Objective:To investigate the quantitative assessment efficacy of chest CT combined with serum Vanin-1 and SPP1 in determining the progression stage of chronic obstructive pulmonary disease(COPD).Methods:A total of 100...Objective:To investigate the quantitative assessment efficacy of chest CT combined with serum Vanin-1 and SPP1 in determining the progression stage of chronic obstructive pulmonary disease(COPD).Methods:A total of 100 COPD subjects from our hospital from January 2020 to December 2023 were included and randomly divided into a healthy control group and an experimental group(50 cases each).The healthy control group underwent slow vital capacity measurement using a spirometer,while the experimental group underwent high-resolution thin-slice CT scans and serum Vanin-1 and SPP1 concentration measurements.Pulmonary function parameters,symptom burden,biomarker concentrations,and imaging characteristics were compared between the two groups.Results:The FEV1/FVC ratio in the experimental group(58.3±7.2)was lower than that in the healthy control group(92.1±4.8);the total CAT score(22.4±3.5)was higher than that in the healthy control group(3.1±1.2);both Vanin-1(18.7±2.3μg/L)and SPP1(25.6±4.1μg/L)levels were higher than those in the healthy control group;LAA%-950(38.7±6.2%)and WA%(68.5±5.3%)were significantly higher than those in the healthy control group(all p<0.001).Conclusion:Chest CT combined with serum Vanin-1 and SPP1 can accurately quantify the pathological progression of COPD,providing a dual basis for clinical staging and individualized intervention.展开更多
Antibiotics are widespread in aquatic environments due to their extensive use in human healthcare and ani-mal husbandry.However,research on the occurrence and bioaccumulation of antibiotics in aquatic organisms within...Antibiotics are widespread in aquatic environments due to their extensive use in human healthcare and ani-mal husbandry.However,research on the occurrence and bioaccumulation of antibiotics in aquatic organisms within shallow wetland lakes remains limited.This study investigated the occurrence and bioaccumulation of ten commonly used antibiotics in the Baiyang Lake,northern China’s largest shallow wetland lake.The results indicated that sulfonamides and fluoroquinolones were the predominant antibiotics in surface water,whereas fluoroquinolones and macrolides were more prevalent in sediment.Fluoroquinolones demonstrated significant potential for bioaccumulation in targeted aquatic organisms,including both animals and plants(Carassius au-ratus and Phragmites australis).The bioaccumulation of antibiotics in Carassius auratus was correlated with their solubility,whereas in Phragmites australis,this was associated with their octanol-water partition coefficients and molecular weights.Ecological risk assessment indicated that most antibiotics posed minimal to low risk levels.However,four antibiotics were exceptions:clarithromycin(12.5%)and sulfamethoxazole(6.25%)presented a high risk in surface water samples,while norfloxacin(25.0%)and ciprofloxacin(25.0%)posed a high risk in sediment samples.Norfloxacin,ciprofloxacin,and roxithromycin were identified as key indicator antibiotics for enhancing the local monitoring and control of antibiotic contamination based on four criteria:(1)high con-centrations,(2)frequent detection,(3)capacity for bioaccumulation,and(4)ecological risk levels.This study contributes to a deeper understanding of the status of antibiotic contamination,bioaccumulation characteristics,and ecological risk in Baiyang Lake,thereby supporting efforts to monitor and regulate antibiotic pollution.展开更多
Iris domestica,a perennial herb of the Iridaceae family,is widely recognized for its rich isoflavone content and broad therapeutic properties.To elucidate the biosynthetic pathway of these medicinally significant comp...Iris domestica,a perennial herb of the Iridaceae family,is widely recognized for its rich isoflavone content and broad therapeutic properties.To elucidate the biosynthetic pathway of these medicinally significant compounds,we constructed a haplotype-resolved genome assembly of this species.Transcriptomic and metabolomic analyses revealed tissue-specific accumulation of isoflavone,particularly in rhizomes and roots.Functional characterization identified two candidate isoflavone synthase genes,among which IdIFS was confirmed to promote the biosynthesis of key compounds tectorigenin and irisflorentin.The high-quality genome assembly presented here provides a foundational resource for further research into the evolution,secondary metabolite,and environmental adaptation of I.domestica.展开更多
Fungi play crucial roles in nutrient acquisition,plant growth promotion,and the enhancement of resistance to both abiotic and biotic stresses.However,studies on the fungal communities associated with peas (Pisum sativ...Fungi play crucial roles in nutrient acquisition,plant growth promotion,and the enhancement of resistance to both abiotic and biotic stresses.However,studies on the fungal communities associated with peas (Pisum sativum L.) remain limited.In this study,we systematically investigated the ecological effects of host niches (soil,root,stem,leaf,and pod) and genotypes on the diversity and composition of fungal communities in peas using a multi-level approach that encompassed pattern recognition (β-diversity decomposition),mechanism validation (neutral community model testing),and dynamic tracking methods (migration pathway source-tracking).The results revealed that the dominant fungal phyla across niches and genotypes were Ascomycota,Basidiomycota,and Mortierellomycota,and the community structures of the soil–plant continuum were primarily determined by the pea niches rather than genotypes.β-diversity decomposition was largely attributed to species replacement rather than richness differences,indicating strong niche specificity and microbial replacement across microhabitats.Neutral model analysis revealed that stochastic processes influenced genotypeassociated communities,while deterministic processes played a dominant role in niche-based community assembly.Source-tracking analysis identified niche-to-niche fungal migration,with Erysiphe,Fusarium,Cephaliophora,Ascobolus,Alternaria,and Aspergillus as the key genera.Migration rates from exogenous to endogenous niches were low (1.3–61.5%),whereas those within exogenous (64.4–83.7%) or endogenous (73.9–96.4%) compartments were much higher,suggesting that the pea epidermis acts as a selective barrier that filters and enriches microbial communities prior to internal colonization.This study provides comprehensive insights into the mechanisms of host filtering,enrichment and microbial sourcing,which increases our understanding of the assembly rules of the pea-associated fungal microbiome.展开更多
Non-structural carbohydrates(NSCs)are crucial for tree growth and survival under climatic stress,yet their spatial dynamics across broad climate gradients remain unclear.Pines(Pinus spp.),one of the most widely distri...Non-structural carbohydrates(NSCs)are crucial for tree growth and survival under climatic stress,yet their spatial dynamics across broad climate gradients remain unclear.Pines(Pinus spp.),one of the most widely distributed tree genera worldwide,provide an ideal system for investigating large-scale spatial patterns of NSC within a single genus along extensive climatic gradients.Here,we compiled a global NSC database for pines across 74 sites,and assessed the spatial variation in total NSC,starch(St),and soluble sugars(SS)concentrations in stem sapwood,the primary reserve tissue,along site-specific mean annual temperature(MAT)and precipitation(MAP).Our results show that MAP exerted a stronger influence(R^(2)=20%–47%)on the spatial variation in total NSC and its components than did MAT(R^(2)=6%–16%).Tota concentrations declined nonlinearly with increasing MAP,with the rate of decline slowing beyond approximately 800 mm.While MAT had weaker effects on total NSC concentrations,both MAT and MAP jointly regulated NSC partitioning:Higher MAT and MAP were associated with reduced St concentrations but elevated SS concentrations and SS:St ratios.These findings suggest that pine species in cold and arid environments prioritize storing NSC as St,whereas in relatively warm and humid environments,NSC are preferentially mobilized into SS to support immediate metabolic and growth demands.展开更多
In the context of power generation companies, vast amounts of specialized data and expert knowledge have been accumulated. However, challenges such as data silos and fragmented knowledge hinder the effective utilizati...In the context of power generation companies, vast amounts of specialized data and expert knowledge have been accumulated. However, challenges such as data silos and fragmented knowledge hinder the effective utilization of this information. This study proposes a novel framework for intelligent Question-and-Answer (Q&A) systems based on Retrieval-Augmented Generation (RAG) to address these issues. The system efficiently acquires domain-specific knowledge by leveraging external databases, including Relational Databases (RDBs) and graph databases, without additional fine-tuning for Large Language Models (LLMs). Crucially, the framework integrates a Dynamic Knowledge Base Updating Mechanism (DKBUM) and a Weighted Context-Aware Similarity (WCAS) method to enhance retrieval accuracy and mitigate inherent limitations of LLMs, such as hallucinations and lack of specialization. Additionally, the proposed DKBUM dynamically adjusts knowledge weights within the database, ensuring that the most recent and relevant information is utilized, while WCAS refines the alignment between queries and knowledge items by enhanced context understanding. Experimental validation demonstrates that the system can generate timely, accurate, and context-sensitive responses, making it a robust solution for managing complex business logic in specialized industries.展开更多
Aqueous aluminum ion batteries(AAIBs)have garnered extensive attention due to their environmental friendliness,high theoretical capacity,and low cost.However,the sluggish reaction kinetics and severe structural collap...Aqueous aluminum ion batteries(AAIBs)have garnered extensive attention due to their environmental friendliness,high theoretical capacity,and low cost.However,the sluggish reaction kinetics and severe structural collapse of the cathode material,especially manganese oxide,during the cycling process have hindered its further application.Herein,Cu^(2+)pre-interca la ted layeredδ-MnO_(2)was synthesized via a hydrothermal method.The pre-intercalated Cu^(2+)ions not only improve the conductivity of MnO_(2)cathode but also stabilize the structure to enhance stability.X-ray absorption fine structure(XAFS)combined with density functional theory(DFT)calculations confirm the formation of the covalent bond between Cu and O,increasing the electronegativity of O atoms and enhancing the H^(+)adsorption energy.Moreover,ex-situ measurements not only elucidate the Al^(3+)/H^(+)co-insertion energy storage mechanism but also demonstrate the high reversibility of the Cu-MnO_(2)cathode during cycling.This work provides a promising modification approach for the application of manganese oxides in AAIBs.展开更多
Tenebrionid beetles represent a crucial arthropod taxon in the Gobi desert ecosystems owing to their species richness and high biomass,both of which are essential for maintaining ecosystem health and stability.However...Tenebrionid beetles represent a crucial arthropod taxon in the Gobi desert ecosystems owing to their species richness and high biomass,both of which are essential for maintaining ecosystem health and stability.However,the spatiotemporal variations of tenebrionid beetle assemblages in the Gobi desert remain poorly understood.In this study,the monthly dynamics of tenebrionid beetles in the central part of the Hexi Corridor,Northwest China,a representative area of the Gobi desert ecosystems,were monitored using pitfall trapping during 2015-2020.The following results were showed:(1)monthly activity of tenebrionid beetles was observed from March to October,with monthly activity peaking in spring and summer,and monthly activity periods and peak of tenebrionid beetle species exhibited interspecific differences that varied from year to year;(2)spatial distribution of tenebrionid beetle community was influenced by structural factors.Specifically,at a spatial scale of 24.00 m,tenebrionid beetle community was strongly and positively correlated with the dominant species,with distinct spatial distribution patterns observed for Blaps gobiensis and Microdera kraatzi alashanica;(3)abundance of tenebrionid beetles was positively correlated with monthly mean precipitation and monthly mean temperature,whereas monthly abundance of B.gobiensis and M.kraatzi alashanica was positively correlated with monthly mean precipitation;and(4)the cover of Reaumuria soongarica(Pall.)Maxim.and Nitraria sphaerocarpa Maxim.had a positive influence on the number of tenebrionid beetles captured.In conclusion,monthly variation in precipitation significantly influences the community dynamic of tenebrionid beetles,with precipitation and shrub cover jointly determining the spatial distribution pattern of these beetles in the Gobi desert ecosystems.展开更多
[Objective]To construct an Escherichia coli mutant strain that accumulates pyruvate by genetic modification guided by the genome-scale metabolic network model.[Methods]Using a genome-scale metabolic network model as a...[Objective]To construct an Escherichia coli mutant strain that accumulates pyruvate by genetic modification guided by the genome-scale metabolic network model.[Methods]Using a genome-scale metabolic network model as a guide,we simulated pyruvate production of E.coli,screened key genes in metabolic pathways,and developed gene editing procedures accordingly.We knocked out the acetate kinase gene ackA,phosphate acetyltransferase gene pta,alcohol dehydrogenase adhE,glycogen synthase gene glgA,glycogen phosphorylase gene glgP,phosphoribosyl pyrophosphate(PRPP)synthase gene prs,ribose 1,5-bisphosphate phosphokinase gene phnN,and transporter encoding gene proP.Furthermore,we knocked in the transporter encoding gene ompC,flavonoid toxin gene fldA,and D-serine ammonia lyase gene dsdA.[Results]A shake flask process with the genetically edited mutant strain MG1655-6-2 under anaerobic conditions produced pyruvate at a titer of 10.46 g/L and a yield of 0.69 g/g.Metabolomic analysis revealed a significant increase in the pyruvate level in the fermentation broth,accompanied by notable decreases in the levels of certain related metabolic byproducts.Through 5 L fed-batch fermentation and an adaptive laboratory evolution,the strain finally achieved a pyruvate titer of 45.86 g/L.[Conclusion]This study illustrated the efficacy of a gene editing strategy predicted by a genome-scale metabolic network model in enhancing pyruvate accumulation in E.coli under anaerobic conditions and provided novel insights for microbial metabolic engineering.展开更多
BACKGROUND Primary biliary cholangitis(PBC)is a chronic autoimmune-mediated cholestatic liver disease.Nanoparticles encapsulating rapamycin(ImmTOR)suppress adaptive immune responses and induce the hepatic tolerogenic ...BACKGROUND Primary biliary cholangitis(PBC)is a chronic autoimmune-mediated cholestatic liver disease.Nanoparticles encapsulating rapamycin(ImmTOR)suppress adaptive immune responses and induce the hepatic tolerogenic immune response.AIM To investigate the effects of ImmTOR in PBC mouse models.METHODS PBC models were induced in C57BL/6 mice by two immunizations of 2-octynoic acid-coupled bovine serum albumin at two-week intervals,and polycytidylic acid every three days.The PBC mouse models were separated into the treatment group and the control group.The levels of alkaline phosphatase(ALP)and alanine aminotransferase in the mice were detected using an automatic biochemical analyzer.Liver and spleen mononuclear cells were analyzed by flow cytometry,and serum anti-mitochondrial antibodies(AMA)and the related cytokines were analyzed by enzyme-linked immunosorbent assay.Liver histopathology was examined by hematoxylin and eosin staining and scored.RESULTS After treatment with ImmTOR,the ALP level was significantly decreased(189.60 U/L±27.25 U/L vs 156.00 U/L±17.21 U/L,P<0.05),the level of AMA was reduced(1.28 ng/mL±0.27 ng/mL vs 0.56 ng/mL±0.07 ng/mL,P<0.001)and the expression levels of interferon gamma and tumor necrosis factorαwere significantly decreased(48.29 pg/mL±10.84 pg/mL vs 25.01 pg/mL±1.49 pg/mL,P<0.0001)and(84.24 pg/mL±23.47 pg/mL vs 40.66 pg/mL±14.65 pg/mL,P<0.001).The CD4+T lymphocytes,CD8+T lymphocytes and B lymphocytes in the liver were significantly reduced,with statistically significant differences(24.21%±6.55%vs 15.98%±3.03%,P<0.05;9.09%±1.91%vs 5.49%±1.00%,P<0.001;80.51%±2.96%vs 75.31%±4.34%,P<0.05).The expression of CD8+T lymphocytes and B lymphocytes in the ImmTOR treatment group also decreased(9.09%±1.91%vs 5.49%±1.00%,P<0.001;80.51%±2.96%vs 75.31%±4.34%,P<0.05).The liver pathology of PBC mice in the treatment group showed reduced inflammation and a decreased total pathology score,and the difference in the scores was statistically significant(4.50±2.88 vs 1.75±1.28,P<0.05).CONCLUSION ImmTOR can improve biochemistry and pathology of liver obvious by inhibiting the expression of CD8+T cells and B cells,and reducing the titer of AMA.展开更多
The preparation of immobilized enzyme with excellent performance is one of the difficulties that restrict the application of enzyme catalysis technology.Here,Candida rugosa lipase(CRL)was firstly adsorbed on the surfa...The preparation of immobilized enzyme with excellent performance is one of the difficulties that restrict the application of enzyme catalysis technology.Here,Candida rugosa lipase(CRL)was firstly adsorbed on the surface of magnetic zeolitic imidazolate framework-8(ZIF-8)nanospheres,which was further encapsulated with a mesoporous SiO_(2)nano-membrane formed by tetraethyl orthosilicate(TEOS)polycondensation.Consequently,lipase could be firmly immobilized on carrier surface by physical binding rather than chemical binding,which did not damage the active conformation of enzyme.There were mesopores on the silica nano-membrane,which could improve the accessibility of enzyme and its apparent catalytic activity.Moreover,silica membrane encapsulation could also improve the stability of enzyme,suggesting an effective enzyme immobilization strategy.It showed that TEOS amount and the encapsulation time had significant effects on the thickness of silica membrane and the enzyme activity.The analysis in enzyme activity and protein secondary structure showed that lipase encapsulated in silica membrane retained the active conformation to the greatest extent.Compared with the adsorbed lipase,the encapsulated lipase increased its thermostability by 3 times and resistance to chemical denaturants by 7 times.The relative enzyme activity remained around 80%after 8 repetitions,while the adsorbed lipase only remained at7.3%.展开更多
Utilizing data from 5,481 village-level service stations(VS)in Baoding,China,this study empirically investigates the impact of digital inclusive finance(DIF)and VS infrastructure on rural e-commerce(RE)development.Res...Utilizing data from 5,481 village-level service stations(VS)in Baoding,China,this study empirically investigates the impact of digital inclusive finance(DIF)and VS infrastructure on rural e-commerce(RE)development.Results demonstrate that DIF significantly promotes RE by reducing transaction and financing costs(β=0.783,P<0.01).VS as physical infrastructure significantly drives RE growth(β=0.654,P<0.01).Crucially,DIF and VS exhibit synergistic effects(interactionβ=0.421,P<0.01),producing a“1+1>2”enhancement.Regional economic development,population density,and education levels positively influence RE.Current challenges include financial misallocation,infrastructure deficits,and skill gaps.We propose a“One Core,Three Wings”framework—Core:Develop tailored financial products for specialty industries(luggage,textiles,mushrooms);Wings:(1)Upgrade digital infrastructure,(2)Optimize policy synergy,(3)Enhance inclusive capacity through elderly-friendly technologies and training.Implementation strategies include establishing risk-sharing mechanisms,expanding VS functionality,and creating DIF-RE-VS alliances to foster sustainable rural revitalization.展开更多
Objective:To explore the effect of comprehensive nursing on relieving psychological pressure in patients with pulmonary micro-nodules.Methods:One hundred and twenty patients with pulmonary micro-nodules who received d...Objective:To explore the effect of comprehensive nursing on relieving psychological pressure in patients with pulmonary micro-nodules.Methods:One hundred and twenty patients with pulmonary micro-nodules who received diagnosis and treatment in our hospital from January 2024 to December 2024 were randomly divided into control and observation groups.The control group received routine nursing,while the observation group received comprehensive nursing.The Self-Rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)were used to evaluate the patients’psychological states before and after nursing.Patient satisfaction with nursing was analyzed using a nursing satisfaction survey scale.Results:After nursing,the SAS and SDS scores of the observation group were significantly lower than those of the control group(P<0.05).The nursing satisfaction rates of the observation and control groups were 98.33%and 83.33%,respectively,with statistically significant differences(P<0.05).Conclusion:Comprehensive nursing intervention for patients with pulmonary micro-nodules can effectively relieve their psychological pressure and improve nursing satisfaction,demonstrating clinical value.展开更多
BACKGROUND The efficacy of laparoscopic surgery for the treatment of T3-T4a colon cancer remains a subject of debate in the medical community.AIM To explore the surgical techniques,perioperative outcomes,follow-up res...BACKGROUND The efficacy of laparoscopic surgery for the treatment of T3-T4a colon cancer remains a subject of debate in the medical community.AIM To explore the surgical techniques,perioperative outcomes,follow-up results,patient prognosis,and survival status associated with laparoscopic surgery for T3-T4a colon cancer.METHODS A total of 202 patients with T3-T4a colon cancer treated at the Affiliated Hospital of Hebei University between January 2020 and December 2024 were selected for this study and divided into two groups based on the type of surgery:Open surgery group(101 cases)and laparoscopic surgery group(LAP group,101 cases).Perioperative indicators(surgical time,postoperative drainage,first flatus,hospital stay,intraoperative blood loss,and number of lymph nodes removed),disease-free survival,and overall survival at 1-year and 3-year follow-ups,as well as the incidence of complications,were compared between the two groups.RESULTS The LAP group had longer surgical times and a greater number of lymph nodes removed compared to the open surgery group(P<0.05).The LAP group also had less blood loss,shorter drainage time,faster time to flatus,and a lower incidence of complications compared to the open surgery group(P<0.05).There was no significant difference in hospital stay,disease-free survival,or overall survival between the two groups during the follow-up period,and this remained true even after adjusting for subgroups based on left-sided colon,right-sided colon,and T4a stage(P>0.05).CONCLUSION The long-term outcomes of laparoscopic radical surgery for T3-T4a colon cancer are comparable to those of open surgery and can accelerate patient recovery and reduce the risk of short-term complications,offering better immediate outcomes.展开更多
As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utili...As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.展开更多
As the core department in medical institutions responsible for cleaning,disinfecting,sterilizing,and supplying reusable medical devices,instruments,and items,the quality of work in the disinfection supply center direc...As the core department in medical institutions responsible for cleaning,disinfecting,sterilizing,and supplying reusable medical devices,instruments,and items,the quality of work in the disinfection supply center directly impacts medical safety and infection control effectiveness.Professional protective training for personnel is crucial to ensure operational quality in this department.Systematic training enhances staff awareness of occupational exposure risks,standardizes protective measures in procedures,reduces cross-infection risks caused by improper operations,and ultimately lowers infection transmission risks.This paper analyzes the core content,implementation approaches,and practical role of professional protective training for disinfection supply center personnel in infection control.It aims to clarify the significant value of such training,providing references for medical institutions to optimize disinfection center management and strengthen infection control systems,thereby contributing to improved overall medical safety standards.展开更多
Manganese dioxide is widely used as a cathode material in aqueous zinc-ion batteries,and the cathode material is a key factor limiting the performance of these batteries.In this study,β-manganese dioxide was used as ...Manganese dioxide is widely used as a cathode material in aqueous zinc-ion batteries,and the cathode material is a key factor limiting the performance of these batteries.In this study,β-manganese dioxide was used as the base material to synthesize two hybrid materials,i.e.manganese dioxide-3D graphene carbon nanotube hybrids(MnO_(2)@3D-GPE/CNT)and manganese dioxide-3D-graphene hybrids(MnO_(2)@3D-GPE),via intermittent highenergy vibration ball milling.Electrochemical tests revealed that the CNT-containing hybrid materials exhibited a higher specific capacity of 480 mAh g^(-1)and superior cycling stability,maintaining over 80%of its initial capacity after 1000 cycles at 500 mA g^(-1)with a Coulombic efficiency close to 100%.MnO_(2)@3D-GPE/CNT had a smaller particle size distribution and a larger specific surface area than MnO_(2)@3D-GPE,explaining its enhanced electrochemical performance.Additionally,MnO_(2)@3D-GPE/CNT exhibited lower electrode impedance,further supporting its efficacy as a cathode material.展开更多
Hyaline Membrane Disease(HMD)in newborns,also known as neonatal respiratory distress syndrome,is a common critical illness in premature infants,with an incidence inversely correlated with gestational age,posing a seri...Hyaline Membrane Disease(HMD)in newborns,also known as neonatal respiratory distress syndrome,is a common critical illness in premature infants,with an incidence inversely correlated with gestational age,posing a serious threat to the life and health of newborns.This paper systematically reviews the core pathogenesis of HMD,focusing on the abnormal metabolism of pulmonary surfactant(PS),genetic factors,immature lung development,and the synergistic effects of inflammatory oxidative stress.It highlights the advances in non-invasive ventilation(NIV)therapy for HMD,including the mechanisms of action,clinical application effects,and optimization strategies of mainstream modalities such as nasal continuous positive airway pressure ventilation(NCPAP),nasal intermittent positive pressure ventilation(NIPPV),and heated humidified high-flow nasal cannula ventilation(HHHFNC).The aim is to provide references for standardized clinical treatment.展开更多
Objective:This study investigates the preventive and therapeutic effects of medical radiation protection spray(Bergmann)compared to triethanolamine cream in patients undergoing radiotherapy following breast cancer sur...Objective:This study investigates the preventive and therapeutic effects of medical radiation protection spray(Bergmann)compared to triethanolamine cream in patients undergoing radiotherapy following breast cancer surgery.Methods:Ninety patients with breast cancer who received postoperative radiotherapy between July 2018 and July 2021 were randomly divided into the Bergmann treatment(experimental)group and the triethanolamine cream treatment(control)group,with 45 patients in each group.Radiodermatitis severity was assessed using the RTOG radiodermatitis grading standards.Results:The radiation dose required to develop grade I radiodermatitis was significantly higher in the experimental group compared to the control group,at(36.13±1.17 Gy)and(25.38±0.63 Gy),respectively.At a radiation dose of 30 Gy,the proportion of grade I radiodermatitis cases in the experimental group was significantly lower than in the control group(P=0.002).At radiation doses of 40 Gy and 50 Gy,the proportion of grade II radiodermatitis cases in the experimental group was also significantly lower than in the control group(P<0.001).No cases of grade III or higher radiodermatitis were observed in the experimental group,while three cases of grade III radiodermatitis occurred in the control group,although the difference was not statistically significant.No patients in the experimental group discontinued treatment due to radiodermatitis or mucosal reactions,whereas two patients in the control group interrupted treatment due to these reactions but eventually completed therapy.Conclusion:Bergmann spray effectively prevents radiodermatitis in patients undergoing radiotherapy after breast cancer surgery and is more effective than triethanolamine cream in treating skin lesions.Its ease of use improves the quality of life for patients undergoing radiotherapy and ensures successful treatment completion.Bergmann is suitable for clinical promotion and application.展开更多
Microneedles(MNs)are an innovative and viable option for drug delivery that offer the distinct advantages of minimal invasiveness,painlessness,stable drug loading,efficient drug permeation,and biocompatibility.MNs wer...Microneedles(MNs)are an innovative and viable option for drug delivery that offer the distinct advantages of minimal invasiveness,painlessness,stable drug loading,efficient drug permeation,and biocompatibility.MNs were first used to penetrate the skin surface and facilitate transcutaneous drug delivery with great success.Recent applications of MNs have extended to non-transdermal drug delivery,specifically,to various tissues and organs.This review captures the fabrication methods for MNs,discusses advanced design strategies for achieving controlled drug release,and summarizes current MN applications in delivering multiple therapeutic agents to the cardiovascular,digestive(e.g.,oral cavity),reproductive,and central nervous systems.The findings in this review would contribute toward the improved designs of MN systems that can be modified according to purpose,including material selection,structural design,choice of fabrication methods,and tissue considerations,to determine the optimal therapeutic regimen for the target treatment area.展开更多
基金Baoding Science and Technology Plan Project(Project No.:2341ZF214)。
文摘Objective:To investigate the quantitative assessment efficacy of chest CT combined with serum Vanin-1 and SPP1 in determining the progression stage of chronic obstructive pulmonary disease(COPD).Methods:A total of 100 COPD subjects from our hospital from January 2020 to December 2023 were included and randomly divided into a healthy control group and an experimental group(50 cases each).The healthy control group underwent slow vital capacity measurement using a spirometer,while the experimental group underwent high-resolution thin-slice CT scans and serum Vanin-1 and SPP1 concentration measurements.Pulmonary function parameters,symptom burden,biomarker concentrations,and imaging characteristics were compared between the two groups.Results:The FEV1/FVC ratio in the experimental group(58.3±7.2)was lower than that in the healthy control group(92.1±4.8);the total CAT score(22.4±3.5)was higher than that in the healthy control group(3.1±1.2);both Vanin-1(18.7±2.3μg/L)and SPP1(25.6±4.1μg/L)levels were higher than those in the healthy control group;LAA%-950(38.7±6.2%)and WA%(68.5±5.3%)were significantly higher than those in the healthy control group(all p<0.001).Conclusion:Chest CT combined with serum Vanin-1 and SPP1 can accurately quantify the pathological progression of COPD,providing a dual basis for clinical staging and individualized intervention.
基金supported by Hebei Natural Science Foundation(No.JZX2023018)Hebei Natural Science Foundation(No.C2022201042)the 100 Foreign Experts Plans of Hebei Province(No.606080123001).
文摘Antibiotics are widespread in aquatic environments due to their extensive use in human healthcare and ani-mal husbandry.However,research on the occurrence and bioaccumulation of antibiotics in aquatic organisms within shallow wetland lakes remains limited.This study investigated the occurrence and bioaccumulation of ten commonly used antibiotics in the Baiyang Lake,northern China’s largest shallow wetland lake.The results indicated that sulfonamides and fluoroquinolones were the predominant antibiotics in surface water,whereas fluoroquinolones and macrolides were more prevalent in sediment.Fluoroquinolones demonstrated significant potential for bioaccumulation in targeted aquatic organisms,including both animals and plants(Carassius au-ratus and Phragmites australis).The bioaccumulation of antibiotics in Carassius auratus was correlated with their solubility,whereas in Phragmites australis,this was associated with their octanol-water partition coefficients and molecular weights.Ecological risk assessment indicated that most antibiotics posed minimal to low risk levels.However,four antibiotics were exceptions:clarithromycin(12.5%)and sulfamethoxazole(6.25%)presented a high risk in surface water samples,while norfloxacin(25.0%)and ciprofloxacin(25.0%)posed a high risk in sediment samples.Norfloxacin,ciprofloxacin,and roxithromycin were identified as key indicator antibiotics for enhancing the local monitoring and control of antibiotic contamination based on four criteria:(1)high con-centrations,(2)frequent detection,(3)capacity for bioaccumulation,and(4)ecological risk levels.This study contributes to a deeper understanding of the status of antibiotic contamination,bioaccumulation characteristics,and ecological risk in Baiyang Lake,thereby supporting efforts to monitor and regulate antibiotic pollution.
文摘Iris domestica,a perennial herb of the Iridaceae family,is widely recognized for its rich isoflavone content and broad therapeutic properties.To elucidate the biosynthetic pathway of these medicinally significant compounds,we constructed a haplotype-resolved genome assembly of this species.Transcriptomic and metabolomic analyses revealed tissue-specific accumulation of isoflavone,particularly in rhizomes and roots.Functional characterization identified two candidate isoflavone synthase genes,among which IdIFS was confirmed to promote the biosynthesis of key compounds tectorigenin and irisflorentin.The high-quality genome assembly presented here provides a foundational resource for further research into the evolution,secondary metabolite,and environmental adaptation of I.domestica.
基金financial y supported by the National Key Research and Development Program of China (2023YFD1900902)the Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (LLSSZ24C030001)+1 种基金the Earmarked Fund for China Agriculture Research System (CARS-08-G-09)sponsored by the K.C.Wong Magna Fund of Ningbo University,China。
文摘Fungi play crucial roles in nutrient acquisition,plant growth promotion,and the enhancement of resistance to both abiotic and biotic stresses.However,studies on the fungal communities associated with peas (Pisum sativum L.) remain limited.In this study,we systematically investigated the ecological effects of host niches (soil,root,stem,leaf,and pod) and genotypes on the diversity and composition of fungal communities in peas using a multi-level approach that encompassed pattern recognition (β-diversity decomposition),mechanism validation (neutral community model testing),and dynamic tracking methods (migration pathway source-tracking).The results revealed that the dominant fungal phyla across niches and genotypes were Ascomycota,Basidiomycota,and Mortierellomycota,and the community structures of the soil–plant continuum were primarily determined by the pea niches rather than genotypes.β-diversity decomposition was largely attributed to species replacement rather than richness differences,indicating strong niche specificity and microbial replacement across microhabitats.Neutral model analysis revealed that stochastic processes influenced genotypeassociated communities,while deterministic processes played a dominant role in niche-based community assembly.Source-tracking analysis identified niche-to-niche fungal migration,with Erysiphe,Fusarium,Cephaliophora,Ascobolus,Alternaria,and Aspergillus as the key genera.Migration rates from exogenous to endogenous niches were low (1.3–61.5%),whereas those within exogenous (64.4–83.7%) or endogenous (73.9–96.4%) compartments were much higher,suggesting that the pea epidermis acts as a selective barrier that filters and enriches microbial communities prior to internal colonization.This study provides comprehensive insights into the mechanisms of host filtering,enrichment and microbial sourcing,which increases our understanding of the assembly rules of the pea-associated fungal microbiome.
基金supported by the National Natural Science Foundation of China(Nos.42430503 and 42271048)the Hebei Natural Science Foundation(No.D2025205003)the Science Foundation of Hebei Normal University(No.L2025B31)。
文摘Non-structural carbohydrates(NSCs)are crucial for tree growth and survival under climatic stress,yet their spatial dynamics across broad climate gradients remain unclear.Pines(Pinus spp.),one of the most widely distributed tree genera worldwide,provide an ideal system for investigating large-scale spatial patterns of NSC within a single genus along extensive climatic gradients.Here,we compiled a global NSC database for pines across 74 sites,and assessed the spatial variation in total NSC,starch(St),and soluble sugars(SS)concentrations in stem sapwood,the primary reserve tissue,along site-specific mean annual temperature(MAT)and precipitation(MAP).Our results show that MAP exerted a stronger influence(R^(2)=20%–47%)on the spatial variation in total NSC and its components than did MAT(R^(2)=6%–16%).Tota concentrations declined nonlinearly with increasing MAP,with the rate of decline slowing beyond approximately 800 mm.While MAT had weaker effects on total NSC concentrations,both MAT and MAP jointly regulated NSC partitioning:Higher MAT and MAP were associated with reduced St concentrations but elevated SS concentrations and SS:St ratios.These findings suggest that pine species in cold and arid environments prioritize storing NSC as St,whereas in relatively warm and humid environments,NSC are preferentially mobilized into SS to support immediate metabolic and growth demands.
文摘In the context of power generation companies, vast amounts of specialized data and expert knowledge have been accumulated. However, challenges such as data silos and fragmented knowledge hinder the effective utilization of this information. This study proposes a novel framework for intelligent Question-and-Answer (Q&A) systems based on Retrieval-Augmented Generation (RAG) to address these issues. The system efficiently acquires domain-specific knowledge by leveraging external databases, including Relational Databases (RDBs) and graph databases, without additional fine-tuning for Large Language Models (LLMs). Crucially, the framework integrates a Dynamic Knowledge Base Updating Mechanism (DKBUM) and a Weighted Context-Aware Similarity (WCAS) method to enhance retrieval accuracy and mitigate inherent limitations of LLMs, such as hallucinations and lack of specialization. Additionally, the proposed DKBUM dynamically adjusts knowledge weights within the database, ensuring that the most recent and relevant information is utilized, while WCAS refines the alignment between queries and knowledge items by enhanced context understanding. Experimental validation demonstrates that the system can generate timely, accurate, and context-sensitive responses, making it a robust solution for managing complex business logic in specialized industries.
基金financially supported by the National Natural Science Foundation of China(52102233)Science and Technology Project of Hebei Education Department(QN2023019)。
文摘Aqueous aluminum ion batteries(AAIBs)have garnered extensive attention due to their environmental friendliness,high theoretical capacity,and low cost.However,the sluggish reaction kinetics and severe structural collapse of the cathode material,especially manganese oxide,during the cycling process have hindered its further application.Herein,Cu^(2+)pre-interca la ted layeredδ-MnO_(2)was synthesized via a hydrothermal method.The pre-intercalated Cu^(2+)ions not only improve the conductivity of MnO_(2)cathode but also stabilize the structure to enhance stability.X-ray absorption fine structure(XAFS)combined with density functional theory(DFT)calculations confirm the formation of the covalent bond between Cu and O,increasing the electronegativity of O atoms and enhancing the H^(+)adsorption energy.Moreover,ex-situ measurements not only elucidate the Al^(3+)/H^(+)co-insertion energy storage mechanism but also demonstrate the high reversibility of the Cu-MnO_(2)cathode during cycling.This work provides a promising modification approach for the application of manganese oxides in AAIBs.
基金funded by the National Natural Science Foundation of China(U23A2063)the Gansu Province Top-notch Leading Talents Project(E339040101)the National Natural Science Foundation of China(41771290,42377043,41773086).
文摘Tenebrionid beetles represent a crucial arthropod taxon in the Gobi desert ecosystems owing to their species richness and high biomass,both of which are essential for maintaining ecosystem health and stability.However,the spatiotemporal variations of tenebrionid beetle assemblages in the Gobi desert remain poorly understood.In this study,the monthly dynamics of tenebrionid beetles in the central part of the Hexi Corridor,Northwest China,a representative area of the Gobi desert ecosystems,were monitored using pitfall trapping during 2015-2020.The following results were showed:(1)monthly activity of tenebrionid beetles was observed from March to October,with monthly activity peaking in spring and summer,and monthly activity periods and peak of tenebrionid beetle species exhibited interspecific differences that varied from year to year;(2)spatial distribution of tenebrionid beetle community was influenced by structural factors.Specifically,at a spatial scale of 24.00 m,tenebrionid beetle community was strongly and positively correlated with the dominant species,with distinct spatial distribution patterns observed for Blaps gobiensis and Microdera kraatzi alashanica;(3)abundance of tenebrionid beetles was positively correlated with monthly mean precipitation and monthly mean temperature,whereas monthly abundance of B.gobiensis and M.kraatzi alashanica was positively correlated with monthly mean precipitation;and(4)the cover of Reaumuria soongarica(Pall.)Maxim.and Nitraria sphaerocarpa Maxim.had a positive influence on the number of tenebrionid beetles captured.In conclusion,monthly variation in precipitation significantly influences the community dynamic of tenebrionid beetles,with precipitation and shrub cover jointly determining the spatial distribution pattern of these beetles in the Gobi desert ecosystems.
基金supported by the Hebei Provincial Key Research and Development Project(21372803D)。
文摘[Objective]To construct an Escherichia coli mutant strain that accumulates pyruvate by genetic modification guided by the genome-scale metabolic network model.[Methods]Using a genome-scale metabolic network model as a guide,we simulated pyruvate production of E.coli,screened key genes in metabolic pathways,and developed gene editing procedures accordingly.We knocked out the acetate kinase gene ackA,phosphate acetyltransferase gene pta,alcohol dehydrogenase adhE,glycogen synthase gene glgA,glycogen phosphorylase gene glgP,phosphoribosyl pyrophosphate(PRPP)synthase gene prs,ribose 1,5-bisphosphate phosphokinase gene phnN,and transporter encoding gene proP.Furthermore,we knocked in the transporter encoding gene ompC,flavonoid toxin gene fldA,and D-serine ammonia lyase gene dsdA.[Results]A shake flask process with the genetically edited mutant strain MG1655-6-2 under anaerobic conditions produced pyruvate at a titer of 10.46 g/L and a yield of 0.69 g/g.Metabolomic analysis revealed a significant increase in the pyruvate level in the fermentation broth,accompanied by notable decreases in the levels of certain related metabolic byproducts.Through 5 L fed-batch fermentation and an adaptive laboratory evolution,the strain finally achieved a pyruvate titer of 45.86 g/L.[Conclusion]This study illustrated the efficacy of a gene editing strategy predicted by a genome-scale metabolic network model in enhancing pyruvate accumulation in E.coli under anaerobic conditions and provided novel insights for microbial metabolic engineering.
基金Supported by Cultivation Project of Hebei Natural Science Foundation-Precision Medicine Joint Fund,No.H2021206239.
文摘BACKGROUND Primary biliary cholangitis(PBC)is a chronic autoimmune-mediated cholestatic liver disease.Nanoparticles encapsulating rapamycin(ImmTOR)suppress adaptive immune responses and induce the hepatic tolerogenic immune response.AIM To investigate the effects of ImmTOR in PBC mouse models.METHODS PBC models were induced in C57BL/6 mice by two immunizations of 2-octynoic acid-coupled bovine serum albumin at two-week intervals,and polycytidylic acid every three days.The PBC mouse models were separated into the treatment group and the control group.The levels of alkaline phosphatase(ALP)and alanine aminotransferase in the mice were detected using an automatic biochemical analyzer.Liver and spleen mononuclear cells were analyzed by flow cytometry,and serum anti-mitochondrial antibodies(AMA)and the related cytokines were analyzed by enzyme-linked immunosorbent assay.Liver histopathology was examined by hematoxylin and eosin staining and scored.RESULTS After treatment with ImmTOR,the ALP level was significantly decreased(189.60 U/L±27.25 U/L vs 156.00 U/L±17.21 U/L,P<0.05),the level of AMA was reduced(1.28 ng/mL±0.27 ng/mL vs 0.56 ng/mL±0.07 ng/mL,P<0.001)and the expression levels of interferon gamma and tumor necrosis factorαwere significantly decreased(48.29 pg/mL±10.84 pg/mL vs 25.01 pg/mL±1.49 pg/mL,P<0.0001)and(84.24 pg/mL±23.47 pg/mL vs 40.66 pg/mL±14.65 pg/mL,P<0.001).The CD4+T lymphocytes,CD8+T lymphocytes and B lymphocytes in the liver were significantly reduced,with statistically significant differences(24.21%±6.55%vs 15.98%±3.03%,P<0.05;9.09%±1.91%vs 5.49%±1.00%,P<0.001;80.51%±2.96%vs 75.31%±4.34%,P<0.05).The expression of CD8+T lymphocytes and B lymphocytes in the ImmTOR treatment group also decreased(9.09%±1.91%vs 5.49%±1.00%,P<0.001;80.51%±2.96%vs 75.31%±4.34%,P<0.05).The liver pathology of PBC mice in the treatment group showed reduced inflammation and a decreased total pathology score,and the difference in the scores was statistically significant(4.50±2.88 vs 1.75±1.28,P<0.05).CONCLUSION ImmTOR can improve biochemistry and pathology of liver obvious by inhibiting the expression of CD8+T cells and B cells,and reducing the titer of AMA.
基金the financial supports from the National Natural Science Foundation of China(Nos.22378093,21878065)Natural Science Foundation of Hebei Province,China(No.E2022201100)+2 种基金the Science and Technology Support Plan of Baoding City(No.2241ZF111)the Medical Science Foundation of Hebei University(No.2021A09)the Foundation of Affiliated Hospital of Hebei University(No.2021Z003)。
文摘The preparation of immobilized enzyme with excellent performance is one of the difficulties that restrict the application of enzyme catalysis technology.Here,Candida rugosa lipase(CRL)was firstly adsorbed on the surface of magnetic zeolitic imidazolate framework-8(ZIF-8)nanospheres,which was further encapsulated with a mesoporous SiO_(2)nano-membrane formed by tetraethyl orthosilicate(TEOS)polycondensation.Consequently,lipase could be firmly immobilized on carrier surface by physical binding rather than chemical binding,which did not damage the active conformation of enzyme.There were mesopores on the silica nano-membrane,which could improve the accessibility of enzyme and its apparent catalytic activity.Moreover,silica membrane encapsulation could also improve the stability of enzyme,suggesting an effective enzyme immobilization strategy.It showed that TEOS amount and the encapsulation time had significant effects on the thickness of silica membrane and the enzyme activity.The analysis in enzyme activity and protein secondary structure showed that lipase encapsulated in silica membrane retained the active conformation to the greatest extent.Compared with the adsorbed lipase,the encapsulated lipase increased its thermostability by 3 times and resistance to chemical denaturants by 7 times.The relative enzyme activity remained around 80%after 8 repetitions,while the adsorbed lipase only remained at7.3%.
文摘Utilizing data from 5,481 village-level service stations(VS)in Baoding,China,this study empirically investigates the impact of digital inclusive finance(DIF)and VS infrastructure on rural e-commerce(RE)development.Results demonstrate that DIF significantly promotes RE by reducing transaction and financing costs(β=0.783,P<0.01).VS as physical infrastructure significantly drives RE growth(β=0.654,P<0.01).Crucially,DIF and VS exhibit synergistic effects(interactionβ=0.421,P<0.01),producing a“1+1>2”enhancement.Regional economic development,population density,and education levels positively influence RE.Current challenges include financial misallocation,infrastructure deficits,and skill gaps.We propose a“One Core,Three Wings”framework—Core:Develop tailored financial products for specialty industries(luggage,textiles,mushrooms);Wings:(1)Upgrade digital infrastructure,(2)Optimize policy synergy,(3)Enhance inclusive capacity through elderly-friendly technologies and training.Implementation strategies include establishing risk-sharing mechanisms,expanding VS functionality,and creating DIF-RE-VS alliances to foster sustainable rural revitalization.
基金Science and Technology Support Program of Baoding City,Hebei Province(Project No.:2241ZF326)。
文摘Objective:To explore the effect of comprehensive nursing on relieving psychological pressure in patients with pulmonary micro-nodules.Methods:One hundred and twenty patients with pulmonary micro-nodules who received diagnosis and treatment in our hospital from January 2024 to December 2024 were randomly divided into control and observation groups.The control group received routine nursing,while the observation group received comprehensive nursing.The Self-Rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)were used to evaluate the patients’psychological states before and after nursing.Patient satisfaction with nursing was analyzed using a nursing satisfaction survey scale.Results:After nursing,the SAS and SDS scores of the observation group were significantly lower than those of the control group(P<0.05).The nursing satisfaction rates of the observation and control groups were 98.33%and 83.33%,respectively,with statistically significant differences(P<0.05).Conclusion:Comprehensive nursing intervention for patients with pulmonary micro-nodules can effectively relieve their psychological pressure and improve nursing satisfaction,demonstrating clinical value.
基金Supported by 2024 Medical Research Program of Hebei Province,No.20240457and 2024 Medically Applicable Technology Track Project of Hebei Province,No.GZ2024099.
文摘BACKGROUND The efficacy of laparoscopic surgery for the treatment of T3-T4a colon cancer remains a subject of debate in the medical community.AIM To explore the surgical techniques,perioperative outcomes,follow-up results,patient prognosis,and survival status associated with laparoscopic surgery for T3-T4a colon cancer.METHODS A total of 202 patients with T3-T4a colon cancer treated at the Affiliated Hospital of Hebei University between January 2020 and December 2024 were selected for this study and divided into two groups based on the type of surgery:Open surgery group(101 cases)and laparoscopic surgery group(LAP group,101 cases).Perioperative indicators(surgical time,postoperative drainage,first flatus,hospital stay,intraoperative blood loss,and number of lymph nodes removed),disease-free survival,and overall survival at 1-year and 3-year follow-ups,as well as the incidence of complications,were compared between the two groups.RESULTS The LAP group had longer surgical times and a greater number of lymph nodes removed compared to the open surgery group(P<0.05).The LAP group also had less blood loss,shorter drainage time,faster time to flatus,and a lower incidence of complications compared to the open surgery group(P<0.05).There was no significant difference in hospital stay,disease-free survival,or overall survival between the two groups during the follow-up period,and this remained true even after adjusting for subgroups based on left-sided colon,right-sided colon,and T4a stage(P>0.05).CONCLUSION The long-term outcomes of laparoscopic radical surgery for T3-T4a colon cancer are comparable to those of open surgery and can accelerate patient recovery and reduce the risk of short-term complications,offering better immediate outcomes.
文摘As the cornerstone of sterile instrument maintenance in endoscopy centers,the quality of endoscope cleaning directly impacts hospital infection control effectiveness.The traceability system for endoscopy centers utilizes digital means to document the entire cleaning process,enabling real-time monitoring and precise quality control.This paper analyzes current quality control practices in endoscope cleaning and addresses existing challenges.It explores how traceability systems standardize procedures,enhance monitoring,and improve management efficiency.The study proposes optimization strategies for traceability system implementation,clarifying its core value in endoscope cleaning quality control.These findings provide theoretical foundations and practical guidance for hospitals to refine management of endoscopy centers,ensure diagnostic safety,and reduce infection risks,ultimately advancing endoscope cleaning quality control toward standardized and informatized development.
文摘As the core department in medical institutions responsible for cleaning,disinfecting,sterilizing,and supplying reusable medical devices,instruments,and items,the quality of work in the disinfection supply center directly impacts medical safety and infection control effectiveness.Professional protective training for personnel is crucial to ensure operational quality in this department.Systematic training enhances staff awareness of occupational exposure risks,standardizes protective measures in procedures,reduces cross-infection risks caused by improper operations,and ultimately lowers infection transmission risks.This paper analyzes the core content,implementation approaches,and practical role of professional protective training for disinfection supply center personnel in infection control.It aims to clarify the significant value of such training,providing references for medical institutions to optimize disinfection center management and strengthen infection control systems,thereby contributing to improved overall medical safety standards.
基金2024 Hebei College students Innovation and Entrepreneurship Training Program project(S202410075065)2025 Hebei College students Innovation and Entrepreneurship Training Program project(DC2005444)Horizontal project 20230048,20230049.
文摘Manganese dioxide is widely used as a cathode material in aqueous zinc-ion batteries,and the cathode material is a key factor limiting the performance of these batteries.In this study,β-manganese dioxide was used as the base material to synthesize two hybrid materials,i.e.manganese dioxide-3D graphene carbon nanotube hybrids(MnO_(2)@3D-GPE/CNT)and manganese dioxide-3D-graphene hybrids(MnO_(2)@3D-GPE),via intermittent highenergy vibration ball milling.Electrochemical tests revealed that the CNT-containing hybrid materials exhibited a higher specific capacity of 480 mAh g^(-1)and superior cycling stability,maintaining over 80%of its initial capacity after 1000 cycles at 500 mA g^(-1)with a Coulombic efficiency close to 100%.MnO_(2)@3D-GPE/CNT had a smaller particle size distribution and a larger specific surface area than MnO_(2)@3D-GPE,explaining its enhanced electrochemical performance.Additionally,MnO_(2)@3D-GPE/CNT exhibited lower electrode impedance,further supporting its efficacy as a cathode material.
文摘Hyaline Membrane Disease(HMD)in newborns,also known as neonatal respiratory distress syndrome,is a common critical illness in premature infants,with an incidence inversely correlated with gestational age,posing a serious threat to the life and health of newborns.This paper systematically reviews the core pathogenesis of HMD,focusing on the abnormal metabolism of pulmonary surfactant(PS),genetic factors,immature lung development,and the synergistic effects of inflammatory oxidative stress.It highlights the advances in non-invasive ventilation(NIV)therapy for HMD,including the mechanisms of action,clinical application effects,and optimization strategies of mainstream modalities such as nasal continuous positive airway pressure ventilation(NCPAP),nasal intermittent positive pressure ventilation(NIPPV),and heated humidified high-flow nasal cannula ventilation(HHHFNC).The aim is to provide references for standardized clinical treatment.
基金supported by the Baoding City Self-Financed Fund Project(Project No.2241ZF339).
文摘Objective:This study investigates the preventive and therapeutic effects of medical radiation protection spray(Bergmann)compared to triethanolamine cream in patients undergoing radiotherapy following breast cancer surgery.Methods:Ninety patients with breast cancer who received postoperative radiotherapy between July 2018 and July 2021 were randomly divided into the Bergmann treatment(experimental)group and the triethanolamine cream treatment(control)group,with 45 patients in each group.Radiodermatitis severity was assessed using the RTOG radiodermatitis grading standards.Results:The radiation dose required to develop grade I radiodermatitis was significantly higher in the experimental group compared to the control group,at(36.13±1.17 Gy)and(25.38±0.63 Gy),respectively.At a radiation dose of 30 Gy,the proportion of grade I radiodermatitis cases in the experimental group was significantly lower than in the control group(P=0.002).At radiation doses of 40 Gy and 50 Gy,the proportion of grade II radiodermatitis cases in the experimental group was also significantly lower than in the control group(P<0.001).No cases of grade III or higher radiodermatitis were observed in the experimental group,while three cases of grade III radiodermatitis occurred in the control group,although the difference was not statistically significant.No patients in the experimental group discontinued treatment due to radiodermatitis or mucosal reactions,whereas two patients in the control group interrupted treatment due to these reactions but eventually completed therapy.Conclusion:Bergmann spray effectively prevents radiodermatitis in patients undergoing radiotherapy after breast cancer surgery and is more effective than triethanolamine cream in treating skin lesions.Its ease of use improves the quality of life for patients undergoing radiotherapy and ensures successful treatment completion.Bergmann is suitable for clinical promotion and application.
基金financial support from the Beijing Natural Science Foundation(No.L234020)the National Natural Science Foundation of China(Nos.12472325 and 12272032)the 111 Project(No.B13003).
文摘Microneedles(MNs)are an innovative and viable option for drug delivery that offer the distinct advantages of minimal invasiveness,painlessness,stable drug loading,efficient drug permeation,and biocompatibility.MNs were first used to penetrate the skin surface and facilitate transcutaneous drug delivery with great success.Recent applications of MNs have extended to non-transdermal drug delivery,specifically,to various tissues and organs.This review captures the fabrication methods for MNs,discusses advanced design strategies for achieving controlled drug release,and summarizes current MN applications in delivering multiple therapeutic agents to the cardiovascular,digestive(e.g.,oral cavity),reproductive,and central nervous systems.The findings in this review would contribute toward the improved designs of MN systems that can be modified according to purpose,including material selection,structural design,choice of fabrication methods,and tissue considerations,to determine the optimal therapeutic regimen for the target treatment area.
