State of research： characteristics, function, and dating of Roman brass tokens Tokens （tesserae） formed part of everyday material culture of both Greeks and Romans.1 Made of wood, bone, clay, or metal, they facilit...State of research： characteristics, function, and dating of Roman brass tokens Tokens （tesserae） formed part of everyday material culture of both Greeks and Romans.1 Made of wood, bone, clay, or metal, they facilitated, for example, entry into the theatre, identification of soldiers, participation in political meetings, or the receipt of a special amount of grain.2展开更多
This article presents the results of a series of ethnographic observations at the Berlin fire brigade control and dispatch center during routine and severe weather situations.The weather-related challenges of a fire b...This article presents the results of a series of ethnographic observations at the Berlin fire brigade control and dispatch center during routine and severe weather situations.The weather-related challenges of a fire brigade lie between the anticipation of events and their potential consequences,and the ad hoc reactions to actual impacts of weather.The results show that decisions and actions related to high impact weather are not necessarily motivated by weather warnings alone.Instead,they are reactions to the experience of impacts,for example,an increased number of missions or emergency calls.Impacts are the main trigger for the decision making.Weather is one additional external factor that influences the operational capability of a fire brigade.While commanding officers in a fire brigade control and dispatch center experience weather primarily through technical equipment,verified by ground truth,observations showed that direct personal contact with the regional weather service and colleagues on the ground takes on a greater role in actual severe weather situations.The observations point to the need for increased interagency communication between the emergency services,the weather service,and other organizations to integrate weather information,impacts,and non-weather-related tasks into coherent weather-related decision making.展开更多
A phase-field model including magnetic field induced dendrite fragmentation was established and applied to the cases with different initial crystal nuclear positions for AA5754 aluminum alloy electromagnetic laser bea...A phase-field model including magnetic field induced dendrite fragmentation was established and applied to the cases with different initial crystal nuclear positions for AA5754 aluminum alloy electromagnetic laser beam welding.Compare the calculated results that include dendrite fragmentation caused by the thermal electromagnetic Lorentz force with the results that consider only the thermal electromagnetic Lorentz force,without fragmentation,at the characteristic time instants.Both in the early and late stages,the small fragmentation at the dendrite tip promotes the number of higher-order branches and their growth,especially in the direction perpendicular to the solidification.The later stage fragmentation has the possibility of breaking one grain into several,which verifies the possibility of grain refinement caused by dendrite fragmentation.The fracture surface caused by fragmentation also makes more solid-liquid interfaces and their growth.In addition,the cases with different initial nuclear positions were compared.The grain growth in the low-temperature zone can be inhibited by the equiaxed grains'fragmentation at the high-temperature area(179.8μm^(2) and 14.7% start at the center,115.4μm^(2) and 9.4% start at the high-temperature corner,134.3μm^(2) and 10.9%start at the low-temperature corner),which is another kind of grain refinement by the dendrite fragmentation.This kind of inhibition effect on grain growth in the low-temperature region will be enhanced with the increasing time interval between the two crystal nuclei’appearance(179.8μm^(2) and 14.7%when virtual grains appear at t=4.3803 s and t=4.3803 s,134.3μm^(2) and 10.9%at t=4.0977 s and t=3.9564 s,and 115.4μm^(2) and 9.4%at t=3.8151 s and t=3.5325 s).展开更多
When a porous rock is subjected to overall compressive loading,either increasing pore pressure or decreasing confining pressure could result in rock failure.The stress path and the applied pressure change rate may aff...When a porous rock is subjected to overall compressive loading,either increasing pore pressure or decreasing confining pressure could result in rock failure.The stress path and the applied pressure change rate may affect the initiation and propagation of fractures within brittle materials.Understanding the physical mechanisms leading to failure is crucial for underground engineering applications and geo-energy exploration and storage.We conducted triaxial compression experiments on porous Bentheim sandstone samples at different stress paths and pressure change rates.First,at a constant confining pressure of 35 MPa and pore pressure of 5 MPa,intact cylindrical samples were axially loaded up to about 85%of the peak strength.Subsequently,the axial piston position was fixed,and then either the pore pressure was increased or the confining pressure was decreased at two different rates(0.5 MPa/min or 2 MPa/min),leading to final catastrophic failure.The mechanical results revealed that samples subjected to higher rates of decreasing effective confining pressure exhibited larger stress drop rates,higher slip rates,higher total breakdown work,higher rates of acoustic emissions(AEs)before failure,and higher post-failure AE decay rates.In contrast,the applied stress path did not significantly affect rock failure characteristics.Comparison of located AE events with post-mortem microstructures of deformed samples shows a good agreement.The AE source type determined from the P-wave first-motion polarity shows that shear failure dominated the fracture process when approaching failure.Gutenberg-Richter b-values revealed a significant decrease before failure in all tests.Our results indicate that,in contrast to the stress path,the rate of effective stress change strongly affects fracturing behavior and AE rate changes.展开更多
Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,includi...Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,including cerebrospinal fluid,varies significantly(Figure 1Α;Yung et al.,2014).LPA actually corresponds to a variety of lipid species that include different stereoisomers with either saturated or unsaturated fatty acids bearing likely differentiated biological activities(Figure 1Α;Yung et al.,2014;Hernández-Araiza et al.,2018).展开更多
A multi-stage stress relaxation test was performed on a granodiorite sample to understand the deformation process prior to the macroscopic failure of brittle rocks,as well as the transient response during stress relax...A multi-stage stress relaxation test was performed on a granodiorite sample to understand the deformation process prior to the macroscopic failure of brittle rocks,as well as the transient response during stress relaxation.Distributed optical fiber sensing was used to measure strains across the sample surface by helically wrapping the single-mode fiber around the cylindrical sample.Close agreement was observed between the circumferential strains obtained from the optical fibers and the extensometer.The reconstructed full-field strain contours show strain heterogeneity from the crack closure phase,and the strains in the later deformation phase are dominantly localized within the former high-strain zone.The Gini coefficient was used to quantify the degree of strain localization and shows an initial increase during the crack closure phase,a decrease during the linear elastic phase,and a subsequent increase during the post-yielding phase.This behavior corresponds to a process of initial localization from an imperfect boundary condition,homogenization,and eventual relocalization prior to the macroscopic failure of the sample.The transient strain rate decay during the stress relaxation phase was quantified using the p-value in the“Omori-like"power law function.A higher initial stress at the onset of relaxation results in a lower p-value,indicating a slower strain rate decay.As the sample approaches macroscopic failure,the lowest p-value shifts from the most damaged zone to adjacent areas,suggesting stress redistribution or crack propagation in deformed crystalline rocks under stress relaxation conditions.展开更多
Tin-lead(Sn-Pb)halide perovskite single crystals combine narrow bandgaps,long carrier diffusion lengths,and low trap densities,positioning them as ideal candidates for near-infrared(NIR)optoelectronics.However,convent...Tin-lead(Sn-Pb)halide perovskite single crystals combine narrow bandgaps,long carrier diffusion lengths,and low trap densities,positioning them as ideal candidates for near-infrared(NIR)optoelectronics.However,conventional growth strategies rely on bulk crystallization at elevated temperatures,leading to uncontrolled nucleation,Sn^(2+)oxidation,and poor compatibility with planar integration.Here,we develop a coordination-engineered crystallization strategy that enables direct,lowtemperature growth of micrometer-thick Sn-Pb single-crystal thin films on device-compatible substrates.By modulating metal-solvent coordination strength using a low-donor number cosolvent system,we delineate a narrow processing window that stabilizes precursor speciation,lowers the nucleation barrier,and guides directional crystal growth under mild thermal conditions(<40℃).The resulting crystal films exhibit smooth morphology,high crystallinity,compositional uniformity,and ultralow trap densities(~3.98×10^(12)cm^(-3)).When integrated into NIR photodetectors,these films deliver high responsivity(0.51 A W^(-1)at 900 nm),specific detectivity up to 3.6×10^(12)Jones,fast response(~188μs),and>25,000 cycles of ambient operational stability.This approach establishes a scalable platform for redox-stable,low-temperature growth of Sn-Pb perovskite crystal films and expands the processing-structure-function landscape for next-generation infrared optoelectronics.展开更多
The poultry gut microbiome plays a key role in nutrient digestion,immune function,and overall health.Differences among various farming systems,including conventional,antibiotic-free,free-range,and organic systems,infl...The poultry gut microbiome plays a key role in nutrient digestion,immune function,and overall health.Differences among various farming systems,including conventional,antibiotic-free,free-range,and organic systems,influence microbial composition and function through variations in diet,genetic selection,environmental exposure,and antibiotic use.Conventional systems typically rely on formulated diets and controlled housing conditions,often with routine antimicrobial use.In contrast,organic systems emphasize natural feed ingredients,including roughage,outdoor access,and strict limitations on the use of antibiotics.These divergent practices shape the gut microbiota differently,with organic systems generally associated with greater exposure to environmental microbes and,consequently,greater microbial diversity.However,the implications of this increased diversity for poultry health and performance are complex,as organic systems may also carry a higher risk of pathogen exposure.This review summarizes current findings on the chicken gut microbiome across conventional and alternative production systems(antibiotic-free,freerange,and organic),focusing on microbial diversity,functional potential,and disease resilience.The need for standardized methodologies and consistent nomenclature in microbiome research is also discussed to improve comparability across studies.Understanding how production systems influence the gut microbiota is essential for improving poultry health and productivity while addressing challenges related to antimicrobial resistance and sustainable farming practices.展开更多
In the past few years,efforts have been made to extend the sensitivity of surface nuclear magnetic resonance(SNMR)to short relaxation times,typical for strongly bound water,which,for example,occurs in partially satura...In the past few years,efforts have been made to extend the sensitivity of surface nuclear magnetic resonance(SNMR)to short relaxation times,typical for strongly bound water,which,for example,occurs in partially saturated soils.The two limiting factors for the sensitivity are the dead time after the excitation pulse and the duration of the pulse itself.To enable short pulses,while also achieving proper depths of investigation,high pulse amplitudes are needed.This makes it necessary to consider the Bloch-Siegert effect,i.e.the counter-rotating component and the parallel component of the excitation field have significant influence on the excitation.If an untuned transmitter circuit is used,the pulse shape will also be non-sinusoidal.In this paper,we demonstrate that this influences SNMR measurements with short pulses in two ways:On one hand,the pulse shape influences the phase of the fundamental frequency oscillation.On the other,at very high pulse amplitudes,other frequency components of the excitation field start to influence the excitation.The behavior of the macroscopic magnetizations in the subsurface during the pulse is simulated by solving the Bloch equations,using the pulse shape as an input.Since these calculations are computational expensive,we propose a lookup scheme that allows a time efficient modeling of the obtained SNMR data.展开更多
The rapid growth in available network bandwidth has directly contributed to an exponential increase in mobile data traffic,creating significant challenges for network energy consumption.Also,with the extraordinary gro...The rapid growth in available network bandwidth has directly contributed to an exponential increase in mobile data traffic,creating significant challenges for network energy consumption.Also,with the extraordinary growth of mobile communications,the data traffic has dramatically expanded,which has led to massive grid power consumption and incurred high operating expenditure(OPEX).However,the majority of current network designs struggle to efficientlymanage a massive amount of data using little power,which degrades energy efficiency performance.Thereby,it is necessary to have an efficient mechanism to reduce power consumption when processing large amounts of data in network data centers.Utilizing renewable energy sources to power the Cloud Radio Access Network(C-RAN)greatly reduces the need to purchase energy from the utility grid.In this paper,we propose a bandwidth-aware hybrid energypowered C-RAN that focuses on throughput and energy efficiency(EE)by lowering grid usage,aiming to enhance the EE.This paper examines the energy efficiency,spectral efficiency(SE),and average on-grid energy consumption,dealing with the major challenges of the temporal and spatial nature of traffic and renewable energy generation across various network setups.To assess the effectiveness of the suggested network by changing the transmission bandwidth,a comprehensive simulation has been conducted.The numerical findings support the efficacy of the suggested approach.展开更多
Great Snipe(Gallinago media) is a shore bird which has a Near Threatened status on the global scale.However,little is known about its migration strategy from the breeding range in Russia.This study is the first one ai...Great Snipe(Gallinago media) is a shore bird which has a Near Threatened status on the global scale.However,little is known about its migration strategy from the breeding range in Russia.This study is the first one aiming to reveal migration routes,stopovers and wintering grounds of adult Great Snipes from their breeding range in Russia using GPS devices.We also analyzed connectivity of Great Snipes from different breeding populations of this species during non-breeding season.In 2021,we equipped seven males and three females with satellite transmitters,ICARUS Basic Tags,in the breeding range in central European Russia(56°75′N,37°65 E).One female appeared later in tundra of north-eastern Europe.In the second half of July to early September,birds migrated to Africa in a fairly wide front and made stopovers in Europe before crossing seas and the Sahara.Our data allowed to suppose high mortality of birds on migration,especially during the trans-Saharan flight.Only four Great Snipes reached Africa alive during southward migration.These birds spread over across wide area from Eritrea to Ghana after the trans-Saharan flight,after which they moved in a general westward direction and made final prolonged stopovers in Ghana or to the south of Chad Lake.In October/December birds relocated to wintering grounds in Sub-Equatorial Afrotropics as far as the south of Democratic Republic of the Congo and Zambia;with intermediate winter sites in low and middle reaches of the Congo Basin.Together with other published results,our data showed wide overlap of African non-breeding grounds of birds coming from lowland Eastern European and mountain Scandinavian breeding populations.The results also indicated insufficient conservation status of migration stopovers and wintering sites,used by Great Snipes,and demonstrated high importance of West Africa for conservation of this species.展开更多
Background:Integrins facilitate binding to the extracellular matrix and other cells.Their subunit β2 is exclusively expressed by leukocytes,binds to the intercellular cell adhesion molecule 1(ICAM-1),and is pivotal f...Background:Integrins facilitate binding to the extracellular matrix and other cells.Their subunit β2 is exclusively expressed by leukocytes,binds to the intercellular cell adhesion molecule 1(ICAM-1),and is pivotal for their recruitment to sites of inflammation such as the atherosclerotic plaque.Methods:To investigate β2-integrin-mediated adhesiveness,a well-established assay for human whole blood was adapted for the analysis of murine T cell subsets.Changes in avidity and affinity were assessed by incubation of murine complexes ICAM-1 in murine whole blood and consecutive stimulation with PMA and Mg^(2+)/EGTA.Underlying signaling pathways in β2-integrin-mediated adhesiveness upon chemokine stimulation with CCL-19 were identified by incubation with reducing substances,and a Ca^(2+)chelator and ROS and Ca^(2+)measurements were carried out.Results:Incubation of murine whole blood with PMA leads to 30-fold and Mg^(2+)/EGTA to 65-fold increase in β2-integrin-mediated adhesiveness of T cells.Specificity of the assay was proven by preincubation of a blocking antibody,leading to a 60%reduction in adhesion capacity.ROS species and Ca^(2+)are crucial for chemokine-mediated β2-integrin activation.In vivo relevance was proven by induction of T cell adhesiveness in whole blood of mice upon myocardial infarction.Conclusions:Our assay allows specific quantification of β2-integrin-mediated affinity and avidity of T cells in whole blood samples.In congruence to human adhesion,these mechanisms are ROS and Ca^(2+)dependent and significantly elevated after myocardial infarction.Our refined and robust assay may be of particular use in phenotyping involved mechanisms in T cell activation in atherosclerotic cardiovascular disease.展开更多
文摘State of research： characteristics, function, and dating of Roman brass tokens Tokens （tesserae） formed part of everyday material culture of both Greeks and Romans.1 Made of wood, bone, clay, or metal, they facilitated, for example, entry into the theatre, identification of soldiers, participation in political meetings, or the receipt of a special amount of grain.2
基金This research network of universities,research institutes,and the Deutscher Wetterdienst is funded by the BMVI(Federal Ministry of Transport and Digital Infrastructure).
文摘This article presents the results of a series of ethnographic observations at the Berlin fire brigade control and dispatch center during routine and severe weather situations.The weather-related challenges of a fire brigade lie between the anticipation of events and their potential consequences,and the ad hoc reactions to actual impacts of weather.The results show that decisions and actions related to high impact weather are not necessarily motivated by weather warnings alone.Instead,they are reactions to the experience of impacts,for example,an increased number of missions or emergency calls.Impacts are the main trigger for the decision making.Weather is one additional external factor that influences the operational capability of a fire brigade.While commanding officers in a fire brigade control and dispatch center experience weather primarily through technical equipment,verified by ground truth,observations showed that direct personal contact with the regional weather service and colleagues on the ground takes on a greater role in actual severe weather situations.The observations point to the need for increased interagency communication between the emergency services,the weather service,and other organizations to integrate weather information,impacts,and non-weather-related tasks into coherent weather-related decision making.
基金supported by the Alexander von Humboldt Foundation,and Deutsche Forschungsgemeinschaft(DFG,German Research Foundation,Project No.506270597 and No.466939224).
文摘A phase-field model including magnetic field induced dendrite fragmentation was established and applied to the cases with different initial crystal nuclear positions for AA5754 aluminum alloy electromagnetic laser beam welding.Compare the calculated results that include dendrite fragmentation caused by the thermal electromagnetic Lorentz force with the results that consider only the thermal electromagnetic Lorentz force,without fragmentation,at the characteristic time instants.Both in the early and late stages,the small fragmentation at the dendrite tip promotes the number of higher-order branches and their growth,especially in the direction perpendicular to the solidification.The later stage fragmentation has the possibility of breaking one grain into several,which verifies the possibility of grain refinement caused by dendrite fragmentation.The fracture surface caused by fragmentation also makes more solid-liquid interfaces and their growth.In addition,the cases with different initial nuclear positions were compared.The grain growth in the low-temperature zone can be inhibited by the equiaxed grains'fragmentation at the high-temperature area(179.8μm^(2) and 14.7% start at the center,115.4μm^(2) and 9.4% start at the high-temperature corner,134.3μm^(2) and 10.9%start at the low-temperature corner),which is another kind of grain refinement by the dendrite fragmentation.This kind of inhibition effect on grain growth in the low-temperature region will be enhanced with the increasing time interval between the two crystal nuclei’appearance(179.8μm^(2) and 14.7%when virtual grains appear at t=4.3803 s and t=4.3803 s,134.3μm^(2) and 10.9%at t=4.0977 s and t=3.9564 s,and 115.4μm^(2) and 9.4%at t=3.8151 s and t=3.5325 s).
文摘When a porous rock is subjected to overall compressive loading,either increasing pore pressure or decreasing confining pressure could result in rock failure.The stress path and the applied pressure change rate may affect the initiation and propagation of fractures within brittle materials.Understanding the physical mechanisms leading to failure is crucial for underground engineering applications and geo-energy exploration and storage.We conducted triaxial compression experiments on porous Bentheim sandstone samples at different stress paths and pressure change rates.First,at a constant confining pressure of 35 MPa and pore pressure of 5 MPa,intact cylindrical samples were axially loaded up to about 85%of the peak strength.Subsequently,the axial piston position was fixed,and then either the pore pressure was increased or the confining pressure was decreased at two different rates(0.5 MPa/min or 2 MPa/min),leading to final catastrophic failure.The mechanical results revealed that samples subjected to higher rates of decreasing effective confining pressure exhibited larger stress drop rates,higher slip rates,higher total breakdown work,higher rates of acoustic emissions(AEs)before failure,and higher post-failure AE decay rates.In contrast,the applied stress path did not significantly affect rock failure characteristics.Comparison of located AE events with post-mortem microstructures of deformed samples shows a good agreement.The AE source type determined from the P-wave first-motion polarity shows that shear failure dominated the fracture process when approaching failure.Gutenberg-Richter b-values revealed a significant decrease before failure in all tests.Our results indicate that,in contrast to the stress path,the rate of effective stress change strongly affects fracturing behavior and AE rate changes.
基金supported by the Hellenic Foundation for Research and Innovation,HFRI,“2nd Call for HFRI Research Projects to support Faculty Members&Researchers”Project 02667 to GL.
文摘Lysophosphatidic acid(LPA)is a pleiotropic lipid agonist essential for functions of the central nervous system(CNS).It is abundant in the developing and adult brain while its concentration in biological fluids,including cerebrospinal fluid,varies significantly(Figure 1Α;Yung et al.,2014).LPA actually corresponds to a variety of lipid species that include different stereoisomers with either saturated or unsaturated fatty acids bearing likely differentiated biological activities(Figure 1Α;Yung et al.,2014;Hernández-Araiza et al.,2018).
基金support of her postdoctoral research at the GFZ Helmholtz Centre for Geosciences.P.Pan acknowledges the financial support of the National Natural Science Foundation of China(Grant No.52339001)H.Hofmann and Y.Ji acknowledge the financial support of the Helmholtz Association's Initiative and Networking Fund for the Helmholtz Young Investigator Group ARES(contract number VH-NG-1516).
文摘A multi-stage stress relaxation test was performed on a granodiorite sample to understand the deformation process prior to the macroscopic failure of brittle rocks,as well as the transient response during stress relaxation.Distributed optical fiber sensing was used to measure strains across the sample surface by helically wrapping the single-mode fiber around the cylindrical sample.Close agreement was observed between the circumferential strains obtained from the optical fibers and the extensometer.The reconstructed full-field strain contours show strain heterogeneity from the crack closure phase,and the strains in the later deformation phase are dominantly localized within the former high-strain zone.The Gini coefficient was used to quantify the degree of strain localization and shows an initial increase during the crack closure phase,a decrease during the linear elastic phase,and a subsequent increase during the post-yielding phase.This behavior corresponds to a process of initial localization from an imperfect boundary condition,homogenization,and eventual relocalization prior to the macroscopic failure of the sample.The transient strain rate decay during the stress relaxation phase was quantified using the p-value in the“Omori-like"power law function.A higher initial stress at the onset of relaxation results in a lower p-value,indicating a slower strain rate decay.As the sample approaches macroscopic failure,the lowest p-value shifts from the most damaged zone to adjacent areas,suggesting stress redistribution or crack propagation in deformed crystalline rocks under stress relaxation conditions.
基金support received from the National Research Foundation of Korea(NRF)through the Ministry of Science,ICT(Information and Communication Technology),under grant numbers RS-2023-00302646 and RS-2025-02316700.
文摘Tin-lead(Sn-Pb)halide perovskite single crystals combine narrow bandgaps,long carrier diffusion lengths,and low trap densities,positioning them as ideal candidates for near-infrared(NIR)optoelectronics.However,conventional growth strategies rely on bulk crystallization at elevated temperatures,leading to uncontrolled nucleation,Sn^(2+)oxidation,and poor compatibility with planar integration.Here,we develop a coordination-engineered crystallization strategy that enables direct,lowtemperature growth of micrometer-thick Sn-Pb single-crystal thin films on device-compatible substrates.By modulating metal-solvent coordination strength using a low-donor number cosolvent system,we delineate a narrow processing window that stabilizes precursor speciation,lowers the nucleation barrier,and guides directional crystal growth under mild thermal conditions(<40℃).The resulting crystal films exhibit smooth morphology,high crystallinity,compositional uniformity,and ultralow trap densities(~3.98×10^(12)cm^(-3)).When integrated into NIR photodetectors,these films deliver high responsivity(0.51 A W^(-1)at 900 nm),specific detectivity up to 3.6×10^(12)Jones,fast response(~188μs),and>25,000 cycles of ambient operational stability.This approach establishes a scalable platform for redox-stable,low-temperature growth of Sn-Pb perovskite crystal films and expands the processing-structure-function landscape for next-generation infrared optoelectronics.
基金supported by funds of the Federal Ministry of Agriculture,Food and Regional Identity(BMLEH)based on a decision of the parliament of the Federal Republic of Germany via the Federal Office for Agriculture and Food(BLE)under the Federal Programme for Ecological Farming and Other Forms of Sustainable Agriculture(FKZ 2821OE034)。
文摘The poultry gut microbiome plays a key role in nutrient digestion,immune function,and overall health.Differences among various farming systems,including conventional,antibiotic-free,free-range,and organic systems,influence microbial composition and function through variations in diet,genetic selection,environmental exposure,and antibiotic use.Conventional systems typically rely on formulated diets and controlled housing conditions,often with routine antimicrobial use.In contrast,organic systems emphasize natural feed ingredients,including roughage,outdoor access,and strict limitations on the use of antibiotics.These divergent practices shape the gut microbiota differently,with organic systems generally associated with greater exposure to environmental microbes and,consequently,greater microbial diversity.However,the implications of this increased diversity for poultry health and performance are complex,as organic systems may also carry a higher risk of pathogen exposure.This review summarizes current findings on the chicken gut microbiome across conventional and alternative production systems(antibiotic-free,freerange,and organic),focusing on microbial diversity,functional potential,and disease resilience.The need for standardized methodologies and consistent nomenclature in microbiome research is also discussed to improve comparability across studies.Understanding how production systems influence the gut microbiota is essential for improving poultry health and productivity while addressing challenges related to antimicrobial resistance and sustainable farming practices.
基金funded by the German Research Foundation(Deutsche Forschungsgemeinschaft-DFG)under grant MU 3318/8-1.
文摘In the past few years,efforts have been made to extend the sensitivity of surface nuclear magnetic resonance(SNMR)to short relaxation times,typical for strongly bound water,which,for example,occurs in partially saturated soils.The two limiting factors for the sensitivity are the dead time after the excitation pulse and the duration of the pulse itself.To enable short pulses,while also achieving proper depths of investigation,high pulse amplitudes are needed.This makes it necessary to consider the Bloch-Siegert effect,i.e.the counter-rotating component and the parallel component of the excitation field have significant influence on the excitation.If an untuned transmitter circuit is used,the pulse shape will also be non-sinusoidal.In this paper,we demonstrate that this influences SNMR measurements with short pulses in two ways:On one hand,the pulse shape influences the phase of the fundamental frequency oscillation.On the other,at very high pulse amplitudes,other frequency components of the excitation field start to influence the excitation.The behavior of the macroscopic magnetizations in the subsurface during the pulse is simulated by solving the Bloch equations,using the pulse shape as an input.Since these calculations are computational expensive,we propose a lookup scheme that allows a time efficient modeling of the obtained SNMR data.
文摘The rapid growth in available network bandwidth has directly contributed to an exponential increase in mobile data traffic,creating significant challenges for network energy consumption.Also,with the extraordinary growth of mobile communications,the data traffic has dramatically expanded,which has led to massive grid power consumption and incurred high operating expenditure(OPEX).However,the majority of current network designs struggle to efficientlymanage a massive amount of data using little power,which degrades energy efficiency performance.Thereby,it is necessary to have an efficient mechanism to reduce power consumption when processing large amounts of data in network data centers.Utilizing renewable energy sources to power the Cloud Radio Access Network(C-RAN)greatly reduces the need to purchase energy from the utility grid.In this paper,we propose a bandwidth-aware hybrid energypowered C-RAN that focuses on throughput and energy efficiency(EE)by lowering grid usage,aiming to enhance the EE.This paper examines the energy efficiency,spectral efficiency(SE),and average on-grid energy consumption,dealing with the major challenges of the temporal and spatial nature of traffic and renewable energy generation across various network setups.To assess the effectiveness of the suggested network by changing the transmission bandwidth,a comprehensive simulation has been conducted.The numerical findings support the efficacy of the suggested approach.
基金A support for different activities in the framework of this research was provided by Max Planck Institute of Animal Behavior,the Russian space agency (Roskosmos),German Aerospace Center and Institute for Geography of the Russian Academy of Sciences via International Cooperation for Animal Research Using Space as well as by NABU–The Nature and Biodiversity Conservation Union2021 was carried out as a joint project of Birds Russia and Manfred-Hermsen Stiftung+2 种基金funded under state assignments of the Severtsov Institute of Ecology and Evolution of the Russian Academy of Science (No. 0089-2021-0004, FFER-2024-0013No. 0089-2021-0010, FFER-2024-0022No. 1022040700480-0-1.6.15)。
文摘Great Snipe(Gallinago media) is a shore bird which has a Near Threatened status on the global scale.However,little is known about its migration strategy from the breeding range in Russia.This study is the first one aiming to reveal migration routes,stopovers and wintering grounds of adult Great Snipes from their breeding range in Russia using GPS devices.We also analyzed connectivity of Great Snipes from different breeding populations of this species during non-breeding season.In 2021,we equipped seven males and three females with satellite transmitters,ICARUS Basic Tags,in the breeding range in central European Russia(56°75′N,37°65 E).One female appeared later in tundra of north-eastern Europe.In the second half of July to early September,birds migrated to Africa in a fairly wide front and made stopovers in Europe before crossing seas and the Sahara.Our data allowed to suppose high mortality of birds on migration,especially during the trans-Saharan flight.Only four Great Snipes reached Africa alive during southward migration.These birds spread over across wide area from Eritrea to Ghana after the trans-Saharan flight,after which they moved in a general westward direction and made final prolonged stopovers in Ghana or to the south of Chad Lake.In October/December birds relocated to wintering grounds in Sub-Equatorial Afrotropics as far as the south of Democratic Republic of the Congo and Zambia;with intermediate winter sites in low and middle reaches of the Congo Basin.Together with other published results,our data showed wide overlap of African non-breeding grounds of birds coming from lowland Eastern European and mountain Scandinavian breeding populations.The results also indicated insufficient conservation status of migration stopovers and wintering sites,used by Great Snipes,and demonstrated high importance of West Africa for conservation of this species.
基金DZHK(German Centre for Cardiovascular Research)。
文摘Background:Integrins facilitate binding to the extracellular matrix and other cells.Their subunit β2 is exclusively expressed by leukocytes,binds to the intercellular cell adhesion molecule 1(ICAM-1),and is pivotal for their recruitment to sites of inflammation such as the atherosclerotic plaque.Methods:To investigate β2-integrin-mediated adhesiveness,a well-established assay for human whole blood was adapted for the analysis of murine T cell subsets.Changes in avidity and affinity were assessed by incubation of murine complexes ICAM-1 in murine whole blood and consecutive stimulation with PMA and Mg^(2+)/EGTA.Underlying signaling pathways in β2-integrin-mediated adhesiveness upon chemokine stimulation with CCL-19 were identified by incubation with reducing substances,and a Ca^(2+)chelator and ROS and Ca^(2+)measurements were carried out.Results:Incubation of murine whole blood with PMA leads to 30-fold and Mg^(2+)/EGTA to 65-fold increase in β2-integrin-mediated adhesiveness of T cells.Specificity of the assay was proven by preincubation of a blocking antibody,leading to a 60%reduction in adhesion capacity.ROS species and Ca^(2+)are crucial for chemokine-mediated β2-integrin activation.In vivo relevance was proven by induction of T cell adhesiveness in whole blood of mice upon myocardial infarction.Conclusions:Our assay allows specific quantification of β2-integrin-mediated affinity and avidity of T cells in whole blood samples.In congruence to human adhesion,these mechanisms are ROS and Ca^(2+)dependent and significantly elevated after myocardial infarction.Our refined and robust assay may be of particular use in phenotyping involved mechanisms in T cell activation in atherosclerotic cardiovascular disease.
