The global mining industry,particularly deep high-stress hard-rock mining,confronts prominent challenges of massive energy consumption and low crushing/grinding efficiency.Optimized blasting,as an alternative to grind...The global mining industry,particularly deep high-stress hard-rock mining,confronts prominent challenges of massive energy consumption and low crushing/grinding efficiency.Optimized blasting,as an alternative to grinding,effectively reduces energy usage and improves transportation efficiency.Despite extensive research on the effects of confining stress to cut blasting,studies focusing on fragmentation characteristics of deep confined blasting remain scarce.This study integrates theoretical analysis,similarity model tests,and SPH-FEM simulations to investigate fragmentation size distribution and energy dissipation under varying confining stresses.Results show that the Swebrec(SWE)function achieves superior fitting to fragmentation data(goodness-offit>0.95).With increasing confining stress,the fractal dimension of specimens increases(ranging from 2.16 to 2.42 in model tests),while fragmentation energy decreases—55.23% lower under high confining stress than no confining stress in tests,and 50.61%lower at 40 MPa than 0 MPa in simulations.The ratio of fragmentation energy to blasting energy is 2%-10%.Distinct from previous studies emphasizing confining stress macroeffects on cut blasting,this work explores fragmentation distribution functions and energy under biaxial confining stress,providing valuable insights for blasting efficiency evaluation and promoting energy conservation and emission reduction in post-mineral processing.展开更多
目的系统评价吡咯替尼联用卡培他滨(Pyr-Cap)与奈拉替尼联用卡培他滨(Ner-Cap)、拉帕替尼联用卡培他滨(Lap-Cap)、恩美曲妥珠单抗(T-DM1)治疗人表皮生长因子受体2(HER2)阳性晚期乳腺癌的有效性和安全性。方法计算机检索PubMed、EMbase、...目的系统评价吡咯替尼联用卡培他滨(Pyr-Cap)与奈拉替尼联用卡培他滨(Ner-Cap)、拉帕替尼联用卡培他滨(Lap-Cap)、恩美曲妥珠单抗(T-DM1)治疗人表皮生长因子受体2(HER2)阳性晚期乳腺癌的有效性和安全性。方法计算机检索PubMed、EMbase、Cochrane Library、Web of Science、中国知网、万方、维普网等数据库,检索Pyr-Cap、Ner-Cap、Lap-Cap、TDM-1、Cap治疗HER2阳性晚期乳腺癌的随机对照试验(RCT),检索时间自2005年1月1日至2024年12月31日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用R软件进行网状Meta分析。结果共纳入6项RCT研究。按概率累积排序曲线下面积排序,在无进展生存期和客观缓解率方面,Pyr-Cap方案最优;在总生存期方面,T-DM1方案和Pyr-Cap方案排名前两位;安全性方面,Pyr-Cap方案出现了3级及以上不良事件的可能性最高,主要为腹泻,但总体可控。结论当前证据显示,Pyr-Cap方案治疗HER2阳性晚期乳腺癌可能具有较好的有效性和安全性。展开更多
基金supported by the Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology(No.2024yjrc71)State Key Laboratory of Precision Blasting,Jianghan University(No.PBSKL25B15)+2 种基金Foundation of Anhui Engineering Research Center of New Explosive Materials and Blasting Technology(No.AHBP2024B11)National Natural Science Foundation of China(No.52208384)Auhui Provincial Key Laboratory of Urban Rail Transit Safety and Emergency Management,Hefei University(No.2024GD003)。
文摘The global mining industry,particularly deep high-stress hard-rock mining,confronts prominent challenges of massive energy consumption and low crushing/grinding efficiency.Optimized blasting,as an alternative to grinding,effectively reduces energy usage and improves transportation efficiency.Despite extensive research on the effects of confining stress to cut blasting,studies focusing on fragmentation characteristics of deep confined blasting remain scarce.This study integrates theoretical analysis,similarity model tests,and SPH-FEM simulations to investigate fragmentation size distribution and energy dissipation under varying confining stresses.Results show that the Swebrec(SWE)function achieves superior fitting to fragmentation data(goodness-offit>0.95).With increasing confining stress,the fractal dimension of specimens increases(ranging from 2.16 to 2.42 in model tests),while fragmentation energy decreases—55.23% lower under high confining stress than no confining stress in tests,and 50.61%lower at 40 MPa than 0 MPa in simulations.The ratio of fragmentation energy to blasting energy is 2%-10%.Distinct from previous studies emphasizing confining stress macroeffects on cut blasting,this work explores fragmentation distribution functions and energy under biaxial confining stress,providing valuable insights for blasting efficiency evaluation and promoting energy conservation and emission reduction in post-mineral processing.
文摘目的系统评价吡咯替尼联用卡培他滨(Pyr-Cap)与奈拉替尼联用卡培他滨(Ner-Cap)、拉帕替尼联用卡培他滨(Lap-Cap)、恩美曲妥珠单抗(T-DM1)治疗人表皮生长因子受体2(HER2)阳性晚期乳腺癌的有效性和安全性。方法计算机检索PubMed、EMbase、Cochrane Library、Web of Science、中国知网、万方、维普网等数据库,检索Pyr-Cap、Ner-Cap、Lap-Cap、TDM-1、Cap治疗HER2阳性晚期乳腺癌的随机对照试验(RCT),检索时间自2005年1月1日至2024年12月31日。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用R软件进行网状Meta分析。结果共纳入6项RCT研究。按概率累积排序曲线下面积排序,在无进展生存期和客观缓解率方面,Pyr-Cap方案最优;在总生存期方面,T-DM1方案和Pyr-Cap方案排名前两位;安全性方面,Pyr-Cap方案出现了3级及以上不良事件的可能性最高,主要为腹泻,但总体可控。结论当前证据显示,Pyr-Cap方案治疗HER2阳性晚期乳腺癌可能具有较好的有效性和安全性。
