The effects of administering similar doses of some simple alkylating agents to rats by different regimens have been compared.Two of the compounds were methylating agents,nitrosodimeth- ylamine and azoxymethane;two wer...The effects of administering similar doses of some simple alkylating agents to rats by different regimens have been compared.Two of the compounds were methylating agents,nitrosodimeth- ylamine and azoxymethane;two were ethylating agents,nitrosodiethylamine and azoxyethane and nitrosomethylethylamine was both a methylating and an ethylating agent.The treatments gave rise to tumors in almost all treated rats.The results indicate the importance ofpharmacoki- netics in determining which organs are the targets of the alkylating carcinogens.1989 Academic Press.Inc.展开更多
The carcinogenic effects of a number of alkylnitrosoureas in Syrian golden hamsters have been compared by administering them by gavage as solutions in corn oil/ethyl acetate.The compounds were methyl-,ethyl-,2-hydroxy...The carcinogenic effects of a number of alkylnitrosoureas in Syrian golden hamsters have been compared by administering them by gavage as solutions in corn oil/ethyl acetate.The compounds were methyl-,ethyl-,2-hydroxyethyl-,2-oxopropyl-,and 2-phenylethylnitrosourea and the dialkylnitrosoureas dimethyl- and diethylnitrosourea,ethylnitrosohydroxyethylurea, ethylnitroso-2-oxopropylurea,2-oxopropylnitrosochloroethylurea,and hydroxyethylnitroso- ethylurea.All were given at approximately equimolar doses and,in most cases,to male and female hamsters.Most of the hamsters died with tumors associated with the treatments.Methyl- nitrosourea,ethylnitrosourea,and hydroxyethylnitrosourea,but not oxopropylnitrosourea, gave rise to a high incidence of tumors of the forestomach,while the dialkylnitrosoureas pro- duced smaller numbers of forestomach tumors.All of the alkylnitrosoureas induced hemangio- sarcomas of the spleen,which was the most common tumor produced by these carcinogens. Tumors of other types were uncommon,except that ethylnitrosourea and ethylnitrosohydroxy- ethylurea induced tumors of the cervix in about half of the animals and ethylnitrosooxopropyl- urea induced some nervous system tumors.The small number of common target organs of alkylnitrosoureas in hamsters contrasted sharply with the broad spectrum of tumors they in- duced in rats,depending on the nature of the alkyl groups,and with a quite different order of potency in the latter species,1989 Academic Press.Inc.展开更多
文摘The effects of administering similar doses of some simple alkylating agents to rats by different regimens have been compared.Two of the compounds were methylating agents,nitrosodimeth- ylamine and azoxymethane;two were ethylating agents,nitrosodiethylamine and azoxyethane and nitrosomethylethylamine was both a methylating and an ethylating agent.The treatments gave rise to tumors in almost all treated rats.The results indicate the importance ofpharmacoki- netics in determining which organs are the targets of the alkylating carcinogens.1989 Academic Press.Inc.
文摘The carcinogenic effects of a number of alkylnitrosoureas in Syrian golden hamsters have been compared by administering them by gavage as solutions in corn oil/ethyl acetate.The compounds were methyl-,ethyl-,2-hydroxyethyl-,2-oxopropyl-,and 2-phenylethylnitrosourea and the dialkylnitrosoureas dimethyl- and diethylnitrosourea,ethylnitrosohydroxyethylurea, ethylnitroso-2-oxopropylurea,2-oxopropylnitrosochloroethylurea,and hydroxyethylnitroso- ethylurea.All were given at approximately equimolar doses and,in most cases,to male and female hamsters.Most of the hamsters died with tumors associated with the treatments.Methyl- nitrosourea,ethylnitrosourea,and hydroxyethylnitrosourea,but not oxopropylnitrosourea, gave rise to a high incidence of tumors of the forestomach,while the dialkylnitrosoureas pro- duced smaller numbers of forestomach tumors.All of the alkylnitrosoureas induced hemangio- sarcomas of the spleen,which was the most common tumor produced by these carcinogens. Tumors of other types were uncommon,except that ethylnitrosourea and ethylnitrosohydroxy- ethylurea induced tumors of the cervix in about half of the animals and ethylnitrosooxopropyl- urea induced some nervous system tumors.The small number of common target organs of alkylnitrosoureas in hamsters contrasted sharply with the broad spectrum of tumors they in- duced in rats,depending on the nature of the alkyl groups,and with a quite different order of potency in the latter species,1989 Academic Press.Inc.
