We report here the application of a medicinally important plant Amaranthus spinosus for the synthesis of gold nanoparticles (AuNPs). Different concentrations of ethanolic leaf extract of the plant were reacted with aq...We report here the application of a medicinally important plant Amaranthus spinosus for the synthesis of gold nanoparticles (AuNPs). Different concentrations of ethanolic leaf extract of the plant were reacted with aqueous solution of HAuCl4·4H2O under mild reaction conditions. Synthesis of AuNPs was confirmed from the UV-Vis study of surface plasmon resonance property of the colloidal solution. Transmission electron microscopy (TEM) revealed particles as spherical and triangular in shape. X-ray diffraction (XRD) confirmed the crystalline nature of AuNPs with average size of 10.74 nm as determined by Debye-Scherrer’s Equation. Fourier transform infra-red (FT-IR) analysis of leaf extract and lyophilized AuNPs showed the presence of various functional groups present in diverse phytochemicals. Energy dispersive X-ray (EDX) of purified AuNPs confirmed the formation of AuNPs and surface adsorption of biomolecules. We further investigated the toxicity of the synthesized AuNPs and found non toxic to the cancer cell lines and could be used for biomedical applications.展开更多
Silk-based biomaterials have gained significant importance making them a promising choice for the future of med-ical technology due to their versatility and biocompatibility.They can be fabricated and tailored through...Silk-based biomaterials have gained significant importance making them a promising choice for the future of med-ical technology due to their versatility and biocompatibility.They can be fabricated and tailored through various processing methods such as electrospinning,freeze-drying,and 3D printing,to achieve specific properties and structures namely sponges,hydrogels,films,and scaffolds that can be utilized for different biomedical applica-tions.Biocompatibility,a unique property of silk-based biomaterials,has been demonstrated through both in vivo and in vitro studies and to date many studies have reported the successful use of these silk-based biomaterials in different fields of medicine.In this review,we have elaborately discussed different types of silk,their structural composition,and biophysical properties.Also,the current review focuses on highlighting various biomedical ap-plications of engineered and fabricated silk-based biomaterials which aid in the treatment of certain infections and diseases related to skin,eyes,teeth,bone,heart,nerves,and liver.Furthermore,we have consolidated the advancements of silk-based biomaterials in the different fields of biotechnology such as sensors,food coating and packaging,textiles,drug delivery,and cosmetics.However,the research in this field continues to expand and more significant observations must be generated with feasible results for their reliable use in different biomedical applications.展开更多
Silver nanoparticles are among the most widely researched and used for nanotechnology-derived structures due to their extraordinary inherent optical properties,chemical stability,catalytic activity,and high conductivi...Silver nanoparticles are among the most widely researched and used for nanotechnology-derived structures due to their extraordinary inherent optical properties,chemical stability,catalytic activity,and high conductivity.These idiosyncratic properties can be attributed to their unique physico-chemical characteristics,such as ultrafine sizes,high surface area,diverse shapes,and strong localized surface plasmon resonance.These distinctive features can be tailored using various physical,chemical,and biological synthesis methods.Various physical techniques are viable for producing silver nanoparticles on a large scale,but they suffer from drawbacks such as high-power con-sumption,expensive set-up,and limited control over nanoparticle size distribution.Chemical methods provide benefits like high yield,consistent shape and size distribution,and cost efficiency,but the residual toxicity of the chemicals involved hinders their biological applications.Biological synthesis approaches effectively overcome the limitations of both physical and chemical methods by eliminating the need for hazardous chemicals,requiring less energy,enabling diverse nanoparticle morphologies,and offering eco-friendliness and exceptional biocom-patibility.The novel and promising properties of nanosilver-based biomaterials have been demonstrated to be suitable for a wide range of pharmacological and therapeutic biomedical applications.Their extensive application in wound healing,dentistry,cardiovascular disease treatment,nerve tissue engineering,cancer treatment,and biosensing can be attributed to their inherent antimicrobial and antibiofilm activity,antithrombotic properties,potential for nerve regeneration,photothermal conversion efficiency and sensitivity,respectively.This review discusses the different methods employed for synthesising silver nanoparticles and focuses on using nanosilver-based biomaterials for various biomedical applications.展开更多
文摘We report here the application of a medicinally important plant Amaranthus spinosus for the synthesis of gold nanoparticles (AuNPs). Different concentrations of ethanolic leaf extract of the plant were reacted with aqueous solution of HAuCl4·4H2O under mild reaction conditions. Synthesis of AuNPs was confirmed from the UV-Vis study of surface plasmon resonance property of the colloidal solution. Transmission electron microscopy (TEM) revealed particles as spherical and triangular in shape. X-ray diffraction (XRD) confirmed the crystalline nature of AuNPs with average size of 10.74 nm as determined by Debye-Scherrer’s Equation. Fourier transform infra-red (FT-IR) analysis of leaf extract and lyophilized AuNPs showed the presence of various functional groups present in diverse phytochemicals. Energy dispersive X-ray (EDX) of purified AuNPs confirmed the formation of AuNPs and surface adsorption of biomolecules. We further investigated the toxicity of the synthesized AuNPs and found non toxic to the cancer cell lines and could be used for biomedical applications.
基金funded by the Science and Engineering Research Board (SERB),Govt.of India,vide project sanction no:EEQ/2021/000372.
文摘Silk-based biomaterials have gained significant importance making them a promising choice for the future of med-ical technology due to their versatility and biocompatibility.They can be fabricated and tailored through various processing methods such as electrospinning,freeze-drying,and 3D printing,to achieve specific properties and structures namely sponges,hydrogels,films,and scaffolds that can be utilized for different biomedical applica-tions.Biocompatibility,a unique property of silk-based biomaterials,has been demonstrated through both in vivo and in vitro studies and to date many studies have reported the successful use of these silk-based biomaterials in different fields of medicine.In this review,we have elaborately discussed different types of silk,their structural composition,and biophysical properties.Also,the current review focuses on highlighting various biomedical ap-plications of engineered and fabricated silk-based biomaterials which aid in the treatment of certain infections and diseases related to skin,eyes,teeth,bone,heart,nerves,and liver.Furthermore,we have consolidated the advancements of silk-based biomaterials in the different fields of biotechnology such as sensors,food coating and packaging,textiles,drug delivery,and cosmetics.However,the research in this field continues to expand and more significant observations must be generated with feasible results for their reliable use in different biomedical applications.
基金funded by the Science and Engineering Research Board(SERB),Govt.of India,vide project sanction no:EEQ/2021/000372.
文摘Silver nanoparticles are among the most widely researched and used for nanotechnology-derived structures due to their extraordinary inherent optical properties,chemical stability,catalytic activity,and high conductivity.These idiosyncratic properties can be attributed to their unique physico-chemical characteristics,such as ultrafine sizes,high surface area,diverse shapes,and strong localized surface plasmon resonance.These distinctive features can be tailored using various physical,chemical,and biological synthesis methods.Various physical techniques are viable for producing silver nanoparticles on a large scale,but they suffer from drawbacks such as high-power con-sumption,expensive set-up,and limited control over nanoparticle size distribution.Chemical methods provide benefits like high yield,consistent shape and size distribution,and cost efficiency,but the residual toxicity of the chemicals involved hinders their biological applications.Biological synthesis approaches effectively overcome the limitations of both physical and chemical methods by eliminating the need for hazardous chemicals,requiring less energy,enabling diverse nanoparticle morphologies,and offering eco-friendliness and exceptional biocom-patibility.The novel and promising properties of nanosilver-based biomaterials have been demonstrated to be suitable for a wide range of pharmacological and therapeutic biomedical applications.Their extensive application in wound healing,dentistry,cardiovascular disease treatment,nerve tissue engineering,cancer treatment,and biosensing can be attributed to their inherent antimicrobial and antibiofilm activity,antithrombotic properties,potential for nerve regeneration,photothermal conversion efficiency and sensitivity,respectively.This review discusses the different methods employed for synthesising silver nanoparticles and focuses on using nanosilver-based biomaterials for various biomedical applications.
