Objective To report evaluat of division region of abdominal wall large defect after tumors resection and repair methods by tissue flaps with pedicle. Methods Form October 1992 to September 2001, 8 cases large abdomina...Objective To report evaluat of division region of abdominal wall large defect after tumors resection and repair methods by tissue flaps with pedicle. Methods Form October 1992 to September 2001, 8 cases large abdominal wall defect after malignant tumors resection(10 × 10 cm-32 cm×32 cm) were reviewed. The defectcontributed:Ⅰ region, 2 cases; twin-Ⅱ region, 2; Ⅲ region, 2; Ⅰ and Ⅱ region of one side, 1 and total abdominal wall,one case, The tissue flaps of transposition included: gracilis myocutaneous flaps, 4; retus abdominal myocutaneous flaps, 2; external abdominal obligue musculo-fascia flaps, 2; latissimus dorsi muscle, tensor fasciae latae muscle and retus femoris muscle flaps each, 1. One patient used MycroMesh also. Results In the course of peroperation, the incisions of 8 cases healed in first time; total tissue flaps survived and all pateints started exercise left the bed in 3 weeks. All 8 patients were followed up average of 2 years and 5 months: the success rate of reconstruction展开更多
Objective To investigate the preventive efficacy of triamcinolone acetonide injection on esophageal stenosis after endoscopic submucosal dissection(ESD).Methods From February 1,2021 to October 31,2023,82 patients who ...Objective To investigate the preventive efficacy of triamcinolone acetonide injection on esophageal stenosis after endoscopic submucosal dissection(ESD).Methods From February 1,2021 to October 31,2023,82 patients who underwent ESD for esophageal lesions at the Affiliated Cancer Hospital of Nanjing Medical University(Jiangsu Cancer Hospital)were enrolled.展开更多
Objective To explore the effects and underlying mechanisms of high glucose on in vitro invasiveness of human breast cancer cell line MDA-MB-435. Methods The invasiveness of MDA-MB-435 was determined by Matrigel-coated...Objective To explore the effects and underlying mechanisms of high glucose on in vitro invasiveness of human breast cancer cell line MDA-MB-435. Methods The invasiveness of MDA-MB-435 was determined by Matrigel-coated transwell chambers.展开更多
Objective To investigate the clinical value of ^125I seeds implantation in the treatment of primary liver cancer with portal vein tumor thrombus.Methods A total of 218 patients(184 males and 34 females,age:(53.8±...Objective To investigate the clinical value of ^125I seeds implantation in the treatment of primary liver cancer with portal vein tumor thrombus.Methods A total of 218 patients(184 males and 34 females,age:(53.8±9.2)years)with primary liver cancer with portal vein tumor thrombus between January 2015 and June 2018 were retrospectively analyzed.展开更多
Objective To explore the effect of combination regimenof interferon alpha-1b,interleukin-2 and thalidomide(ITI regimen) on minimal residual disease (MRD)in patients with acute myeloid leukemia ( AML) whowere in hemato...Objective To explore the effect of combination regimenof interferon alpha-1b,interleukin-2 and thalidomide(ITI regimen) on minimal residual disease (MRD)in patients with acute myeloid leukemia ( AML) whowere in hematologic remission but MRD-positive. MethodsEighteen patients (17 from Tumor Hospital of ZhengzhouUniversity and 1 from the First People's Hospital ofPingdingshan City) with AML admitted from July 2016 toJune 2018,who were in hematologic remission but MRDpositivewere treated with different doses of ITI regimen,and the MRD levels were monitored. Results Among 18patients who received a conventional dose of ITI regimenfor 1 to 2 months,7 patients had undetectable MRD,3had significant decrease in MRD levels,3 had elevatedMRD level and had hematologic recurrence. Three patientswith elevated MRD level received a higher dose ofITI regimen,2 of them turned to MRD negative and theother 1 patient had decreased MRD level.展开更多
Objective To study the effect of transforming growth factor-βactivated kinase-1 (TAK1) gene silencing on the proliferation and apoptosis of Kasumi-1 cells induced by arsenic trioxide (As2O3) .Methods Acute
Objective To investigate the efficacy,adverse events and long-term survival of cyclophosphamide,vindesine,cytarabine,dexamethasone and bleomycin (COAD-B) regimen for relapsed and refractory nonHodgkin lymphoma (NHL) ....Objective To investigate the efficacy,adverse events and long-term survival of cyclophosphamide,vindesine,cytarabine,dexamethasone and bleomycin (COAD-B) regimen for relapsed and refractory nonHodgkin lymphoma (NHL) .Methods Eighty six patients diagnosed with relapsed or refractory NHL were included in our study from January 2007 to January 2013.The chemotherapy regimen was COAD-B,the therapeutic efficacy was evaluated every 2 courses.Once the stable disease (SD) or progress of the disease (PD) achieved,展开更多
Objective To detect the expression of CRLF2 in adult Ph negative acute B lymphocytic leukemia(B-ALL)in newly diagnosed cases,and to investigate the relationship between CRLF2 and the general clinical characteristics,e...Objective To detect the expression of CRLF2 in adult Ph negative acute B lymphocytic leukemia(B-ALL)in newly diagnosed cases,and to investigate the relationship between CRLF2 and the general clinical characteristics,efficacy and prognosis.Methods 103 cases of newly diagnosed adult B-ALL patients were investigated from Apr 2016 to Dec 2017 in the Department of Hematology,Henan Cancer Hospital.Bone marrow samples were used to detect the expression of CRLF2 in leukemic cells.The expression of CRLF2≥20% was defined as CRLF2-high group and<20% was defined as CRLF2-low group.The clinical characteristics and prognosis of the two groups were compared.Results The Median overall survival(OS)and disease free survial(DFS)in CRLF2-high group were 9.0 months and 4.25 months,respectively.CRLF2-low group was 15.5 months and 10.25 months,respectively.There was a statistically significant difference in median OS and DFS between the two groups(P=0.007,P=0.000).The 18-month OS and DFS in CRLF2-high group were 38.6% and 25.1%,respectively.CRLF2-low group was 57.8% and 42.3%,respectively.Multivariate analysis showed high expression of CRLF2 was an independent risk factor for OS(HR=2.991,95% CI 1.429-6.261,P=0.004)and DFS(HR=2.374,95% CI 1.146-4.960,P=0.041)in patients.Conclusion Patients with high expression of CRLF2 have poor prognosis.展开更多
Objective To evaluate the efficacy of unrelated do-nor allogeneic hematopoietic stem cell transplantation(URD allo-HSCT).for children and adolescents with severe aplastic anemia(SAA).Methods Clinical data of34 SAA chi...Objective To evaluate the efficacy of unrelated do-nor allogeneic hematopoietic stem cell transplantation(URD allo-HSCT).for children and adolescents with severe aplastic anemia(SAA).Methods Clinical data of34 SAA children and adolescents undergoing allo-HSCT were retrospectively analyzed from October 2001 to October 2015.According to the source of donor,the展开更多
Objective To explore the relationship between the expression of neuropilin-1 (NRP-1) on Treg cells and its ligands semaphorins-3 A (Sema3A),transforming growth factor-β_(1) (TGF-β_(1)) as well as the balance of type...Objective To explore the relationship between the expression of neuropilin-1 (NRP-1) on Treg cells and its ligands semaphorins-3 A (Sema3A),transforming growth factor-β_(1) (TGF-β_(1)) as well as the balance of type 1helper T cells (Th_(1)) and type 2 helper T cells (Th_(2))cells.展开更多
Objective To explore the clinical efficacy and prognostic factors of first-generation and second-generation tyrosine kinase inhibitors(TKI)based regimen in the treatment of patients with BCR-ABL positive acute lymphob...Objective To explore the clinical efficacy and prognostic factors of first-generation and second-generation tyrosine kinase inhibitors(TKI)based regimen in the treatment of patients with BCR-ABL positive acute lymphoblastic leukemia(ALL).Methods Retrospectively analyzed the clinical characteristics and prognostic factors of 89 patients with BCR-ABL positive ALL from April 2012 to June 2018 in our hospital,and the clinical efficacy of first-generation and second-generation TKI was compared.Results 60 patients were classified into the first-generation TKI(imatinib)group.展开更多
Objective To evaluate risk factors and available treatments of extramedullary relapse (EMR) afterallogeneic hematopoietic stem cell transplantation (alloHSCT) in patients with myeloid leukemia.Methods A total of 280 p...Objective To evaluate risk factors and available treatments of extramedullary relapse (EMR) afterallogeneic hematopoietic stem cell transplantation (alloHSCT) in patients with myeloid leukemia.Methods A total of 280 patients were retrospectively analyzed from January 2008 to December 2018 in Affiliated Cancer Hospital of Zhengzhou University.展开更多
Objective To observe the compliance to Imatinib(IM)400 mg/d in 513 patients with chronic myeloid leukemia chronic phase(CML-CP)referred to Henan Province Tumor Hospital from March 2013 through March2015 and its influe...Objective To observe the compliance to Imatinib(IM)400 mg/d in 513 patients with chronic myeloid leukemia chronic phase(CML-CP)referred to Henan Province Tumor Hospital from March 2013 through March2015 and its influence on cytogenetic response at 12months.Methods Of 513 patients with CML-CP展开更多
文摘Objective To report evaluat of division region of abdominal wall large defect after tumors resection and repair methods by tissue flaps with pedicle. Methods Form October 1992 to September 2001, 8 cases large abdominal wall defect after malignant tumors resection(10 × 10 cm-32 cm×32 cm) were reviewed. The defectcontributed:Ⅰ region, 2 cases; twin-Ⅱ region, 2; Ⅲ region, 2; Ⅰ and Ⅱ region of one side, 1 and total abdominal wall,one case, The tissue flaps of transposition included: gracilis myocutaneous flaps, 4; retus abdominal myocutaneous flaps, 2; external abdominal obligue musculo-fascia flaps, 2; latissimus dorsi muscle, tensor fasciae latae muscle and retus femoris muscle flaps each, 1. One patient used MycroMesh also. Results In the course of peroperation, the incisions of 8 cases healed in first time; total tissue flaps survived and all pateints started exercise left the bed in 3 weeks. All 8 patients were followed up average of 2 years and 5 months: the success rate of reconstruction
文摘Objective To investigate the preventive efficacy of triamcinolone acetonide injection on esophageal stenosis after endoscopic submucosal dissection(ESD).Methods From February 1,2021 to October 31,2023,82 patients who underwent ESD for esophageal lesions at the Affiliated Cancer Hospital of Nanjing Medical University(Jiangsu Cancer Hospital)were enrolled.
文摘Objective To explore the effects and underlying mechanisms of high glucose on in vitro invasiveness of human breast cancer cell line MDA-MB-435. Methods The invasiveness of MDA-MB-435 was determined by Matrigel-coated transwell chambers.
文摘Objective To investigate the clinical value of ^125I seeds implantation in the treatment of primary liver cancer with portal vein tumor thrombus.Methods A total of 218 patients(184 males and 34 females,age:(53.8±9.2)years)with primary liver cancer with portal vein tumor thrombus between January 2015 and June 2018 were retrospectively analyzed.
文摘Objective To explore the effect of combination regimenof interferon alpha-1b,interleukin-2 and thalidomide(ITI regimen) on minimal residual disease (MRD)in patients with acute myeloid leukemia ( AML) whowere in hematologic remission but MRD-positive. MethodsEighteen patients (17 from Tumor Hospital of ZhengzhouUniversity and 1 from the First People's Hospital ofPingdingshan City) with AML admitted from July 2016 toJune 2018,who were in hematologic remission but MRDpositivewere treated with different doses of ITI regimen,and the MRD levels were monitored. Results Among 18patients who received a conventional dose of ITI regimenfor 1 to 2 months,7 patients had undetectable MRD,3had significant decrease in MRD levels,3 had elevatedMRD level and had hematologic recurrence. Three patientswith elevated MRD level received a higher dose ofITI regimen,2 of them turned to MRD negative and theother 1 patient had decreased MRD level.
文摘Objective To study the effect of transforming growth factor-βactivated kinase-1 (TAK1) gene silencing on the proliferation and apoptosis of Kasumi-1 cells induced by arsenic trioxide (As2O3) .Methods Acute
文摘Objective To investigate the efficacy,adverse events and long-term survival of cyclophosphamide,vindesine,cytarabine,dexamethasone and bleomycin (COAD-B) regimen for relapsed and refractory nonHodgkin lymphoma (NHL) .Methods Eighty six patients diagnosed with relapsed or refractory NHL were included in our study from January 2007 to January 2013.The chemotherapy regimen was COAD-B,the therapeutic efficacy was evaluated every 2 courses.Once the stable disease (SD) or progress of the disease (PD) achieved,
文摘Objective To detect the expression of CRLF2 in adult Ph negative acute B lymphocytic leukemia(B-ALL)in newly diagnosed cases,and to investigate the relationship between CRLF2 and the general clinical characteristics,efficacy and prognosis.Methods 103 cases of newly diagnosed adult B-ALL patients were investigated from Apr 2016 to Dec 2017 in the Department of Hematology,Henan Cancer Hospital.Bone marrow samples were used to detect the expression of CRLF2 in leukemic cells.The expression of CRLF2≥20% was defined as CRLF2-high group and<20% was defined as CRLF2-low group.The clinical characteristics and prognosis of the two groups were compared.Results The Median overall survival(OS)and disease free survial(DFS)in CRLF2-high group were 9.0 months and 4.25 months,respectively.CRLF2-low group was 15.5 months and 10.25 months,respectively.There was a statistically significant difference in median OS and DFS between the two groups(P=0.007,P=0.000).The 18-month OS and DFS in CRLF2-high group were 38.6% and 25.1%,respectively.CRLF2-low group was 57.8% and 42.3%,respectively.Multivariate analysis showed high expression of CRLF2 was an independent risk factor for OS(HR=2.991,95% CI 1.429-6.261,P=0.004)and DFS(HR=2.374,95% CI 1.146-4.960,P=0.041)in patients.Conclusion Patients with high expression of CRLF2 have poor prognosis.
文摘Objective To evaluate the efficacy of unrelated do-nor allogeneic hematopoietic stem cell transplantation(URD allo-HSCT).for children and adolescents with severe aplastic anemia(SAA).Methods Clinical data of34 SAA children and adolescents undergoing allo-HSCT were retrospectively analyzed from October 2001 to October 2015.According to the source of donor,the
文摘Objective To explore the relationship between the expression of neuropilin-1 (NRP-1) on Treg cells and its ligands semaphorins-3 A (Sema3A),transforming growth factor-β_(1) (TGF-β_(1)) as well as the balance of type 1helper T cells (Th_(1)) and type 2 helper T cells (Th_(2))cells.
文摘Objective To explore the clinical efficacy and prognostic factors of first-generation and second-generation tyrosine kinase inhibitors(TKI)based regimen in the treatment of patients with BCR-ABL positive acute lymphoblastic leukemia(ALL).Methods Retrospectively analyzed the clinical characteristics and prognostic factors of 89 patients with BCR-ABL positive ALL from April 2012 to June 2018 in our hospital,and the clinical efficacy of first-generation and second-generation TKI was compared.Results 60 patients were classified into the first-generation TKI(imatinib)group.
文摘Objective To evaluate risk factors and available treatments of extramedullary relapse (EMR) afterallogeneic hematopoietic stem cell transplantation (alloHSCT) in patients with myeloid leukemia.Methods A total of 280 patients were retrospectively analyzed from January 2008 to December 2018 in Affiliated Cancer Hospital of Zhengzhou University.
文摘Objective To observe the compliance to Imatinib(IM)400 mg/d in 513 patients with chronic myeloid leukemia chronic phase(CML-CP)referred to Henan Province Tumor Hospital from March 2013 through March2015 and its influence on cytogenetic response at 12months.Methods Of 513 patients with CML-CP
