Objectives(1) Review the etiology of cardiac arrest in children to identify the rationale for medication interventions.(2) Review the phases of cardiac arrest and early resuscitation as potential targets for medicatio...Objectives(1) Review the etiology of cardiac arrest in children to identify the rationale for medication interventions.(2) Review the phases of cardiac arrest and early resuscitation as potential targets for medication interve-tion.(3) Review the current evidence for or against specific medications during cardiac arrest, and compare datain children with adults.(4) Understand how the timing, duration and intensity of medication intervention may affect resuscitationoutcome.(5) Summarize the relative benefit of mechanical circulation of blood (early, effective and continuous CPR)compared to late medication interventions.(6) Identify several medication strategies on the horizon for treatment of cardiac arrest in children.展开更多
6.1 Vasopressors Epinephrine (adrenaline) is an endogenous catecholamine with potent alpha and beta stimulating properties. The alpha-adrenergic action (vasoconstriction) increases systemic and pulmonary vascular resi...6.1 Vasopressors Epinephrine (adrenaline) is an endogenous catecholamine with potent alpha and beta stimulating properties. The alpha-adrenergic action (vasoconstriction) increases systemic and pulmonary vascular resistance, increasing both systolic and diastolic blood pressure. The rise in diastolic blood pressure directly increases coronary perfusion pressure, thereby increasing coronary blood flow and increasing the likelihood of return of spontaneous circulation. Epinephrine also increases cerebral blood flow during CPR because peripheralgreater proportion of flowvasoconstriction directs a to the cerebral circulation.展开更多
文摘Objectives(1) Review the etiology of cardiac arrest in children to identify the rationale for medication interventions.(2) Review the phases of cardiac arrest and early resuscitation as potential targets for medication interve-tion.(3) Review the current evidence for or against specific medications during cardiac arrest, and compare datain children with adults.(4) Understand how the timing, duration and intensity of medication intervention may affect resuscitationoutcome.(5) Summarize the relative benefit of mechanical circulation of blood (early, effective and continuous CPR)compared to late medication interventions.(6) Identify several medication strategies on the horizon for treatment of cardiac arrest in children.
文摘6.1 Vasopressors Epinephrine (adrenaline) is an endogenous catecholamine with potent alpha and beta stimulating properties. The alpha-adrenergic action (vasoconstriction) increases systemic and pulmonary vascular resistance, increasing both systolic and diastolic blood pressure. The rise in diastolic blood pressure directly increases coronary perfusion pressure, thereby increasing coronary blood flow and increasing the likelihood of return of spontaneous circulation. Epinephrine also increases cerebral blood flow during CPR because peripheralgreater proportion of flowvasoconstriction directs a to the cerebral circulation.
