This article presents a detailed theoretical hybrid analysis of the magnetism and the thermal radiative heat transfer in the presence of heat generation affecting the behavior of the dispersed gold nanoparticles(AuNPs...This article presents a detailed theoretical hybrid analysis of the magnetism and the thermal radiative heat transfer in the presence of heat generation affecting the behavior of the dispersed gold nanoparticles(AuNPs)through the blood vessels of the human body.The rheology of gold-blood nanofluid is treated as magnetohydrodynamic(MHD)flow with ferromagnetic properties.The AuNPs take different shapes as bricks,cylinders,and platelets which are considered in changing the nanofluid flow behavior.Physiologically,the blood is circulated under the kinetics of the peristaltic action.The mixed properties of the slip flow,the gravity,the space porosity,the transverse ferromagnetic field,the thermal radiation,the nanoparticles shape factors,the peristaltic amplitude ratio,and the concentration of the AuNPs are interacted and analyzed for the gold-blood circulation in the inclined tube.The appropriate model for the thermal conductivity of the nanofluid is chosen to be the effective Hamilton-Crosser model.The undertaken nanofluid can be treated as incompressible non-Newtonian ferromagnetic fluid.The solutions of the partial differential governing equations of the MHD nanofluid flow are executed by the strategy of perturbation approach under the assumption of long wavelength and low Reynolds number.Graphs for the streamwise velocity distributions,temperature distributions,pressure gradients,pressure drops,and streamlines are presented under the influences of the pertinent properties.The practical implementation of this research finds application in treating cancer through a technique known as photothermal therapy(PTT).The results indicate the control role of the magnetism,the heat generation,the shape factors of the AuNPs,and its concentration on the enhancement of the thermal properties and the streamwise velocity of the nanofluid.The results reveal a marked enhancement in the temperature profiles of the nanofluid,prominently influenced by both the intensified heat source and the heightened volume fractions of the nanoparticles.Furthermore,the platelet shape is regarded as most advantageous for heat conduction owing to its highest effective thermal conductivity.AuNPs proved strong efficiency in delivering and targeting the drug to reach the affected area with tumors.These results offer valuable insights into evaluating the effectiveness of PTT in addressing diverse cancer conditions and regulating their progression.展开更多
Lanthanum-bearing iron lithium borate glass is a quaternary system for oxide glasses and was prepared via the melt-quenching method.The present article correlates the structure,optical,ligand field and M?ssbauer data ...Lanthanum-bearing iron lithium borate glass is a quaternary system for oxide glasses and was prepared via the melt-quenching method.The present article correlates the structure,optical,ligand field and M?ssbauer data on iron lithium borate glass co ntaining La^(3+).The density was measured,while the molar volume was calculated.Other physical parameters are well-described.With increasing the La_(2)O_(3) content within the glass network,infrared spectra analysis reveals structural modifications such as the increase in BO_(4) units and the decline in both BO_(3) units and NBO bonds content.Furthermore,optical absorption spectra were measured.The absorption spectra disclose a plethora of electronic transitions that are related to Fe^(3+)in tetrahedral and octahedral sites,however,Fe^(2+)phase is not observed in optical spectra,but it has a clear signature in M?ssbauer spectra.Besides,the glass absorption edges undergo a clear blue shift,reflecting an increased band gap energy(1.96-2.28 eV).The decline in NBO bonds justifies this trend.Bewitchingly,the values of crystal field splitting are increased,while the values of Racah parameters are decreased.This trend is justified by the decline in NBO bonds and increases electron localization around Fe cations.M?ssbauer spectra confirm the existence of Fe^(3+)in tetrahedral and octahedral sites,while Fe^(2+)exists in only a tetrahedral state.With increasing La_(2)O_(3) content,the isomer shift of Fe^(3+)in tetrahedral sites changes to be 0.312-0.329 mm/s,while the isomer shift of octahedral Fe^(3+)is 0.424-0.456 mm/s.These findings coincide with optical data.While the isomer shift of tetrahedral Fe^(2+)is 0.902-0.911 mm/s.Our results of structural,optical and ligand field associated with M?ssbauer spectra open more vistas toward the utility of these samples in the optics realm.展开更多
Background:In the field of genetic diagnostics,DNA sequencing is an important tool because the depth and complexity of this field have major implications in light of the genetic architectures of diseases and the ident...Background:In the field of genetic diagnostics,DNA sequencing is an important tool because the depth and complexity of this field have major implications in light of the genetic architectures of diseases and the identification of risk factors associated with genetic disorders.Methods:Our study introduces a novel two-tiered analytical framework to raise the precision and reliability of genetic data interpretation.It is initiated by extracting and analyzing salient features from DNA sequences through a CNN-based feature analysis,taking advantage of the power inherent in Convolutional neural networks(CNNs)to attain complex patterns and minute mutations in genetic data.This study embraces an elite collection of machine learning classifiers interweaved through a stern voting mechanism,which synergistically joins the predictions made from multiple classifiers to generate comprehensive and well-balanced interpretations of the genetic data.Results:This state-of-the-art method was further tested by carrying out an empirical analysis on a variants'dataset of DNA sequences taken from patients affected by breast cancer,juxtaposed with a control group composed of healthy people.Thus,the integration of CNNs with a voting-based ensemble of classifiers returned outstanding outcomes,with performance metrics accuracy,precision,recall,and F1-scorereaching the outstanding rate of 0.88,outperforming previous models.Conclusions:This dual accomplishment underlines the transformative potential that integrating deep learning techniques with ensemble machine learning might provide in real added value for further genetic diagnostics and prognostics.These results from this study set a new benchmark in the accuracy of disease diagnosis through DNA sequencing and promise future studies on improved personalized medicine and healthcare approaches with precise genetic information.展开更多
We present the essential stellar parameters of the close visual triple system HD 2893 using Al-Wardat's method for analyzing binary and multiple star systems in conjunction with Kurucz's model atmospheres.This...We present the essential stellar parameters of the close visual triple system HD 2893 using Al-Wardat's method for analyzing binary and multiple star systems in conjunction with Kurucz's model atmospheres.This method accurately computes the spectrophotometric stellar masses through a combined synthetic spectral energy distribution approach that compares the results with observed data.The vigorous approach uses spectroscopic,photometric,and dynamical analysis to yield precise results.The method implements Gaia DR3 measurements and other measurements like those of Hipparcos and 2MASS All-Sky Catalog as a guide for the best fit between the synthetic spectra and observed photometry.The analysis gives precise spectrophotometric stellar masses for the system being M_(Sph)^(A)=1.20±0.07M⊙,M_(Sph)^(B)=1.09±0.06M⊙,and M_(Sph)^(C)=0.46±0.01M⊙.It shows that the three components are main sequence stars with an estimated age of around 1.0 Gyr.When integrated with the dynamical analysis,a new dynamical parallax for the system is obtained,π_(dyn)=13.8528±0.20 mas.Additionally,the discussion covers the formation and evolution of the triple system.展开更多
The existence of T_periodic solutions of the nonlinear system with multiple delays is studied. By using the topological degree method, sufficient conditions are obtained for the existence of T_periodic solutions. As a...The existence of T_periodic solutions of the nonlinear system with multiple delays is studied. By using the topological degree method, sufficient conditions are obtained for the existence of T_periodic solutions. As an application, the existence of positive periodic solution for a logarithmic population model is established under some conditions.展开更多
This paper deals with the dyeing of cotton fabrics with microwave irradiation.The compara-tive experiments of the microwave dyeing to the conventional dyeing were carried out and themechanism was also discussed.Being ...This paper deals with the dyeing of cotton fabrics with microwave irradiation.The compara-tive experiments of the microwave dyeing to the conventional dyeing were carried out and themechanism was also discussed.Being subjected to microwave irradiation,the penetration of dyesand chemicals into the fabric can be achieved in a short time with a good color yield.The irradiatedmaterials generate heat via dielectric heating by high frequency electro-magnetic field and as a re-sult,energy saving can be realized.Based on the examination and analysis with X-ray diffraction,IR,SEM,and XPS,the reduction in crystallinity,the formation of active carbonyl groups of freeradicals containing oxygen and the morphological changes in the irradiated cottom fibers werefound.All of these may be believed in favour of the dyeing process.展开更多
The replication of HIV-1 requires the integration of its cyclic DNA into host DNA by HIV-1 integrase （IN）, which includes two important reactions, 3＇-processing and strand transfer, both catalyzed by HIV-1 IN. Disr...The replication of HIV-1 requires the integration of its cyclic DNA into host DNA by HIV-1 integrase （IN）, which includes two important reactions, 3＇-processing and strand transfer, both catalyzed by HIV-1 IN. Disrupting either of the reactions will fulfill the purpose of inhibiting the replication of HIV-1. In this paper, pharmacophore modeling and molecular docking are employed to investigate the inhibition mechanism of the HIV-1 IN strand transfer inhibitors （INSTIs）. Based on the results, we suggest that the inhibition mechanism of INSTIs involves the inhibitor chelating the cofactors Mg2＋ and its forming hydrogen bonds with some crucial residues adjacent to the DDE active center.展开更多
In this paper,we used time delay feedback to minimize the vibrations of a hybrid Rayleigh–van der Pol–Duffing oscillator.This system is a one-degree-offreedom containing the cubic and fifth nonlinear terms and an ex...In this paper,we used time delay feedback to minimize the vibrations of a hybrid Rayleigh–van der Pol–Duffing oscillator.This system is a one-degree-offreedom containing the cubic and fifth nonlinear terms and an external force.We applied the multiple scales method to get the solution from first approximation.Graphically and numerically,we studied the system before and after adding time delay feedback at the primary resonance case(ffi!).We used MATLAB program to simulate the efficacy of different parameters and the time delay on the main system.展开更多
Medical ultrasound imaging with Doppler plays an essential role in the diagnosis of vascular disease. This study intended to review the clinical use of "to-and-fro" waveform at duplex Doppler ultrasonography...Medical ultrasound imaging with Doppler plays an essential role in the diagnosis of vascular disease. This study intended to review the clinical use of "to-and-fro" waveform at duplex Doppler ultrasonography(DDU) in the diagnosis of pseudoaneurysms in the arterial vessels of upper and lower extremities, abdominal aorta, carotid and vertebral arteries as well as to review our personal experiences of "to-and-fro" waveform at DDU also. After receiving institutional review board approval, an inclusive literature review was carried out in order to review the scientific foundation of "toand-fro" waveform at DDU and its clinical use in the diagnosis of pseudoaneurysms in various arterial vessels. Articles published in the English language between 2000 and 2013 were evaluated in this review study. Pseudoaneurysms in arterial vessels of the upper and lower extremities, abdominal aorta, carotid and vertebral arteries characterized by an extraluminal pattern of blood flow, which shows variable echogenicity, interval complexity, and "to-and-fro" flow pattern on color Doppler ultrasonography. In these arterial vessels, Duplex ultrasonography can demonstrate the degree of clotting, pseudoaneurysm communication, the blood flow patterns and velocities. Spectral Doppler applied to pseudoaneurysms lumen revealed systolic and diastolic turbulent blood flow with traditional "toand-fro" waveform in the communicating channel. Accurate diagnosis of pseudoaneurysm by spectral Doppler is based on the documentation of the "to-andfro" waveform. The size of pseudoaneurysm determines the appropriate treatment approach as surgical or conservative.展开更多
A nanometer porphyrin dimer was synthesized with fumaryl chloride as a bridge-linked reagent. The characterization was carried out with elemental analyses, ^1H NMR, UV-Vis, and IR spectrometries, and then the electroc...A nanometer porphyrin dimer was synthesized with fumaryl chloride as a bridge-linked reagent. The characterization was carried out with elemental analyses, ^1H NMR, UV-Vis, and IR spectrometries, and then the electrochemical properties of the porphyrins were studied. The authors found that there was moderate electronic communication between the two porphyrin rings in the nanometer porphyrin dimer.展开更多
In this paper,a discrete Lotka-Volterra predator-prey model is proposed that considers mixed functional responses of Holling types I and III.The equilibrium points of the model are obtained,and their stability is test...In this paper,a discrete Lotka-Volterra predator-prey model is proposed that considers mixed functional responses of Holling types I and III.The equilibrium points of the model are obtained,and their stability is tested.The dynamical behavior of this model is studied according to the change of the control parameters.We find that the complex dynamical behavior extends from a stable state to chaotic attractors.Finally,the analytical results are clarified by some numerical simulations.展开更多
Objective:To extract,quantify,and evaluate the phenolic content in Opuntia ficus-indica skin for their antioxidant capacity with three different methods(ABTS,DPPH,and lipid oxidation)and to optimize the extraction con...Objective:To extract,quantify,and evaluate the phenolic content in Opuntia ficus-indica skin for their antioxidant capacity with three different methods(ABTS,DPPH,and lipid oxidation)and to optimize the extraction conditions[time,temperature and ethanol concentration)in a reflux system.Methods:The extraction process was done using a reflux system.A San CristobalⅡexperimental design with three variables and three levels was used.The variables evaluated were time of extraction(h),concentration of ethanol(%,v/v)and temperature(°C).The extraction process was optimized using a response surface methodology.Results:It was observed that at higher temperature more phenolic compounds were extracted,but the antioxidant capacity was decreased.The optimum conditions for phenolic compounds extraction and antioxidant capacity mixing the three methods were as Follows:45%of ethanol,80℃and 2 hours of extraction.Values obtained in our results are little higher that other previously reported.Conclusions:It can he concluded the by-products of Opuntia ficus-indica represent a good source of natural antioxidants with possible applications in food,cosmetics or drugs industries.展开更多
Peristaltic motion induced by a surface acoustic wave of a viscous, compressible and electrically conducting Maxwell fluid in a confined parallel-plane microchannel through a porous medium is investigated in the prese...Peristaltic motion induced by a surface acoustic wave of a viscous, compressible and electrically conducting Maxwell fluid in a confined parallel-plane microchannel through a porous medium is investigated in the presence of a constant magnetic field. The slip velocity is considered and the problem is discussed only for the free pumping case. A perturbation technique is employed to analyze the problem in terms of a small amplitude ratio. The phenomenon of a “backward flow” is found to exist in the center and at the boundaries of the channel. In the second order approximation, the net axial velocity is calculated for various values of the fluid parameters. Finally, the effects of the parameters of interest on the mean axial velocity, the reversal flow, and the perturbation function are discussed and shown graphically. We find that in the non-Newtonian regime, there is a possibility of a fluid flow in the direction opposite to the propagation of the traveling wave. This work is the most general model of peristalsis created to date with wide-ranging applications in biological, geophysical and industrial fluid dynamics.展开更多
The peristaltic flow of a non-Newtonian nanofluid with swimming oxytactic microorganisms through a space between two infinite coaxial conduits is investigated. A variable magnetic field is applied on the flow. The bio...The peristaltic flow of a non-Newtonian nanofluid with swimming oxytactic microorganisms through a space between two infinite coaxial conduits is investigated. A variable magnetic field is applied on the flow. The bioconvection flow and heat transfer in the porous annulus are formulated, and appropriate transformations are used, leading to the non-dimensionalized ruling partial differential equation model. The model is then solved by using the homotopy perturbation scheme. The effects of the germane parameters on the velocity profile, temperature distribution, concentration distribution, motile microorganism profile, oxytactic profile, pressure rise, and outer and inner tube friction forces for the blood clot and endoscopic effects are analyzed and presented graphically.It is noticed that the pressure rise and friction forces attain smaller values for the endoscopic model than for the blood clot model. The present analysis is believed to aid applications constituting hemodynamic structures playing indispensable roles inside the human body since some blood clotting disorders, e.g., haemophilia, occur when some blood constituents on the artery wall get confined away from the wall joining the circulation system.展开更多
Neuraminidase(NA) plays a biologically vital role in the replication of influenza virus, and NA inhibitors(NAIs) are most widely used in the clinical anti-flu therapy. NA of 2009 H1 N1 influenza virus(09 N1) possesses...Neuraminidase(NA) plays a biologically vital role in the replication of influenza virus, and NA inhibitors(NAIs) are most widely used in the clinical anti-flu therapy. NA of 2009 H1 N1 influenza virus(09 N1) possesses a different substrate-binding cavity compared with other NA subtypes, making 09 N1 a more appropriate starting point for the discovery of potent 09 N1 inhibitors. As natural products are of great structural diversity, research on the interaction between natural NAIs and 09 N1 can throw light on the design of new structural NAIs. In this study, we, for the first time, conducted molecular docking procedure with GOLD on 10 natural inhibitors to 09 N1, and acquired their binding modes with 09 N1. The docking results showed that the active site S1 was important in the binding of NAIs to 09 N1. Then five scaffolds were extracted from these NAIs with interactions to site S1, and these could be used in the structural modification of NAIs. Besides, we found that the addition of H-bonding interaction with the active site could improve the NA inhibitory activity of NAIs, and it might be the reason why the approved NAIs showed high efficiency. Two terminal hydrophobic sites(Terminal 1 and Terminal 2) with no interactions to the approved NAI zanamivir were found in the 09 N1 active cavity, and four NAIs were first found to bind with the terminals. Till now, there are few studies on the meaning of Terminal 2 in the binding of NAI to NA, which could be a new direction for the rational design of NAIs.展开更多
This paper deals with the problem of the postbuckling response of a thin cantilever beam ofnon-linear material, subjected to subtangential follower forces. Based on the well-knownBernoulli-Euler bending moment-curvatu...This paper deals with the problem of the postbuckling response of a thin cantilever beam ofnon-linear material, subjected to subtangential follower forces. Based on the well-knownBernoulli-Euler bending moment-curvature relation, the proposed problem is reduced to a specialeigenvalue problem of non-linear differential equation. An approximate solution is achieved byusing a simple and very effective technique, which leads to reliable results even in the case of verylarge deflections. The initial postbuckling path depending on the subtangential follower forces inequilibrium is then obtained. Moreover, the individual and coupling effect of the subtangential fol-lower force, the material non-linearity and the beam slenderness ratio on the initial postbucklingpath are also discussed in detail.展开更多
Parasitic angiosperm Alectra vogelii Benth is a growing problem in Malawi, particularly with current emphasis on legumes. Therefore, two studies were set in order to understand the possible mechanisms of resistance in...Parasitic angiosperm Alectra vogelii Benth is a growing problem in Malawi, particularly with current emphasis on legumes. Therefore, two studies were set in order to understand the possible mechanisms of resistance in cowpea genotypes on their reaction to the parasitic weed. In the first experiment, Mkanakaufiti, IT99K-7-21-2-2XIT82E-16, Sudan 1 and IT82E-16 were grown in Alectra infested and non-infested pots. The experiment (2*4 factorial treatment combination) was arranged in an RCBD and replicated eight times. The second experiment, involved Petri-dish techniques where 4 genotype roots were assessed on their ability to stimulate the germination of A. vogelii as a proxy for germination stimulant production. The experiment was arranged in an RCBD and replicated five times. In the first experiment, data was collected on;the number of days to first Alectra emergence, Alectra shoot counts at 6, 8, 10, and 12 weeks after planting (WAP), Alectra attachment at 5 and 12 WAP, Alectra biomass at 12 WAP, cowpea biomass parameters at 5 and 12 WAP, yield and yield components per pot. While in the second experiment, number of germinated Alectra seeds per Petri dishes was recorded. The results indicated that IT82E-16 (33.25 days) and Sudan 1 (34.25 days) were earlier infested whilst late on IT99K-7-21-2-2XIT82E-16 (38 days) which correlated to the number of Alectra attachments. There were significant differences (p = 0.05) in weekly Alectra counts between cowpea varieties from 6 up to 10 WAP. Mkanakaufiti and IT99K-7-21-2-2XIT82E-16 were observed with no and few Alectra shoots infestation respectively which was an indicator of resistance mechanism in the study. Number of pods, grain weight (g) and harvest index per pot were significantly affected by inoculation protocol with lower yield on infested cowpea genotypes. The same trend was observed on cowpea varieties where Mkanakaufiti (21.9 g/pot) shown higher yield followed by IT82E-16 (12.5 g/pot) which is susceptible but with tolerance ability to the parasitic weed. The study has shown that resistance mechanisms can be categorized as no or few Alectra shoots, death of Alectra shoots and late infestation. In the Petri dishes, only 3 WAP grown Mkanakaufiti root media failed to induce the germination of Alectra seeds while the opposite occurred on IT82E-16, Sudan 1 and IT99K-7-21-2-2XIT82E-16. On the contrary, 4 WAP grown root media of the four genotypes stimulated Alectra germination which shed more light on the seed behaviour in the soil. This is worth exploring as more could be known to what causes termination of Alectra shoots on Mkanakaufiti. Still, intensifying resistant genotypes should be a goal in order to reduce Alectra seed banks in the soil, thereby, increasing cowpea yield.展开更多
The effects of TiO2 on sintering and nonlinear electrical properties of(98.5-x)ZnO–0.5MnO2–0.5Co2O3-0.5Bi2O3–xTiO2(x=0.3,0.5,0.7,0.9 mol%)ceramic varistors prepared by the ceramic technique are investigated in this...The effects of TiO2 on sintering and nonlinear electrical properties of(98.5-x)ZnO–0.5MnO2–0.5Co2O3-0.5Bi2O3–xTiO2(x=0.3,0.5,0.7,0.9 mol%)ceramic varistors prepared by the ceramic technique are investigated in this work.The optimum sintering temperature of the prepared samples is deduced by determining the firing shrinkage and water absorption percentages.The optimum sintering temperature is found to be 1200℃,at which each of the samples shows a maximum firing shrinkage and minimum water absorption.Also minimum water absorption appears in a sample of x=0.9 mol%.Higher sintering temperature and longer sintering time give rise to a reduction in bulk density due to the increased amount of porosity between the large grains of ZnO resulting from the rapid grain growth induced by the liquid phase sintering.The crystal size of ZnO decreases with increasing TiO2 doping.The addition of TiO2 improves the nonlinear coefficient and attains its maximum value at x=0.7 mol%of TiO2,further addition negatively affects it.A decrease in capacitance consequently in the dielectric constant is recorded with increasing the frequency in a range of 30 kHz–200 kHz.The temperature and composition dependences of the dielectric constant and AC conductivity are also studied.The increase of temperature raises the dielectric constant because it increases ionic response to the field at any particular frequency.展开更多
文摘This article presents a detailed theoretical hybrid analysis of the magnetism and the thermal radiative heat transfer in the presence of heat generation affecting the behavior of the dispersed gold nanoparticles(AuNPs)through the blood vessels of the human body.The rheology of gold-blood nanofluid is treated as magnetohydrodynamic(MHD)flow with ferromagnetic properties.The AuNPs take different shapes as bricks,cylinders,and platelets which are considered in changing the nanofluid flow behavior.Physiologically,the blood is circulated under the kinetics of the peristaltic action.The mixed properties of the slip flow,the gravity,the space porosity,the transverse ferromagnetic field,the thermal radiation,the nanoparticles shape factors,the peristaltic amplitude ratio,and the concentration of the AuNPs are interacted and analyzed for the gold-blood circulation in the inclined tube.The appropriate model for the thermal conductivity of the nanofluid is chosen to be the effective Hamilton-Crosser model.The undertaken nanofluid can be treated as incompressible non-Newtonian ferromagnetic fluid.The solutions of the partial differential governing equations of the MHD nanofluid flow are executed by the strategy of perturbation approach under the assumption of long wavelength and low Reynolds number.Graphs for the streamwise velocity distributions,temperature distributions,pressure gradients,pressure drops,and streamlines are presented under the influences of the pertinent properties.The practical implementation of this research finds application in treating cancer through a technique known as photothermal therapy(PTT).The results indicate the control role of the magnetism,the heat generation,the shape factors of the AuNPs,and its concentration on the enhancement of the thermal properties and the streamwise velocity of the nanofluid.The results reveal a marked enhancement in the temperature profiles of the nanofluid,prominently influenced by both the intensified heat source and the heightened volume fractions of the nanoparticles.Furthermore,the platelet shape is regarded as most advantageous for heat conduction owing to its highest effective thermal conductivity.AuNPs proved strong efficiency in delivering and targeting the drug to reach the affected area with tumors.These results offer valuable insights into evaluating the effectiveness of PTT in addressing diverse cancer conditions and regulating their progression.
文摘Lanthanum-bearing iron lithium borate glass is a quaternary system for oxide glasses and was prepared via the melt-quenching method.The present article correlates the structure,optical,ligand field and M?ssbauer data on iron lithium borate glass co ntaining La^(3+).The density was measured,while the molar volume was calculated.Other physical parameters are well-described.With increasing the La_(2)O_(3) content within the glass network,infrared spectra analysis reveals structural modifications such as the increase in BO_(4) units and the decline in both BO_(3) units and NBO bonds content.Furthermore,optical absorption spectra were measured.The absorption spectra disclose a plethora of electronic transitions that are related to Fe^(3+)in tetrahedral and octahedral sites,however,Fe^(2+)phase is not observed in optical spectra,but it has a clear signature in M?ssbauer spectra.Besides,the glass absorption edges undergo a clear blue shift,reflecting an increased band gap energy(1.96-2.28 eV).The decline in NBO bonds justifies this trend.Bewitchingly,the values of crystal field splitting are increased,while the values of Racah parameters are decreased.This trend is justified by the decline in NBO bonds and increases electron localization around Fe cations.M?ssbauer spectra confirm the existence of Fe^(3+)in tetrahedral and octahedral sites,while Fe^(2+)exists in only a tetrahedral state.With increasing La_(2)O_(3) content,the isomer shift of Fe^(3+)in tetrahedral sites changes to be 0.312-0.329 mm/s,while the isomer shift of octahedral Fe^(3+)is 0.424-0.456 mm/s.These findings coincide with optical data.While the isomer shift of tetrahedral Fe^(2+)is 0.902-0.911 mm/s.Our results of structural,optical and ligand field associated with M?ssbauer spectra open more vistas toward the utility of these samples in the optics realm.
文摘Background:In the field of genetic diagnostics,DNA sequencing is an important tool because the depth and complexity of this field have major implications in light of the genetic architectures of diseases and the identification of risk factors associated with genetic disorders.Methods:Our study introduces a novel two-tiered analytical framework to raise the precision and reliability of genetic data interpretation.It is initiated by extracting and analyzing salient features from DNA sequences through a CNN-based feature analysis,taking advantage of the power inherent in Convolutional neural networks(CNNs)to attain complex patterns and minute mutations in genetic data.This study embraces an elite collection of machine learning classifiers interweaved through a stern voting mechanism,which synergistically joins the predictions made from multiple classifiers to generate comprehensive and well-balanced interpretations of the genetic data.Results:This state-of-the-art method was further tested by carrying out an empirical analysis on a variants'dataset of DNA sequences taken from patients affected by breast cancer,juxtaposed with a control group composed of healthy people.Thus,the integration of CNNs with a voting-based ensemble of classifiers returned outstanding outcomes,with performance metrics accuracy,precision,recall,and F1-scorereaching the outstanding rate of 0.88,outperforming previous models.Conclusions:This dual accomplishment underlines the transformative potential that integrating deep learning techniques with ensemble machine learning might provide in real added value for further genetic diagnostics and prognostics.These results from this study set a new benchmark in the accuracy of disease diagnosis through DNA sequencing and promise future studies on improved personalized medicine and healthcare approaches with precise genetic information.
基金a joint project of the University of Massachusetts and the Infrared Processing and Analysis Center/California Institute of Technology,funded by the National Aeronautics and Space Administration and the National Science Foundation。
文摘We present the essential stellar parameters of the close visual triple system HD 2893 using Al-Wardat's method for analyzing binary and multiple star systems in conjunction with Kurucz's model atmospheres.This method accurately computes the spectrophotometric stellar masses through a combined synthetic spectral energy distribution approach that compares the results with observed data.The vigorous approach uses spectroscopic,photometric,and dynamical analysis to yield precise results.The method implements Gaia DR3 measurements and other measurements like those of Hipparcos and 2MASS All-Sky Catalog as a guide for the best fit between the synthetic spectra and observed photometry.The analysis gives precise spectrophotometric stellar masses for the system being M_(Sph)^(A)=1.20±0.07M⊙,M_(Sph)^(B)=1.09±0.06M⊙,and M_(Sph)^(C)=0.46±0.01M⊙.It shows that the three components are main sequence stars with an estimated age of around 1.0 Gyr.When integrated with the dynamical analysis,a new dynamical parallax for the system is obtained,π_(dyn)=13.8528±0.20 mas.Additionally,the discussion covers the formation and evolution of the triple system.
文摘The existence of T_periodic solutions of the nonlinear system with multiple delays is studied. By using the topological degree method, sufficient conditions are obtained for the existence of T_periodic solutions. As an application, the existence of positive periodic solution for a logarithmic population model is established under some conditions.
文摘This paper deals with the dyeing of cotton fabrics with microwave irradiation.The compara-tive experiments of the microwave dyeing to the conventional dyeing were carried out and themechanism was also discussed.Being subjected to microwave irradiation,the penetration of dyesand chemicals into the fabric can be achieved in a short time with a good color yield.The irradiatedmaterials generate heat via dielectric heating by high frequency electro-magnetic field and as a re-sult,energy saving can be realized.Based on the examination and analysis with X-ray diffraction,IR,SEM,and XPS,the reduction in crystallinity,the formation of active carbonyl groups of freeradicals containing oxygen and the morphological changes in the irradiated cottom fibers werefound.All of these may be believed in favour of the dyeing process.
基金supported by the National Natural Science Foundation of China (No. 30472166)the Tianjin Commission of Science and Technology (06YFGZSH07000)
文摘The replication of HIV-1 requires the integration of its cyclic DNA into host DNA by HIV-1 integrase （IN）, which includes two important reactions, 3＇-processing and strand transfer, both catalyzed by HIV-1 IN. Disrupting either of the reactions will fulfill the purpose of inhibiting the replication of HIV-1. In this paper, pharmacophore modeling and molecular docking are employed to investigate the inhibition mechanism of the HIV-1 IN strand transfer inhibitors （INSTIs）. Based on the results, we suggest that the inhibition mechanism of INSTIs involves the inhibitor chelating the cofactors Mg2＋ and its forming hydrogen bonds with some crucial residues adjacent to the DDE active center.
文摘In this paper,we used time delay feedback to minimize the vibrations of a hybrid Rayleigh–van der Pol–Duffing oscillator.This system is a one-degree-offreedom containing the cubic and fifth nonlinear terms and an external force.We applied the multiple scales method to get the solution from first approximation.Graphically and numerically,we studied the system before and after adding time delay feedback at the primary resonance case(ffi!).We used MATLAB program to simulate the efficacy of different parameters and the time delay on the main system.
基金Supported by College of Applied Medical Sciences Research Center and the Deanship of Scientific Research at King Saud University,Riyadh,Saudi Arabia
文摘Medical ultrasound imaging with Doppler plays an essential role in the diagnosis of vascular disease. This study intended to review the clinical use of "to-and-fro" waveform at duplex Doppler ultrasonography(DDU) in the diagnosis of pseudoaneurysms in the arterial vessels of upper and lower extremities, abdominal aorta, carotid and vertebral arteries as well as to review our personal experiences of "to-and-fro" waveform at DDU also. After receiving institutional review board approval, an inclusive literature review was carried out in order to review the scientific foundation of "toand-fro" waveform at DDU and its clinical use in the diagnosis of pseudoaneurysms in various arterial vessels. Articles published in the English language between 2000 and 2013 were evaluated in this review study. Pseudoaneurysms in arterial vessels of the upper and lower extremities, abdominal aorta, carotid and vertebral arteries characterized by an extraluminal pattern of blood flow, which shows variable echogenicity, interval complexity, and "to-and-fro" flow pattern on color Doppler ultrasonography. In these arterial vessels, Duplex ultrasonography can demonstrate the degree of clotting, pseudoaneurysm communication, the blood flow patterns and velocities. Spectral Doppler applied to pseudoaneurysms lumen revealed systolic and diastolic turbulent blood flow with traditional "toand-fro" waveform in the communicating channel. Accurate diagnosis of pseudoaneurysm by spectral Doppler is based on the documentation of the "to-andfro" waveform. The size of pseudoaneurysm determines the appropriate treatment approach as surgical or conservative.
基金National Natural Science Foundation of China(No. 20071014)
文摘A nanometer porphyrin dimer was synthesized with fumaryl chloride as a bridge-linked reagent. The characterization was carried out with elemental analyses, ^1H NMR, UV-Vis, and IR spectrometries, and then the electrochemical properties of the porphyrins were studied. The authors found that there was moderate electronic communication between the two porphyrin rings in the nanometer porphyrin dimer.
基金the Deanship of Scientific Research at King Khalid University for funding this work through the Big Research Group Project under grant number(R.G.P2/16/40).
文摘In this paper,a discrete Lotka-Volterra predator-prey model is proposed that considers mixed functional responses of Holling types I and III.The equilibrium points of the model are obtained,and their stability is tested.The dynamical behavior of this model is studied according to the change of the control parameters.We find that the complex dynamical behavior extends from a stable state to chaotic attractors.Finally,the analytical results are clarified by some numerical simulations.
基金Supported by the Universidad Autonoma de Coahuila and the Consejo Nacional de Ciencia y Tecnologia(CONACYT).Grant number:COAH-2010C13-147563
文摘Objective:To extract,quantify,and evaluate the phenolic content in Opuntia ficus-indica skin for their antioxidant capacity with three different methods(ABTS,DPPH,and lipid oxidation)and to optimize the extraction conditions[time,temperature and ethanol concentration)in a reflux system.Methods:The extraction process was done using a reflux system.A San CristobalⅡexperimental design with three variables and three levels was used.The variables evaluated were time of extraction(h),concentration of ethanol(%,v/v)and temperature(°C).The extraction process was optimized using a response surface methodology.Results:It was observed that at higher temperature more phenolic compounds were extracted,but the antioxidant capacity was decreased.The optimum conditions for phenolic compounds extraction and antioxidant capacity mixing the three methods were as Follows:45%of ethanol,80℃and 2 hours of extraction.Values obtained in our results are little higher that other previously reported.Conclusions:It can he concluded the by-products of Opuntia ficus-indica represent a good source of natural antioxidants with possible applications in food,cosmetics or drugs industries.
文摘Peristaltic motion induced by a surface acoustic wave of a viscous, compressible and electrically conducting Maxwell fluid in a confined parallel-plane microchannel through a porous medium is investigated in the presence of a constant magnetic field. The slip velocity is considered and the problem is discussed only for the free pumping case. A perturbation technique is employed to analyze the problem in terms of a small amplitude ratio. The phenomenon of a “backward flow” is found to exist in the center and at the boundaries of the channel. In the second order approximation, the net axial velocity is calculated for various values of the fluid parameters. Finally, the effects of the parameters of interest on the mean axial velocity, the reversal flow, and the perturbation function are discussed and shown graphically. We find that in the non-Newtonian regime, there is a possibility of a fluid flow in the direction opposite to the propagation of the traveling wave. This work is the most general model of peristalsis created to date with wide-ranging applications in biological, geophysical and industrial fluid dynamics.
基金TWAS-Italy for the financial support of her visit to UNAM under the TWAS-UNESCO Associateshipthe FORDECYTCONACYT for the financial support under the aforementioned agreement。
文摘The peristaltic flow of a non-Newtonian nanofluid with swimming oxytactic microorganisms through a space between two infinite coaxial conduits is investigated. A variable magnetic field is applied on the flow. The bioconvection flow and heat transfer in the porous annulus are formulated, and appropriate transformations are used, leading to the non-dimensionalized ruling partial differential equation model. The model is then solved by using the homotopy perturbation scheme. The effects of the germane parameters on the velocity profile, temperature distribution, concentration distribution, motile microorganism profile, oxytactic profile, pressure rise, and outer and inner tube friction forces for the blood clot and endoscopic effects are analyzed and presented graphically.It is noticed that the pressure rise and friction forces attain smaller values for the endoscopic model than for the blood clot model. The present analysis is believed to aid applications constituting hemodynamic structures playing indispensable roles inside the human body since some blood clotting disorders, e.g., haemophilia, occur when some blood constituents on the artery wall get confined away from the wall joining the circulation system.
基金National Nature Science Foundation of China (Grant No. 81241114)Basic Research Project of Logistics University of PAP (Grant No. WHJ201401)Fund for Scientific Research and Innovation Team of Logistics University of PAP。
文摘Neuraminidase(NA) plays a biologically vital role in the replication of influenza virus, and NA inhibitors(NAIs) are most widely used in the clinical anti-flu therapy. NA of 2009 H1 N1 influenza virus(09 N1) possesses a different substrate-binding cavity compared with other NA subtypes, making 09 N1 a more appropriate starting point for the discovery of potent 09 N1 inhibitors. As natural products are of great structural diversity, research on the interaction between natural NAIs and 09 N1 can throw light on the design of new structural NAIs. In this study, we, for the first time, conducted molecular docking procedure with GOLD on 10 natural inhibitors to 09 N1, and acquired their binding modes with 09 N1. The docking results showed that the active site S1 was important in the binding of NAIs to 09 N1. Then five scaffolds were extracted from these NAIs with interactions to site S1, and these could be used in the structural modification of NAIs. Besides, we found that the addition of H-bonding interaction with the active site could improve the NA inhibitory activity of NAIs, and it might be the reason why the approved NAIs showed high efficiency. Two terminal hydrophobic sites(Terminal 1 and Terminal 2) with no interactions to the approved NAI zanamivir were found in the 09 N1 active cavity, and four NAIs were first found to bind with the terminals. Till now, there are few studies on the meaning of Terminal 2 in the binding of NAI to NA, which could be a new direction for the rational design of NAIs.
文摘This paper deals with the problem of the postbuckling response of a thin cantilever beam ofnon-linear material, subjected to subtangential follower forces. Based on the well-knownBernoulli-Euler bending moment-curvature relation, the proposed problem is reduced to a specialeigenvalue problem of non-linear differential equation. An approximate solution is achieved byusing a simple and very effective technique, which leads to reliable results even in the case of verylarge deflections. The initial postbuckling path depending on the subtangential follower forces inequilibrium is then obtained. Moreover, the individual and coupling effect of the subtangential fol-lower force, the material non-linearity and the beam slenderness ratio on the initial postbucklingpath are also discussed in detail.
文摘Parasitic angiosperm Alectra vogelii Benth is a growing problem in Malawi, particularly with current emphasis on legumes. Therefore, two studies were set in order to understand the possible mechanisms of resistance in cowpea genotypes on their reaction to the parasitic weed. In the first experiment, Mkanakaufiti, IT99K-7-21-2-2XIT82E-16, Sudan 1 and IT82E-16 were grown in Alectra infested and non-infested pots. The experiment (2*4 factorial treatment combination) was arranged in an RCBD and replicated eight times. The second experiment, involved Petri-dish techniques where 4 genotype roots were assessed on their ability to stimulate the germination of A. vogelii as a proxy for germination stimulant production. The experiment was arranged in an RCBD and replicated five times. In the first experiment, data was collected on;the number of days to first Alectra emergence, Alectra shoot counts at 6, 8, 10, and 12 weeks after planting (WAP), Alectra attachment at 5 and 12 WAP, Alectra biomass at 12 WAP, cowpea biomass parameters at 5 and 12 WAP, yield and yield components per pot. While in the second experiment, number of germinated Alectra seeds per Petri dishes was recorded. The results indicated that IT82E-16 (33.25 days) and Sudan 1 (34.25 days) were earlier infested whilst late on IT99K-7-21-2-2XIT82E-16 (38 days) which correlated to the number of Alectra attachments. There were significant differences (p = 0.05) in weekly Alectra counts between cowpea varieties from 6 up to 10 WAP. Mkanakaufiti and IT99K-7-21-2-2XIT82E-16 were observed with no and few Alectra shoots infestation respectively which was an indicator of resistance mechanism in the study. Number of pods, grain weight (g) and harvest index per pot were significantly affected by inoculation protocol with lower yield on infested cowpea genotypes. The same trend was observed on cowpea varieties where Mkanakaufiti (21.9 g/pot) shown higher yield followed by IT82E-16 (12.5 g/pot) which is susceptible but with tolerance ability to the parasitic weed. The study has shown that resistance mechanisms can be categorized as no or few Alectra shoots, death of Alectra shoots and late infestation. In the Petri dishes, only 3 WAP grown Mkanakaufiti root media failed to induce the germination of Alectra seeds while the opposite occurred on IT82E-16, Sudan 1 and IT99K-7-21-2-2XIT82E-16. On the contrary, 4 WAP grown root media of the four genotypes stimulated Alectra germination which shed more light on the seed behaviour in the soil. This is worth exploring as more could be known to what causes termination of Alectra shoots on Mkanakaufiti. Still, intensifying resistant genotypes should be a goal in order to reduce Alectra seed banks in the soil, thereby, increasing cowpea yield.
文摘The effects of TiO2 on sintering and nonlinear electrical properties of(98.5-x)ZnO–0.5MnO2–0.5Co2O3-0.5Bi2O3–xTiO2(x=0.3,0.5,0.7,0.9 mol%)ceramic varistors prepared by the ceramic technique are investigated in this work.The optimum sintering temperature of the prepared samples is deduced by determining the firing shrinkage and water absorption percentages.The optimum sintering temperature is found to be 1200℃,at which each of the samples shows a maximum firing shrinkage and minimum water absorption.Also minimum water absorption appears in a sample of x=0.9 mol%.Higher sintering temperature and longer sintering time give rise to a reduction in bulk density due to the increased amount of porosity between the large grains of ZnO resulting from the rapid grain growth induced by the liquid phase sintering.The crystal size of ZnO decreases with increasing TiO2 doping.The addition of TiO2 improves the nonlinear coefficient and attains its maximum value at x=0.7 mol%of TiO2,further addition negatively affects it.A decrease in capacitance consequently in the dielectric constant is recorded with increasing the frequency in a range of 30 kHz–200 kHz.The temperature and composition dependences of the dielectric constant and AC conductivity are also studied.The increase of temperature raises the dielectric constant because it increases ionic response to the field at any particular frequency.
