Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the u...Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.展开更多
Sepsis,a life-threatening condition,can lead to acute skin failure characterized by extensive skin damage.This is often due to decreased blood flow,inflammation,and increased susceptibility to infection.Acute skin fai...Sepsis,a life-threatening condition,can lead to acute skin failure characterized by extensive skin damage.This is often due to decreased blood flow,inflammation,and increased susceptibility to infection.Acute skin failure in people with sepsis is often associated with sleep disturbances,anxiety,and poor mood.Inflammatory markers and lactate levels correlate with these psychiatric symptoms,suggesting a link between skin and brain function.The skin and the central nervous system(CNS)have bidirectional communication.The CNS is also in close contact with the digestive tract.The gut,skin,and brain influence each other’s functions thr-ough nervous,hormonal,and immune pathways,forming a gut-skin-brain axis.Understanding the interaction among the gut,skin,and CNS is critical to the diag-nosis and treatment of various skin and neurological disorders.By recognizing individual variations in gut microbiota,immune responses,and neural pathways,treatments can be tailored to specific patient needs,enhancing efficacy and minimizing side effects.The gut plays a large role in mental health.Under-standing the gut skin brain axis,will lead to improved mental health outcomes.展开更多
Attention is the cornerstone of effective functioning in a complex and information-rich world.While the neural activity of attention has been extensively studied in the cortex,the brain-wide neural activity patterns a...Attention is the cornerstone of effective functioning in a complex and information-rich world.While the neural activity of attention has been extensively studied in the cortex,the brain-wide neural activity patterns are largely unknown.In this study,we conducted a comprehensive analysis of neural activity across the mouse brain during attentional processing using EEG and c-Fos staining,utilizing hierarchical clustering and c-Fos-based functional network analysis to evaluate the c-Fos activation patterns.Our findings reveal that a wide range of brain regions are activated,notably in the high-order cortex,thalamus,and brain stem regions involved in advanced cognition and arousal regulation,with the central lateral nucleus of the thalamus as a strong hub,suggesting the crucial role of the thalamus in attention control.These results provide valuable insights into the neural network mechanisms underlying attention,offering a foundation for formulating functional hypotheses and conducting circuit-level testing.展开更多
BACKGROUND Nutritional psychiatry is a rapidly expanding field of research,with mounting evidence suggesting that nutritional factors may play a role in the development of psychiatric disorders.AIM To examine the leve...BACKGROUND Nutritional psychiatry is a rapidly expanding field of research,with mounting evidence suggesting that nutritional factors may play a role in the development of psychiatric disorders.AIM To examine the level of evidence for nutritional psychiatry.METHODS A scoping review was conducted to assess the current state of nutritional psychiatry,including a search for randomized controlled trials(RCTs).RESULTS The review identified a total of seven papers,with many concentrating on the relationship between depression and the gut microbiome.A salient issue that emerged from this review was the paucity of sample size in many studies.The inherent complexity of nutritional studies,characterized by a multitude of potential factors and exposures that often act as confounders,poses significant challenges to the development of effective RCT designs.The analysis revealed that probiotics,though demonstrating efficacy,exhibited a modest effect size.CONCLUSION Conducting RCTs with effective markers is imperative from these studies.The implementation of Mendelian randomization and the investigation of mechanisms in basic research are essential complementary approaches.展开更多
The present paper addresses two issues pertaining to the use of virtual reality(VR).One issue pertains to the equipment utilized.VR technology can be classified into two main categories:Immersive and non-immersive.The...The present paper addresses two issues pertaining to the use of virtual reality(VR).One issue pertains to the equipment utilized.VR technology can be classified into two main categories:Immersive and non-immersive.The immersive type of technology necessitates the use of substantial equipment,yet it is demonstrably efficacious.Furthermore,the efficacy of this approach is enhanced when combined with relaxation and biofeedback techniques.The other issue is that the efficacy of this approach is diminished when applied to chronic pain,in comparison to acute pain.The relief of chronic pain is a challenging endeavor due to the diminished functionality of the medial prefrontal cortex(mPFC)within the default mode network.Given the close relationship between the mPFC and the reward system dopamine,it is essential to develop a program that activates the reward system dopamine through the use of VR technology.展开更多
Hypertension,a prevalent condition among older adults,has been identified as a risk factor for cognitive decline.Nutritional status is a pivotal factor in preserving cognitive function in hypertensive older adults.Nut...Hypertension,a prevalent condition among older adults,has been identified as a risk factor for cognitive decline.Nutritional status is a pivotal factor in preserving cognitive function in hypertensive older adults.Nutritional psychiatry underscores the significance of anti-inflammatory diets in promoting mental and cognitive health.This article examined the mechanisms by which body mass index,serum hemoglobin,serum albumin,and alkaline phosphatase levels predict cognitive function in hypertensive older adults.Nutrition emerges as a modifiable factor that can be targeted to maintain cognitive function in these patients.展开更多
文摘Medical procedures are inherently invasive and carry the risk of inducing pain to the mind and body.Recently,efforts have been made to alleviate the discomfort associated with invasive medical procedures through the use of virtual reality(VR)technology.VR has been demonstrated to be an effective treatment for pain associated with medical procedures,as well as for chronic pain conditions for which no effective treatment has been established.The precise mechanism by which the diversion from reality facilitated by VR contributes to the diminution of pain and anxiety has yet to be elucidated.However,the provision of positive images through VR-based visual stimulation may enhance the functionality of brain networks.The salience network is diminished,while the default mode network is enhanced.Additionally,the medial prefrontal cortex may establish a stronger connection with the default mode network,which could result in a reduction of pain and anxiety.Further research into the potential of VR technology to alleviate pain could lead to a reduction in the number of individuals who overdose on painkillers and contribute to positive change in the medical field.
文摘Sepsis,a life-threatening condition,can lead to acute skin failure characterized by extensive skin damage.This is often due to decreased blood flow,inflammation,and increased susceptibility to infection.Acute skin failure in people with sepsis is often associated with sleep disturbances,anxiety,and poor mood.Inflammatory markers and lactate levels correlate with these psychiatric symptoms,suggesting a link between skin and brain function.The skin and the central nervous system(CNS)have bidirectional communication.The CNS is also in close contact with the digestive tract.The gut,skin,and brain influence each other’s functions thr-ough nervous,hormonal,and immune pathways,forming a gut-skin-brain axis.Understanding the interaction among the gut,skin,and CNS is critical to the diag-nosis and treatment of various skin and neurological disorders.By recognizing individual variations in gut microbiota,immune responses,and neural pathways,treatments can be tailored to specific patient needs,enhancing efficacy and minimizing side effects.The gut plays a large role in mental health.Under-standing the gut skin brain axis,will lead to improved mental health outcomes.
文摘Attention is the cornerstone of effective functioning in a complex and information-rich world.While the neural activity of attention has been extensively studied in the cortex,the brain-wide neural activity patterns are largely unknown.In this study,we conducted a comprehensive analysis of neural activity across the mouse brain during attentional processing using EEG and c-Fos staining,utilizing hierarchical clustering and c-Fos-based functional network analysis to evaluate the c-Fos activation patterns.Our findings reveal that a wide range of brain regions are activated,notably in the high-order cortex,thalamus,and brain stem regions involved in advanced cognition and arousal regulation,with the central lateral nucleus of the thalamus as a strong hub,suggesting the crucial role of the thalamus in attention control.These results provide valuable insights into the neural network mechanisms underlying attention,offering a foundation for formulating functional hypotheses and conducting circuit-level testing.
文摘BACKGROUND Nutritional psychiatry is a rapidly expanding field of research,with mounting evidence suggesting that nutritional factors may play a role in the development of psychiatric disorders.AIM To examine the level of evidence for nutritional psychiatry.METHODS A scoping review was conducted to assess the current state of nutritional psychiatry,including a search for randomized controlled trials(RCTs).RESULTS The review identified a total of seven papers,with many concentrating on the relationship between depression and the gut microbiome.A salient issue that emerged from this review was the paucity of sample size in many studies.The inherent complexity of nutritional studies,characterized by a multitude of potential factors and exposures that often act as confounders,poses significant challenges to the development of effective RCT designs.The analysis revealed that probiotics,though demonstrating efficacy,exhibited a modest effect size.CONCLUSION Conducting RCTs with effective markers is imperative from these studies.The implementation of Mendelian randomization and the investigation of mechanisms in basic research are essential complementary approaches.
文摘The present paper addresses two issues pertaining to the use of virtual reality(VR).One issue pertains to the equipment utilized.VR technology can be classified into two main categories:Immersive and non-immersive.The immersive type of technology necessitates the use of substantial equipment,yet it is demonstrably efficacious.Furthermore,the efficacy of this approach is enhanced when combined with relaxation and biofeedback techniques.The other issue is that the efficacy of this approach is diminished when applied to chronic pain,in comparison to acute pain.The relief of chronic pain is a challenging endeavor due to the diminished functionality of the medial prefrontal cortex(mPFC)within the default mode network.Given the close relationship between the mPFC and the reward system dopamine,it is essential to develop a program that activates the reward system dopamine through the use of VR technology.
文摘Hypertension,a prevalent condition among older adults,has been identified as a risk factor for cognitive decline.Nutritional status is a pivotal factor in preserving cognitive function in hypertensive older adults.Nutritional psychiatry underscores the significance of anti-inflammatory diets in promoting mental and cognitive health.This article examined the mechanisms by which body mass index,serum hemoglobin,serum albumin,and alkaline phosphatase levels predict cognitive function in hypertensive older adults.Nutrition emerges as a modifiable factor that can be targeted to maintain cognitive function in these patients.
