Diabetes,an intricate chronic metabolic disorder,remains constituting a substantial global health concern,claiming millions of lives each year with no definitive cure currently available to date.Left untreated,diabete...Diabetes,an intricate chronic metabolic disorder,remains constituting a substantial global health concern,claiming millions of lives each year with no definitive cure currently available to date.Left untreated,diabetes consequently leads to the development of both microvascular as well as macrovascular complications,which are major contributors to the mortality rates among diabetic individuals.The pathogenesis of these complications involves a range of biochemical pathways,including aberrant metabolic pathways,oxidative stress,advanced glycation end products,the activation of protein kinase C,and the implication of various pro-inflammatory cytokines and adipokines.Strategies such as the design of specific inhibitors and antioxidant therapy have shown promise in managing these biochemical processes.In addition,pharmacological approaches have been explored to address the underlying mechanisms of diabetic complications,particularly the polyol pathway.In parallel,nutritional management has emerged as a key component in restoring metabolic balance and improving outcomes for individuals with diabetes.Dietary and diet interventions play a pivotal role in regulating glycemic levels,ameliorating inflammation,and supporting overall metabolic health in diabetic patients.This comprehensive review aims to shed light on the intricate biochemical basis of diabetic complications and explores the latest advancements in pharmacological and nutritional interventions for the effective control of diabetes and its associated consequences.By integrating cutting-edge research findings and practical strategies,this review seeks to provide valuable insights into the multifaceted approach required to combat the challenges posed by diabetes and enhance the quality of care for affected individuals.展开更多
Superhydrophobic bagasse paper was successfully engineered by facile spray coating with a zeolitic imidazolate framework composite modified by 3,3,3-trifluoropropyltrimethoxysilane(FAS)and used as a filter membrane wi...Superhydrophobic bagasse paper was successfully engineered by facile spray coating with a zeolitic imidazolate framework composite modified by 3,3,3-trifluoropropyltrimethoxysilane(FAS)and used as a filter membrane with special wettability for oil/water separation.Surface characteristics such as surface morphology,surface moieties,roughness,and wettability were observed.The addition of FAS decreased the apparent surface energy between solid surfaces and liquids with a polar contribution of surface free energy as low as 0 mN m−1.The formation of the FAS layer was confirmed by transmission electron microscopy and X-ray photoelectron spectroscopy core-level spectra.Three-dimensional surface topography revealed an increase in the spray coating cycle that enhanced the hydrophobicity of the coated paper.The results confirmed that not only microstructures but also the presence of functional groups with low surface energy(such as FAS)can promote surface hydrophobicity.The spray-coated paper with FAS/ZIF in the presence of a small amount of nanocellulose provided a superhydrophobic surface after the first spray cycle.The separation efficiency was up to 85%and was slightly affected by oil viscosity.Moreover,this can be used as a filter membrane for water-in-oil emulsions.In the present work,simple spray-coated paper is a promising candidate material for gravity-driven oil/water separation and water repellent coating.展开更多
文摘Diabetes,an intricate chronic metabolic disorder,remains constituting a substantial global health concern,claiming millions of lives each year with no definitive cure currently available to date.Left untreated,diabetes consequently leads to the development of both microvascular as well as macrovascular complications,which are major contributors to the mortality rates among diabetic individuals.The pathogenesis of these complications involves a range of biochemical pathways,including aberrant metabolic pathways,oxidative stress,advanced glycation end products,the activation of protein kinase C,and the implication of various pro-inflammatory cytokines and adipokines.Strategies such as the design of specific inhibitors and antioxidant therapy have shown promise in managing these biochemical processes.In addition,pharmacological approaches have been explored to address the underlying mechanisms of diabetic complications,particularly the polyol pathway.In parallel,nutritional management has emerged as a key component in restoring metabolic balance and improving outcomes for individuals with diabetes.Dietary and diet interventions play a pivotal role in regulating glycemic levels,ameliorating inflammation,and supporting overall metabolic health in diabetic patients.This comprehensive review aims to shed light on the intricate biochemical basis of diabetic complications and explores the latest advancements in pharmacological and nutritional interventions for the effective control of diabetes and its associated consequences.By integrating cutting-edge research findings and practical strategies,this review seeks to provide valuable insights into the multifaceted approach required to combat the challenges posed by diabetes and enhance the quality of care for affected individuals.
基金the Thailand Research Fund under the Distinguished Professor Grant No.DPG6080001 for Professor Suda Kiatkamjornwong,Thammasat University Research Fund(Contract no.TUFT 81/2564)Thammasat University Research Unit in Bioenergy and Catalysis.
文摘Superhydrophobic bagasse paper was successfully engineered by facile spray coating with a zeolitic imidazolate framework composite modified by 3,3,3-trifluoropropyltrimethoxysilane(FAS)and used as a filter membrane with special wettability for oil/water separation.Surface characteristics such as surface morphology,surface moieties,roughness,and wettability were observed.The addition of FAS decreased the apparent surface energy between solid surfaces and liquids with a polar contribution of surface free energy as low as 0 mN m−1.The formation of the FAS layer was confirmed by transmission electron microscopy and X-ray photoelectron spectroscopy core-level spectra.Three-dimensional surface topography revealed an increase in the spray coating cycle that enhanced the hydrophobicity of the coated paper.The results confirmed that not only microstructures but also the presence of functional groups with low surface energy(such as FAS)can promote surface hydrophobicity.The spray-coated paper with FAS/ZIF in the presence of a small amount of nanocellulose provided a superhydrophobic surface after the first spray cycle.The separation efficiency was up to 85%and was slightly affected by oil viscosity.Moreover,this can be used as a filter membrane for water-in-oil emulsions.In the present work,simple spray-coated paper is a promising candidate material for gravity-driven oil/water separation and water repellent coating.
