近年来随着大量肝细胞癌(hepatocellular carcinoma,HCC)临床研究数据的公布,美国肝病研究学会(American Association for the Study of Liver Diseases,AASLD)、美国国家综合癌症网络(National Comprehensive Cancer Network,NCCN)、...近年来随着大量肝细胞癌(hepatocellular carcinoma,HCC)临床研究数据的公布,美国肝病研究学会(American Association for the Study of Liver Diseases,AASLD)、美国国家综合癌症网络(National Comprehensive Cancer Network,NCCN)、美国临床肿瘤学会(American Society of Clinical Oncology,ASCO)和我国国家卫生健康委员会均针对HCC做出诊疗指南更新。AASLD 2023、NCCN 2024与中国《原发性肝癌诊疗指南(2024年版)》(CNLC 2024)对于HCC风险人群的定义不存在差异,其中CNLC 2024根据我国罹患肝癌人群的特征,针对HCC高危因素与早期筛查手段做出更新。4部指南对于HCC新辅助和辅助治疗、局部治疗、系统治疗等方面的更新较多。CNLC 2024细化了局部治疗适应证,完善了系统治疗策略,新增甲磺酸阿帕替尼联合卡瑞利珠单抗、替雷利珠单抗作为一线用药。AASLD 2023、NCCN 2024和ASCO 2024推荐的晚期二线方案纳武利尤单抗+伊匹木单抗或成为晚期HCC的新一线药物治疗选择。笔者对该4部指南进行了比较解读。展开更多
Lianas are distributed as ornamental, perennial plants that are widely used in landscaping and popular all over the world. However, in recent times, ornamental lianas have also been used for vertical landscaping in re...Lianas are distributed as ornamental, perennial plants that are widely used in landscaping and popular all over the world. However, in recent times, ornamental lianas have also been used for vertical landscaping in residential buildings. Today, many lianas occupy a leading position among plants, due to their landscape features, such as the colorfulness of flowers, the variety of leaf shapes, and their aroma. The practice of growing flowers in Uzbekistan dates back to ancient times. Floriculture came to our republic through the Great Silk Road from China, Egypt, and India. Because of this, ornamental plants have been widely used for landscaping in cities such as Samarkand, Bukhara, Khiva, Shahrisabz, Kokand, and Margilan. Nowadays, perennial lianas are planted on the grounds of the Botanical Garden at Samarkand State University, and collections of these plants have been created. The garden area contains various species of lianas, including Lonicera japonica Thunb, Clematis florida Thunb, Parthenocissus quinquefolia (L.) Planch, Parthenocissus inserta (A.Kern) Fritsch, Hedera spiral L, Hedera canariensis Willd, Campsis radicans L, Wisteria sinensis (Sims) DC, Actinidia chinensis var. deliciosa (A.Chev.), Humulus lupulus L, Aristolochia clematitis L, and several varieties of Rosa canina L. such as Golden Celebration, Paprika, Aspirin, Burgund, and Rosarium Uetersen.展开更多
The article presents data on the screening of rhizobacteria and active isolates isolated from the humus layer of natural humus soils against phytopathogenic fungi Rhizoctonia solani and Fusarium oxysporum and their re...The article presents data on the screening of rhizobacteria and active isolates isolated from the humus layer of natural humus soils against phytopathogenic fungi Rhizoctonia solani and Fusarium oxysporum and their resistance to various concentrations of NaCl (0%, 1%, 5%, 7%, 10%). The results of studies on the synthesis of phytohormones with the properties of microorganisms that enhance plant growth and development are presented. Antagonistically active bacterial strains that grew even at high salt concentrations were identified using MALDI-TOF analysis. They were identified as XD 4.3 Bacillus subtilis and XDN6 Bacillus cereus, respectively.展开更多
Cold atmospheric plasma(CAP)has emerged as a promising technology for the degradation of organic dyes,but the underlying mechanisms at the molecular level remain poorly understood.Using density-functional tight-bindin...Cold atmospheric plasma(CAP)has emerged as a promising technology for the degradation of organic dyes,but the underlying mechanisms at the molecular level remain poorly understood.Using density-functional tight-binding(DFTB)-based quantum chemical molecular dynamics at 300 K,we have performed numerical simulations to investigate the degradation mechanism of Disperse Red 1(DR)interacting with CAP-generated oxygen radicals.One hundred directdynamics trajectories were calculated for up to 100 ps simulation time,after which hydrogenabstraction,benzene ring-opening/expanding,formaldehyde formation and modification in the chromophoric azo group which can lead to color-losing were observed.The latter was obtained with yields of around 6%at the given temperature.These findings not only enhance our understanding of CAP treatment processes but also have implications for the development of optimized purification systems for sustainable wastewater treatment.This study underscores the utility of DFTB simulations in unraveling complex chemical processes and guiding the design of advanced treatment strategies in the context of CAP technology.展开更多
文摘近年来随着大量肝细胞癌(hepatocellular carcinoma,HCC)临床研究数据的公布,美国肝病研究学会(American Association for the Study of Liver Diseases,AASLD)、美国国家综合癌症网络(National Comprehensive Cancer Network,NCCN)、美国临床肿瘤学会(American Society of Clinical Oncology,ASCO)和我国国家卫生健康委员会均针对HCC做出诊疗指南更新。AASLD 2023、NCCN 2024与中国《原发性肝癌诊疗指南(2024年版)》(CNLC 2024)对于HCC风险人群的定义不存在差异,其中CNLC 2024根据我国罹患肝癌人群的特征,针对HCC高危因素与早期筛查手段做出更新。4部指南对于HCC新辅助和辅助治疗、局部治疗、系统治疗等方面的更新较多。CNLC 2024细化了局部治疗适应证,完善了系统治疗策略,新增甲磺酸阿帕替尼联合卡瑞利珠单抗、替雷利珠单抗作为一线用药。AASLD 2023、NCCN 2024和ASCO 2024推荐的晚期二线方案纳武利尤单抗+伊匹木单抗或成为晚期HCC的新一线药物治疗选择。笔者对该4部指南进行了比较解读。
文摘Lianas are distributed as ornamental, perennial plants that are widely used in landscaping and popular all over the world. However, in recent times, ornamental lianas have also been used for vertical landscaping in residential buildings. Today, many lianas occupy a leading position among plants, due to their landscape features, such as the colorfulness of flowers, the variety of leaf shapes, and their aroma. The practice of growing flowers in Uzbekistan dates back to ancient times. Floriculture came to our republic through the Great Silk Road from China, Egypt, and India. Because of this, ornamental plants have been widely used for landscaping in cities such as Samarkand, Bukhara, Khiva, Shahrisabz, Kokand, and Margilan. Nowadays, perennial lianas are planted on the grounds of the Botanical Garden at Samarkand State University, and collections of these plants have been created. The garden area contains various species of lianas, including Lonicera japonica Thunb, Clematis florida Thunb, Parthenocissus quinquefolia (L.) Planch, Parthenocissus inserta (A.Kern) Fritsch, Hedera spiral L, Hedera canariensis Willd, Campsis radicans L, Wisteria sinensis (Sims) DC, Actinidia chinensis var. deliciosa (A.Chev.), Humulus lupulus L, Aristolochia clematitis L, and several varieties of Rosa canina L. such as Golden Celebration, Paprika, Aspirin, Burgund, and Rosarium Uetersen.
文摘The article presents data on the screening of rhizobacteria and active isolates isolated from the humus layer of natural humus soils against phytopathogenic fungi Rhizoctonia solani and Fusarium oxysporum and their resistance to various concentrations of NaCl (0%, 1%, 5%, 7%, 10%). The results of studies on the synthesis of phytohormones with the properties of microorganisms that enhance plant growth and development are presented. Antagonistically active bacterial strains that grew even at high salt concentrations were identified using MALDI-TOF analysis. They were identified as XD 4.3 Bacillus subtilis and XDN6 Bacillus cereus, respectively.
基金the financial support from the Ministry of Higher Education,Science,and Innovations of the Republic of Uzbekistan (Nos.AL-4821012320 and AL-5921122141)。
文摘Cold atmospheric plasma(CAP)has emerged as a promising technology for the degradation of organic dyes,but the underlying mechanisms at the molecular level remain poorly understood.Using density-functional tight-binding(DFTB)-based quantum chemical molecular dynamics at 300 K,we have performed numerical simulations to investigate the degradation mechanism of Disperse Red 1(DR)interacting with CAP-generated oxygen radicals.One hundred directdynamics trajectories were calculated for up to 100 ps simulation time,after which hydrogenabstraction,benzene ring-opening/expanding,formaldehyde formation and modification in the chromophoric azo group which can lead to color-losing were observed.The latter was obtained with yields of around 6%at the given temperature.These findings not only enhance our understanding of CAP treatment processes but also have implications for the development of optimized purification systems for sustainable wastewater treatment.This study underscores the utility of DFTB simulations in unraveling complex chemical processes and guiding the design of advanced treatment strategies in the context of CAP technology.
