Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections,thrombosis,and intimal lesions caused by surface friction.However,achieving effective prevention of both bloodstream-...Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections,thrombosis,and intimal lesions caused by surface friction.However,achieving effective prevention of both bloodstream-associated infections and thrombosis poses a challenge due to the conflicting nature of antibacterial and antithrombotic activities,specifically regarding electrostatic interactions.This study introduced a novel biocompatible hydrogel of sodium alginate and zwitterionic carboxymethyl chitosan(ZW@CMC)with antibacterial and antithrombotic activities for use in catheters.The ZW@CMC hydrogel demonstrates a superhydrophilic surface and good hygroscopic properties,which facilitate the formation of a stable hydration layer with low friction.The zwitterionic-functionalized CMC incorporates an additional negative sulfone group and increased negative charge density in the carboxyl group.This augmentation enhances electrostatic repulsion and facilitates the formation of hydration layer.This leads to exceptional prevention of blood clotting factor adhesion and inhibition of biofilm formation.Subsequently,the ZW@CMC hydrogel exhibited biocompatibility with tests of in vitro cytotoxicity,hemolysis,and catheter friction.Furthermore,in vivo tests of antithrombotic and systemic inflammation models with catheterization indicated that ZW@CMC has significant advantages for practical applications in cardiovascular-related and sepsis treatment.This study opens a new avenue for the development of chitosan-based multifunctional hydrogel for applications in blood-contacting devices.展开更多
Individuals who are unable to walk independently spend most of the day in a wheelchair.This population is at high risk for developing pressure injuries caused by sitting.However,early diagnosis and prevention of these...Individuals who are unable to walk independently spend most of the day in a wheelchair.This population is at high risk for developing pressure injuries caused by sitting.However,early diagnosis and prevention of these injuries still remain challenging.Herein,we introduce battery-free,wireless,multimodal sensors and a movable system for continuous measurement of pressure,temperature,and hydration at skin interfaces.The device design includes a crack-activated pressure sensor with nanoscale encapsulations for enhanced sensitivity,a temperature sensor for measuring skin temperature,and a galvanic skin response sensor for measuring skin hydration levels.The movable system enables power harvesting,and data communication to multiple wireless devices mounted at skin-cushion interfaces of wheelchair users over full body coverage.Experimental evaluations and numerical simulations of the devices,together with clinical trials for wheelchair patients,demonstrate the feasibility and stability of the sensor system for preventing pressure injuries caused by sitting.展开更多
基金supported by the Korea Evaluation Institute of Industrial Technology(KEIT)grant funded by the South Korea government(MOTIE)(No.1415187426,RS-2023-00238181)supported by the institutional program funded by the Korea Institute of Industrial Technology(JA230007)the National Research Foundation of Korea(NRF)grant funded by the South Korea government(MSIT)(No.2022R1F1A1074255,No.RS-2022-00144435).
文摘Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections,thrombosis,and intimal lesions caused by surface friction.However,achieving effective prevention of both bloodstream-associated infections and thrombosis poses a challenge due to the conflicting nature of antibacterial and antithrombotic activities,specifically regarding electrostatic interactions.This study introduced a novel biocompatible hydrogel of sodium alginate and zwitterionic carboxymethyl chitosan(ZW@CMC)with antibacterial and antithrombotic activities for use in catheters.The ZW@CMC hydrogel demonstrates a superhydrophilic surface and good hygroscopic properties,which facilitate the formation of a stable hydration layer with low friction.The zwitterionic-functionalized CMC incorporates an additional negative sulfone group and increased negative charge density in the carboxyl group.This augmentation enhances electrostatic repulsion and facilitates the formation of hydration layer.This leads to exceptional prevention of blood clotting factor adhesion and inhibition of biofilm formation.Subsequently,the ZW@CMC hydrogel exhibited biocompatibility with tests of in vitro cytotoxicity,hemolysis,and catheter friction.Furthermore,in vivo tests of antithrombotic and systemic inflammation models with catheterization indicated that ZW@CMC has significant advantages for practical applications in cardiovascular-related and sepsis treatment.This study opens a new avenue for the development of chitosan-based multifunctional hydrogel for applications in blood-contacting devices.
基金supported by the Technology Innovation Program(00144157,Development of Heterogeneous Multi-Sensor Micro-System Platform)funded By the Ministry of Trade,Industry&Energy(MOTIE,korea)and the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(no.2021R1A2C3008742)supported by the MSIT(Ministry of Science and ICT),Korea,under the Grand Information Technology Research Center support program(IITP-2022-2016-0-00318)supervised by the IITP(Institute for Information&communications Technology Planning&Evaluation)Z.X.acknowledges the support from the National Natural Science Foundation of China(Grant No.12072057).
文摘Individuals who are unable to walk independently spend most of the day in a wheelchair.This population is at high risk for developing pressure injuries caused by sitting.However,early diagnosis and prevention of these injuries still remain challenging.Herein,we introduce battery-free,wireless,multimodal sensors and a movable system for continuous measurement of pressure,temperature,and hydration at skin interfaces.The device design includes a crack-activated pressure sensor with nanoscale encapsulations for enhanced sensitivity,a temperature sensor for measuring skin temperature,and a galvanic skin response sensor for measuring skin hydration levels.The movable system enables power harvesting,and data communication to multiple wireless devices mounted at skin-cushion interfaces of wheelchair users over full body coverage.Experimental evaluations and numerical simulations of the devices,together with clinical trials for wheelchair patients,demonstrate the feasibility and stability of the sensor system for preventing pressure injuries caused by sitting.
