AIM： To analyze, retrospectively in a populationbased study, the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorec...AIM： To analyze, retrospectively in a populationbased study, the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision （TME）. METHODS： All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection （632 patients） were selected from the Amsterdam Cancer Registry. For patients with recurrent disease, information on treatment of the recurrence was collected from the medical records. RESULTS： Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients （10%）. Thirty-two patients had an isolated local recurrence. Ten of these 32 patients （31%） underwent radical re-resection and experienced the highest survival （three quarters survived for at least 3 years）. Eight patients （25%） underwent non-radical surgery （median survival 24 rno）, seven patients （22%） were treated with radio- and/or chemotherapy without surgery （median survival 15 mo） and seven patients （22%） only received best supportive care （median survival 5 too）. Distant dissemination occurred in 124 patients （20%） of whom 30 patients also had a local recurrence. The majority （54%） of these patients were treated with radio- and/or chemotherapy without surgery （median survival 15 mo）. Twenty-seven percent of these patients only received best supportive care （median survival 6 mo）, while 16% underwent surgery for their recurrence. Survival was best in the latter group （median survival 32 mo）. CONCLUSION： Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TME, patients can benefit from additional treatment, especially if a radical resection is feasible.展开更多
本文评估了在过去20年间(2005-2024),管理学研究如何响应联合国可持续发展目标(Sustainable Development Goals,简称SDGs)。具体而言,本文比较了涵盖会计、金融、管理、市场营销与运营管理五大学科的18本国际顶尖商学与管理学期刊,以及...本文评估了在过去20年间(2005-2024),管理学研究如何响应联合国可持续发展目标(Sustainable Development Goals,简称SDGs)。具体而言,本文比较了涵盖会计、金融、管理、市场营销与运营管理五大学科的18本国际顶尖商学与管理学期刊,以及专注于中国管理研究的Management and Organization Review(MOR)在SDGs关注度上的差异。本文采用三种人工智能工具扫描论文摘要,并评估其与17项SDGs的契合度。结果显示,自2015年SDGs提出以来的10年间,其相关研究显著多于此前10年,增长最为显著的领域集中在SDG08(体面工作与经济增长)、SDG09(产业、创新与基础设施)以及SDG16(和平、正义与健全制度)。在所分析的期刊中,MOR在SDGs相关研究方面表现突出,凸显了其在负责任研究(Responsible Research)方面的学术引领重要作用。基于负责任研究的理念,本文进一步探讨了在学术研究中关注全体利益相关者(而非仅限股东)福祉的重要性。展开更多
Both fractional crystallization and fluid-melt-crystal interaction are involved in the formation of highly fractionated granites.This paper assessed those two processes using geochemistry of muscovite and tourmaline a...Both fractional crystallization and fluid-melt-crystal interaction are involved in the formation of highly fractionated granites.This paper assessed those two processes using geochemistry of muscovite and tourmaline and bulkrock chemistry of multi-phase Wangxianling granitoids,South China.Compositional variations suggest the coarse-grained muscovite granite is produced from fractional crystallization of the two-mica granite whereas the fine-grained muscovite granite represents a distinct magma pulse.Progressive fractionation of quartz,feldspar and biotite leads to elevated boron and aluminum content in melt which promoted muscovite and tourmaline to crystallize,which promotes two-mica granite evolving towards tourmaline-bearing muscovite granite.Fluid-melt-crystal interaction occurred at the magmatichydrothermal transitional stage and resulted in the textural and chemical zonings of tourmaline and muscovite in finegrained muscovite granite.The rims of both tourmaline and muscovite are characterized by the enrichment of fluid mobile elements such as Li,Mn,Cs and Zn and heavierδ^(11)B values of the tourmaline rims(-15.0‰to-13.6‰)compared to cores(-15.7‰to-14.3‰).Meanwhile,significant M-type REE tetrad effects(TE_(1,3)=1.07-1.18)and low K/Rb ratios(48-52)also correspond to fluid-melt-crystal interaction.This study shows zoned muscovite and tourmaline can be excellent tracers of fractional crystallization and late-stage fluid-melt-crystal interaction in highly evolved magmatic systems.展开更多
Addressing the existing gap in ethical research surrounding distinct technical characteristics of Robotic Process Automation enhanced with Artificial Intelligence (AI-RPA), this analysis examines the unique ethical di...Addressing the existing gap in ethical research surrounding distinct technical characteristics of Robotic Process Automation enhanced with Artificial Intelligence (AI-RPA), this analysis examines the unique ethical dimensions by positioning AI-RPA as a distinct technological subdivision. From an analytical perspective, this study highlights key characteristics such as minimal reliance on programming, rapid development cycles, and restricted algorithmic control, which differentiate AI-RPA from traditional AI systems. These characteristics underscore the need for tailored ethical considerations, to identify ethical perils within AI-RPA’s technological origins. By positioning AI-RPA as a distinct subdivision and examining its unique characteristics alongside their emerging ethical challenges, this paper enriches the evolving discourse on AI ethics, providing valuable insights for researchers, policymakers, and organizations implementing AI-RPA technologies.展开更多
The color cluster red,black and white occurs in the artistic,ritual and magical activities of virtually all cultures around the world,suggesting their preeminence in human symbolic thought.Among the various explanatio...The color cluster red,black and white occurs in the artistic,ritual and magical activities of virtually all cultures around the world,suggesting their preeminence in human symbolic thought.Among the various explanations that have been brought forth to account for the special status of these three colors are:1)evolutionary/ecological arguments,drawing support from vision science,perceptual philosophy and primate biology;2)cognitive arguments,which pay attention to how human beings categorize and create meaning out of perceptual experiences;3)linguistic arguments,as these are the earliest lexicalized color words in most languages;4)and diverse socio-cultural arguments.This paper will explore the manifestation of red,black and white–both in concrete terms,through the use and manipulation of materials,as well as abstract ideas–in Assyrian and Babylonian magical and ritual activities.It will highlight how meaning is created and communicated by relating colors to natural and supernatural phenomena and will further attempt to provide a methodological framework for the analysis of color symbolism.展开更多
BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is a leading cause of chronic liver disease globally.Current diagnostic methods,such as liver biopsies,are invasive and have limitations,highli...BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is a leading cause of chronic liver disease globally.Current diagnostic methods,such as liver biopsies,are invasive and have limitations,highlighting the need for non-invasive alternatives.AIM To investigate extracellular vesicles(EVs)as potential biomarkers for diagnosing and staging steatosis in patients with MASLD using machine learning(ML)and explainable artificial intelligence(XAI).METHODS In this single-center observational study,798 patients with metabolic dysfunction were enrolled.Of these,194 met the eligibility criteria,and 76 successfully completed all study procedures.Transient elastography was used for steatosis and fibrosis staging,and circulating plasma EV characteristics were analyzed through nanoparticle tracking.Twenty ML models were developed:Six to differentiate non-steatosis(S0)from steatosis(S1-S3);and fourteen to identify severe steatosis(S3).Models utilized EV features(size and concentration),clinical(advanced fibrosis and presence of type 2 diabetes mellitus),and anthropomorphic(sex,age,height,weight,body mass index)data.Their performance was assessed using receiver operating characteristic(ROC)-area under the curve(AUC),specificity,and sensitivity,while correlation and XAI analysis were also conducted.RESULTS The CatBoost C1a model achieved an ROC-AUC of 0.71/0.86(train/test)on average across ten random five-fold cross-validations,using EV features alone to distinguish S0 from S1-S3.The CatBoost C2h-21 model achieved an ROC-AUC of 0.81/1.00(train/test)on average across ten random three-fold cross-validations,using engineered features including EVs,clinical features like diabetes and advanced fibrosis,and anthropomorphic data like body mass index and weight for identifying severe steatosis(S3).Key predictors included EV mean size and concentration.Correlation,XAI,and SHapley Additive exPlanations analysis revealed non-linear feature relationships with steatosis stages.CONCLUSION The EV-based ML models demonstrated that the mean size and concentration of circulating plasma EVs constituted key predictors for distinguishing the absence of significant steatosis(S0)in patients with metabolic dysfunction,while the combination of EV,clinical,and anthropomorphic features improved the diagnostic accuracy for the identification of severe steatosis.The algorithmic approach using ML and XAI captured non-linear patterns between disease features and provided interpretable MASLD staging insights.However,further large multicenter studies,comparisons,and validation with histopathology and advanced imaging methods are needed.展开更多
Complex genetic relationships between neurodegenerative disorders and neuropsychiatric symptoms have been shown, suggesting shared pathogenic mechanisms and emphasizing the potential for developing common therapeutic ...Complex genetic relationships between neurodegenerative disorders and neuropsychiatric symptoms have been shown, suggesting shared pathogenic mechanisms and emphasizing the potential for developing common therapeutic targets. Apolipoprotein E(APOE) genotypes and their corresponding protein(Apo E) isoforms may influence the biophysical properties of the cell membrane lipid bilayer. However, the role of APOE in central nervous system pathophysiology extended beyond its lipid transport function. In the present review article, we analyzed the links existing between APOE genotypes and the neurobiology of neuropsychiatric symptoms in neurodegenerative and vascular diseases. APOE genotypes(APOE ε2, APOE ε3, and APOE ε4) were implicated in common mechanisms underlying a wide spectrum of neurodegenerative diseases, including sporadic Alzheimer's disease, synucleinopathies such as Parkinson's disease and Lewy body disease, stroke, and traumatic brain injury. These shared pathways often involved neuroinflammation, abnormal protein accumulation, or responses to acute detrimental events. Across these conditions, APOE variants are believed to contribute to the modulation of inflammatory responses, the regulation of amyloid and tau pathology, as well as the clearance of proteins such as α-synuclein. The bidirectional interactions among Apo E, amyloid and mitochondrial metabolism, immunomodulatory effects, neuronal repair, and remodeling underscored the complexity of Apo E's role in neuropsychiatric symptoms associated with these conditions since from early phases of cognitive impairment such as mild cognitive impairment and mild behavioral impairment. Besides Apo E-specific isoforms' link to increased neuropsychiatric symptoms in Alzheimer's disease(depression, psychosis, aberrant motor behaviors, and anxiety, not apathy), the APOE ε4 genotype was also considered a significant genetic risk factor for Lewy body disease and its worse cognitive outcomes. Conversely, the APOE ε2 variant has been observed not to exert a protective effect equally in all neurodegenerative diseases. Specifically, in Lewy body disease, this variant may delay disease onset, paralleling its protective role in Alzheimer's disease, although its role in frontotemporal dementia is uncertain. The APOE ε4 genotype has been associated with adverse cognitive outcomes across other various neurodegenerative conditions. In Parkinson's disease, the APOE ε4 allele significantly impacted cognitive performance, increasing the risk of developing dementia, even in cases of pure synucleinopathies with minimal co-pathology from Alzheimer's disease. Similarly, in traumatic brain injury, recovery rates varied, with APOE ε4 carriers demonstrating a greater risk of poor long-term cognitive outcomes and elevated levels of neuropsychiatric symptoms. Furthermore, APOE ε4 influenced the age of onset and severity of stroke, as well as the likelihood of developing stroke-associated dementia, potentially due to its role in compromising endothelial integrity and promoting blood–brain barrier dysfunction.展开更多
BACKGROUND Bile spillage occurs more frequently in patients with incidental gallbladder carcinoma(iGBC)and may be associated with poor survival due to presumed high risk of peritoneal seeding.AIM To investigate the im...BACKGROUND Bile spillage occurs more frequently in patients with incidental gallbladder carcinoma(iGBC)and may be associated with poor survival due to presumed high risk of peritoneal seeding.AIM To investigate the impact of bile spillage during primary surgery on the survival of patients with iGBC.METHODS Medical records of patients with iGBC diagnosed between 2000 and 2019 in 27 Dutch secondary centers and 5 tertiary centers were retrospectively reviewed.Patient medical records were assessed.Predictors for overall survival(OS)were determined using multivariable Cox regression.RESULTS Of the 346 included patients with iGBC,138(39.9%)had bile spillage,which was associated with higher American Society of Anesthesiologists classification(P=0.020),cholecystitis(P<0.001),higher tumor stage(P=0.005),and non-radical resection(P<0.001).Bile spillage was associated with poor OS[hazard ratio=1.97,95%confidence interval(CI):1.48-2.63,P<0.001]with a median OS of 12 months(95%CI:7-18 months)vs 34 months(95%CI:14-55 months,P<0.001).In multivariable analysis,spillage was not an independent prognostic factor for survival(hazard ratio=1.21,95%CI:0.84-1.74,P=0.313).CONCLUSION Although bile spillage correlates with prognostic factors,it lacks independent prognostic significance for survival.Patients with an indication for additional treatment should be promptly referred to a specialized hepatopancreatobiliary center,irrespective of whether bile spillage has occurred.展开更多
The abandonment of rural activities in the Mediterranean mid-mountains has led to the activation of revegetation processes,as well as the subsequent implementation of various management measures to mitigate the associ...The abandonment of rural activities in the Mediterranean mid-mountains has led to the activation of revegetation processes,as well as the subsequent implementation of various management measures to mitigate the associated ecosystem disservices.Focusing on soil environment and its growing importance in a climate change scenario,it is of great interest to study how land management and landscape changes can affect,not only the soil carbon storage process,but also its dynamics.A study was conducted in La Rioja(Iberian System,Spain),comparing three post-abandonment management strategies:secondary succession,forest management,and shrub clearing and extensive grazing.These strategies were analysed in two types of soil environments(acid and alkaline)and for two depth ranges(0–20 cm and 20–40 cm).Laboratory analyses were performed on aggregate stability and soil organic carbon fractionation with regard to three aggregate sizes(<2 mm,2–5 mm,>5 mm)and three density fractions(free labile,occluded,and heavy fraction).The results showed that:1)SOC content in aggregates<2 mm(relative to total SOC)increases with shrub clearing and grazing strategy in acid environments;2)aggregate stability benefits from the implementation of afforestation in acid environments and from all three study strategies in alkaline ones;3)in acid environments,the percentage of labile fractions(free and occluded)in afforested sites is significantly higher compared with shrubland,while in alkaline environments,recalcitrant SOC is significantly higher in shrub clearing sites.Thus,land management should be focused on SOC storage after land abandonment in Mediterranean mountainous environments.展开更多
Background Conditional relative survival(CRS),the probability of survival given that an individual has already survived a certain period post-diagnosis,is a more clinically relevant measure for long-term survival than...Background Conditional relative survival(CRS),the probability of survival given that an individual has already survived a certain period post-diagnosis,is a more clinically relevant measure for long-term survival than standard relative survival(RS).This study aims to evaluate the 5-year CRS among adolescent and young adult(AYA)breast cancer patients by age,tumor stage,and receptor subtype to guide disclosure periods for insurance.Methods Data of all females aged 18–39 years and diagnosed with invasive breast cancer between 2003 and 2021(n=13,075)were obtained from The Netherlands Cancer Registry(NCR).The five-year CRS was calculated annually up to 10 years post-diagnosis using a hybrid analysis approach.Results For the total AYA breast cancer study population the 5-year CRS exceeded 90%from diagnosis and increased beyond 95%7 years post-diagnosis.Patients aged 18–24 reached 95%9 years post-diagnosis,those aged 25–29 after 5 years,and those aged 30–34 and 35–39 after 8 years.For stage I,the 5-year CRS reached 95%from diagnosis,for stage II after 6 years,while the 5-year CRS for stages III and IV did not reach the 95%threshold during the 10-year follow-up.Triple-negative tumors exceeded 95%after 4 years,human epidermal growth factor receptor 2(HER2)positive tumors after 6 years,while hormone receptor(HR)positive tumors did not reach 95%.Conclusion Excess mortality among AYA breast cancer patients tends to be little(CRS 90%–95%)from diagnosis and becomes minimal(CRS>95%)over time compared to the general population.These results can enhance expectation management and inform policymakers,suggesting a shorter disclosure period.展开更多
Introduction:Consumer wearables increasingly provide users with Composite Health Scores(CHS)–integrated biometric indices that claim to quantify readiness,recovery,stress,or overall well-being.Despite their growing a...Introduction:Consumer wearables increasingly provide users with Composite Health Scores(CHS)–integrated biometric indices that claim to quantify readiness,recovery,stress,or overall well-being.Despite their growing adoption,the validity,transparency,and physiological relevance of these scores remain unclear.This study systematically evaluates CHS fromleading wearablemanufacturers to assess their underlying methodologies,contributors,and scientific basis.Content:Information was synthesised from publicly available company documentation,including technical white papers,user manuals,app interfaces,and research literature where available.We identified 14 CHS across 10 major wearable manufacturers,including Fitbit(Daily Readiness),Garmin(Body Battery^(TM)and Training Readiness),Oura(Readiness and Resilience),WHOOP(Strain,Recovery,and Stress Monitor),Polar(Nightly Recharge^(TM)),Samsung(Energy Score),Suunto(Body Resources),Ultrahuman(Dynamic Recovery),Coros(Daily Stress),and Withings(Health Improvement Score).The most frequently incorporated biometric contributors in this catalogue of CHS were heart rate variability(86%),resting heart rate(79%),physical activity(71%),and sleep duration(71%).However,significant discrepancies were identified in data collection timeframes,metric weighting,and proprietary scoring methodologies.None of the manufacturers disclosed their exact algorithmic formulas,and few provided empirical validation or peer-reviewed evidence supporting the accuracy or clinical relevance of their scores.Summary and outlook:While the concept of CHS represent a promising innovation in digital health,their scientific validity,transparency,and clinical applicability remain uncertain.Future research should focus on establishing standardized sensor fusion frameworks,improving algorithmic transparency,and evaluating CHS across diverse populations.Greater collaboration between industry,researchers,and clinicians is essential to ensure these indices serve as meaningful health metrics rather than opaque consumer tools.展开更多
During the non-breeding season(September-April),Black-tailed Godwits(Limosa limosa)are commonly seen in coastal and inland wetlands of the Ganges-Brahmaputra-Meghna Delta in Bangladesh.We hypothesize that the Ganges-B...During the non-breeding season(September-April),Black-tailed Godwits(Limosa limosa)are commonly seen in coastal and inland wetlands of the Ganges-Brahmaputra-Meghna Delta in Bangladesh.We hypothesize that the Ganges-Brahmaputra-Meghna Delta,at the overlap between the Central Asian and East Asian-Australasian flyways,may host three subspecies that breed in disjunct areas of temperate and northern Asia:L.l.limosa,L.l.melanuroides,and L.l.bohaii.We used mitochondrial DNA(mt DNA)haplotype network and biometric analysis to determine subspecies in captured individuals,and deployed GPS-GSM transmitters to verify breeding areas of individuals with subspecies assignments.To test for differential habitat preferences,we sampled birds at two ecologically distinct habitats known to host the largest concentrations of non-breeding Black-tailed Godwits in Bangladesh:Nijhum Dweep National Park,a tidal coastal habitat with brackish water on the south-central coast,and Tanguar Haor(‘backmarsh'),a seasonal freshwater floodplain in the north.During the non-breeding seasons of 2021-2022 and 2022-2023,we sampled and measured 93 Black-tailed Godwits,54 of which were equipped with GPS-GSM transmitters.Our mt DNA haplotype network analysis confirmed the presence of limosa,melanuroides,and bohaii subspecies at the study sites.Thus,indeed,Black-tailed Godwits subspecies,despite having distinct breeding ranges,exhibit(partially)overlapping non-breeding ranges in Asia.The subspecies composition differed significantly between sites,with limosa and bohaii dominating in Tanguar Haor and melanuroides in Nijhum Dweep.Of the 21 individuals that were tracked to their breeding grounds,18 migrated to the expected breeding range of their respective subspecies.However,one bird with a limosa haplotype migrated to a known breeding area of bohaii,whereas two birds with melanuroides haplotypes migrated to the supposed breeding range of limosa.Therefore,while ecological factors at both ends of the flyways may shape the morphological and behavioural differences between Black-tailed Godwit subspecies,their delineations and possible gene flow require further studies.展开更多
Climate change is expected to alter the popu-lation dynamics of pioneer tree species and their planned use in sustainable forest management,but we have a lim-ited understanding of how their demographic rates change in...Climate change is expected to alter the popu-lation dynamics of pioneer tree species and their planned use in sustainable forest management,but we have a lim-ited understanding of how their demographic rates change in response to climate changes during ecological restora-tion.Based on 12 years of demographic data for a pioneer tree species(Pinus massoniana)censused in three plots that correspond to three stages of ecological restoration in south-eastern China.We built integral projection models(IPMs)to assess vital rates(survival,growth,reproduction)and population growth in each plot,then evaluated demographic changes to simulated changes in seasonal mean temperature and precipitation in the current and previous census period.The plot representing the medium restoration stage had the highest population growth rate(λ=0.983).Mean population survival probability increased with ecological restoration,and reproduction probability was significantly suppressed at the high restoration stage.Survival is always the most important vital rate forλ,and climate affectsλprimarily via survival at each restoration stage.The current spring tem-perature was the most critical climate variable forλin the low and medium restoration stages,and previous summer temperature was most critical in the high restoration stage.Simulated warming leads to a decrease in the stochastic population growth rate(λ_(s))of P.massoniana in every stage.These findings suggest that during ecological restoration,P.massoniana responds to habitat change via modified demo-graphic performance,thus altering its response to climate change.Despite diverse responses to climate change,the persistence of P.massoniana populations is facing a wide-spread threat of warming states at each restoration stages.展开更多
文摘AIM： To analyze, retrospectively in a populationbased study, the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision （TME）. METHODS： All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection （632 patients） were selected from the Amsterdam Cancer Registry. For patients with recurrent disease, information on treatment of the recurrence was collected from the medical records. RESULTS： Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients （10%）. Thirty-two patients had an isolated local recurrence. Ten of these 32 patients （31%） underwent radical re-resection and experienced the highest survival （three quarters survived for at least 3 years）. Eight patients （25%） underwent non-radical surgery （median survival 24 rno）, seven patients （22%） were treated with radio- and/or chemotherapy without surgery （median survival 15 mo） and seven patients （22%） only received best supportive care （median survival 5 too）. Distant dissemination occurred in 124 patients （20%） of whom 30 patients also had a local recurrence. The majority （54%） of these patients were treated with radio- and/or chemotherapy without surgery （median survival 15 mo）. Twenty-seven percent of these patients only received best supportive care （median survival 6 mo）, while 16% underwent surgery for their recurrence. Survival was best in the latter group （median survival 32 mo）. CONCLUSION： Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TME, patients can benefit from additional treatment, especially if a radical resection is feasible.
文摘本文评估了在过去20年间(2005-2024),管理学研究如何响应联合国可持续发展目标(Sustainable Development Goals,简称SDGs)。具体而言,本文比较了涵盖会计、金融、管理、市场营销与运营管理五大学科的18本国际顶尖商学与管理学期刊,以及专注于中国管理研究的Management and Organization Review(MOR)在SDGs关注度上的差异。本文采用三种人工智能工具扫描论文摘要,并评估其与17项SDGs的契合度。结果显示,自2015年SDGs提出以来的10年间,其相关研究显著多于此前10年,增长最为显著的领域集中在SDG08(体面工作与经济增长)、SDG09(产业、创新与基础设施)以及SDG16(和平、正义与健全制度)。在所分析的期刊中,MOR在SDGs相关研究方面表现突出,凸显了其在负责任研究(Responsible Research)方面的学术引领重要作用。基于负责任研究的理念,本文进一步探讨了在学术研究中关注全体利益相关者(而非仅限股东)福祉的重要性。
基金funded by the National Natural Science Foundation of China(Grant Nos.42072089 and 41530206)。
文摘Both fractional crystallization and fluid-melt-crystal interaction are involved in the formation of highly fractionated granites.This paper assessed those two processes using geochemistry of muscovite and tourmaline and bulkrock chemistry of multi-phase Wangxianling granitoids,South China.Compositional variations suggest the coarse-grained muscovite granite is produced from fractional crystallization of the two-mica granite whereas the fine-grained muscovite granite represents a distinct magma pulse.Progressive fractionation of quartz,feldspar and biotite leads to elevated boron and aluminum content in melt which promoted muscovite and tourmaline to crystallize,which promotes two-mica granite evolving towards tourmaline-bearing muscovite granite.Fluid-melt-crystal interaction occurred at the magmatichydrothermal transitional stage and resulted in the textural and chemical zonings of tourmaline and muscovite in finegrained muscovite granite.The rims of both tourmaline and muscovite are characterized by the enrichment of fluid mobile elements such as Li,Mn,Cs and Zn and heavierδ^(11)B values of the tourmaline rims(-15.0‰to-13.6‰)compared to cores(-15.7‰to-14.3‰).Meanwhile,significant M-type REE tetrad effects(TE_(1,3)=1.07-1.18)and low K/Rb ratios(48-52)also correspond to fluid-melt-crystal interaction.This study shows zoned muscovite and tourmaline can be excellent tracers of fractional crystallization and late-stage fluid-melt-crystal interaction in highly evolved magmatic systems.
文摘Addressing the existing gap in ethical research surrounding distinct technical characteristics of Robotic Process Automation enhanced with Artificial Intelligence (AI-RPA), this analysis examines the unique ethical dimensions by positioning AI-RPA as a distinct technological subdivision. From an analytical perspective, this study highlights key characteristics such as minimal reliance on programming, rapid development cycles, and restricted algorithmic control, which differentiate AI-RPA from traditional AI systems. These characteristics underscore the need for tailored ethical considerations, to identify ethical perils within AI-RPA’s technological origins. By positioning AI-RPA as a distinct subdivision and examining its unique characteristics alongside their emerging ethical challenges, this paper enriches the evolving discourse on AI ethics, providing valuable insights for researchers, policymakers, and organizations implementing AI-RPA technologies.
文摘The color cluster red,black and white occurs in the artistic,ritual and magical activities of virtually all cultures around the world,suggesting their preeminence in human symbolic thought.Among the various explanations that have been brought forth to account for the special status of these three colors are:1)evolutionary/ecological arguments,drawing support from vision science,perceptual philosophy and primate biology;2)cognitive arguments,which pay attention to how human beings categorize and create meaning out of perceptual experiences;3)linguistic arguments,as these are the earliest lexicalized color words in most languages;4)and diverse socio-cultural arguments.This paper will explore the manifestation of red,black and white–both in concrete terms,through the use and manipulation of materials,as well as abstract ideas–in Assyrian and Babylonian magical and ritual activities.It will highlight how meaning is created and communicated by relating colors to natural and supernatural phenomena and will further attempt to provide a methodological framework for the analysis of color symbolism.
文摘BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD)is a leading cause of chronic liver disease globally.Current diagnostic methods,such as liver biopsies,are invasive and have limitations,highlighting the need for non-invasive alternatives.AIM To investigate extracellular vesicles(EVs)as potential biomarkers for diagnosing and staging steatosis in patients with MASLD using machine learning(ML)and explainable artificial intelligence(XAI).METHODS In this single-center observational study,798 patients with metabolic dysfunction were enrolled.Of these,194 met the eligibility criteria,and 76 successfully completed all study procedures.Transient elastography was used for steatosis and fibrosis staging,and circulating plasma EV characteristics were analyzed through nanoparticle tracking.Twenty ML models were developed:Six to differentiate non-steatosis(S0)from steatosis(S1-S3);and fourteen to identify severe steatosis(S3).Models utilized EV features(size and concentration),clinical(advanced fibrosis and presence of type 2 diabetes mellitus),and anthropomorphic(sex,age,height,weight,body mass index)data.Their performance was assessed using receiver operating characteristic(ROC)-area under the curve(AUC),specificity,and sensitivity,while correlation and XAI analysis were also conducted.RESULTS The CatBoost C1a model achieved an ROC-AUC of 0.71/0.86(train/test)on average across ten random five-fold cross-validations,using EV features alone to distinguish S0 from S1-S3.The CatBoost C2h-21 model achieved an ROC-AUC of 0.81/1.00(train/test)on average across ten random three-fold cross-validations,using engineered features including EVs,clinical features like diabetes and advanced fibrosis,and anthropomorphic data like body mass index and weight for identifying severe steatosis(S3).Key predictors included EV mean size and concentration.Correlation,XAI,and SHapley Additive exPlanations analysis revealed non-linear feature relationships with steatosis stages.CONCLUSION The EV-based ML models demonstrated that the mean size and concentration of circulating plasma EVs constituted key predictors for distinguishing the absence of significant steatosis(S0)in patients with metabolic dysfunction,while the combination of EV,clinical,and anthropomorphic features improved the diagnostic accuracy for the identification of severe steatosis.The algorithmic approach using ML and XAI captured non-linear patterns between disease features and provided interpretable MASLD staging insights.However,further large multicenter studies,comparisons,and validation with histopathology and advanced imaging methods are needed.
文摘Complex genetic relationships between neurodegenerative disorders and neuropsychiatric symptoms have been shown, suggesting shared pathogenic mechanisms and emphasizing the potential for developing common therapeutic targets. Apolipoprotein E(APOE) genotypes and their corresponding protein(Apo E) isoforms may influence the biophysical properties of the cell membrane lipid bilayer. However, the role of APOE in central nervous system pathophysiology extended beyond its lipid transport function. In the present review article, we analyzed the links existing between APOE genotypes and the neurobiology of neuropsychiatric symptoms in neurodegenerative and vascular diseases. APOE genotypes(APOE ε2, APOE ε3, and APOE ε4) were implicated in common mechanisms underlying a wide spectrum of neurodegenerative diseases, including sporadic Alzheimer's disease, synucleinopathies such as Parkinson's disease and Lewy body disease, stroke, and traumatic brain injury. These shared pathways often involved neuroinflammation, abnormal protein accumulation, or responses to acute detrimental events. Across these conditions, APOE variants are believed to contribute to the modulation of inflammatory responses, the regulation of amyloid and tau pathology, as well as the clearance of proteins such as α-synuclein. The bidirectional interactions among Apo E, amyloid and mitochondrial metabolism, immunomodulatory effects, neuronal repair, and remodeling underscored the complexity of Apo E's role in neuropsychiatric symptoms associated with these conditions since from early phases of cognitive impairment such as mild cognitive impairment and mild behavioral impairment. Besides Apo E-specific isoforms' link to increased neuropsychiatric symptoms in Alzheimer's disease(depression, psychosis, aberrant motor behaviors, and anxiety, not apathy), the APOE ε4 genotype was also considered a significant genetic risk factor for Lewy body disease and its worse cognitive outcomes. Conversely, the APOE ε2 variant has been observed not to exert a protective effect equally in all neurodegenerative diseases. Specifically, in Lewy body disease, this variant may delay disease onset, paralleling its protective role in Alzheimer's disease, although its role in frontotemporal dementia is uncertain. The APOE ε4 genotype has been associated with adverse cognitive outcomes across other various neurodegenerative conditions. In Parkinson's disease, the APOE ε4 allele significantly impacted cognitive performance, increasing the risk of developing dementia, even in cases of pure synucleinopathies with minimal co-pathology from Alzheimer's disease. Similarly, in traumatic brain injury, recovery rates varied, with APOE ε4 carriers demonstrating a greater risk of poor long-term cognitive outcomes and elevated levels of neuropsychiatric symptoms. Furthermore, APOE ε4 influenced the age of onset and severity of stroke, as well as the likelihood of developing stroke-associated dementia, potentially due to its role in compromising endothelial integrity and promoting blood–brain barrier dysfunction.
文摘BACKGROUND Bile spillage occurs more frequently in patients with incidental gallbladder carcinoma(iGBC)and may be associated with poor survival due to presumed high risk of peritoneal seeding.AIM To investigate the impact of bile spillage during primary surgery on the survival of patients with iGBC.METHODS Medical records of patients with iGBC diagnosed between 2000 and 2019 in 27 Dutch secondary centers and 5 tertiary centers were retrospectively reviewed.Patient medical records were assessed.Predictors for overall survival(OS)were determined using multivariable Cox regression.RESULTS Of the 346 included patients with iGBC,138(39.9%)had bile spillage,which was associated with higher American Society of Anesthesiologists classification(P=0.020),cholecystitis(P<0.001),higher tumor stage(P=0.005),and non-radical resection(P<0.001).Bile spillage was associated with poor OS[hazard ratio=1.97,95%confidence interval(CI):1.48-2.63,P<0.001]with a median OS of 12 months(95%CI:7-18 months)vs 34 months(95%CI:14-55 months,P<0.001).In multivariable analysis,spillage was not an independent prognostic factor for survival(hazard ratio=1.21,95%CI:0.84-1.74,P=0.313).CONCLUSION Although bile spillage correlates with prognostic factors,it lacks independent prognostic significance for survival.Patients with an indication for additional treatment should be promptly referred to a specialized hepatopancreatobiliary center,irrespective of whether bile spillage has occurred.
基金supported by the MANMOUNT project(PID2019-105983RB-100)funded by the MICINN-FEDER(MICIU/AEI/10.13039/501100011033)the 570 PRX21/00375 project funded by the Ministry of Universities of Spain from the“Salvador de Madariaga”programme+1 种基金The‘Geoenvironmental Processes and Global Change’(E02_23R)research group is financed by the Aragon Government and the European Social Fund(ESF-FSE)The first author is working with an FPI contract(PRE2020-094509)from the Spanish Ministry of Economy and Competitiveness associated to the MANMOUNT project.
文摘The abandonment of rural activities in the Mediterranean mid-mountains has led to the activation of revegetation processes,as well as the subsequent implementation of various management measures to mitigate the associated ecosystem disservices.Focusing on soil environment and its growing importance in a climate change scenario,it is of great interest to study how land management and landscape changes can affect,not only the soil carbon storage process,but also its dynamics.A study was conducted in La Rioja(Iberian System,Spain),comparing three post-abandonment management strategies:secondary succession,forest management,and shrub clearing and extensive grazing.These strategies were analysed in two types of soil environments(acid and alkaline)and for two depth ranges(0–20 cm and 20–40 cm).Laboratory analyses were performed on aggregate stability and soil organic carbon fractionation with regard to three aggregate sizes(<2 mm,2–5 mm,>5 mm)and three density fractions(free labile,occluded,and heavy fraction).The results showed that:1)SOC content in aggregates<2 mm(relative to total SOC)increases with shrub clearing and grazing strategy in acid environments;2)aggregate stability benefits from the implementation of afforestation in acid environments and from all three study strategies in alkaline ones;3)in acid environments,the percentage of labile fractions(free and occluded)in afforested sites is significantly higher compared with shrubland,while in alkaline environments,recalcitrant SOC is significantly higher in shrub clearing sites.Thus,land management should be focused on SOC storage after land abandonment in Mediterranean mountainous environments.
基金supported by The Netherlands Organization for Scientific Research VIDI(grant number:198.007).
文摘Background Conditional relative survival(CRS),the probability of survival given that an individual has already survived a certain period post-diagnosis,is a more clinically relevant measure for long-term survival than standard relative survival(RS).This study aims to evaluate the 5-year CRS among adolescent and young adult(AYA)breast cancer patients by age,tumor stage,and receptor subtype to guide disclosure periods for insurance.Methods Data of all females aged 18–39 years and diagnosed with invasive breast cancer between 2003 and 2021(n=13,075)were obtained from The Netherlands Cancer Registry(NCR).The five-year CRS was calculated annually up to 10 years post-diagnosis using a hybrid analysis approach.Results For the total AYA breast cancer study population the 5-year CRS exceeded 90%from diagnosis and increased beyond 95%7 years post-diagnosis.Patients aged 18–24 reached 95%9 years post-diagnosis,those aged 25–29 after 5 years,and those aged 30–34 and 35–39 after 8 years.For stage I,the 5-year CRS reached 95%from diagnosis,for stage II after 6 years,while the 5-year CRS for stages III and IV did not reach the 95%threshold during the 10-year follow-up.Triple-negative tumors exceeded 95%after 4 years,human epidermal growth factor receptor 2(HER2)positive tumors after 6 years,while hormone receptor(HR)positive tumors did not reach 95%.Conclusion Excess mortality among AYA breast cancer patients tends to be little(CRS 90%–95%)from diagnosis and becomes minimal(CRS>95%)over time compared to the general population.These results can enhance expectation management and inform policymakers,suggesting a shorter disclosure period.
基金funded by the Health Research Board in Ireland(Grant ID:HRB ILP-PHR-2024-005)Research Ireland(Grant ID:12/RC/2289_P2).
文摘Introduction:Consumer wearables increasingly provide users with Composite Health Scores(CHS)–integrated biometric indices that claim to quantify readiness,recovery,stress,or overall well-being.Despite their growing adoption,the validity,transparency,and physiological relevance of these scores remain unclear.This study systematically evaluates CHS fromleading wearablemanufacturers to assess their underlying methodologies,contributors,and scientific basis.Content:Information was synthesised from publicly available company documentation,including technical white papers,user manuals,app interfaces,and research literature where available.We identified 14 CHS across 10 major wearable manufacturers,including Fitbit(Daily Readiness),Garmin(Body Battery^(TM)and Training Readiness),Oura(Readiness and Resilience),WHOOP(Strain,Recovery,and Stress Monitor),Polar(Nightly Recharge^(TM)),Samsung(Energy Score),Suunto(Body Resources),Ultrahuman(Dynamic Recovery),Coros(Daily Stress),and Withings(Health Improvement Score).The most frequently incorporated biometric contributors in this catalogue of CHS were heart rate variability(86%),resting heart rate(79%),physical activity(71%),and sleep duration(71%).However,significant discrepancies were identified in data collection timeframes,metric weighting,and proprietary scoring methodologies.None of the manufacturers disclosed their exact algorithmic formulas,and few provided empirical validation or peer-reviewed evidence supporting the accuracy or clinical relevance of their scores.Summary and outlook:While the concept of CHS represent a promising innovation in digital health,their scientific validity,transparency,and clinical applicability remain uncertain.Future research should focus on establishing standardized sensor fusion frameworks,improving algorithmic transparency,and evaluating CHS across diverse populations.Greater collaboration between industry,researchers,and clinicians is essential to ensure these indices serve as meaningful health metrics rather than opaque consumer tools.
基金supported by The Embassy of the Royal Kingdom of the Netherlands in Dhaka,The Embassy of France in Dhaka,and Bangabandhu Science and Technology Fellowship Trust,MoST,Bangladesh。
文摘During the non-breeding season(September-April),Black-tailed Godwits(Limosa limosa)are commonly seen in coastal and inland wetlands of the Ganges-Brahmaputra-Meghna Delta in Bangladesh.We hypothesize that the Ganges-Brahmaputra-Meghna Delta,at the overlap between the Central Asian and East Asian-Australasian flyways,may host three subspecies that breed in disjunct areas of temperate and northern Asia:L.l.limosa,L.l.melanuroides,and L.l.bohaii.We used mitochondrial DNA(mt DNA)haplotype network and biometric analysis to determine subspecies in captured individuals,and deployed GPS-GSM transmitters to verify breeding areas of individuals with subspecies assignments.To test for differential habitat preferences,we sampled birds at two ecologically distinct habitats known to host the largest concentrations of non-breeding Black-tailed Godwits in Bangladesh:Nijhum Dweep National Park,a tidal coastal habitat with brackish water on the south-central coast,and Tanguar Haor(‘backmarsh'),a seasonal freshwater floodplain in the north.During the non-breeding seasons of 2021-2022 and 2022-2023,we sampled and measured 93 Black-tailed Godwits,54 of which were equipped with GPS-GSM transmitters.Our mt DNA haplotype network analysis confirmed the presence of limosa,melanuroides,and bohaii subspecies at the study sites.Thus,indeed,Black-tailed Godwits subspecies,despite having distinct breeding ranges,exhibit(partially)overlapping non-breeding ranges in Asia.The subspecies composition differed significantly between sites,with limosa and bohaii dominating in Tanguar Haor and melanuroides in Nijhum Dweep.Of the 21 individuals that were tracked to their breeding grounds,18 migrated to the expected breeding range of their respective subspecies.However,one bird with a limosa haplotype migrated to a known breeding area of bohaii,whereas two birds with melanuroides haplotypes migrated to the supposed breeding range of limosa.Therefore,while ecological factors at both ends of the flyways may shape the morphological and behavioural differences between Black-tailed Godwit subspecies,their delineations and possible gene flow require further studies.
基金supported by the National Natural Science Foundation of China(grant no.31971638)the Public Welfare Project of Fujian Science and Technology Department(grant no.2024R1002001).
文摘Climate change is expected to alter the popu-lation dynamics of pioneer tree species and their planned use in sustainable forest management,but we have a lim-ited understanding of how their demographic rates change in response to climate changes during ecological restora-tion.Based on 12 years of demographic data for a pioneer tree species(Pinus massoniana)censused in three plots that correspond to three stages of ecological restoration in south-eastern China.We built integral projection models(IPMs)to assess vital rates(survival,growth,reproduction)and population growth in each plot,then evaluated demographic changes to simulated changes in seasonal mean temperature and precipitation in the current and previous census period.The plot representing the medium restoration stage had the highest population growth rate(λ=0.983).Mean population survival probability increased with ecological restoration,and reproduction probability was significantly suppressed at the high restoration stage.Survival is always the most important vital rate forλ,and climate affectsλprimarily via survival at each restoration stage.The current spring tem-perature was the most critical climate variable forλin the low and medium restoration stages,and previous summer temperature was most critical in the high restoration stage.Simulated warming leads to a decrease in the stochastic population growth rate(λ_(s))of P.massoniana in every stage.These findings suggest that during ecological restoration,P.massoniana responds to habitat change via modified demo-graphic performance,thus altering its response to climate change.Despite diverse responses to climate change,the persistence of P.massoniana populations is facing a wide-spread threat of warming states at each restoration stages.
