Ribosomopathies encompass a spectrum of disorders arising from impaired ribosome biogenesis and reduced functionality.Mutation or dysexpression of the genes that disturb any finely regulated steps of ribosome biogenes...Ribosomopathies encompass a spectrum of disorders arising from impaired ribosome biogenesis and reduced functionality.Mutation or dysexpression of the genes that disturb any finely regulated steps of ribosome biogenesis can result in different types of ribosomopathies in clinic,collectively known as ribosomopathy genes.Emerging data suggest that ribosomopathy patients exhibit a significantly heightened susceptibility to cancer.Abnormal ribosome biogenesis and dysregulation of some ribosomopathy genes have also been found to be intimately associated with cancer development.The correlation between ribosome biogenesis or ribosomopathy and the development of malignancies has been well established.This work aims to review the recent advances in the research of ribosomopathy genes among human cancers and meanwhile,to excavate the potential role of these genes,which have not or rarely been reported in cancer,in the disease development across cancers.We plan to establish a theoretical framework between the ribosomopathy gene and cancer development,to further facilitate the potential of these genes as diagnostic biomarker as well as pharmaceutical targets for cancer treatment.展开更多
T ertiary lymphoid organs(TLOs)are structures that resemble lymph nodes that can be found in chronically inflamed tissues in a number of inflammatory conditions.TLOs can host ongoing immune responses that can potentia...T ertiary lymphoid organs(TLOs)are structures that resemble lymph nodes that can be found in chronically inflamed tissues in a number of inflammatory conditions.TLOs can host ongoing immune responses that can potentially contribute to disease pathogenesis.The development of TLOs has been thought in large part to recapitulate the development of secondary lymphoid organs,but the regulation of TLO development has not been well understood.In a recent article in Nature Immunology,Troy Randall and colleagues1 identify IL-17,a cytokine that contributes to the pathogenesis of a number of inflammatory diseases,as a novel critical player in TLO formation in inflamed lungs.TLOs can be found in the joints of patients with rheumatoid arthritis,in the inflamed salivary glands of patients with Sjogren’s syndrome,in the meninges of patients with multiple sclerosis,and in the lungs of patients with pulmonary inflammation or infection.In the lungs,induced bronchus-associated lymphoid tissues(iBALTs)are TLOs that are located along the small airways.展开更多
基金the National Natural Science Foundation of China(Grant No.:82360542)Jiangxi Provincial Natural Science Foundation,China(Grant Nos.:20224BAB214030 and 20224BAB216072)+2 种基金Doctoral Startup Fund of Gannan Medical University,China(Grant Nos.:QD202136 and QD202132)Science and Technology Planning Projects of Fuzhou,China(Grant No.:2021FZR0101)the Natural Science Foundation of Fujian Province,China(Grant No.:2022YZ0104).
文摘Ribosomopathies encompass a spectrum of disorders arising from impaired ribosome biogenesis and reduced functionality.Mutation or dysexpression of the genes that disturb any finely regulated steps of ribosome biogenesis can result in different types of ribosomopathies in clinic,collectively known as ribosomopathy genes.Emerging data suggest that ribosomopathy patients exhibit a significantly heightened susceptibility to cancer.Abnormal ribosome biogenesis and dysregulation of some ribosomopathy genes have also been found to be intimately associated with cancer development.The correlation between ribosome biogenesis or ribosomopathy and the development of malignancies has been well established.This work aims to review the recent advances in the research of ribosomopathy genes among human cancers and meanwhile,to excavate the potential role of these genes,which have not or rarely been reported in cancer,in the disease development across cancers.We plan to establish a theoretical framework between the ribosomopathy gene and cancer development,to further facilitate the potential of these genes as diagnostic biomarker as well as pharmaceutical targets for cancer treatment.
文摘T ertiary lymphoid organs(TLOs)are structures that resemble lymph nodes that can be found in chronically inflamed tissues in a number of inflammatory conditions.TLOs can host ongoing immune responses that can potentially contribute to disease pathogenesis.The development of TLOs has been thought in large part to recapitulate the development of secondary lymphoid organs,but the regulation of TLO development has not been well understood.In a recent article in Nature Immunology,Troy Randall and colleagues1 identify IL-17,a cytokine that contributes to the pathogenesis of a number of inflammatory diseases,as a novel critical player in TLO formation in inflamed lungs.TLOs can be found in the joints of patients with rheumatoid arthritis,in the inflamed salivary glands of patients with Sjogren’s syndrome,in the meninges of patients with multiple sclerosis,and in the lungs of patients with pulmonary inflammation or infection.In the lungs,induced bronchus-associated lymphoid tissues(iBALTs)are TLOs that are located along the small airways.
