Objective:To determine the safety and the role of modulating cytokines and proteases in the immune response to intravesical Bacillus Calmette-Guérin(BCG)when primed with systemic intradermal BCG.Methods:Phase 1 a...Objective:To determine the safety and the role of modulating cytokines and proteases in the immune response to intravesical Bacillus Calmette-Guérin(BCG)when primed with systemic intradermal BCG.Methods:Phase 1 and mechanistic longitudinal,prospective,single-blind randomized study(NCT04806178).Twenty-one non-muscle invasive urothelial bladder cancer patients undergoing intravesical adjuvant BCG after transurethral resection of bladder tumor(TURBT)in a teaching hospital between September 2021 and April 2023 were randomized to 0.1 mL of intradermal BCG vaccine or placebo(0.9%saline)administered 15 days before the start of intravesical BCG therapy.Blood samples were evaluated mechanistically regarding eight cytokines serum levels interferon-induced transmembrane protein 3 Gene(IFITM3),Interleukin 1 beta(IL1-BETA),interleukin-2 receptor alpha chain(IL2 RA),Interleukin 6(IL 6),Interleukin 10(IL 10),Tumor necrosis factor alpha(TNF-α),Interferon-β,AXL,and one protease CASPASE 8.Results:After 1 exclusion,twenty patients were randomized to intradermal BCG(n=11)and intradermal placebo(n=9).There was no difference in adverse effects emerging from the intravesical Onco-BCG therapy,and no difference in the expression of the cytokines and proteases analyzed between control and intervention,and over time.Conclusions:Intradermal BCG administration before intravesical application was safe,with no increase in adverse effects.It also does not seem to change the analyzed targets during the intravesical induction-phase BCG.Other immune targets should be explored in the future.The Brazilian tuberculosis-endemic status,where BCG vaccination is mandatory,might have affected the results.展开更多
The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates ...The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that were successful in preclinical Parkinson's disease animal models have repeatedly failed when tested in clinical trials.While these failures have many possible explanations,it is perhaps time to recognize that the problem lies with the animal models rather than the putative candidate.In other words,the lack of adequate animal models of Parkinson's disease currently represents the main barrier to preclinical identification of potential disease-modifying therapies likely to succeed in clinical trials.However,this barrier may be overcome by the recent introduction of novel generations of viral vectors coding for different forms of alpha-synuclein species and related genes.Although still facing several limitations,these models have managed to mimic the known neuropathological hallmarks of Parkinson's disease with unprecedented accuracy,delineating a more optimistic scenario for the near future.展开更多
The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-gener...The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-generation(5G)networks transformed mobile broadband and machine-type communications at massive scales,their properties of scaling,interference management,and latency remain a limitation in dense high mobility settings.To overcome these limitations,artificial intelligence(AI)and unmanned aerial vehicles(UAVs)have emerged as potential solutions to develop versatile,dynamic,and energy-efficient communication systems.The study proposes an AI-based UAV architecture that utilizes cooperative reinforcement learning(CoRL)to manage an autonomous network.The UAVs collaborate by sharing local observations and real-time state exchanges to optimize user connectivity,movement directions,allocate power,and resource distribution.Unlike conventional centralized or autonomous methods,CoRL involves joint state sharing and conflict-sensitive reward shaping,which ensures fair coverage,less interference,and enhanced adaptability in a dynamic urban environment.Simulations conducted in smart city scenarios with 10 UAVs and 50 ground users demonstrate that the proposed CoRL-based UAV system increases user coverage by up to 10%,achieves convergence 40%faster,and reduces latency and energy consumption by 30%compared with centralized and decentralized baselines.Furthermore,the distributed nature of the algorithm ensures scalability and flexibility,making it well-suited for future large-scale 6G deployments.The results highlighted that AI-enabled UAV systems enhance connectivity,support ultra-reliable low-latency communications(URLLC),and improve 6G network efficiency.Future work will extend the framework with adaptive modulation,beamforming-aware positioning,and real-world testbed deployment.展开更多
A novel siphon-based divide-and-conquer(SbDaC)policy is presented in this paper for the synthesis of Petri net(PN)based liveness-enforcing supervisors(LES)for flexible manufacturing systems(FMS)prone to deadlocks or l...A novel siphon-based divide-and-conquer(SbDaC)policy is presented in this paper for the synthesis of Petri net(PN)based liveness-enforcing supervisors(LES)for flexible manufacturing systems(FMS)prone to deadlocks or livelocks.The proposed method takes an uncontrolled and bounded PN model(UPNM)of the FMS.Firstly,the reduced PNM(RPNM)is obtained from the UPNM by using PN reduction rules to reduce the computation burden.Then,the set of strict minimal siphons(SMSs)of the RPNM is computed.Next,the complementary set of SMSs is computed from the set of SMSs.By the union of these two sets,the superset of SMSs is computed.Finally,the set of subnets of the RPNM is obtained by applying the PN reduction rules to the superset of SMSs.All these subnets suffer from deadlocks.These subnets are then ordered from the smallest one to the largest one based on a criterion.To enforce liveness on these subnets,a set of control places(CPs)is computed starting from the smallest subnet to the largest one.Once all subnets are live,this process provides the LES,consisting of a set of CPs to be used for the UPNM.The live controlled PN model(CPNM)is constructed by merging the LES with the UPNM.The SbDaC policy is applicable to all classes of PNs related to FMS prone to deadlocks or livelocks.Several FMS examples are considered from the literature to highlight the applicability of the SbDaC policy.In particular,three examples are utilized to emphasize the importance,applicability and effectiveness of the SbDaC policy to realistic FMS with very large state spaces.展开更多
For the chip integration of MEMS(micro-electromechanical system) safety and arming device, a miniature detonator needs to be developed to reduce the weight and volume of explosive train. A Si-based micro-detonator is ...For the chip integration of MEMS(micro-electromechanical system) safety and arming device, a miniature detonator needs to be developed to reduce the weight and volume of explosive train. A Si-based micro-detonator is designed and fabricated, which meets the requirement of MEMS safety and arming device. The firing sensitivity of micro-detonator is tested according to GJB/z377A-94 sensitivity test methods:Langlie. The function time of micro-detonator is measured using wire probe and photoelectric transducer. The result shows the average firing voltage is 6.4 V when the discharge capacitance of firing electro-circuit is 33 mF. And the average function time is 5.48 ms. The firing energy actually utilized by Si-based micro-detonator is explored.展开更多
Colorectal cancer is the third most common cancer and is highly fatal. During the last several years, research has been primarily based on the study of expression profiles using microarray technology. But now, investi...Colorectal cancer is the third most common cancer and is highly fatal. During the last several years, research has been primarily based on the study of expression profiles using microarray technology. But now, investigators are putting into practice proteomic analyses of cancer tissues and cells to identify new diagnostic or therapeutic biomarkers for this cancer. Because the proteome reflects the state of a cell, tissue or organism more accurately, much is expected from proteomics to yield better tumor markers for disease diagnosis and therapy monitoring. This review summarizes the most relevant applications of proteomics the biomarker discovery for colorectal cancer.展开更多
This paper summarizes the results of the researches on the middle and upper atmosphere obtained by Chinese scientists in 2008-2010.The focuses are specifically placed on the researches being associated with ground-bas...This paper summarizes the results of the researches on the middle and upper atmosphere obtained by Chinese scientists in 2008-2010.The focuses are specifically placed on the researches being associated with ground-based observation capability development,dynamical processes,the property of atmospheric circulation and the chemistry-climate coupling of the middle atmospheric layers.展开更多
Therapeutic experiments are commonly performed on laboratory animals to inves-tigate the possible mechanism(s)of action of toxic agents as well as drugs or sub-stances under consideration.The use of toxins in laborato...Therapeutic experiments are commonly performed on laboratory animals to inves-tigate the possible mechanism(s)of action of toxic agents as well as drugs or sub-stances under consideration.The use of toxins in laboratory animal models,including rats,is intended to cause toxicity.This study aimed to investigate different models of hepatotoxicity and nephrotoxicity in laboratory animals to help researchers advance their research goals.The current narrative review used databases such as Medline,Web of Science,Scopus,and Embase and appropriate keywords until June 2021.Nephrotoxicity and hepatotoxicity models derived from some toxic agents such as cisplatin,acetaminophen,doxorubicin,some anticancer drugs,and other materials through various signaling pathways are investigated.To understand the models of renal or hepatotoxicity in laboratory animals,we have provided a list of toxic agents and their toxicity procedures in this review.展开更多
An algorithm of broadband minimum variance distortionless response(MVDR) based on the frequency energy normalization is proposed.First,every narrowband frequency component of the broadband signal is normalized by the ...An algorithm of broadband minimum variance distortionless response(MVDR) based on the frequency energy normalization is proposed.First,every narrowband frequency component of the broadband signal is normalized by the total narrowband energy of all array elements,and the narrowband power is calculated by MVDR.Finally,final spatial energy spectrum can be obtained by averaging or summing all results of every narrowband frequency bin.Any prior-information about the noise or the signal is unnecessary for the proposed method in this paper.The processing gain of the proposed method compared to the conventional broadband MVDR can be obtained as long as the amplitude fluctuation of the array noise frequency spectrum is severer than that of the target signal.The validity of the method is validated by the optimal signal detection theory.Simulation and real data are used to validate the performance of the method.Analysis results show that about 4 dB processing gain compared to the general broadband MVDR can be reached by the proposed method.展开更多
In this report we summarize the research results by Chinese scientists in 2012–2014. The focuses are placed on the researches of the middle and upper atmosphere, specifically the researches related to ground-based ob...In this report we summarize the research results by Chinese scientists in 2012–2014. The focuses are placed on the researches of the middle and upper atmosphere, specifically the researches related to ground-based observation capability development, dynamical processes, the property of circulation and chemistry-climate coupling of the middle atmospheric layers.展开更多
Rheumatoid arthritis(RA)is a common autoimmune disease characterized by progressive joint inflammation and destruction,deformity,loss of mobility,and permanent disability.Although the cellular and molecular mechanisms...Rheumatoid arthritis(RA)is a common autoimmune disease characterized by progressive joint inflammation and destruction,deformity,loss of mobility,and permanent disability.Although the cellular and molecular mechanisms involved in RA are understood in detail,no drugs or therapies can completely cure RA.Many long-term efforts have been directed towards a better understanding of RA pathogenesis and the development of new classes of therapeutics.Thus,the ongoing elucidation of pathogenic events underlying RA mostly relies on studies of animal models.Herein,we comprehensively review and discuss the characteristics,challenges,and unresolved of issues of various experimental models of RA to provide a basis and reference for the rational selection of experimental RA models for basic investigations into traditional Chinese medicine(TCM).展开更多
During the past two years,space environment has achieved great development in space environment monitoring,model research,system developing and space environment service in China.In this paper,we mainly introduce spac...During the past two years,space environment has achieved great development in space environment monitoring,model research,system developing and space environment service in China.In this paper,we mainly introduce space environment safety support for Shenzhou-7 manned spacecraft,two typical space environment operation platforms,and the advance of Re-locatable Atmospheric Observatory(RAO).At the last part of this paper,the Sub-committee on Space Environment(SSE) which was set up in 2009 under the Technical Committee on Space Technology and Operation of Standardization Administration of China is briefly introduced.展开更多
This brief report summarized the latest advances of the heliospheric physics research in China during the period of 2002-2003, made independently by Chinese space physicists and through international collaboration. Th...This brief report summarized the latest advances of the heliospheric physics research in China during the period of 2002-2003, made independently by Chinese space physicists and through international collaboration. The report covers all aspects of the heliospheric physics, including theoretical studies, numerical simulation and data analysis.展开更多
This brief report summarized the latest advances of the interplanetary physics research in China during the period of 2004-2005, made independently by Chinese space physicists and through international collaboration. ...This brief report summarized the latest advances of the interplanetary physics research in China during the period of 2004-2005, made independently by Chinese space physicists and through international collaboration. The report covers all aspects of the interplanetary physics, including theoretical studies, numerical simulation and data analysis.展开更多
This paper presents the recent progress of space environment research and service in China.During the past two years,many models of space environment forecast and analysis methods of space environment effects have bee...This paper presents the recent progress of space environment research and service in China.During the past two years,many models of space environment forecast and analysis methods of space environment effects have been developed for tailored space environment service for Chinese space mission.A new Re-locatable Atmospheric Observatory(RAO) for monitoring atmospheric wind,temperature,density and pressure of the near space from 20km up to 120km altitudes is being constructed.In space environment service space environment safety was provided to ensure the safety of CE-1 for its launch and operation in 2007.展开更多
This brief report summarized the latest advances of the interplanetary physics research in China during the period of 2006—2007,made independently by Chinese space physicists and through international collaboration.T...This brief report summarized the latest advances of the interplanetary physics research in China during the period of 2006—2007,made independently by Chinese space physicists and through international collaboration.The report covers all aspects of the interplanetary physics,including theoretical studies,numerical simulation and data analysis.展开更多
The scientific objective of solar corona and interplanetary research is the understanding of the various phenomena related to solar activities and their effects on the space environments of the Earth.Great progress ha...The scientific objective of solar corona and interplanetary research is the understanding of the various phenomena related to solar activities and their effects on the space environments of the Earth.Great progress has been made in the study of solar corona and interplanetary physics by the Chinese space physics community during the past years.This paper will give a brief report about the latest progress of the corona and interplanetary research in China during the years of 2010-2012.The paper can be divided into the following parts:solar corona and solar wind.CMEICME, magnetic reconnection,energetic particles,space plasma,space weather numerical modeling by 3D SIP-CESE MHD model,space weather prediction methods,and proposed missions.They constitute the abundant content of study for the complicated phenomena that originate from the solar corona,propagate in interplanetary space,and produce geomagnetic disturbances.All these progresses are acquired by the Chinese space physicists,either independently or through international collaborations.展开更多
Longan originates from southern China and has high nutritional and health value.Recent phytochemistry and pharmacology studies have shown that polysaccharides are a main bioactive component of longan.Longan polysaccha...Longan originates from southern China and has high nutritional and health value.Recent phytochemistry and pharmacology studies have shown that polysaccharides are a main bioactive component of longan.Longan polysaccharides possess antioxidant,anti-aging,anti-tumor,immunomodulatory,and other bioactivities.Hot-water extraction,ethanol precipitation,and ultrasonic extraction are generally used to extract water-soluble longan polysaccharides.However,the relationship between the structure and bioactivity of longan polysaccharides remains unclear,requiring further investigation.The aim of this review is to evaluate the current literature focusing on the extraction,purification,structural characterization,and biological activity of longan polysaccharides.We believe that this review would provide a useful bibliography for further innovation and a basis for using longan polysaccharides in functional food.展开更多
Abstract This paper presents the recent research progress on space environment in China. The space environment here includes space environment models, forecast methodology and space environment effects on spacecrafts....Abstract This paper presents the recent research progress on space environment in China. The space environment here includes space environment models, forecast methodology and space environment effects on spacecrafts. Finally the development trends of China's space environment research are discussed.展开更多
基金National Council for Scientific and Technological Development,CNPq,Research Productivity,grant numbers:304747/2018-1/310135/2022-2(Reis LO).
文摘Objective:To determine the safety and the role of modulating cytokines and proteases in the immune response to intravesical Bacillus Calmette-Guérin(BCG)when primed with systemic intradermal BCG.Methods:Phase 1 and mechanistic longitudinal,prospective,single-blind randomized study(NCT04806178).Twenty-one non-muscle invasive urothelial bladder cancer patients undergoing intravesical adjuvant BCG after transurethral resection of bladder tumor(TURBT)in a teaching hospital between September 2021 and April 2023 were randomized to 0.1 mL of intradermal BCG vaccine or placebo(0.9%saline)administered 15 days before the start of intravesical BCG therapy.Blood samples were evaluated mechanistically regarding eight cytokines serum levels interferon-induced transmembrane protein 3 Gene(IFITM3),Interleukin 1 beta(IL1-BETA),interleukin-2 receptor alpha chain(IL2 RA),Interleukin 6(IL 6),Interleukin 10(IL 10),Tumor necrosis factor alpha(TNF-α),Interferon-β,AXL,and one protease CASPASE 8.Results:After 1 exclusion,twenty patients were randomized to intradermal BCG(n=11)and intradermal placebo(n=9).There was no difference in adverse effects emerging from the intravesical Onco-BCG therapy,and no difference in the expression of the cytokines and proteases analyzed between control and intervention,and over time.Conclusions:Intradermal BCG administration before intravesical application was safe,with no increase in adverse effects.It also does not seem to change the analyzed targets during the intravesical induction-phase BCG.Other immune targets should be explored in the future.The Brazilian tuberculosis-endemic status,where BCG vaccination is mandatory,might have affected the results.
基金supported by grants PID2020-120308RB-I00 and PID2023-147802OB-I00 funded by MICIU/AEI/10.13039/501100011033FEDER,UE,by Aligning Science Across Parkinson’s(ref.ASAP-020505)through the Michael J.Fox Foundation for Parkinson’s Research+1 种基金by CiberNed Intramural Collaborative Projects(ref.PI2020/09)by the Spanish Fundación Mutua Madrile?a de Investigación Médica(to JLL)。
文摘The development of clinical candidates that modify the natural progression of sporadic Parkinson's disease and related synucleinopathies is a praiseworthy endeavor,but extremely challenging.Therapeutic candidates that were successful in preclinical Parkinson's disease animal models have repeatedly failed when tested in clinical trials.While these failures have many possible explanations,it is perhaps time to recognize that the problem lies with the animal models rather than the putative candidate.In other words,the lack of adequate animal models of Parkinson's disease currently represents the main barrier to preclinical identification of potential disease-modifying therapies likely to succeed in clinical trials.However,this barrier may be overcome by the recent introduction of novel generations of viral vectors coding for different forms of alpha-synuclein species and related genes.Although still facing several limitations,these models have managed to mimic the known neuropathological hallmarks of Parkinson's disease with unprecedented accuracy,delineating a more optimistic scenario for the near future.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government(MSIT)(RS-2025-00559546)supported by the IITP(Institute of Information&Coummunications Technology Planning&Evaluation)-ITRC(Information Technology Research Center)grant funded by the Korea government(Ministry of Science and ICT)(IITP-2025-RS-2023-00259004).
文摘The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-generation(5G)networks transformed mobile broadband and machine-type communications at massive scales,their properties of scaling,interference management,and latency remain a limitation in dense high mobility settings.To overcome these limitations,artificial intelligence(AI)and unmanned aerial vehicles(UAVs)have emerged as potential solutions to develop versatile,dynamic,and energy-efficient communication systems.The study proposes an AI-based UAV architecture that utilizes cooperative reinforcement learning(CoRL)to manage an autonomous network.The UAVs collaborate by sharing local observations and real-time state exchanges to optimize user connectivity,movement directions,allocate power,and resource distribution.Unlike conventional centralized or autonomous methods,CoRL involves joint state sharing and conflict-sensitive reward shaping,which ensures fair coverage,less interference,and enhanced adaptability in a dynamic urban environment.Simulations conducted in smart city scenarios with 10 UAVs and 50 ground users demonstrate that the proposed CoRL-based UAV system increases user coverage by up to 10%,achieves convergence 40%faster,and reduces latency and energy consumption by 30%compared with centralized and decentralized baselines.Furthermore,the distributed nature of the algorithm ensures scalability and flexibility,making it well-suited for future large-scale 6G deployments.The results highlighted that AI-enabled UAV systems enhance connectivity,support ultra-reliable low-latency communications(URLLC),and improve 6G network efficiency.Future work will extend the framework with adaptive modulation,beamforming-aware positioning,and real-world testbed deployment.
基金The authors extend their appreciation to King Saud University,Saudi Arabia for funding this work through the Ongoing Research Funding Program(ORF-2025-704),King Saud University,Riyadh,Saudi Arabia.
文摘A novel siphon-based divide-and-conquer(SbDaC)policy is presented in this paper for the synthesis of Petri net(PN)based liveness-enforcing supervisors(LES)for flexible manufacturing systems(FMS)prone to deadlocks or livelocks.The proposed method takes an uncontrolled and bounded PN model(UPNM)of the FMS.Firstly,the reduced PNM(RPNM)is obtained from the UPNM by using PN reduction rules to reduce the computation burden.Then,the set of strict minimal siphons(SMSs)of the RPNM is computed.Next,the complementary set of SMSs is computed from the set of SMSs.By the union of these two sets,the superset of SMSs is computed.Finally,the set of subnets of the RPNM is obtained by applying the PN reduction rules to the superset of SMSs.All these subnets suffer from deadlocks.These subnets are then ordered from the smallest one to the largest one based on a criterion.To enforce liveness on these subnets,a set of control places(CPs)is computed starting from the smallest subnet to the largest one.Once all subnets are live,this process provides the LES,consisting of a set of CPs to be used for the UPNM.The live controlled PN model(CPNM)is constructed by merging the LES with the UPNM.The SbDaC policy is applicable to all classes of PNs related to FMS prone to deadlocks or livelocks.Several FMS examples are considered from the literature to highlight the applicability of the SbDaC policy.In particular,three examples are utilized to emphasize the importance,applicability and effectiveness of the SbDaC policy to realistic FMS with very large state spaces.
文摘For the chip integration of MEMS(micro-electromechanical system) safety and arming device, a miniature detonator needs to be developed to reduce the weight and volume of explosive train. A Si-based micro-detonator is designed and fabricated, which meets the requirement of MEMS safety and arming device. The firing sensitivity of micro-detonator is tested according to GJB/z377A-94 sensitivity test methods:Langlie. The function time of micro-detonator is measured using wire probe and photoelectric transducer. The result shows the average firing voltage is 6.4 V when the discharge capacitance of firing electro-circuit is 33 mF. And the average function time is 5.48 ms. The firing energy actually utilized by Si-based micro-detonator is explored.
文摘Colorectal cancer is the third most common cancer and is highly fatal. During the last several years, research has been primarily based on the study of expression profiles using microarray technology. But now, investigators are putting into practice proteomic analyses of cancer tissues and cells to identify new diagnostic or therapeutic biomarkers for this cancer. Because the proteome reflects the state of a cell, tissue or organism more accurately, much is expected from proteomics to yield better tumor markers for disease diagnosis and therapy monitoring. This review summarizes the most relevant applications of proteomics the biomarker discovery for colorectal cancer.
基金Supported by the National Natural Sciences Foundation of China under grant (40830102,40333034)the Knowledge Innovation Project of Chinese Academy of Sciences under Grant (KZCX2-YW-123)
文摘This paper summarizes the results of the researches on the middle and upper atmosphere obtained by Chinese scientists in 2008-2010.The focuses are specifically placed on the researches being associated with ground-based observation capability development,dynamical processes,the property of atmospheric circulation and the chemistry-climate coupling of the middle atmospheric layers.
文摘Therapeutic experiments are commonly performed on laboratory animals to inves-tigate the possible mechanism(s)of action of toxic agents as well as drugs or sub-stances under consideration.The use of toxins in laboratory animal models,including rats,is intended to cause toxicity.This study aimed to investigate different models of hepatotoxicity and nephrotoxicity in laboratory animals to help researchers advance their research goals.The current narrative review used databases such as Medline,Web of Science,Scopus,and Embase and appropriate keywords until June 2021.Nephrotoxicity and hepatotoxicity models derived from some toxic agents such as cisplatin,acetaminophen,doxorubicin,some anticancer drugs,and other materials through various signaling pathways are investigated.To understand the models of renal or hepatotoxicity in laboratory animals,we have provided a list of toxic agents and their toxicity procedures in this review.
基金Sponsored by New Century Excellent Talent Support Project (NCET-04-0545)
文摘An algorithm of broadband minimum variance distortionless response(MVDR) based on the frequency energy normalization is proposed.First,every narrowband frequency component of the broadband signal is normalized by the total narrowband energy of all array elements,and the narrowband power is calculated by MVDR.Finally,final spatial energy spectrum can be obtained by averaging or summing all results of every narrowband frequency bin.Any prior-information about the noise or the signal is unnecessary for the proposed method in this paper.The processing gain of the proposed method compared to the conventional broadband MVDR can be obtained as long as the amplitude fluctuation of the array noise frequency spectrum is severer than that of the target signal.The validity of the method is validated by the optimal signal detection theory.Simulation and real data are used to validate the performance of the method.Analysis results show that about 4 dB processing gain compared to the general broadband MVDR can be reached by the proposed method.
文摘In this report we summarize the research results by Chinese scientists in 2012–2014. The focuses are placed on the researches of the middle and upper atmosphere, specifically the researches related to ground-based observation capability development, dynamical processes, the property of circulation and chemistry-climate coupling of the middle atmospheric layers.
基金funding support from the Science and Technology Innovation Program of Hunan Province(No.XKJ[2021]43-2021RC4035)supported by the Hunan Furong Distinguished Scholar Program(No.XJT[2020]58)the Chinese Academy of Engineering Academician LIU Liang’s Workstation of Hunan(No.XKXT[2020]34)。
文摘Rheumatoid arthritis(RA)is a common autoimmune disease characterized by progressive joint inflammation and destruction,deformity,loss of mobility,and permanent disability.Although the cellular and molecular mechanisms involved in RA are understood in detail,no drugs or therapies can completely cure RA.Many long-term efforts have been directed towards a better understanding of RA pathogenesis and the development of new classes of therapeutics.Thus,the ongoing elucidation of pathogenic events underlying RA mostly relies on studies of animal models.Herein,we comprehensively review and discuss the characteristics,challenges,and unresolved of issues of various experimental models of RA to provide a basis and reference for the rational selection of experimental RA models for basic investigations into traditional Chinese medicine(TCM).
文摘During the past two years,space environment has achieved great development in space environment monitoring,model research,system developing and space environment service in China.In this paper,we mainly introduce space environment safety support for Shenzhou-7 manned spacecraft,two typical space environment operation platforms,and the advance of Re-locatable Atmospheric Observatory(RAO).At the last part of this paper,the Sub-committee on Space Environment(SSE) which was set up in 2009 under the Technical Committee on Space Technology and Operation of Standardization Administration of China is briefly introduced.
文摘This brief report summarized the latest advances of the heliospheric physics research in China during the period of 2002-2003, made independently by Chinese space physicists and through international collaboration. The report covers all aspects of the heliospheric physics, including theoretical studies, numerical simulation and data analysis.
基金Supported by the National Natural Science Foundation of China (40325010)
文摘This brief report summarized the latest advances of the interplanetary physics research in China during the period of 2004-2005, made independently by Chinese space physicists and through international collaboration. The report covers all aspects of the interplanetary physics, including theoretical studies, numerical simulation and data analysis.
文摘This paper presents the recent progress of space environment research and service in China.During the past two years,many models of space environment forecast and analysis methods of space environment effects have been developed for tailored space environment service for Chinese space mission.A new Re-locatable Atmospheric Observatory(RAO) for monitoring atmospheric wind,temperature,density and pressure of the near space from 20km up to 120km altitudes is being constructed.In space environment service space environment safety was provided to ensure the safety of CE-1 for its launch and operation in 2007.
基金the National Natural Science Foundation of China (40621003)
文摘This brief report summarized the latest advances of the interplanetary physics research in China during the period of 2006—2007,made independently by Chinese space physicists and through international collaboration.The report covers all aspects of the interplanetary physics,including theoretical studies,numerical simulation and data analysis.
基金Supported by the National Natural Science Foundation of China(40921063,40890162,41074122)the Specialized Research Fund for State Key Laboratories
文摘The scientific objective of solar corona and interplanetary research is the understanding of the various phenomena related to solar activities and their effects on the space environments of the Earth.Great progress has been made in the study of solar corona and interplanetary physics by the Chinese space physics community during the past years.This paper will give a brief report about the latest progress of the corona and interplanetary research in China during the years of 2010-2012.The paper can be divided into the following parts:solar corona and solar wind.CMEICME, magnetic reconnection,energetic particles,space plasma,space weather numerical modeling by 3D SIP-CESE MHD model,space weather prediction methods,and proposed missions.They constitute the abundant content of study for the complicated phenomena that originate from the solar corona,propagate in interplanetary space,and produce geomagnetic disturbances.All these progresses are acquired by the Chinese space physicists,either independently or through international collaborations.
基金the National Natural Science Foundation of China(32201969,82204668)Natural Science Foundation of Henan Province(212300410297)+3 种基金Hebei Natural Science Foundation(H2022423376)Basic Research Plan of Higher Education School Key Scientific Research Project of Henan Province(21A550014)Doctoral Research Foundation of Zhengzhou University of Light Industry(2020BSJJ015)Science and Technology Research Project of Higher Education in Hebei Province(QN2020233).
文摘Longan originates from southern China and has high nutritional and health value.Recent phytochemistry and pharmacology studies have shown that polysaccharides are a main bioactive component of longan.Longan polysaccharides possess antioxidant,anti-aging,anti-tumor,immunomodulatory,and other bioactivities.Hot-water extraction,ethanol precipitation,and ultrasonic extraction are generally used to extract water-soluble longan polysaccharides.However,the relationship between the structure and bioactivity of longan polysaccharides remains unclear,requiring further investigation.The aim of this review is to evaluate the current literature focusing on the extraction,purification,structural characterization,and biological activity of longan polysaccharides.We believe that this review would provide a useful bibliography for further innovation and a basis for using longan polysaccharides in functional food.
文摘Abstract This paper presents the recent research progress on space environment in China. The space environment here includes space environment models, forecast methodology and space environment effects on spacecrafts. Finally the development trends of China's space environment research are discussed.
