Objective To evaluate the feasibility,safety and efficacy of percutaneous stent implantation for treating left main coronary artery(LMCA)stenosis.Methods Consecutive patients with unprotected left main coronary artery...Objective To evaluate the feasibility,safety and efficacy of percutaneous stent implantation for treating left main coronary artery(LMCA)stenosis.Methods Consecutive patients with unprotected left main coronary artery disease treated by stent-based percutaneous intervention(PCI)at 6 medical centers in China were enrolled.Procedural data and clinical outcomes were obtained from all patients.Results From January 2001 to December 2004,138 patients(79 males and 59 females;mean age:69.7±5.8 years)underwent PCI for LMCA stenosis.Bare metal stents(BMS)were implanted in 51 patients with non-bifurcational lesions and in 5 patients with bifurcational lesions from January of 2001 to June of 2003(BMS group);.Drug eluting stents(DES)were used unselectively to cover both bifurcational and non-bifurcational lesions in 86 patients from July of 2003 to December of 2004(DES group).Procedural success rate of the 138 cases was 98%(135/138).One patient(0.7%)with bifurcation lesion who was treated with DES died from severe heart failure 2 weeks after the procedure.During a mean follow up period of 21.3±5.6 months,one patient died from renal failure,one from sudden cardiac death,4 underwent target lesion revascularization(TLR)in the BMS group,which all occurred in patients with bifurcational lesions;whereas in the DES group no deaths occurred and only one patient with bifurcational lesion had TLR.Conclusions(1)PCI is feasible and relatively safe to treat unprotected left main coronary artery disease in elderly patients at medical centers with experienced professionals.(2)BMS and DES have similar immediate and long-term efficacy in the treatment of ostium and shaft lesions of the LMCA.(3)DES are strongly suggested in the therapy of distal bifurcation lesion of unprotected LMCA.展开更多
Aging is a slow and progressive natural process that compromises the normal functions of cells,tissues,organs,and systems.The aging of the hypothalamic median eminence(ME),a structural gate linking neural and endocrin...Aging is a slow and progressive natural process that compromises the normal functions of cells,tissues,organs,and systems.The aging of the hypothalamic median eminence(ME),a structural gate linking neural and endocrine systems,may impair hormone release,energy homeostasis,and central sensing of circulating molecules,leading to systemic and reproductive aging.However,the molecular and cellular features of ME aging remain largely unknown.Here,we describe the transcriptional landscape of young and middleaged mouse ME at single-cell resolution,revealing the common and cell type-specific transcriptional changes with age.The transcriptional changes in cell-intrinsic programs,cell-cell crosstalk,and cellextrinsic factors highlight five molecular features of ME aging and also implicate several potentially druggable targets at cellular,signaling,and molecular levels.Importantly,our results suggest that vascular and leptomeningeal cells may lead the asynchronized aging process among diverse cell types and drive local inflammation and cellular senescence via a unique secretome.Together,our study uncovers how intrinsic and extrinsic features of each cell type in the hypothalamic ME are changed by the aging process,which will facilitate our understanding of brain aging and provide clues for efficient anti-aging intervention at the middle-aged stage.展开更多
Objective: to apply global nursing intervention in interventional therapy of coronary heart disease and explore its nursing effect. Methods: 70 patients were included in this study, all of whom were coronary heart dis...Objective: to apply global nursing intervention in interventional therapy of coronary heart disease and explore its nursing effect. Methods: 70 patients were included in this study, all of whom were coronary heart disease patients undergoing interventional therapy in our hospital from January 2019 to December 2019. According to the principle of odd-even distribution, they were divided into 35 cases of nursing group A and 35 cases of nursing group B. The effect of nursing intervention was compared between the two groups. Results: compared with the nursing effect of the two groups, nursing group A was 82.86%, nursing group B was 94.29%, and the nursing effective rate of nursing group B was high (χ2=6.455, P < 0.05). Compared with the length of stay in bed and hospitalization, the nursing group B was shorter (t=27.288, 37.383, P<0.05). Conclusion: the application of global nursing intervention can improve the interventional treatment effect of coronary heart disease, shorten the hospitalization time of patients and reduce the medical burden of patients.展开更多
Objective: to explore the effect of nasal endoscopic surgery on chronic sinusitis and nasal polyp, and to analyze the impact on sleep quality of patients. Methods: a total of 92 patients were selected from the patient...Objective: to explore the effect of nasal endoscopic surgery on chronic sinusitis and nasal polyp, and to analyze the impact on sleep quality of patients. Methods: a total of 92 patients were selected from the patient data from January 2020 to March 2021, and divided into groups according to the principle of double-blind method, with 46 patients in each group. The control group received conventional surgery, and the study group received nasal endoscopic surgery. Finally from the two groups of efficacy, sleep quality of patients to compare the two indicators, analysis of more advantageous treatment methods. Results: the effective rate was 95.65% in the study group and 89.13% in the control group, P < 0.05. In terms of sleep quality, the study group was better at different time after surgery (P < 0.05). Conclusion: nasal endoscopy can be used to treat chronic sinusitis and nasal polyp. This method can improve the effect of conventional surgery, and ensure the safety and effectiveness of patient treatment;at the same time, it can also improve sleep quality and has obvious advantages, so it can be further promoted.展开更多
Background Corneal dystrophy is a group of inherited blinding diseases of the cornea. This study was to identify the mutations of the keratoepithelin (KE) gene for proper diagnosis of corneal dystrophy. Methods Thre...Background Corneal dystrophy is a group of inherited blinding diseases of the cornea. This study was to identify the mutations of the keratoepithelin (KE) gene for proper diagnosis of corneal dystrophy. Methods Three families with corneal dystrophy were analysed. Thirteen individuals at risk for corneal dystrophy in family A, the proband and her son in family B, and the proband in family C were examined after their blood samples were obtained. Mutation screening of human transforming growth factor β-induced gene (BIGH3 gene) was performed. Results Five individuals in family A were found by clinical evaluation to be affected with granular corneal dystrophy and carried the BIGH3 mutation W555R. However, both probands in families B and C, also diagnosed with granular corneal dystrophy, harboured the BIGH3 mutation R124H. Conclusion Molecular genetic analysis can improve accurate diagnosis of corneal dystrophy.展开更多
文摘Objective To evaluate the feasibility,safety and efficacy of percutaneous stent implantation for treating left main coronary artery(LMCA)stenosis.Methods Consecutive patients with unprotected left main coronary artery disease treated by stent-based percutaneous intervention(PCI)at 6 medical centers in China were enrolled.Procedural data and clinical outcomes were obtained from all patients.Results From January 2001 to December 2004,138 patients(79 males and 59 females;mean age:69.7±5.8 years)underwent PCI for LMCA stenosis.Bare metal stents(BMS)were implanted in 51 patients with non-bifurcational lesions and in 5 patients with bifurcational lesions from January of 2001 to June of 2003(BMS group);.Drug eluting stents(DES)were used unselectively to cover both bifurcational and non-bifurcational lesions in 86 patients from July of 2003 to December of 2004(DES group).Procedural success rate of the 138 cases was 98%(135/138).One patient(0.7%)with bifurcation lesion who was treated with DES died from severe heart failure 2 weeks after the procedure.During a mean follow up period of 21.3±5.6 months,one patient died from renal failure,one from sudden cardiac death,4 underwent target lesion revascularization(TLR)in the BMS group,which all occurred in patients with bifurcational lesions;whereas in the DES group no deaths occurred and only one patient with bifurcational lesion had TLR.Conclusions(1)PCI is feasible and relatively safe to treat unprotected left main coronary artery disease in elderly patients at medical centers with experienced professionals.(2)BMS and DES have similar immediate and long-term efficacy in the treatment of ostium and shaft lesions of the LMCA.(3)DES are strongly suggested in the therapy of distal bifurcation lesion of unprotected LMCA.
基金supported by the National Key R&D Program of China(2019YFA0801900 and 2018YFA0801104)the National Natural Science Foundation of China(31771131,81891002,31921002,and 32070972)+3 种基金the Strategic Priority Research Program of Chinese Academy of Sciences(XDB32020000)the Hundred-Talent Program(Chinese Academy of Sciences)the Beijing Municipal Science&Technology Commission(Z210010 and Z181100001518001)the Baoding Technical Program(2141ZF027)。
文摘Aging is a slow and progressive natural process that compromises the normal functions of cells,tissues,organs,and systems.The aging of the hypothalamic median eminence(ME),a structural gate linking neural and endocrine systems,may impair hormone release,energy homeostasis,and central sensing of circulating molecules,leading to systemic and reproductive aging.However,the molecular and cellular features of ME aging remain largely unknown.Here,we describe the transcriptional landscape of young and middleaged mouse ME at single-cell resolution,revealing the common and cell type-specific transcriptional changes with age.The transcriptional changes in cell-intrinsic programs,cell-cell crosstalk,and cellextrinsic factors highlight five molecular features of ME aging and also implicate several potentially druggable targets at cellular,signaling,and molecular levels.Importantly,our results suggest that vascular and leptomeningeal cells may lead the asynchronized aging process among diverse cell types and drive local inflammation and cellular senescence via a unique secretome.Together,our study uncovers how intrinsic and extrinsic features of each cell type in the hypothalamic ME are changed by the aging process,which will facilitate our understanding of brain aging and provide clues for efficient anti-aging intervention at the middle-aged stage.
文摘Objective: to apply global nursing intervention in interventional therapy of coronary heart disease and explore its nursing effect. Methods: 70 patients were included in this study, all of whom were coronary heart disease patients undergoing interventional therapy in our hospital from January 2019 to December 2019. According to the principle of odd-even distribution, they were divided into 35 cases of nursing group A and 35 cases of nursing group B. The effect of nursing intervention was compared between the two groups. Results: compared with the nursing effect of the two groups, nursing group A was 82.86%, nursing group B was 94.29%, and the nursing effective rate of nursing group B was high (χ2=6.455, P < 0.05). Compared with the length of stay in bed and hospitalization, the nursing group B was shorter (t=27.288, 37.383, P<0.05). Conclusion: the application of global nursing intervention can improve the interventional treatment effect of coronary heart disease, shorten the hospitalization time of patients and reduce the medical burden of patients.
文摘Objective: to explore the effect of nasal endoscopic surgery on chronic sinusitis and nasal polyp, and to analyze the impact on sleep quality of patients. Methods: a total of 92 patients were selected from the patient data from January 2020 to March 2021, and divided into groups according to the principle of double-blind method, with 46 patients in each group. The control group received conventional surgery, and the study group received nasal endoscopic surgery. Finally from the two groups of efficacy, sleep quality of patients to compare the two indicators, analysis of more advantageous treatment methods. Results: the effective rate was 95.65% in the study group and 89.13% in the control group, P < 0.05. In terms of sleep quality, the study group was better at different time after surgery (P < 0.05). Conclusion: nasal endoscopy can be used to treat chronic sinusitis and nasal polyp. This method can improve the effect of conventional surgery, and ensure the safety and effectiveness of patient treatment;at the same time, it can also improve sleep quality and has obvious advantages, so it can be further promoted.
文摘Background Corneal dystrophy is a group of inherited blinding diseases of the cornea. This study was to identify the mutations of the keratoepithelin (KE) gene for proper diagnosis of corneal dystrophy. Methods Three families with corneal dystrophy were analysed. Thirteen individuals at risk for corneal dystrophy in family A, the proband and her son in family B, and the proband in family C were examined after their blood samples were obtained. Mutation screening of human transforming growth factor β-induced gene (BIGH3 gene) was performed. Results Five individuals in family A were found by clinical evaluation to be affected with granular corneal dystrophy and carried the BIGH3 mutation W555R. However, both probands in families B and C, also diagnosed with granular corneal dystrophy, harboured the BIGH3 mutation R124H. Conclusion Molecular genetic analysis can improve accurate diagnosis of corneal dystrophy.
