GM)to support information transmission and coordination within brain networks or circuits.Despite the overwhelming emphasis of human brain imaging on GM,few would deny the importance of the functional contributions of WM to human cognition and behavior.For in vivo brain studies,diffusion magnetic resonance imaging(MRI)has been widely used to delineate WM fibers and measure their microstructural properties,but diffusion MRI reveals little about functional activity.For a long time,we have lacked an in vivo way to quantify functional metrics of wM.In contrast to the widespread application of functional MRI(fMRI)based on blood oxygenation-level-dependent(BOLD)signals to assess GM functions[1],BOLD effects in WM have been regarded as noise or nuisance variables in most neuroimaging studies.
