Oil-fired construction machinery(OCM)is a major source of urban air pollutants and CO_(2) emissions,and elec-trification is a crucial pathway for improving air quality and achieving China’s dual carbon goals;however,...Oil-fired construction machinery(OCM)is a major source of urban air pollutants and CO_(2) emissions,and elec-trification is a crucial pathway for improving air quality and achieving China’s dual carbon goals;however,its feasibility has not been fully explored.This study uses data envelopment analysis and the analytic hierarchy process to establish a development potential index,covering technical efficiency,economic cost,application sce-narios,and charging time and range,with an empirical analysis conducted in Beijing.The findings indicated the high feasibility of replacing OCM with electric alternatives,especially within the low-power range.Based on 2023 registered coding dat1,it is projected that by 2030,electrification could reduce regional average con-centrations of CO,NO_(x),PM_(2.5) and VOCs by 12.2%to 56.4%and reduce CO_(2) by 11.7%to 56.9%.Owing to economic considerations,small-and medium-sized machinery are particularly feasible for electrification.Key recommendations include prioritizing the electrification of forklifts,lifting platforms,and small-sized machinery in high-emission areas,particularly in central urban districts.Policies such as carbon taxes,carbon markets,and performance grading systems are suggested to incentivize electrification,along with expanding high-emission restriction zones and improving energy infrastructure to support widespread electrification.展开更多
Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco...Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco use^([1]).Adolescents are especially prone to developing persistent smoking habits,with many adult smokers having started before the age of 18.In China,16.7%of secondary school students have tried smoking and 4.7%are current smokers,highlighting the critical need for targeted tobacco control interventions among the youth.展开更多
Respiratory infections are associated with high morbidity and mortality and are a major global health problem[1].Acute respiratory infections are caused by multiple respiratory pathogens,including viruses and bacteria...Respiratory infections are associated with high morbidity and mortality and are a major global health problem[1].Acute respiratory infections are caused by multiple respiratory pathogens,including viruses and bacteria.Viral-bacterial co-infections,which have become increasingly common and a global concern,can lead to substantial complications,causing higher morbidity and adverse prognosis[2].Previous studies have reported low positive detection rates of targeted pathogens related to acute respiratory infections,owing to the limited number of detected pathogens and variations in the sensitivity of diagnostic methods[3-4].Low positive detection rates may impede our understanding of respiratory pathogen characteristics and hamper the development of precise treatment and prevention strategies.展开更多
Couplets,as a vital symbol of Chinese traditional culture,hold prominent cultural significance in Beijing’s urban neighborhoods.This paper assesses the current state of cultural communication efficacy regarding coupl...Couplets,as a vital symbol of Chinese traditional culture,hold prominent cultural significance in Beijing’s urban neighborhoods.This paper assesses the current state of cultural communication efficacy regarding couplets in Beijing’s neighborhoods,identifying challenges including fragile cultural ecosystems,limitations of communication agents,homogeneity in content and forms,and outdated dissemination mechanisms.To address these issues,the study conducts an in-depth analysis of strategies to enhance the cultural dissemination capacity of Beijing’s neighborhood couplet culture,proposing comprehensive enhancement pathways.The research aims to effectively elevate the cultural influence of Beijing’s neighborhood couplet culture and facilitate the city’s development as a national cultural center.展开更多
The Beijing-Tianjin-Hebei Plain is among the regions in China that feature the largest scale and the fastest growth in medium and deep geothermal heating.Based on tests of 82 geothermal fluid samples from 7 geothermal...The Beijing-Tianjin-Hebei Plain is among the regions in China that feature the largest scale and the fastest growth in medium and deep geothermal heating.Based on tests of 82 geothermal fluid samples from 7 geothermal fields in Hebei Province,2 geothermal fields in Henan Province,and 2 geothermal fields in Shandong Province,and combined with previous studies on the chemical characteristics of karst geothermal water in Beijing and Tianjin,this paper systematically analyzes the migration characteristics of geothermal fluids in karst geothermal reservoirs within the Beijing-Tianjin-Hebei Plain.The hydrochemical characteristics of karst geothermal water in the research areas exhibit certain differences.The geothermal water in Hebei is more mature than that in its neighboring provinces.The distribution of total dissolved solids(TDS)and strontium elements in the area is characterized by being low in the north and south and high in the middle,suggesting that the overall flow direction of geothermal fluid is from the north and south towards the middle.Combined with the groundwater flow field and the changing trend of the hydrochemical characteristics of geothermal wells along the geological section,a geothermal water migration model has been established.The geothermal fluids originating from Taihang Mountain,Yanshan Mountain,and Western Shandong Mountain enter the basin and continue to migrate towards the central part of the basin along water-conducting faults.However,the migration characteristics of geothermal fluids with the same supply direction are not identical.The geothermal fluids from Taihang Mountain are cut off by the Niudong Fault in the north and terminate in the central uplift belt of the Jizhong Depression,while in the south,they enter the east of the Jizhong Depression relatively quickly along the Hengshui Conversion Belt.The geothermal fluids from Yanshan Mountain migrate into the basin along the Cangdong Fault,yet this fault also disrupts the hydraulic connection between the tectonic units.Considering the effective dynamic conditions,it is recommended to further expand the scale of the scientific development and utilization of geothermal energy in the geothermal water catchment areas around Xiongxian County and southwest Cangzhou City.展开更多
In the context of global climate change,the increasing frequency of extreme weather events presents significant challenges to urban water systems.This study focuses on the Beijing section of the Beijing-Hangzhou Grand...In the context of global climate change,the increasing frequency of extreme weather events presents significant challenges to urban water systems.This study focuses on the Beijing section of the Beijing-Hangzhou Grand Canal,introduces the SEE model,and develops an integrated“comprehensive water environment simulation model”to systematically examine the path for enhancing its climate resilience.Through the coupling of multiple models(MIKE 11,MIKE URBAN,MIKE 21)and scenario simulations,this study analyzes the response mechanisms of various governance strategies under extreme climate conditions.The research proposes four specific measures to enhance resilience:dual-scenario simulation of climate and governance,identification and reinforcement of weak points in resilience,parametric modeling of ecological restoration interventions,and the development of a“digital twin canal system”.The research findings indicate that the system integration of the SEE model substantially improves the adaptability,endurance,and recovery capacity of canals in response to climate shocks,including heavy rainfall and drought.This provides a scientific foundation and a practical path for achieving long-term resilience and sustainable development of urban water systems.展开更多
Promoting the deep integration of advanced manufacturing and producer services is not only a key path for metropolitan to climb the global value chain,but also an important new driving force for optimizing urban spati...Promoting the deep integration of advanced manufacturing and producer services is not only a key path for metropolitan to climb the global value chain,but also an important new driving force for optimizing urban spatial structure.Based on the two dimen-sions of industrial linkage and spatial co-agglomeration from the perspective of industrial integration,taking Beijing,China as a case,using industrial input-output data,micro-enterprise spatial data,and methods such as industrial linkage model,standard deviation el-lipse,and spatial similarity coefficient,this study explores the coupling relationship between industrial linkage and spatial co-agglomer-ation of advanced manufacturing and producer services from 2007 to 2020.The results demonstrate that:1)the industrial linkage between advanced manufacturing and producer services in Beijing has an upward trend,in which the business services have the most significant improvement,in which the business services have the most improvement while the technology services have the most de-crease,but in general,the industrial linkage between the two industries shows a low level.2)Producer services were more spatially clustered than advanced manufacturing,and the degree of spatial co-agglomeration of the two also showed an increasing trend,with strong regional and industrial heterogeneity characteristics,among which the pairing industry involving commerce services and techno-logy services had a more obvious improvement.3)The coupling analysis found that the spatial dependence between advanced manufac-turing and producer services decreased,showing a weak positive correlation and a decreasing trend between industrial linkage and spa-tial co-agglomeration;the heterogeneity among subdivision pairs is prominent,and the strong correlation between industries does not mean that there is an inevitable spatial co-agglomeration.4)Based on the differences in coupling relationships and influence mechan-isms,four coupling modes are identified:H-H type,H-L type,L-L type,and L-H type.Finally,this study proposes three policy implica-tions for the integration of advanced manufacturing and producer services in metropolitan areas.展开更多
The construction of“park cities”requires a systematic thinking to coordinate the networked development of park system and break through the limitation of emphasizing scale and grade and neglecting dynamic correlatio...The construction of“park cities”requires a systematic thinking to coordinate the networked development of park system and break through the limitation of emphasizing scale and grade and neglecting dynamic correlation in traditional planning.Taking Haidian District of Beijing as an example,the social network analysis method is introduced to construct the network model of park green spaces.Through indicators such as clustering coefficient,network density and node centrality,the characteristics of its spatial structure and hierarchical relationship are analyzed.It is found that the network integrity presents the characteristics of“highly local concentration and global fragmentation”,fragmented park green space network and missing spatial connection,isolated clusters and collaborative failure,as well as the spatial mismatch between population and resource supply and demand.Hierarchical issues include“structural imbalance and functional disorder”,disorder between network hierarchy and park level,misalignment of functional hierarchy leading to weakened network risk resistance capacity,and a relatively dense distribution of core nodes,etc.In response to the above problems,a multi-level spatial intervention strategy should be adopted to solve the overall problem of the network.Meanwhile,it is needed to clarify the positioning of a park itself and improve the hierarchical system,so as to construct a multi-level and multi-scale park green space network,contribute to the construction of a park city,and provide residents with more diverse activity venues.展开更多
In recent years,incidents of simultaneous exceedance of PM_(2.5)and O_(3) concentrations,termed PM_(2.5)and O_(3) co-pollution events,have frequently occurred in China.This study conducted atmospheric circulation anal...In recent years,incidents of simultaneous exceedance of PM_(2.5)and O_(3) concentrations,termed PM_(2.5)and O_(3) co-pollution events,have frequently occurred in China.This study conducted atmospheric circulation analysis on two typical co-pollution events in Beijing,occurring from July 22 to July 28,2019,and from April 25 to May 2,2020.These events were categorized into pre-trough southerly airflow type(Type 1)and post-trough northwest flow type(Type 2).Subsequently,sensitivity analyses using the GRAPES-CUACE adjoint model were performed to quantify the contributions of precursor emissions from Beijing and surrounding areas to PM_(2.5)and O_(3) concentrations in Beijing for two types of co-pollution.The results indicated that the spatiotemporal distribution of sensitive source region varied among different circulation types.Primary PM_(2.5)(PPM_(2.5))emissions from Hebei contributed the most to the 24-hour average PM_(2.5)(24-h PM_(2.5))peak concentration(41.6%-45.4%),followed by Beijing emissions(31%-35.7%).The maximum daily 8-hour average ozone peak concentration was primarily influenced by the emissions from Hebei and Beijing,with contribution ratios respectively of 32.8%-44.8% and 29%-42.1%.Additionally,NO_(x)emissions were the main contributors in Type 1,while both NO_(x)and VOCs emissions contributed similarly in Type 2.The iterative emission reduction experiments for two types of co-pollution indicated that Type 1 required emission reductions in NO_(x)(52.4%-71.8%)and VOCs(14.1%-33.8%)only.In contrast,Type 2 required combined emission reductions in NO_(x)(37.0%-65.1%),VOCs(30.7%-56.2%),and PPM_(2.5)(31%-46.9%).This study provided a reference for controlling co-pollution events and improving air quality in Beijing.展开更多
A novel digital twin(DT)enabled channel model for 6G vehicular communications in Beijing Central Business District(Beijing CBD)is proposed,which can support the design of intelligent transportation systems(ITSs).A DT ...A novel digital twin(DT)enabled channel model for 6G vehicular communications in Beijing Central Business District(Beijing CBD)is proposed,which can support the design of intelligent transportation systems(ITSs).A DT space for Beijing CBD is constructed,and two typical transportation periods,i.e.,peak and off-peak hours,are considered to characterize the vehicular communication channel better.Based on the constructed DT space,a DT-enabled vehicular communication dataset is developed,including light detection and ranging(LiDAR)point clouds,RGB images,and channel information.With the assistance of LiDAR point clouds and RGB images,the scatterer parameters,including number,distance,angle,power,and velocity,are analyzed under different transportation periods.The channel non-stationarity and consistency are mimicked in the proposed model.The key channel statistical properties are derived and simulated.Compared to ray-tracing(RT)results,the accuracy of the proposed model is verified.展开更多
To understand the smoke level and NO_(x)emission characteristics of in-use construction machinery in Beijing,we selected 905 construction machines in Beijing from August 2022 to April 2023 to monitor the emission leve...To understand the smoke level and NO_(x)emission characteristics of in-use construction machinery in Beijing,we selected 905 construction machines in Beijing from August 2022 to April 2023 to monitor the emission level of smoke and NO_(x).The exhaust smoke level and excessive emission situation of different machinery types were identified,and their NO_(x)emission levels were monitored according to the free acceleration method.We investigated the correlation of NO_(x)and smoke emission,and proposed suggestions for controlling pollution discharge from construction machinery in the future.The results show that the exhaust smoke level was 0–2.62 m^(−1),followed a log-normal distribution(μ=-1.73,δ=1.09,R^(2)=0.99),with a 5.64%exceedance rate.Differenceswere observed amongmachinery types,with low-power engine forklifts showing higher smoke levels.The NO_(x)emission range was 71–1516 ppm,followed a normal distribution(μ=565.54,δ=309.51,R^(2)=0.83).Differences among machinery types were relatively small.Engine rated net power had the most significant impact on NO_(x)emissions.Thus,NO_(x)emissions from construction machinery need further attention.Furthermore,we found a weak negative correlation(p<0.05)between the emission level of smoke and NO_(x),that is the synergic emission reduction effect is poor,emphasizing the need for NO_(x)emission limits.In the future,the oversight in Beijing should prioritize phasing out ChinaⅠand ChinaⅡmachinery,and monitor emissions from highpower engine ChinaⅢmachinery.展开更多
Although air pollutant emissions have sharply reduced in recent years,the occurrence of PM_(2.5) pollution events remains an intractable environmental problem in Beijing,and regional transport is the key influence fac...Although air pollutant emissions have sharply reduced in recent years,the occurrence of PM_(2.5) pollution events remains an intractable environmental problem in Beijing,and regional transport is the key influence factor.However,it has been difficult to identify regional transport characteristics and the main contributors to pollution events in recent years.In this study,the relative contribution of regional transport was quantified(61.3%)in PM_(2.5) pollution events during 2018-2021 by the Community Multiscale Air Quality model embedded with the Integrated Source Apportionment Model(CMAQ-ISAM).The four regions with the largest fractional contributions to Beijing for all events were Shandong(7.7%),South Hebei(7.3%),Baoding(6.2%),and Langfang(5.8%).Pollution events were classified into the following types based on regional transport directions:local,southwest(SW),southeast(SE),south-mixed(SM),and others.Based on the transport distance,the SW,SE,and SM types can be subdivided into SW-short,SW-long,SE-short,SE-long,SM-short,SM-long distance from southwest,SM-long distance from southeast,and SM-long distance from southwest and southeast.SE-long was regarded as the most important type,with the highest relative frequency(20%).The transport directions were related to the southwest wind at 925 hPa and southeast wind at 1000 hPa in the south of the Beijing–Tianjin–Hebei(BTH)region,and the distance was mainly controlled by wind strength.The wind-field difference can be attributed to the low-pressure and high-pressure systems that control the BTH region.The results suggest that regional joint pollution control should be optimized based on the transport type.展开更多
Objective:Postpartum nutrition plays a critical role in maternal recovery and long-term health.However,the nutritional status of working mothers in the postpartum period remains understudied.This study aimed to assess...Objective:Postpartum nutrition plays a critical role in maternal recovery and long-term health.However,the nutritional status of working mothers in the postpartum period remains understudied.This study aimed to assess the dietary quality of postpartum women in urban Beijing,identify occupational-related factors influencing their diet,and explore potential interventions to improve maternal nutrition during the postpartum period.Methods:In this cross-sectional analysis,554 women one year after delivery were recruited from ten community health centers.Sociodemographic,occupational and postpartum care variables were collected via questionnaire.Dietary intake over the preceding year was assessed using a food frequency questionnaire.The modified dietary balance index for postpartum women were used for dietary quality assessment.Results:The study revealed severe dietary imbalances among postpartum women,characterized by excessive consumption of cereals,eggs,and meats,while their intake of vegetables,fruits,and dairy products was inadequate.According to dietary balance index for postpartum women,66.25%of mothers showed varying degrees of excessive intake.45.31%of mothers experienced varying levels of insufficient intake,with only 19.86%of participants having a relatively balanced diet.Occupational differences were observed,with women in the commercial employment group showing higher levels of excessive food intake.The analysis of influencing factors showed that family monthly income,maternity leave,and postpartum care significantly affected the dietary quality.Conclusions:Postpartum women in Beijing experience widespread dietary imbalances,with both excesses and deficiencies.Occupational context and related factors significantly shape diet quality.These findings highlight the need for targeted nutritional interventions tailored to the specific challenges of different occupational groups.展开更多
Current models of national conditions education for international students often fall short in facilitating their transition from passive observers of culture to active communicators.Using Beijing International Studie...Current models of national conditions education for international students often fall short in facilitating their transition from passive observers of culture to active communicators.Using Beijing International Studies University as a case study,this paper examines how a systematic educational model enables international students to shift from passive observation to active narration of Chinese society and culture.The study identifies and elaborates on three core mechanisms of this model:an institutional integration mechanism centered on convergent management,a practical cognition mechanism through experiential learning,and a narrative empowerment mechanism utilizing converged media platforms.Together,these components form a glocalized educational framework that integrates global issues with local practices,connecting macro narratives with personal experiences.Case analysis demonstrates that by immersing students in authentic sociocultural contexts and granting them narrative agency,this model effectively fosters deep understanding and cross-cultural identity.It thus provides a new theoretical framework and practical pathway for reconstructing international student education in China with an emphasis on student agency and interculturality.展开更多
Urban areas face environmental pollution and greenhouse emissions challenges,demand collaborative efforts to mitigation.Urban forests play a crucial role in absorbing CO_(2) emissions and contributing to carbon seques...Urban areas face environmental pollution and greenhouse emissions challenges,demand collaborative efforts to mitigation.Urban forests play a crucial role in absorbing CO_(2) emissions and contributing to carbon sequestration potential,but they also release biogenic volatile organic compounds(BVOCs),which contribute to the formation of tropospheric ozone and secondary organic aerosols(SOA).This study aimed to understand the role of urban forests in carbon stock and BVOCs emission by establishing optimal biomass models for six typical tree species(Robinia pseudoacacia,Quercus,Populus,Pinus tabulaeformis,Betula platyphylla,and Larix gmelinii)in Beijing.Biomass models were developed using field surveys and remote sensing data,with R^(2) values ranging from 0.364 to 0.921.Applying these models to forest resource inventory data,carbon stock and BVOCs emission models were constructed.In 2021,the total carbon stock for these pure forest tree species was estimated at 5.638 million tons,with a carbon density of 58.86 t/ha.The carbon density ranking for pure forest tree species was:Robinia pseudoacacia>Populus tomentosa>Betula platyphylla>Quercus Linn>Pinus tabulaeformis>Larix gmelinii.Total BVOCs emission in 2021 from the studied species were calculated at 25,789.72 t,with an average emission of 0.27 t/ha.Populus tomentosa had the highest BVOCs emission per unit area,followed by Robinia pseudoacacia,and Larix gmelinii had the smallest.Betula platyphylla and Robinia pseudoacacia were identified as species with high carbon stock and low BVOCs emissions in Beijing,offering insights for future urban forest planning and eco-friendly urban environment development strategies.展开更多
Emergency medical services (EMS) are a vital element of the public healthcare system in China,^([1])providing an opportunity to respond to critical medical conditions and save people’s lives.^([2])The accessibility o...Emergency medical services (EMS) are a vital element of the public healthcare system in China,^([1])providing an opportunity to respond to critical medical conditions and save people’s lives.^([2])The accessibility of EMS has received considerable attention in health and transport geography studies.^([3])One of the optimal gauges for evaluating the accessibility of EMS is the response time,which is defined as the time from receiving an emergency call to the arrival of an ambulance.^([4])Beijing has already reduced the response time to approximately12 min,and the next goal is to ensure that the response time across Beijing does not exceed 12 min (the information comes from the Beijing Emergency Medical Center).展开更多
Against the backdrop of the comprehensive advancement of curriculum ideological and political construction in colleges and universities,art general education courses,as important carriers for the integration of aesthe...Against the backdrop of the comprehensive advancement of curriculum ideological and political construction in colleges and universities,art general education courses,as important carriers for the integration of aesthetic education and moral education,have their educational value awaiting systematic exploration.This article takes the"Accordion Performance Art"course at Beijing International Studies University as the research object and systematically expounds on the ideological and political construction path from skill training to cultural education.It constructs a three-dimensional educational framework of"technique-aesthetics-value",focuses on analyzing characteristic practices such as the infiltration of red music culture,the penetration of ethnic music elements,and the application of Marxist philosophical principles,and innovatively proposes a progressive teaching model of"situational experience-dialectical thinking-cultural communication".Through the reconstruction of teaching content,innovation of teaching methods,and optimization of evaluation systems,the organic integration of accordion performance teaching and ideological and political education has been realized,providing an operable practical reference paradigm for the ideological and political construction of art general education courses.The research shows that the ideological and political construction of art courses must be based on the characteristics of the discipline,with artistic practice as the carrier and cultural inheritance as the link,in order to achieve the in-depth goal of"educating people with aesthetics and cultivating people with culture".展开更多
Taking the Ming Tombs Forest Farm in Beijing as the research object,this research applied multi-source data fusion and GIS heat-map overlay analysis techniques,systematically collected bird observation point data from...Taking the Ming Tombs Forest Farm in Beijing as the research object,this research applied multi-source data fusion and GIS heat-map overlay analysis techniques,systematically collected bird observation point data from the Global Biodiversity Information Facility(GBIF),population distribution data from the Oak Ridge National Laboratory(ORNL)in the United States,as well as information on the composition of tree species in suitable forest areas for birds and the forest geographical information of the Ming Tombs Forest Farm,which is based on literature research and field investigations.By using GIS technology,spatial processing was carried out on bird observation points and population distribution data to identify suitable bird-watching areas in different seasons.Then,according to the suitability value range,these areas were classified into different grades(from unsuitable to highly suitable).The research findings indicated that there was significant spatial heterogeneity in the bird-watching suitability of the Ming Tombs Forest Farm.The north side of the reservoir was generally a core area with high suitability in all seasons.The deep-aged broad-leaved mixed forests supported the overlapping co-existence of the ecological niches of various bird species,such as the Zosterops simplex and Urocissa erythrorhyncha.In contrast,the shallow forest-edge coniferous pure forests and mixed forests were more suitable for specialized species like Carduelis sinica.The southern urban area and the core area of the mausoleums had relatively low suitability due to ecological fragmentation or human interference.Based on these results,this paper proposed a three-level protection framework of“core area conservation—buffer zone management—isolation zone construction”and a spatio-temporal coordinated human-bird co-existence strategy.It was also suggested that the human-bird co-existence space could be optimized through measures such as constructing sound and light buffer interfaces,restoring ecological corridors,and integrating cultural heritage elements.This research provided an operational technical approach and decision-making support for the scientific planning of bird-watching sites and the coordination of ecological protection and tourism development.展开更多
Background:C hina is a high-burden country for multidrug-r esistant tuberculosis/rifampin-resistant tuberculosis(MDR/RR-T B).Fluoroquinolones(FQs)are key drugs for the treatment of patients with MDR/RR-T B.However,res...Background:C hina is a high-burden country for multidrug-r esistant tuberculosis/rifampin-resistant tuberculosis(MDR/RR-T B).Fluoroquinolones(FQs)are key drugs for the treatment of patients with MDR/RR-T B.However,research on the resistance of FQs in Beijing is limited.Methods:W e collected clinical isolates from all patients with pulmonary TB in Beijing from January 2016 to December 2021,conducted drug-s ensitivity tests and sequencing for levofloxacin(LFX)and moxifloxacin(MFX),and collected the treatment plans and outcomes of the patients.Results:A total of 8512 clinical isolates were collected from patients with pulmonary TB,and 261 RR-T B strains were screened.The proportions of drug-s ensitive and drugresistant strains significantly differed by age group and treatment history.The rates of LFX and MFX resistance were 27.6%(72/261)and 36.4%(95/261),respectively.The detection rates of MDR-T B and pre-e xtensively drug-resistant TB(pre-X DR-T B)were 73.2%(191/261)and 36.4%(95/261),respectively,and the trends were significant(χ^(2)trend=9.995,p=0.002;χ^(2)trend=12.744,p=0.026).Among the 261 RR-T B strains,14.9%(24/261)were sensitive to LFX but resistant to MFX.Among the four patients with LFX-r esistant TB who received LFX treatment failed in three patients(Fisher's exact test,p=0.009).The common mutation sites were 94 and 90 in gyrA.A novel mutation Ala90Ser was discovered.Conclusions:F Qs resistance trends in RR-T B patients in Beijing are striking.Strains showed incomplete cross-resistance to LFX and MFX.Testing for FQs resistance and developing a reasonable treatment plan are recommended.Attention should be given to the changing trends in MDR-T B and pre-X DR-TB.展开更多
This study summarizes the examination data of registration labels for ordinary cosmetics in Beijing from May 2021 to April 2024.It analyzes and categorizes the issues identified during label evaluations,explores the u...This study summarizes the examination data of registration labels for ordinary cosmetics in Beijing from May 2021 to April 2024.It analyzes and categorizes the issues identified during label evaluations,explores the underlying causes,and proposes regulatory countermeasures and recommendations for registrants,regulatory authorities,and social organizations.The objective is to offer practical insights and regulatory guidance to support the enhancement of cosmetic registration and regulatory standards.展开更多
基金supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2024ZD1200200).
文摘Oil-fired construction machinery(OCM)is a major source of urban air pollutants and CO_(2) emissions,and elec-trification is a crucial pathway for improving air quality and achieving China’s dual carbon goals;however,its feasibility has not been fully explored.This study uses data envelopment analysis and the analytic hierarchy process to establish a development potential index,covering technical efficiency,economic cost,application sce-narios,and charging time and range,with an empirical analysis conducted in Beijing.The findings indicated the high feasibility of replacing OCM with electric alternatives,especially within the low-power range.Based on 2023 registered coding dat1,it is projected that by 2030,electrification could reduce regional average con-centrations of CO,NO_(x),PM_(2.5) and VOCs by 12.2%to 56.4%and reduce CO_(2) by 11.7%to 56.9%.Owing to economic considerations,small-and medium-sized machinery are particularly feasible for electrification.Key recommendations include prioritizing the electrification of forklifts,lifting platforms,and small-sized machinery in high-emission areas,particularly in central urban districts.Policies such as carbon taxes,carbon markets,and performance grading systems are suggested to incentivize electrification,along with expanding high-emission restriction zones and improving energy infrastructure to support widespread electrification.
基金supported by the World Health Organization Global Youth Tobacco Survey(WPDHP1206671)the Global Health Capacity Building and Tobacco Control Project:Tobacco Epidemic Monitoring and Comprehensive Tobacco Control Intervention。
文摘Adolescent smoking constitutes a critical public health challenge as early initiation increases the risk of premature mortality and smoking-related chronic diseases due to longer exposure and higher cumulative tobacco use^([1]).Adolescents are especially prone to developing persistent smoking habits,with many adult smokers having started before the age of 18.In China,16.7%of secondary school students have tried smoking and 4.7%are current smokers,highlighting the critical need for targeted tobacco control interventions among the youth.
基金supported by the Beijing Science and Technology Planning Project of the Beijing Science and Technology Commission(Z241100009024047)the High-Level Public Health Technical Talent Training Plan(lingjunrencai-01-02).
文摘Respiratory infections are associated with high morbidity and mortality and are a major global health problem[1].Acute respiratory infections are caused by multiple respiratory pathogens,including viruses and bacteria.Viral-bacterial co-infections,which have become increasingly common and a global concern,can lead to substantial complications,causing higher morbidity and adverse prognosis[2].Previous studies have reported low positive detection rates of targeted pathogens related to acute respiratory infections,owing to the limited number of detected pathogens and variations in the sensitivity of diagnostic methods[3-4].Low positive detection rates may impede our understanding of respiratory pathogen characteristics and hamper the development of precise treatment and prevention strategies.
文摘Couplets,as a vital symbol of Chinese traditional culture,hold prominent cultural significance in Beijing’s urban neighborhoods.This paper assesses the current state of cultural communication efficacy regarding couplets in Beijing’s neighborhoods,identifying challenges including fragile cultural ecosystems,limitations of communication agents,homogeneity in content and forms,and outdated dissemination mechanisms.To address these issues,the study conducts an in-depth analysis of strategies to enhance the cultural dissemination capacity of Beijing’s neighborhood couplet culture,proposing comprehensive enhancement pathways.The research aims to effectively elevate the cultural influence of Beijing’s neighborhood couplet culture and facilitate the city’s development as a national cultural center.
基金support received from the National Major Special Project titled“Exploration and Evaluation of Deep Geothermal Energy in Key Regions”(Project No.2024ZD1003600)the Science and Technology Department of Sinopec(Project No.JP24071).
文摘The Beijing-Tianjin-Hebei Plain is among the regions in China that feature the largest scale and the fastest growth in medium and deep geothermal heating.Based on tests of 82 geothermal fluid samples from 7 geothermal fields in Hebei Province,2 geothermal fields in Henan Province,and 2 geothermal fields in Shandong Province,and combined with previous studies on the chemical characteristics of karst geothermal water in Beijing and Tianjin,this paper systematically analyzes the migration characteristics of geothermal fluids in karst geothermal reservoirs within the Beijing-Tianjin-Hebei Plain.The hydrochemical characteristics of karst geothermal water in the research areas exhibit certain differences.The geothermal water in Hebei is more mature than that in its neighboring provinces.The distribution of total dissolved solids(TDS)and strontium elements in the area is characterized by being low in the north and south and high in the middle,suggesting that the overall flow direction of geothermal fluid is from the north and south towards the middle.Combined with the groundwater flow field and the changing trend of the hydrochemical characteristics of geothermal wells along the geological section,a geothermal water migration model has been established.The geothermal fluids originating from Taihang Mountain,Yanshan Mountain,and Western Shandong Mountain enter the basin and continue to migrate towards the central part of the basin along water-conducting faults.However,the migration characteristics of geothermal fluids with the same supply direction are not identical.The geothermal fluids from Taihang Mountain are cut off by the Niudong Fault in the north and terminate in the central uplift belt of the Jizhong Depression,while in the south,they enter the east of the Jizhong Depression relatively quickly along the Hengshui Conversion Belt.The geothermal fluids from Yanshan Mountain migrate into the basin along the Cangdong Fault,yet this fault also disrupts the hydraulic connection between the tectonic units.Considering the effective dynamic conditions,it is recommended to further expand the scale of the scientific development and utilization of geothermal energy in the geothermal water catchment areas around Xiongxian County and southwest Cangzhou City.
基金Sponsored by 2025 Postgraduate Teaching Reform Project of North China University of Technology。
文摘In the context of global climate change,the increasing frequency of extreme weather events presents significant challenges to urban water systems.This study focuses on the Beijing section of the Beijing-Hangzhou Grand Canal,introduces the SEE model,and develops an integrated“comprehensive water environment simulation model”to systematically examine the path for enhancing its climate resilience.Through the coupling of multiple models(MIKE 11,MIKE URBAN,MIKE 21)and scenario simulations,this study analyzes the response mechanisms of various governance strategies under extreme climate conditions.The research proposes four specific measures to enhance resilience:dual-scenario simulation of climate and governance,identification and reinforcement of weak points in resilience,parametric modeling of ecological restoration interventions,and the development of a“digital twin canal system”.The research findings indicate that the system integration of the SEE model substantially improves the adaptability,endurance,and recovery capacity of canals in response to climate shocks,including heavy rainfall and drought.This provides a scientific foundation and a practical path for achieving long-term resilience and sustainable development of urban water systems.
基金Under the auspices of National Natural Science Foundation of China(No.42371181)。
文摘Promoting the deep integration of advanced manufacturing and producer services is not only a key path for metropolitan to climb the global value chain,but also an important new driving force for optimizing urban spatial structure.Based on the two dimen-sions of industrial linkage and spatial co-agglomeration from the perspective of industrial integration,taking Beijing,China as a case,using industrial input-output data,micro-enterprise spatial data,and methods such as industrial linkage model,standard deviation el-lipse,and spatial similarity coefficient,this study explores the coupling relationship between industrial linkage and spatial co-agglomer-ation of advanced manufacturing and producer services from 2007 to 2020.The results demonstrate that:1)the industrial linkage between advanced manufacturing and producer services in Beijing has an upward trend,in which the business services have the most significant improvement,in which the business services have the most improvement while the technology services have the most de-crease,but in general,the industrial linkage between the two industries shows a low level.2)Producer services were more spatially clustered than advanced manufacturing,and the degree of spatial co-agglomeration of the two also showed an increasing trend,with strong regional and industrial heterogeneity characteristics,among which the pairing industry involving commerce services and techno-logy services had a more obvious improvement.3)The coupling analysis found that the spatial dependence between advanced manufac-turing and producer services decreased,showing a weak positive correlation and a decreasing trend between industrial linkage and spa-tial co-agglomeration;the heterogeneity among subdivision pairs is prominent,and the strong correlation between industries does not mean that there is an inevitable spatial co-agglomeration.4)Based on the differences in coupling relationships and influence mechan-isms,four coupling modes are identified:H-H type,H-L type,L-L type,and L-H type.Finally,this study proposes three policy implica-tions for the integration of advanced manufacturing and producer services in metropolitan areas.
文摘The construction of“park cities”requires a systematic thinking to coordinate the networked development of park system and break through the limitation of emphasizing scale and grade and neglecting dynamic correlation in traditional planning.Taking Haidian District of Beijing as an example,the social network analysis method is introduced to construct the network model of park green spaces.Through indicators such as clustering coefficient,network density and node centrality,the characteristics of its spatial structure and hierarchical relationship are analyzed.It is found that the network integrity presents the characteristics of“highly local concentration and global fragmentation”,fragmented park green space network and missing spatial connection,isolated clusters and collaborative failure,as well as the spatial mismatch between population and resource supply and demand.Hierarchical issues include“structural imbalance and functional disorder”,disorder between network hierarchy and park level,misalignment of functional hierarchy leading to weakened network risk resistance capacity,and a relatively dense distribution of core nodes,etc.In response to the above problems,a multi-level spatial intervention strategy should be adopted to solve the overall problem of the network.Meanwhile,it is needed to clarify the positioning of a park itself and improve the hierarchical system,so as to construct a multi-level and multi-scale park green space network,contribute to the construction of a park city,and provide residents with more diverse activity venues.
基金supported by the National Key Research and Development Program of China(No.2022YFC3701205)the National Natural Science Foundation of China(No.41975173)the Science and Technology Development Fund of the Chinese Academy of Meteorological Sciences(No.2021KJ011)。
文摘In recent years,incidents of simultaneous exceedance of PM_(2.5)and O_(3) concentrations,termed PM_(2.5)and O_(3) co-pollution events,have frequently occurred in China.This study conducted atmospheric circulation analysis on two typical co-pollution events in Beijing,occurring from July 22 to July 28,2019,and from April 25 to May 2,2020.These events were categorized into pre-trough southerly airflow type(Type 1)and post-trough northwest flow type(Type 2).Subsequently,sensitivity analyses using the GRAPES-CUACE adjoint model were performed to quantify the contributions of precursor emissions from Beijing and surrounding areas to PM_(2.5)and O_(3) concentrations in Beijing for two types of co-pollution.The results indicated that the spatiotemporal distribution of sensitive source region varied among different circulation types.Primary PM_(2.5)(PPM_(2.5))emissions from Hebei contributed the most to the 24-hour average PM_(2.5)(24-h PM_(2.5))peak concentration(41.6%-45.4%),followed by Beijing emissions(31%-35.7%).The maximum daily 8-hour average ozone peak concentration was primarily influenced by the emissions from Hebei and Beijing,with contribution ratios respectively of 32.8%-44.8% and 29%-42.1%.Additionally,NO_(x)emissions were the main contributors in Type 1,while both NO_(x)and VOCs emissions contributed similarly in Type 2.The iterative emission reduction experiments for two types of co-pollution indicated that Type 1 required emission reductions in NO_(x)(52.4%-71.8%)and VOCs(14.1%-33.8%)only.In contrast,Type 2 required combined emission reductions in NO_(x)(37.0%-65.1%),VOCs(30.7%-56.2%),and PPM_(2.5)(31%-46.9%).This study provided a reference for controlling co-pollution events and improving air quality in Beijing.
基金supported in part by the National Natural Science Foundation of China under Grant Nos.62371273,62125101 and 62341101the Taishan Scholars Program under Grant No.tsqn202312307+7 种基金the Young Elite Scientists Sponsorship Program by CAST under Grant No.YESS20230372the Shandong Natural Science Foundation under Grant No.ZR2023YQ058the New Cornerstone Science Foundation through the Xplorer Prizethe Xiaomi Young Talents Programthe open research fund of National Mobile Communications Research Laboratory,Southeast University under Grant No.2025D04the China National Postdoctoral Program for Innovative Talents under Grant No.BX20240007the China Postdoctoral Science Foundation under Grant No.2024M760111the Beijing Natural Science Foundation under Grant No.4254067。
文摘A novel digital twin(DT)enabled channel model for 6G vehicular communications in Beijing Central Business District(Beijing CBD)is proposed,which can support the design of intelligent transportation systems(ITSs).A DT space for Beijing CBD is constructed,and two typical transportation periods,i.e.,peak and off-peak hours,are considered to characterize the vehicular communication channel better.Based on the constructed DT space,a DT-enabled vehicular communication dataset is developed,including light detection and ranging(LiDAR)point clouds,RGB images,and channel information.With the assistance of LiDAR point clouds and RGB images,the scatterer parameters,including number,distance,angle,power,and velocity,are analyzed under different transportation periods.The channel non-stationarity and consistency are mimicked in the proposed model.The key channel statistical properties are derived and simulated.Compared to ray-tracing(RT)results,the accuracy of the proposed model is verified.
基金supported by the Energy Foundation(No.G-2203-33693).
文摘To understand the smoke level and NO_(x)emission characteristics of in-use construction machinery in Beijing,we selected 905 construction machines in Beijing from August 2022 to April 2023 to monitor the emission level of smoke and NO_(x).The exhaust smoke level and excessive emission situation of different machinery types were identified,and their NO_(x)emission levels were monitored according to the free acceleration method.We investigated the correlation of NO_(x)and smoke emission,and proposed suggestions for controlling pollution discharge from construction machinery in the future.The results show that the exhaust smoke level was 0–2.62 m^(−1),followed a log-normal distribution(μ=-1.73,δ=1.09,R^(2)=0.99),with a 5.64%exceedance rate.Differenceswere observed amongmachinery types,with low-power engine forklifts showing higher smoke levels.The NO_(x)emission range was 71–1516 ppm,followed a normal distribution(μ=565.54,δ=309.51,R^(2)=0.83).Differences among machinery types were relatively small.Engine rated net power had the most significant impact on NO_(x)emissions.Thus,NO_(x)emissions from construction machinery need further attention.Furthermore,we found a weak negative correlation(p<0.05)between the emission level of smoke and NO_(x),that is the synergic emission reduction effect is poor,emphasizing the need for NO_(x)emission limits.In the future,the oversight in Beijing should prioritize phasing out ChinaⅠand ChinaⅡmachinery,and monitor emissions from highpower engine ChinaⅢmachinery.
基金supported by the National Key R&D program of China(No.2022YFC3703404)the National Natural Science Foundation of China(No.22188102)the Samsung Advanced Institute of Technology.
文摘Although air pollutant emissions have sharply reduced in recent years,the occurrence of PM_(2.5) pollution events remains an intractable environmental problem in Beijing,and regional transport is the key influence factor.However,it has been difficult to identify regional transport characteristics and the main contributors to pollution events in recent years.In this study,the relative contribution of regional transport was quantified(61.3%)in PM_(2.5) pollution events during 2018-2021 by the Community Multiscale Air Quality model embedded with the Integrated Source Apportionment Model(CMAQ-ISAM).The four regions with the largest fractional contributions to Beijing for all events were Shandong(7.7%),South Hebei(7.3%),Baoding(6.2%),and Langfang(5.8%).Pollution events were classified into the following types based on regional transport directions:local,southwest(SW),southeast(SE),south-mixed(SM),and others.Based on the transport distance,the SW,SE,and SM types can be subdivided into SW-short,SW-long,SE-short,SE-long,SM-short,SM-long distance from southwest,SM-long distance from southeast,and SM-long distance from southwest and southeast.SE-long was regarded as the most important type,with the highest relative frequency(20%).The transport directions were related to the southwest wind at 925 hPa and southeast wind at 1000 hPa in the south of the Beijing–Tianjin–Hebei(BTH)region,and the distance was mainly controlled by wind strength.The wind-field difference can be attributed to the low-pressure and high-pressure systems that control the BTH region.The results suggest that regional joint pollution control should be optimized based on the transport type.
基金supported by an Innovation Fund for Medical Sciences of the Chinese Academy of Medical Sciences (Grant No.2019-I2M-2-007).
文摘Objective:Postpartum nutrition plays a critical role in maternal recovery and long-term health.However,the nutritional status of working mothers in the postpartum period remains understudied.This study aimed to assess the dietary quality of postpartum women in urban Beijing,identify occupational-related factors influencing their diet,and explore potential interventions to improve maternal nutrition during the postpartum period.Methods:In this cross-sectional analysis,554 women one year after delivery were recruited from ten community health centers.Sociodemographic,occupational and postpartum care variables were collected via questionnaire.Dietary intake over the preceding year was assessed using a food frequency questionnaire.The modified dietary balance index for postpartum women were used for dietary quality assessment.Results:The study revealed severe dietary imbalances among postpartum women,characterized by excessive consumption of cereals,eggs,and meats,while their intake of vegetables,fruits,and dairy products was inadequate.According to dietary balance index for postpartum women,66.25%of mothers showed varying degrees of excessive intake.45.31%of mothers experienced varying levels of insufficient intake,with only 19.86%of participants having a relatively balanced diet.Occupational differences were observed,with women in the commercial employment group showing higher levels of excessive food intake.The analysis of influencing factors showed that family monthly income,maternity leave,and postpartum care significantly affected the dietary quality.Conclusions:Postpartum women in Beijing experience widespread dietary imbalances,with both excesses and deficiencies.Occupational context and related factors significantly shape diet quality.These findings highlight the need for targeted nutritional interventions tailored to the specific challenges of different occupational groups.
文摘Current models of national conditions education for international students often fall short in facilitating their transition from passive observers of culture to active communicators.Using Beijing International Studies University as a case study,this paper examines how a systematic educational model enables international students to shift from passive observation to active narration of Chinese society and culture.The study identifies and elaborates on three core mechanisms of this model:an institutional integration mechanism centered on convergent management,a practical cognition mechanism through experiential learning,and a narrative empowerment mechanism utilizing converged media platforms.Together,these components form a glocalized educational framework that integrates global issues with local practices,connecting macro narratives with personal experiences.Case analysis demonstrates that by immersing students in authentic sociocultural contexts and granting them narrative agency,this model effectively fosters deep understanding and cross-cultural identity.It thus provides a new theoretical framework and practical pathway for reconstructing international student education in China with an emphasis on student agency and interculturality.
基金supported by the National Natural Science Foundation of China(No.42077454)the Xiong'an New Area Science and Technology Innovation Project(No.2022XACX1000)the 5·5 Engineering Research&Innovation Team Project of Beijing Forestry University(No.BLRC2023B04).
文摘Urban areas face environmental pollution and greenhouse emissions challenges,demand collaborative efforts to mitigation.Urban forests play a crucial role in absorbing CO_(2) emissions and contributing to carbon sequestration potential,but they also release biogenic volatile organic compounds(BVOCs),which contribute to the formation of tropospheric ozone and secondary organic aerosols(SOA).This study aimed to understand the role of urban forests in carbon stock and BVOCs emission by establishing optimal biomass models for six typical tree species(Robinia pseudoacacia,Quercus,Populus,Pinus tabulaeformis,Betula platyphylla,and Larix gmelinii)in Beijing.Biomass models were developed using field surveys and remote sensing data,with R^(2) values ranging from 0.364 to 0.921.Applying these models to forest resource inventory data,carbon stock and BVOCs emission models were constructed.In 2021,the total carbon stock for these pure forest tree species was estimated at 5.638 million tons,with a carbon density of 58.86 t/ha.The carbon density ranking for pure forest tree species was:Robinia pseudoacacia>Populus tomentosa>Betula platyphylla>Quercus Linn>Pinus tabulaeformis>Larix gmelinii.Total BVOCs emission in 2021 from the studied species were calculated at 25,789.72 t,with an average emission of 0.27 t/ha.Populus tomentosa had the highest BVOCs emission per unit area,followed by Robinia pseudoacacia,and Larix gmelinii had the smallest.Betula platyphylla and Robinia pseudoacacia were identified as species with high carbon stock and low BVOCs emissions in Beijing,offering insights for future urban forest planning and eco-friendly urban environment development strategies.
基金supported by National Key Research & Development Program of China (2022YFC3006201)。
文摘Emergency medical services (EMS) are a vital element of the public healthcare system in China,^([1])providing an opportunity to respond to critical medical conditions and save people’s lives.^([2])The accessibility of EMS has received considerable attention in health and transport geography studies.^([3])One of the optimal gauges for evaluating the accessibility of EMS is the response time,which is defined as the time from receiving an emergency call to the arrival of an ambulance.^([4])Beijing has already reduced the response time to approximately12 min,and the next goal is to ensure that the response time across Beijing does not exceed 12 min (the information comes from the Beijing Emergency Medical Center).
文摘Against the backdrop of the comprehensive advancement of curriculum ideological and political construction in colleges and universities,art general education courses,as important carriers for the integration of aesthetic education and moral education,have their educational value awaiting systematic exploration.This article takes the"Accordion Performance Art"course at Beijing International Studies University as the research object and systematically expounds on the ideological and political construction path from skill training to cultural education.It constructs a three-dimensional educational framework of"technique-aesthetics-value",focuses on analyzing characteristic practices such as the infiltration of red music culture,the penetration of ethnic music elements,and the application of Marxist philosophical principles,and innovatively proposes a progressive teaching model of"situational experience-dialectical thinking-cultural communication".Through the reconstruction of teaching content,innovation of teaching methods,and optimization of evaluation systems,the organic integration of accordion performance teaching and ideological and political education has been realized,providing an operable practical reference paradigm for the ideological and political construction of art general education courses.The research shows that the ideological and political construction of art courses must be based on the characteristics of the discipline,with artistic practice as the carrier and cultural inheritance as the link,in order to achieve the in-depth goal of"educating people with aesthetics and cultivating people with culture".
基金Sponsored by Beijing Youth Innovation Talent Support Program for Urban Greening and Landscaping——The 2024 Special Project for Promoting High-Quality Development of Beijing’s Landscaping through Scientific and Technological Innovation(KJCXQT202410).
文摘Taking the Ming Tombs Forest Farm in Beijing as the research object,this research applied multi-source data fusion and GIS heat-map overlay analysis techniques,systematically collected bird observation point data from the Global Biodiversity Information Facility(GBIF),population distribution data from the Oak Ridge National Laboratory(ORNL)in the United States,as well as information on the composition of tree species in suitable forest areas for birds and the forest geographical information of the Ming Tombs Forest Farm,which is based on literature research and field investigations.By using GIS technology,spatial processing was carried out on bird observation points and population distribution data to identify suitable bird-watching areas in different seasons.Then,according to the suitability value range,these areas were classified into different grades(from unsuitable to highly suitable).The research findings indicated that there was significant spatial heterogeneity in the bird-watching suitability of the Ming Tombs Forest Farm.The north side of the reservoir was generally a core area with high suitability in all seasons.The deep-aged broad-leaved mixed forests supported the overlapping co-existence of the ecological niches of various bird species,such as the Zosterops simplex and Urocissa erythrorhyncha.In contrast,the shallow forest-edge coniferous pure forests and mixed forests were more suitable for specialized species like Carduelis sinica.The southern urban area and the core area of the mausoleums had relatively low suitability due to ecological fragmentation or human interference.Based on these results,this paper proposed a three-level protection framework of“core area conservation—buffer zone management—isolation zone construction”and a spatio-temporal coordinated human-bird co-existence strategy.It was also suggested that the human-bird co-existence space could be optimized through measures such as constructing sound and light buffer interfaces,restoring ecological corridors,and integrating cultural heritage elements.This research provided an operational technical approach and decision-making support for the scientific planning of bird-watching sites and the coordination of ecological protection and tourism development.
基金The Research and Cultivation Spectial Project of Beijing Center for Disease Prevention and Control,Grant/Award Number:2023-KYJH-03。
文摘Background:C hina is a high-burden country for multidrug-r esistant tuberculosis/rifampin-resistant tuberculosis(MDR/RR-T B).Fluoroquinolones(FQs)are key drugs for the treatment of patients with MDR/RR-T B.However,research on the resistance of FQs in Beijing is limited.Methods:W e collected clinical isolates from all patients with pulmonary TB in Beijing from January 2016 to December 2021,conducted drug-s ensitivity tests and sequencing for levofloxacin(LFX)and moxifloxacin(MFX),and collected the treatment plans and outcomes of the patients.Results:A total of 8512 clinical isolates were collected from patients with pulmonary TB,and 261 RR-T B strains were screened.The proportions of drug-s ensitive and drugresistant strains significantly differed by age group and treatment history.The rates of LFX and MFX resistance were 27.6%(72/261)and 36.4%(95/261),respectively.The detection rates of MDR-T B and pre-e xtensively drug-resistant TB(pre-X DR-T B)were 73.2%(191/261)and 36.4%(95/261),respectively,and the trends were significant(χ^(2)trend=9.995,p=0.002;χ^(2)trend=12.744,p=0.026).Among the 261 RR-T B strains,14.9%(24/261)were sensitive to LFX but resistant to MFX.Among the four patients with LFX-r esistant TB who received LFX treatment failed in three patients(Fisher's exact test,p=0.009).The common mutation sites were 94 and 90 in gyrA.A novel mutation Ala90Ser was discovered.Conclusions:F Qs resistance trends in RR-T B patients in Beijing are striking.Strains showed incomplete cross-resistance to LFX and MFX.Testing for FQs resistance and developing a reasonable treatment plan are recommended.Attention should be given to the changing trends in MDR-T B and pre-X DR-TB.
文摘This study summarizes the examination data of registration labels for ordinary cosmetics in Beijing from May 2021 to April 2024.It analyzes and categorizes the issues identified during label evaluations,explores the underlying causes,and proposes regulatory countermeasures and recommendations for registrants,regulatory authorities,and social organizations.The objective is to offer practical insights and regulatory guidance to support the enhancement of cosmetic registration and regulatory standards.
