With the increasing use of web applications,challenges in the field of cybersecurity are becoming more complex.This paper explores the application of fine-tuned large language models(LLMs)for the automatic generation ...With the increasing use of web applications,challenges in the field of cybersecurity are becoming more complex.This paper explores the application of fine-tuned large language models(LLMs)for the automatic generation of synthetic attacks,including XSS(Cross-Site Scripting),SQL Injections,and Command Injections.A web application has been developed that allows penetration testers to quickly generate high-quality payloads without the need for in-depth knowledge of artificial intelligence.The fine-tuned language model demonstrates the capability to produce synthetic payloads that closely resemble real-world attacks.This approach not only improves the model’s precision and dependability but also serves as a practical resource for cybersecurity professionals to enhance the security of web applications.The methodology and structured implementation underscore the importance and potential of advanced language models in cybersecurity,illustrating their effectiveness in generating high-quality synthetic data for penetration testing purposes.The research results demonstrate that this approach enables the identification of vulnerabilities that traditional methods may not uncover,providing deeper insights into potential threats and enhancing overall security measures.The performance evaluation of the model indicated satisfactory results,while further hyperparameter optimization could improve accuracy and generalization capabilities.This research represents a significant step forward in improving web application security and opens new opportunities for the use of LLMs in security testing,thereby contributing to the development of more effective cybersecurity strategies.展开更多
Banks daily interact with a vast number of customers and are still depending on a legacy system. With today’s advances in technology, regarding lifting almost all processes to automation, from start of production to ...Banks daily interact with a vast number of customers and are still depending on a legacy system. With today’s advances in technology, regarding lifting almost all processes to automation, from start of production to finish, there is a need for revolution in archaic monetary management institutes. By not being in tune with the contemporary trends and times, banks are losing on an opportunity to transform some of their business models and relieve humans of repetitive work, prevent frauds, make better decisions and consequently gain losses. Banks can engage in implementation of new Virtual Assistants and Artificial Intelligence (A.I.) machine learning technologies, just as the other industries have engaged in modernizing <i>i.e. </i> medical checks, medical reports and evaluations, and this research paper will elaborate and emphasize the impact of artificial intelligence implementation on the banking sector processes. This research is based on both quantitative and model-based proofs of system performance by using several analytical tools, such as SPSS. The automation process helps institutions to enhance profitability, performance and to reduce human dependency. In a nutshell, Virtual Assistants powered with Artificial Intelligence improve the business process performance in every sector of business, especially the banking sector making it fast, reliable and not human dependent.展开更多
Purpose: Detailed analysis of a patient with epithelial Lewis Y (LeY) positive cancer who received twice 50 mg of the humanized Lewis Y carbohydrate specific mAb IGN311 and developed a clinically significant human ant...Purpose: Detailed analysis of a patient with epithelial Lewis Y (LeY) positive cancer who received twice 50 mg of the humanized Lewis Y carbohydrate specific mAb IGN311 and developed a clinically significant human anti-human antibody (HAHA) response (Ab2). Results: Clinical stabilization of the disease was assigned to in this patient. The HAHA response consisted mainly of IgG1 and was found to be directed against the IGN311 binding site. Consistent with the induction of the HAHA response, CDC activity against Lewis Y positive target cells was completely abolished at day 8 and could not be restored by the second 50 mg infusion indicating complete neutralization of applied IGN311. The ADCC reactivity was also significantly reduced and anti-anti idiotype-specific antibodies (Ab3) were detectable at day 65. Conclusions: Induction of Ab3 antibodies should be considered as an additional factor influencing the efficacy of humanized antibodies. In this context, the potential threat of induced HAHA responses against therapeutic mAbs might have to be reconsidered because they might actually have also beneficial immunological long-term effects leading to an active immunization component induced by therapeutic antibodies.展开更多
In today＇s modem world, a will to succeed is inextricably linked with the acquisition of profit, while sports competition turns into an aggressive fight for the result and prestige. The athletes in professional sport...In today＇s modem world, a will to succeed is inextricably linked with the acquisition of profit, while sports competition turns into an aggressive fight for the result and prestige. The athletes in professional sports, where victory is imperative, often treated as just another object and an obstacle to be overcome. Violence in sports performed primarily athletes themselves. In sports games can be applied aggressive tactics, but the use of violence is considered to be beyond the scope of what is considered to be the good behavior of an athlete. Athletes decide on violence sometimes with a clear goal of hurting the opposing player, and sometimes only for intimidation, in order to win. Extreme exercise, accompanied by great hardships and frequent injuries, are not always sufficient to achieve the required and expected results, and more and more athletes turning to the use of prohibited doping substances, thus trying to improve their own capabilities.展开更多
Purpose: Investigation of safety, tolerability, pharmacokinetics, and anti-tumor activity of the Lewis Y-specific, fully humanized monoclonal antibody (mAb) IGN311 in patients with Lewis Y positive tumors in a Phase I...Purpose: Investigation of safety, tolerability, pharmacokinetics, and anti-tumor activity of the Lewis Y-specific, fully humanized monoclonal antibody (mAb) IGN311 in patients with Lewis Y positive tumors in a Phase I clinical trial. Experimental Design: Twelve patients (pts) were enrolled in an open-label, uncontrolled, dose escalating Phase I study. Three pts received 50 mg, three pts 100 mg and six pts 200 mg IGN311 by i.v. infusion on days 1 and 15. Blood samples were taken immediately before infusion, and 0.5, 4, 8, 24 hours post infusion, as well as on days 3, 5 and 8 after the first and second infusion, respectively, and day 29. A final visit was scheduled for day 43. Results: No drug related adverse events were observed in the 50 mg and 100 mg dose groups. Three out of six patients in the 200 mg dose group showed drug related adverse reactions with nausea, vomiting and hypotension in one patient (NCI CTC grade 3) being the dose limiting toxicities. t1/2 of IGN311 was ~20 days after second infusion of IGN311. Sera of patients receiving IGN311 were capable of lysing Lewis Y positive tumor cells in vitro by both, complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). Circulating tumor cells found in the peripheral blood in two out of twelve pts prior to treatment were reduced after treatment to below the quantification limit of the detection method. None of the patients showed an increase in the number of disseminated tumor cells during treatment period. Conclusions: The good safety and PK profile, the biological activity regarding CDC and ADCC mediated tumor cell lysis, and the elimination of circulating tumor cells warrant further clinical investigation of IGN311.展开更多
基金supported by the Ministry of Science,Technological Development and Innovation of the Republic of Serbia,and these results are parts of Grant No.451-03-66/2024-03/200132 with the University of Kragujevac-Faculty of Technical Sciences Cacak.
文摘With the increasing use of web applications,challenges in the field of cybersecurity are becoming more complex.This paper explores the application of fine-tuned large language models(LLMs)for the automatic generation of synthetic attacks,including XSS(Cross-Site Scripting),SQL Injections,and Command Injections.A web application has been developed that allows penetration testers to quickly generate high-quality payloads without the need for in-depth knowledge of artificial intelligence.The fine-tuned language model demonstrates the capability to produce synthetic payloads that closely resemble real-world attacks.This approach not only improves the model’s precision and dependability but also serves as a practical resource for cybersecurity professionals to enhance the security of web applications.The methodology and structured implementation underscore the importance and potential of advanced language models in cybersecurity,illustrating their effectiveness in generating high-quality synthetic data for penetration testing purposes.The research results demonstrate that this approach enables the identification of vulnerabilities that traditional methods may not uncover,providing deeper insights into potential threats and enhancing overall security measures.The performance evaluation of the model indicated satisfactory results,while further hyperparameter optimization could improve accuracy and generalization capabilities.This research represents a significant step forward in improving web application security and opens new opportunities for the use of LLMs in security testing,thereby contributing to the development of more effective cybersecurity strategies.
文摘Banks daily interact with a vast number of customers and are still depending on a legacy system. With today’s advances in technology, regarding lifting almost all processes to automation, from start of production to finish, there is a need for revolution in archaic monetary management institutes. By not being in tune with the contemporary trends and times, banks are losing on an opportunity to transform some of their business models and relieve humans of repetitive work, prevent frauds, make better decisions and consequently gain losses. Banks can engage in implementation of new Virtual Assistants and Artificial Intelligence (A.I.) machine learning technologies, just as the other industries have engaged in modernizing <i>i.e. </i> medical checks, medical reports and evaluations, and this research paper will elaborate and emphasize the impact of artificial intelligence implementation on the banking sector processes. This research is based on both quantitative and model-based proofs of system performance by using several analytical tools, such as SPSS. The automation process helps institutions to enhance profitability, performance and to reduce human dependency. In a nutshell, Virtual Assistants powered with Artificial Intelligence improve the business process performance in every sector of business, especially the banking sector making it fast, reliable and not human dependent.
文摘Purpose: Detailed analysis of a patient with epithelial Lewis Y (LeY) positive cancer who received twice 50 mg of the humanized Lewis Y carbohydrate specific mAb IGN311 and developed a clinically significant human anti-human antibody (HAHA) response (Ab2). Results: Clinical stabilization of the disease was assigned to in this patient. The HAHA response consisted mainly of IgG1 and was found to be directed against the IGN311 binding site. Consistent with the induction of the HAHA response, CDC activity against Lewis Y positive target cells was completely abolished at day 8 and could not be restored by the second 50 mg infusion indicating complete neutralization of applied IGN311. The ADCC reactivity was also significantly reduced and anti-anti idiotype-specific antibodies (Ab3) were detectable at day 65. Conclusions: Induction of Ab3 antibodies should be considered as an additional factor influencing the efficacy of humanized antibodies. In this context, the potential threat of induced HAHA responses against therapeutic mAbs might have to be reconsidered because they might actually have also beneficial immunological long-term effects leading to an active immunization component induced by therapeutic antibodies.
文摘In today＇s modem world, a will to succeed is inextricably linked with the acquisition of profit, while sports competition turns into an aggressive fight for the result and prestige. The athletes in professional sports, where victory is imperative, often treated as just another object and an obstacle to be overcome. Violence in sports performed primarily athletes themselves. In sports games can be applied aggressive tactics, but the use of violence is considered to be beyond the scope of what is considered to be the good behavior of an athlete. Athletes decide on violence sometimes with a clear goal of hurting the opposing player, and sometimes only for intimidation, in order to win. Extreme exercise, accompanied by great hardships and frequent injuries, are not always sufficient to achieve the required and expected results, and more and more athletes turning to the use of prohibited doping substances, thus trying to improve their own capabilities.
文摘Purpose: Investigation of safety, tolerability, pharmacokinetics, and anti-tumor activity of the Lewis Y-specific, fully humanized monoclonal antibody (mAb) IGN311 in patients with Lewis Y positive tumors in a Phase I clinical trial. Experimental Design: Twelve patients (pts) were enrolled in an open-label, uncontrolled, dose escalating Phase I study. Three pts received 50 mg, three pts 100 mg and six pts 200 mg IGN311 by i.v. infusion on days 1 and 15. Blood samples were taken immediately before infusion, and 0.5, 4, 8, 24 hours post infusion, as well as on days 3, 5 and 8 after the first and second infusion, respectively, and day 29. A final visit was scheduled for day 43. Results: No drug related adverse events were observed in the 50 mg and 100 mg dose groups. Three out of six patients in the 200 mg dose group showed drug related adverse reactions with nausea, vomiting and hypotension in one patient (NCI CTC grade 3) being the dose limiting toxicities. t1/2 of IGN311 was ~20 days after second infusion of IGN311. Sera of patients receiving IGN311 were capable of lysing Lewis Y positive tumor cells in vitro by both, complement-dependent cytotoxicity (CDC) and antibody-dependent cellular cytotoxicity (ADCC). Circulating tumor cells found in the peripheral blood in two out of twelve pts prior to treatment were reduced after treatment to below the quantification limit of the detection method. None of the patients showed an increase in the number of disseminated tumor cells during treatment period. Conclusions: The good safety and PK profile, the biological activity regarding CDC and ADCC mediated tumor cell lysis, and the elimination of circulating tumor cells warrant further clinical investigation of IGN311.
