We report on the theoretical and experimental investigations of the transition of a typical quantum system with mixed regular-integrable classical dynamics to one with violated time-reversal(T)invariance.The measureme...We report on the theoretical and experimental investigations of the transition of a typical quantum system with mixed regular-integrable classical dynamics to one with violated time-reversal(T)invariance.The measurements are performed with a flat superconducting microwave resonator with circular shape in which chaoticity is induced by using either long antennas or inserting two circular disks into the cavity,and by magnetizing a ferrite disk placed at its center,which leads to violation of T invariance.We propose an extension of the Rosenzweig-Porter(RP)model,which interpolates between mixed regular-chaotic instead of integrable dynamics and fully chaotic dynamics with violated T-invariance,and derive a Wigner-surmise like analytical expression for the corresponding nearest-neighbor spacing distribution.We propose a procedure involving this result and those for the RP model to determine the size of T-invariance violation and chaoticity and validate it employing the experimental eigenfrequency spectra.展开更多
Prostate cancer （PCa） is one of the most common malignancies in the world with over 890 000 cases and over 258 000 deaths worldwide each year. Nearly all mortalities from PCa are due to metastatic disease, typically...Prostate cancer （PCa） is one of the most common malignancies in the world with over 890 000 cases and over 258 000 deaths worldwide each year. Nearly all mortalities from PCa are due to metastatic disease, typically through tumors that evolve to be hormone-refractory or castrate-resistant. Despite intensive epidemiological study, there are few known environmental risk factors, and age and family history are the major determinants. However, there is extreme heterogeneity in PCa incidence worldwide, suggesting that major determining factors have not been described. Genome-wide association studies have been performed and a considerable number of significant, but low-risk loci have been identified. In addition, several groups have analyzed PCa by determination of genomic copy number, fusion gene generation and targeted resequencing of candidate genes, as well as exome and whole genome sequencing. These initial studies have examined both primary and metastatic tumors as well as murine xenografts and identified somatic alterations in TP53and other potential driver genes, and the disturbance of androgen response and cell cycle pathways. It is hoped that continued characterization of risk factors as well as gene mutation and misregulation in tumors will aid in understanding, diagnosing and better treating PCa.展开更多
In Uruguay a post pneumococcal conjugate vaccine implementation surveillance of hospitalized children with pneumonia showed an increase of complicated pneumonias, while uncomplicated pneumonias decreased. Out of 151 p...In Uruguay a post pneumococcal conjugate vaccine implementation surveillance of hospitalized children with pneumonia showed an increase of complicated pneumonias, while uncomplicated pneumonias decreased. Out of 151 pleural effusions, 62 were empyemas requiring drainage, the rest of cases were treated with antibiotics with a favorable outcome. Patient’s vaccinated status varied. Pneumococcal etiology was poorly documented. The few identified sero-types were 1 and 3, a fact that urges PCV13 use for their control.展开更多
The 7-valent pneumococcal conjugate vaccine (PCV) was introduced in Uruguay in March 2008. In April 2010, it was replaced by PCV13. Surveillance of both vaccines was performed on hospitalized children with consolidate...The 7-valent pneumococcal conjugate vaccine (PCV) was introduced in Uruguay in March 2008. In April 2010, it was replaced by PCV13. Surveillance of both vaccines was performed on hospitalized children with consolidated pneumonia. The effect of different number of vaccine doses was evaluated in 2008 and 2010 birth cohorts vaccinated with PCV7 and PCV13 respectively. The study aims to estimate the effects of PCV7 and PCV13 different number of doses on consolidated pneumonia, through the study of hospitalized children from 2008 and 2010 birth cohorts. Vaccination records of every child were available providing precise vaccination data;therefore a new approach was used to estimate PCVs effect. Incidence rate was calculated for each year of the study and for the different number of vaccine doses used each year. Exposure was calculated as person per year and rate ratio values determined the decrease of consolidated pneumonias. This decrease in percentage was estimated as the difference between the incidence with no vaccine and the incidence of every one of the doses. Incidence rate ratio revealed significant values for the three vaccine doses of PCVs for both cohorts. Upon comparing incidences, significant reduction percentages of consolidated pneumonia admissions were found. The reduction percentage of consolidated pneumonia for fully vaccinated (3 doses) patients was 69.3% and 84.6 % for PCV7 and PCV13, respectively. These results confirm that PCV7 and PCV13 are highly effective for reducing pediatric hospitalizations due to consolidated pneumonia, as reported by other national publications and demonstrated by international researchers.展开更多
The flourishing of topological photonics in the last decade was achieved mainly due to developments in linear topological photonic structures.However,when nonlinearity is introduced,many intriguing questions arise.For...The flourishing of topological photonics in the last decade was achieved mainly due to developments in linear topological photonic structures.However,when nonlinearity is introduced,many intriguing questions arise.For example,are there universal fingerprints of the underlying topology when modes are coupled by nonlinearity,and what can happen to topological invariants during nonlinear propagation?To explore these questions,we experimentally demonstrate nonlinearity-induced coupling of light into topologically protected edge states using a photonic platform and develop a general theoretical framework for interpreting the mode-coupling dynamics in nonlinear topological systems.Performed on laser-written photonic Su-Schrieffer-Heeger lattices,our experiments show the nonlinear coupling of light into a nontrivial edge or interface defect channel that is otherwise not permissible due to topological protection.Our theory explains all the observations well.Furthermore,we introduce the concepts of inherited and emergent nonlinear topological phenomena as well as a protocol capable of revealing the interplay of nonlinearity and topology.These concepts are applicable to other nonlinear topological systems,both in higher dimensions and beyond our photonic platform.展开更多
We predict the preservation of temporal indistinguishability of photons propagating through helical coupled-resonator optical waveguides(H-CROWs).H-CROWs exhibit a pseudospin-momentum locked dispersion,which we show s...We predict the preservation of temporal indistinguishability of photons propagating through helical coupled-resonator optical waveguides(H-CROWs).H-CROWs exhibit a pseudospin-momentum locked dispersion,which we show suppresscs on-site disorder-induced backscattering and group velocity fluctuations.We simulate numerically the propagation of two-photon wave packets,demonstrating that they exhibit almost perfect Hong-Ou-Mandel dip visibility and then can preserve their quantum coherence even in the presence of moderate disorder,in contrast with regular CROws,which are highly sensitive to disorder.As indistinguishability is the most fundamental resource of quantum information processing,H-CROWs may find applications for the implementation of robust optical links and delay lines in the emerging quantum photonic communication and computational platforms.展开更多
Engineering of the orbital angular momentum(OAM)of light due to interaction with photonic lattices reveals rich physics and motivates potential applications.We report the experimental creation of regularly distributed...Engineering of the orbital angular momentum(OAM)of light due to interaction with photonic lattices reveals rich physics and motivates potential applications.We report the experimental creation of regularly distributed quantized vortex arrays in momentum space by probing the honeycomb and hexagonal photonic lattices with a single focused Gaussian beam.For the honeycomb lattice,the vortices are associated with Dirac points.However,we show that the resulting spatial patterns of vortices are strongly defined by the symmetry of the wave packet evolving in the photonic lattices and not by their topological properties.Our findings reveal the underlying physics by connecting the symmetry and OAM conversion and provide a simple and efficient method to create regularly distributed multiple vortices from unstructured light.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant Nos.11775100,12247101,and 11961131009)the financial support from the China Scholarship Council(Grant No.CSC202306180087)the financial support from the Institute for Basic Science in Korea(Grant No.IBS-R024-D1)。
文摘We report on the theoretical and experimental investigations of the transition of a typical quantum system with mixed regular-integrable classical dynamics to one with violated time-reversal(T)invariance.The measurements are performed with a flat superconducting microwave resonator with circular shape in which chaoticity is induced by using either long antennas or inserting two circular disks into the cavity,and by magnetizing a ferrite disk placed at its center,which leads to violation of T invariance.We propose an extension of the Rosenzweig-Porter(RP)model,which interpolates between mixed regular-chaotic instead of integrable dynamics and fully chaotic dynamics with violated T-invariance,and derive a Wigner-surmise like analytical expression for the corresponding nearest-neighbor spacing distribution.We propose a procedure involving this result and those for the RP model to determine the size of T-invariance violation and chaoticity and validate it employing the experimental eigenfrequency spectra.
文摘Prostate cancer （PCa） is one of the most common malignancies in the world with over 890 000 cases and over 258 000 deaths worldwide each year. Nearly all mortalities from PCa are due to metastatic disease, typically through tumors that evolve to be hormone-refractory or castrate-resistant. Despite intensive epidemiological study, there are few known environmental risk factors, and age and family history are the major determinants. However, there is extreme heterogeneity in PCa incidence worldwide, suggesting that major determining factors have not been described. Genome-wide association studies have been performed and a considerable number of significant, but low-risk loci have been identified. In addition, several groups have analyzed PCa by determination of genomic copy number, fusion gene generation and targeted resequencing of candidate genes, as well as exome and whole genome sequencing. These initial studies have examined both primary and metastatic tumors as well as murine xenografts and identified somatic alterations in TP53and other potential driver genes, and the disturbance of androgen response and cell cycle pathways. It is hoped that continued characterization of risk factors as well as gene mutation and misregulation in tumors will aid in understanding, diagnosing and better treating PCa.
文摘In Uruguay a post pneumococcal conjugate vaccine implementation surveillance of hospitalized children with pneumonia showed an increase of complicated pneumonias, while uncomplicated pneumonias decreased. Out of 151 pleural effusions, 62 were empyemas requiring drainage, the rest of cases were treated with antibiotics with a favorable outcome. Patient’s vaccinated status varied. Pneumococcal etiology was poorly documented. The few identified sero-types were 1 and 3, a fact that urges PCV13 use for their control.
文摘The 7-valent pneumococcal conjugate vaccine (PCV) was introduced in Uruguay in March 2008. In April 2010, it was replaced by PCV13. Surveillance of both vaccines was performed on hospitalized children with consolidated pneumonia. The effect of different number of vaccine doses was evaluated in 2008 and 2010 birth cohorts vaccinated with PCV7 and PCV13 respectively. The study aims to estimate the effects of PCV7 and PCV13 different number of doses on consolidated pneumonia, through the study of hospitalized children from 2008 and 2010 birth cohorts. Vaccination records of every child were available providing precise vaccination data;therefore a new approach was used to estimate PCVs effect. Incidence rate was calculated for each year of the study and for the different number of vaccine doses used each year. Exposure was calculated as person per year and rate ratio values determined the decrease of consolidated pneumonias. This decrease in percentage was estimated as the difference between the incidence with no vaccine and the incidence of every one of the doses. Incidence rate ratio revealed significant values for the three vaccine doses of PCVs for both cohorts. Upon comparing incidences, significant reduction percentages of consolidated pneumonia admissions were found. The reduction percentage of consolidated pneumonia for fully vaccinated (3 doses) patients was 69.3% and 84.6 % for PCV7 and PCV13, respectively. These results confirm that PCV7 and PCV13 are highly effective for reducing pediatric hospitalizations due to consolidated pneumonia, as reported by other national publications and demonstrated by international researchers.
基金supported by the National Key R&D Program of China under Grant No.2017YFA0303800the National Natural Science Foundation(11922408,91750204,11674180),PCSIRT+5 种基金the 111 Project(No.B07013)in Chinasupport in part by the Croatian Science Foundation Grant No.IP-2016-06-5885 SynthMagIAthe QuantiXLie Center of Excellence,a project co-financed by the Croatian Government and European Union through the European Regional Development Fund-the Competitiveness and Cohesion Operational Programme(Grant KK.01.1.1.01.0004)supported by the Australian Research Council(DE19010043)supported by the Institute for Basic Science in Korea(IBS-R024-Y1)support from the Russian Foundation for Basic Research(grant No.19-52-12053).
文摘The flourishing of topological photonics in the last decade was achieved mainly due to developments in linear topological photonic structures.However,when nonlinearity is introduced,many intriguing questions arise.For example,are there universal fingerprints of the underlying topology when modes are coupled by nonlinearity,and what can happen to topological invariants during nonlinear propagation?To explore these questions,we experimentally demonstrate nonlinearity-induced coupling of light into topologically protected edge states using a photonic platform and develop a general theoretical framework for interpreting the mode-coupling dynamics in nonlinear topological systems.Performed on laser-written photonic Su-Schrieffer-Heeger lattices,our experiments show the nonlinear coupling of light into a nontrivial edge or interface defect channel that is otherwise not permissible due to topological protection.Our theory explains all the observations well.Furthermore,we introduce the concepts of inherited and emergent nonlinear topological phenomena as well as a protocol capable of revealing the interplay of nonlinearity and topology.These concepts are applicable to other nonlinear topological systems,both in higher dimensions and beyond our photonic platform.
基金Institute for Basic Science(IBS-R024-Y1,IBS-R024-D1)Australian Research Council(DP190100277).
文摘We predict the preservation of temporal indistinguishability of photons propagating through helical coupled-resonator optical waveguides(H-CROWs).H-CROWs exhibit a pseudospin-momentum locked dispersion,which we show suppresscs on-site disorder-induced backscattering and group velocity fluctuations.We simulate numerically the propagation of two-photon wave packets,demonstrating that they exhibit almost perfect Hong-Ou-Mandel dip visibility and then can preserve their quantum coherence even in the presence of moderate disorder,in contrast with regular CROws,which are highly sensitive to disorder.As indistinguishability is the most fundamental resource of quantum information processing,H-CROWs may find applications for the implementation of robust optical links and delay lines in the emerging quantum photonic communication and computational platforms.
基金supported by the National Key R&D Program of China(Grant Nos.2018YFA0307500 and 2023YFA1407100)the Key Scientific and Technological Innovation Team of Shaanxi Province(Grant No.2021TD-56)+7 种基金the National Natural Science Foundation of China(Grant Nos.12074303,62022066,12074306,and 11804267)the IBS Young Scientist Fellowship(Grant No.IBS-R024-Y3)the Basis Foundation(Grant No.21-1-3-30-1)the support of the European Union’s Horizon 2020 program,through an FET Open research and innovation action(Grant No.964770)(Topo Light)he ANR projects Labex Ga NEXT(Grant No.ANR-11-LABX0014)“NEWAVE”(Grant No.ANR-21-CE24-0019)the ANR program“Investissements d’Avenir”through the IDEX-ISITE initiative 16-IDEX-0001(Grant No.CAP 20-25)support by the Russian Science Foundation(Grant No.22-12-00144)
文摘Engineering of the orbital angular momentum(OAM)of light due to interaction with photonic lattices reveals rich physics and motivates potential applications.We report the experimental creation of regularly distributed quantized vortex arrays in momentum space by probing the honeycomb and hexagonal photonic lattices with a single focused Gaussian beam.For the honeycomb lattice,the vortices are associated with Dirac points.However,we show that the resulting spatial patterns of vortices are strongly defined by the symmetry of the wave packet evolving in the photonic lattices and not by their topological properties.Our findings reveal the underlying physics by connecting the symmetry and OAM conversion and provide a simple and efficient method to create regularly distributed multiple vortices from unstructured light.
