Thermal energy storage(TES)is a key technology for renewable energy utilization and the improvement of the energy efficiency of heat processes.Sectors include industrial process heat and conventional and renewable pow...Thermal energy storage(TES)is a key technology for renewable energy utilization and the improvement of the energy efficiency of heat processes.Sectors include industrial process heat and conventional and renewable power generation.TES systems correct the mismatch between supply and demand of thermal energy.In the medium to high temperature range(100~1000℃),only limited storage technology is commercially available and a strong effort is needed to develop a range of storage technologies which are efficient and economical for the very specific requirements of the different application sectors.At the DLR's Institute of Technical Thermodynamics,the complete spectrum of high temperature storage technologies,from various types of sensible over latent heat to thermochemical heat storages are being developed.Different concepts are proposed depending on the heat transfer fluid(synthetic oil,water/steam,molten salt,air)and the required temperature range.The aim is the development of cost effective,efficient and reliable thermal storage systems.Research focuses on characterization of storage materials,enhancement of internal heat transfer,design of innovative storage concepts and modelling of storage components and systems.Demonstration of the storage technology takes place from laboratory scale to field testing(5 kW^1 MW).The paper gives an overview on DLR's current developments.展开更多
Objective:To validate the 8 th edition of the American Joint Committee on Cancer(AJCC)staging system for pancreatic ductal adenocarcinoma(PDAC)in a Chinese cohort of radically resected patients and to develop a refine...Objective:To validate the 8 th edition of the American Joint Committee on Cancer(AJCC)staging system for pancreatic ductal adenocarcinoma(PDAC)in a Chinese cohort of radically resected patients and to develop a refined staging system for PDAC.Methods:Data were collected from the China Pancreas Data Center(CPDC)for patients with resected PDAC in 2016 and 2017,and cancer-specific survival(CSS)was evaluated using the Kaplan-Meier method and log-rank test.Univariate and multivariate analyses based on Cox regression were performed to identify prognostic factors.The recursive partitioning analysis(RPA),Kaplan-Meier method,and log-rank test were performed on the training dataset to generate a proposed modification for the 8 th TNM staging system utilizing the preoperative carbohydrate antigen(CA)19-9 level.Validation was performed for both staging systems in the validation cohort.Results:A total of 1,676 PDAC patients were retrieved,and the median CSS was significantly different between the 8 th TNM groupings,with no significant difference in survival between stage IB and IIA.The analysis of T and N stages demonstrated a better prognostic value in the N category.Multivariate analysis showed that the preoperative serum CA19-9 level was the strongest prognostic indicator among all the independent risk factors.All patients with CA19-9>500 U/mL had similar survival,and we proposed a new staging system by combining IB and IIA and stratifying all patients with high CA19-9 into stage III.The modified staging system had a better performance for predicting CSS than the 8 th AJCC staging scheme.Conclusions:The 8 th AJCC staging system for PDAC is suitable for a Chinese cohort of resected patients,and the N category has a better prognostic value than the T category.Our modified staging system has superior accuracy in predicting survival than the 8 th AJCC TNM staging system.展开更多
Formation flying Low Earth Orbiters(LEOs)are important for implementing new and advanced concepts in Earth observation missions.Precise Baseline Determination(PBD)is a prerequisite for LEOs to complete specified missi...Formation flying Low Earth Orbiters(LEOs)are important for implementing new and advanced concepts in Earth observation missions.Precise Baseline Determination(PBD)is a prerequisite for LEOs to complete specified mission targets.PBD is usually performed based on space-borne GNSS data,the relative corrections of phase center and code residual variations play crucial roles in achieving the best relative orbit accuracy.Herein,the influences of antenna Relative Phase Centre Variations(RPCVs)and Single-Difference(SD)Melbourne-Wu¨bbena(MW)Combination Residuals Variations(SD MWVs)on PBD are studied.The methods were tested using flight data from Gravity Recovery And Climate Experiment(GRACE)and GRACE Follow-On(GRACE-FO).Results showed that the maximum values for RPCVs and SD MWVs were 14 mm and 0.32 cycles,respectively.Then,the RPCVs correction significantly enhanced the baseline accuracy;the K-Band Ranging(KBR)measurement consistency improved by 30.1%and 37.5%for GRACE and GRACE-FO,respectively.The application of SD MWVs further improved the accuracy and reliability of PBD results.For GRACE,the ambiguities fixing success rate increased from 85.1%to 97.9%and a baseline consistency of 0.57 mm was achieved for the KBR measurements.It was found that the correction of both RPCVs and SD MWVs reduced the carrier phase observation minus computation residuals from double-difference ionosphere-free combination.In addition,in-flight data processing demonstrated that RPCVs and SD MWVs estimations for the current period could be used for the previous and subsequent periods.展开更多
A key component of future lunar missions is the concept of in-situ resource utilization(ISRU),which involves the use of local resources to support human missions and reduce dependence on Earth-based supplies.This pape...A key component of future lunar missions is the concept of in-situ resource utilization(ISRU),which involves the use of local resources to support human missions and reduce dependence on Earth-based supplies.This paper investigates the thermal processing capability of lunar regolith without the addition of binders,with a focus on large-scale applications for the construction of lunar habitats and infrastructure.The study used a simulant of lunar regolith found on the Schr?dinger Basin in the South Pole region.This regolith simulant consists of20 wt%basalt and 80 wt%anorthosite.Experiments were conducted using a high power CO_(2)laser to sinter and melt the regolith in a 80 mm diameter laser spot to evaluate the effectiveness of direct large area thermal processing.Results indicated that sintering begins at approximately 1180℃and reaches full melt at temperatures above 1360℃.Sintering experiments with this material revealed the formation of dense samples up to 11 mm thick,while melting experiments successfully produced larger samples by overlapping molten layers and additive manufacturing up to 50 mm thick.The energy efficiency of the sintering and melting processes was compared.The melting process was about 10 times more energy efficient than sintering in terms of material consolidation,demonstrating the promising potential of laser melting technologies of anorthosite-rich regolith for the production of structural elements.展开更多
BACKGROUND Idiopathic mesenteric phlebosclerosis(IMP)is a rare condition that causes ischaemic colitis,has various clinical manifestations,and may even be asymptomatic,often resulting in clinical misdiagnosis.CASE SUM...BACKGROUND Idiopathic mesenteric phlebosclerosis(IMP)is a rare condition that causes ischaemic colitis,has various clinical manifestations,and may even be asymptomatic,often resulting in clinical misdiagnosis.CASE SUMMARY We report the case of a 44-year-old woman with chief complaints of abdominal pain,vomiting and decreased defecation.One year prior,the patient was asymptomatic and therefore misdiagnosed with inflammatory bowel disease based on incidental findings on an abdominal computed tomography(CT)scan.The present abdominal CT scan revealed an intestinal obstruction,diffuse thickening of the entire colon wall and calcification of the mesenteric and colonic veins.Colonoscopy revealed multiple ulcerations and extensive dark purple discolouration of the oedematous mucosa.Colonic transit studies suggested a decrease in colonic motility.IMP was considered the underlying cause of her pseudoileus,which was potentially linked to her consumption of Chinese medicinal teas for more than 30 years.The patient underwent conservative medical treatment,and her symptoms gradually improved.She exhibited no signs of ileus or other significant discomfort at the outpatient follow-up one year after the discontinuation of Chinese herbal tea consumption.CONCLUSION IMP can present with symptoms of pseudoileus as initial complication.Clinicians can use CT and colonoscopy for differential diagnoses.展开更多
BACKGROUND Pseudomyxoma peritonei(PMP)is a distinct form of peritoneal malignancy characterized by diffuse intra-abdominal gelatinous ascites,with an estimated incidence of 1-3 per 1000000.PMP is predominantly seconda...BACKGROUND Pseudomyxoma peritonei(PMP)is a distinct form of peritoneal malignancy characterized by diffuse intra-abdominal gelatinous ascites,with an estimated incidence of 1-3 per 1000000.PMP is predominantly secondary to appendiceal mucinous neoplasms,with rarer origins including the ovaries,colon,and urachus.However,PMP originating from small intestine is extremely rare.CASE SUMMARY A 60-year-old male patient presented with anorexia and abdominal distension.Computed tomography revealed the presence of abdominopelvic effusions and multiple intra-abdominal space-occupying lesions.Ultrasound-guided aspiration indicated that the aspirated tissue was mucinous.Exploratory laparoscopy and tissue biopsy identified diffuse tumor nodules in peritoneum,omentum,pelvic region,intestinal walls,and mesentery.Histopathological analysis of the resected tumors confirmed the presence of mucinous adenocarcinoma,but the primary lesion was difficult to determine.The patient was referred to our center for further treatment and underwent cytoreductive surgery(CRS)combined with hyperthermic intraperitoneal chemotherapy(HIPEC)under general anesthesia.The intraoperative peritoneal cancer index was 30.The surgery lasted 8 hours,with a blood loss of about 600 mL.A complete cytoreduction(CCR0)was achieved.No serious complications occurred after surgery,and the patient’s condition was good during the telephone follow-up.Postoperative pathology confirmed the diagnosis of small intestinal mucinous adenocarcinoma at proximal jejunum,which was complicated by high-grade PMP.CONCLUSIONPMP originating from small intestine is an exceptionally rare entity that exhibits non-specific clinical features. Thepreferred treatment is CRS + HIPEC.展开更多
The global drive for sustainable energy solutions intensified interest in anion exchange membrane water electrolysis(AEMWE),as a promising hydrogen production pathway,leveraging renewable energy sources.However,widesp...The global drive for sustainable energy solutions intensified interest in anion exchange membrane water electrolysis(AEMWE),as a promising hydrogen production pathway,leveraging renewable energy sources.However,widespread adoption is hindered by the high cost and non-optimised design of crucial components,such as porous transport layers(PTL)and flow fields.This study comprehensively investigates the interplay between structure,mechanics,and electrochemical performance of a low-cost knitted wire mesh PTL,focusing on its potential to enhance cell assembly and operation.Electrochemical characterisation was performed on a single 4 cm^(2)cell,using 1M KOH at 60℃.Knitted wire mesh PTL,characterised by approximately 70%porosity,2mm thickness,and 1.098 tortuosity,delivered a 33%improvement in current density compared to the standard cell configuration.Introducing a knitted PTL interlayer reduced cell voltage by 74 mV at 2 A cm^(−2)by improving compression force distribution across the active area,enhancing gas transport and maintaining optimal electrical and thermal conductivity.These findings highlight the significant potential of innovative PTL designs in AEMWE to improve mechanical and operational efficiency without increasing the cost.展开更多
Linear mRNA vaccines are constrained by exonuclease susceptibility and instability,leading to compromised antigen expression.Circular RNA(circRNA) lacking canonical 5' and 3' untranslated regions demonstrates ...Linear mRNA vaccines are constrained by exonuclease susceptibility and instability,leading to compromised antigen expression.Circular RNA(circRNA) lacking canonical 5' and 3' untranslated regions demonstrates intrinsic exonuclease resistance.Current circularization strategies face three principal limitations:chemical methods produce non-native 2',5'-phosphodiester bonds;ribozyme-mediated approaches are restricted to RNA fragments shorter than 500 nucleotides;the Anabaena Group I intron system retains immunogenic exon sequences.In contrast,the self-splicing Group I intron ribozyme from Tetrahymena enables precisely controlled circularization through autonomous structural rearrangement,yielding exonfree constructs.Through optimized purification protocols,historical scalability challenges are systematically addressed.This Perspective establishes the mechanistic rationale and therapeutic superiority of this engineered RNA circularization platform.展开更多
BACKGROUND Acute-on-chronic liver failure(ACLF)is characterized by severe metabolic disturbances;however,the specific metabolomic features and their predictive value on 90-day prognosis remain unclear.AIM To identify ...BACKGROUND Acute-on-chronic liver failure(ACLF)is characterized by severe metabolic disturbances;however,the specific metabolomic features and their predictive value on 90-day prognosis remain unclear.AIM To identify serum metabolomic changes in patients with ACLF with different prognoses to support clinical prediction of outcomes and treatment decisions.METHODS This non-interventional,observational case-control study enrolled 58 patients with ACLF.Fasting venous blood samples were analyzed using targeted metabolomics.Univariate and multivariate statistical analyses identified differential metabolites among 18 amino acids,11 fatty acids,5 gut microbiota-related metabolites,and 4 bile acid metabolites.Binary logistic regression identified independent mortality risk factors,visualized via forest plots and receiver operating characteristic curves.RESULTS Significant differences(P<0.05)were observed between the death and survival groups in baseline age,model for end-stage liver disease score,model for end-stage liver disease with sodium,neutrophil-to-lymphocyte ratio(NLR),total bilirubin,serum creatinine,blood urea nitrogen,and platelet count.Metabolites,including L-carnitine,creatinine,alanine,arginine(Arg),proline,choline,and oleic acid,also showed statistically significant differences between the groups.Multivariate analysis identified age,NLR,and Arg as independent risk factors for 90-day mortality in patients with ACLF.The predictive model,age-NLR-Arg=-15.481+0.135×age+0.156×NLR+0.203×Arg,with a cutoff of 0.759,achieved an area under the receiver operating characteristic curve of 0.945 with sensitivity of 84.0%and specificity of 87.9%.CONCLUSION The age-NLR-Arg model demonstrates a strong predictive value for 90-day mortality risk in patients with ACLF.展开更多
In order to increase the sustainability of future lunar missions,techniques for in-situ resource utilization(ISRU)must be developed.In this context,the local melting of lunar dust(regolith)by laser radiation for the p...In order to increase the sustainability of future lunar missions,techniques for in-situ resource utilization(ISRU)must be developed.In this context,the local melting of lunar dust(regolith)by laser radiation for the production of parts and larger structures was investigated in detail.With different experimental setups in normal and microgravity,laser spots with diameters from 5 mm to 100 mm were realized to melt the regolith simulant EAC-1A and an 80%/20%mixture of TUBS-T and TUBS-M,which are used as a substitute for the actual lunar soil.In the experiments performed,the critical parameters are the size of the laser spot,the velocity of the laser spot on the surface of the powder bed,the gravity and the wettability of the powder bed by the melt.The stability of the melt pool as a function of these parameters was investigated and it was found that the formation of a stable melt pool is determined by gravity for large melt pool sizes in the range of 50 mm and by surface tension for small melt pool sizes in the range of a few mm.展开更多
The development of magnesium batteries strongly relies on the use of a Mg metal anode and its benefits of high volumetric capacity,reduction potential,low cost and improved safety,however,to date,it still lacks suffic...The development of magnesium batteries strongly relies on the use of a Mg metal anode and its benefits of high volumetric capacity,reduction potential,low cost and improved safety,however,to date,it still lacks sufficient cycling stability and reversibility.Along with the electrolyte selection,the interfacial processes can be affected by the anode itself applying electrode engineering strategies.In this study,six different Mg anode approaches–namely bare Mg metal,Mg foil with an organic and inorganic artificial solid electrolyte interphase,Mg alloy,Mg pellet and a tape-casted Mg slurry–are selected to be investigated by means of electrochemical impedance spectroscopy in Mg|Mg and Mg|S cells.While a plating/stripping overpotential asymmetry was observed and assigned to the desolvation during Mg plating,the impedance spectra of stripping and plating hardly differ for all applied anodes.In contrast,the sulfur species significantly influence the impedance response by altering the surface layer composition.By systematic process assignment of the gained spectra in Mg|Mg and Mg|S cells,specific equivalent circuit models for different anodes and cell conditions are derived.Overall,the study aims to give valuable insights into the interfacial processes of Mg anodes to support their further development toward long-lasting Mg batteries.展开更多
Background:Due to its high relevance in sports and rehabilitation,the exploration of interventions to further optimize flexibility becomes paramount.While stretching might be the most common way to enhance range of mo...Background:Due to its high relevance in sports and rehabilitation,the exploration of interventions to further optimize flexibility becomes paramount.While stretching might be the most common way to enhance range of motion,these increases could be optimized by imposing an additional activation of the muscle,such as mechanical vibratory stimulation.While several original articles provide promising findings,contradictory results on flexibility and underlying mechanisms(e.g.,stiffness),reasonable effect size(ES)pooling remains scarce.With this work we systematically reviewed the available literature to explore the possibility of potentiating flexibility,stiffness,and passive torque adaptations by superimposing mechanical vibration stimulation.Methods:A systematic search of 4 databases(Web of Science,MEDLINE,Scopus,and Cochrane Public Library)was conducted until December2023 to identify studies comparing mechanical vibratory interventions with passive controls or the same intervention without vibration(sham)on range of motion and passive muscle stiffness in acute(immediate effects after single session)and chronic conditions(multiple sessions over a period of time).ES pooling was conducted using robust variance estimation via R to account for multiple study outcomes.Potential moderators of effects were analyzed using meta regression.Results:Overall,65 studies(acute:1162 participants,chronic:788 participants)were included.There was moderate certainty of evidence for acute flexibility(ES=0.71,p<0.001)and stiffness(ES=-0.89,p=0.006)effects of mechanical vibration treatments vs.passive controls without meaningful results against the sham condition(flexibility:ES=0.20,p<0.001;stiffness:ES=-0.19,p=0.076).Similarly,moderate certainty of evidence was found for chronic vibration effects on flexibility(control:ES=0.64,p=0.043;sham:ES=0.65,p<0.001).Lack of studies and large outcome heterogeneity prevented ES pooling for underlying mechanisms.Conclusion:Vibration improved flexibility in acute and chronic interventions compared to the stand-alone intervention,which can possibly be attributed to an accumulated mechanical stimulus through vibration.However,studies on biological mechanisms are needed to explain flexibility and stiffness effects in response to specific vibration modalities and timing.展开更多
Sensorineural hearing loss(SNHL),the most commonly-occurring form of hearing loss,is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea.Numerous environmental and physiolog...Sensorineural hearing loss(SNHL),the most commonly-occurring form of hearing loss,is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea.Numerous environmental and physiological factors have been shown to cause acquired SNHL,such as ototoxic drugs,noise exposure,aging,infections,and diseases.Several programmed cell death(PCD)pathways have been reported to be involved in SNHL,especially some novel PCD pathways that have only recently been reported,such as ferroptosis,necroptosis,and pyroptosis.Here we summarize these PCD pathways and their roles and mechanisms in SNHL,aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways.展开更多
Concentrated solar power(CSP)plants with thermal energy storage(TES)system are emerging as one kind of the most promising power plants in the future renewable energy system,since they can supply dispatchable and low-c...Concentrated solar power(CSP)plants with thermal energy storage(TES)system are emerging as one kind of the most promising power plants in the future renewable energy system,since they can supply dispatchable and low-cost electricity with abundant but intermittent solar energy.In order to significantly reduce the levelized cost of electricity(LCOE)of the present commercial CSP plants,the next generation CSP technology with higher process temperature and energy efficiency is being developed.The TES system in the next generation CSP plants works with new TES materials at higher temperatures(>565℃)compared to that with the commercial nitrate salt mixtures.This paper reviews recent progressin research and development of the next generation CSP and TES technology.Emphasis is given on theadvanced'TES technology based on molten chloride salt mixtures such as MgCl_(2)/NaCl/KCl which hassimilar thermo-physical properties as the commercial nitrate salt mixtures,higher thermal stability(>800℃),and lower costs(<0.35USD·kg^(-1)).Recent progress in the selection/optimization of chloridesalts,determination of molten chloride salt properties,and corrosion control of construction materials(eg.,alloys)in molten chlorides is reviewed.展开更多
AIM To explore the association between Helicobacter pylori(H. pylori) infection and obesity/weight gain in a Chinese population.METHODS Our primary outcome was the change in body mass index(BMI). The generalized linea...AIM To explore the association between Helicobacter pylori(H. pylori) infection and obesity/weight gain in a Chinese population.METHODS Our primary outcome was the change in body mass index(BMI). The generalized linear models were used to explore the association between H. pylori infection and the change of BMI, and the logistic regression models were used to explore the association between H. pylori infection and obesity.RESULTS A total of 3039 subjects were recruited and analyzed, of which 12.8% were obese. The prevalence of H. pylori infection was 53.9%(1639/3039) overall and 54.6%(212/388) in the obese subjects. The change of BMI in the H. pylori(+) group was not significantly higher than that in the H. pylori(-) group after adjustment for potential confounding factors [RR = 0.988, 95%CI:0.924-1.057, P = 0.729]. The prevalence of obesity decreased 1.1% in the H. pylori(+) group and 0.5% in the H. pylori(-) group. The RR of H. pylori infection for obesity was 0.831(95%CI: 0.577-1.197, P = 0.321) after the adjustment.CONCLUSION H. pylori infection was not associated with overweight/obesity observed from the retrospective study in this Chinese population.展开更多
The analysis centers of the Multi-GNSS Pilot Project of the International GNSS Service provide orbit and clock products for the global navigation satellite systems(GNSSs)Global Positioning System(GPS),GLONASS,Galileo,...The analysis centers of the Multi-GNSS Pilot Project of the International GNSS Service provide orbit and clock products for the global navigation satellite systems(GNSSs)Global Positioning System(GPS),GLONASS,Galileo,and BeiDou,as well as for the Japanese regional Quasi-Zenith Satellite System(QZSS).Due to improved solar radiation pressure modeling and other more sophisticated models,the consistency of these products has improved in recent years.The current orbit consistency between different analysis centers is on the level of a few centimeters for GPS,around one decimeter for GLONASS and Galileo,a few decimeters for BeiDou-2,and several decimeters for QZSS.The clock consistency is about 2 cm for GPS,5 cm for GLONASS and Galileo,and 10 cm for BeiDou-2.In terms of carrier phase modeling error for precise point positioning,the various products exhibit consistencies of 2–3 cm for GPS,6–14 cm for GLONASS,3–10 cm for Galileo,and 10–17 cm for BeiDou-2.展开更多
基金funded through the basic DLR funding of the Helmholtz AssociationSpecific support for several projects was given by the German Federal Ministry of Economics and Technology and the German Federal Ministry for the Environment,Nature Conservation and Nuclear SafetyThe CellFlux project is funded by E.ON AG as part of the International Research Initiative.Responsibility for the content of this publication lieswith the authors
文摘Thermal energy storage(TES)is a key technology for renewable energy utilization and the improvement of the energy efficiency of heat processes.Sectors include industrial process heat and conventional and renewable power generation.TES systems correct the mismatch between supply and demand of thermal energy.In the medium to high temperature range(100~1000℃),only limited storage technology is commercially available and a strong effort is needed to develop a range of storage technologies which are efficient and economical for the very specific requirements of the different application sectors.At the DLR's Institute of Technical Thermodynamics,the complete spectrum of high temperature storage technologies,from various types of sensible over latent heat to thermochemical heat storages are being developed.Different concepts are proposed depending on the heat transfer fluid(synthetic oil,water/steam,molten salt,air)and the required temperature range.The aim is the development of cost effective,efficient and reliable thermal storage systems.Research focuses on characterization of storage materials,enhancement of internal heat transfer,design of innovative storage concepts and modelling of storage components and systems.Demonstration of the storage technology takes place from laboratory scale to field testing(5 kW^1 MW).The paper gives an overview on DLR's current developments.
基金supported by grants from the National Natural Science Foundation of China(No.81672353 and 81871954)。
文摘Objective:To validate the 8 th edition of the American Joint Committee on Cancer(AJCC)staging system for pancreatic ductal adenocarcinoma(PDAC)in a Chinese cohort of radically resected patients and to develop a refined staging system for PDAC.Methods:Data were collected from the China Pancreas Data Center(CPDC)for patients with resected PDAC in 2016 and 2017,and cancer-specific survival(CSS)was evaluated using the Kaplan-Meier method and log-rank test.Univariate and multivariate analyses based on Cox regression were performed to identify prognostic factors.The recursive partitioning analysis(RPA),Kaplan-Meier method,and log-rank test were performed on the training dataset to generate a proposed modification for the 8 th TNM staging system utilizing the preoperative carbohydrate antigen(CA)19-9 level.Validation was performed for both staging systems in the validation cohort.Results:A total of 1,676 PDAC patients were retrieved,and the median CSS was significantly different between the 8 th TNM groupings,with no significant difference in survival between stage IB and IIA.The analysis of T and N stages demonstrated a better prognostic value in the N category.Multivariate analysis showed that the preoperative serum CA19-9 level was the strongest prognostic indicator among all the independent risk factors.All patients with CA19-9>500 U/mL had similar survival,and we proposed a new staging system by combining IB and IIA and stratifying all patients with high CA19-9 into stage III.The modified staging system had a better performance for predicting CSS than the 8 th AJCC staging scheme.Conclusions:The 8 th AJCC staging system for PDAC is suitable for a Chinese cohort of resected patients,and the N category has a better prognostic value than the T category.Our modified staging system has superior accuracy in predicting survival than the 8 th AJCC TNM staging system.
基金supported by the National Natural Science Foundation of China(Nos.41874028,61803018)。
文摘Formation flying Low Earth Orbiters(LEOs)are important for implementing new and advanced concepts in Earth observation missions.Precise Baseline Determination(PBD)is a prerequisite for LEOs to complete specified mission targets.PBD is usually performed based on space-borne GNSS data,the relative corrections of phase center and code residual variations play crucial roles in achieving the best relative orbit accuracy.Herein,the influences of antenna Relative Phase Centre Variations(RPCVs)and Single-Difference(SD)Melbourne-Wu¨bbena(MW)Combination Residuals Variations(SD MWVs)on PBD are studied.The methods were tested using flight data from Gravity Recovery And Climate Experiment(GRACE)and GRACE Follow-On(GRACE-FO).Results showed that the maximum values for RPCVs and SD MWVs were 14 mm and 0.32 cycles,respectively.Then,the RPCVs correction significantly enhanced the baseline accuracy;the K-Band Ranging(KBR)measurement consistency improved by 30.1%and 37.5%for GRACE and GRACE-FO,respectively.The application of SD MWVs further improved the accuracy and reliability of PBD results.For GRACE,the ambiguities fixing success rate increased from 85.1%to 97.9%and a baseline consistency of 0.57 mm was achieved for the KBR measurements.It was found that the correction of both RPCVs and SD MWVs reduced the carrier phase observation minus computation residuals from double-difference ionosphere-free combination.In addition,in-flight data processing demonstrated that RPCVs and SD MWVs estimations for the current period could be used for the previous and subsequent periods.
文摘A key component of future lunar missions is the concept of in-situ resource utilization(ISRU),which involves the use of local resources to support human missions and reduce dependence on Earth-based supplies.This paper investigates the thermal processing capability of lunar regolith without the addition of binders,with a focus on large-scale applications for the construction of lunar habitats and infrastructure.The study used a simulant of lunar regolith found on the Schr?dinger Basin in the South Pole region.This regolith simulant consists of20 wt%basalt and 80 wt%anorthosite.Experiments were conducted using a high power CO_(2)laser to sinter and melt the regolith in a 80 mm diameter laser spot to evaluate the effectiveness of direct large area thermal processing.Results indicated that sintering begins at approximately 1180℃and reaches full melt at temperatures above 1360℃.Sintering experiments with this material revealed the formation of dense samples up to 11 mm thick,while melting experiments successfully produced larger samples by overlapping molten layers and additive manufacturing up to 50 mm thick.The energy efficiency of the sintering and melting processes was compared.The melting process was about 10 times more energy efficient than sintering in terms of material consolidation,demonstrating the promising potential of laser melting technologies of anorthosite-rich regolith for the production of structural elements.
文摘BACKGROUND Idiopathic mesenteric phlebosclerosis(IMP)is a rare condition that causes ischaemic colitis,has various clinical manifestations,and may even be asymptomatic,often resulting in clinical misdiagnosis.CASE SUMMARY We report the case of a 44-year-old woman with chief complaints of abdominal pain,vomiting and decreased defecation.One year prior,the patient was asymptomatic and therefore misdiagnosed with inflammatory bowel disease based on incidental findings on an abdominal computed tomography(CT)scan.The present abdominal CT scan revealed an intestinal obstruction,diffuse thickening of the entire colon wall and calcification of the mesenteric and colonic veins.Colonoscopy revealed multiple ulcerations and extensive dark purple discolouration of the oedematous mucosa.Colonic transit studies suggested a decrease in colonic motility.IMP was considered the underlying cause of her pseudoileus,which was potentially linked to her consumption of Chinese medicinal teas for more than 30 years.The patient underwent conservative medical treatment,and her symptoms gradually improved.She exhibited no signs of ileus or other significant discomfort at the outpatient follow-up one year after the discontinuation of Chinese herbal tea consumption.CONCLUSION IMP can present with symptoms of pseudoileus as initial complication.Clinicians can use CT and colonoscopy for differential diagnoses.
基金Supported by 2024 Aerospace Center Hospital Scientific Research Fund,No.YN202410.
文摘BACKGROUND Pseudomyxoma peritonei(PMP)is a distinct form of peritoneal malignancy characterized by diffuse intra-abdominal gelatinous ascites,with an estimated incidence of 1-3 per 1000000.PMP is predominantly secondary to appendiceal mucinous neoplasms,with rarer origins including the ovaries,colon,and urachus.However,PMP originating from small intestine is extremely rare.CASE SUMMARY A 60-year-old male patient presented with anorexia and abdominal distension.Computed tomography revealed the presence of abdominopelvic effusions and multiple intra-abdominal space-occupying lesions.Ultrasound-guided aspiration indicated that the aspirated tissue was mucinous.Exploratory laparoscopy and tissue biopsy identified diffuse tumor nodules in peritoneum,omentum,pelvic region,intestinal walls,and mesentery.Histopathological analysis of the resected tumors confirmed the presence of mucinous adenocarcinoma,but the primary lesion was difficult to determine.The patient was referred to our center for further treatment and underwent cytoreductive surgery(CRS)combined with hyperthermic intraperitoneal chemotherapy(HIPEC)under general anesthesia.The intraoperative peritoneal cancer index was 30.The surgery lasted 8 hours,with a blood loss of about 600 mL.A complete cytoreduction(CCR0)was achieved.No serious complications occurred after surgery,and the patient’s condition was good during the telephone follow-up.Postoperative pathology confirmed the diagnosis of small intestinal mucinous adenocarcinoma at proximal jejunum,which was complicated by high-grade PMP.CONCLUSIONPMP originating from small intestine is an exceptionally rare entity that exhibits non-specific clinical features. Thepreferred treatment is CRS + HIPEC.
基金supported by the European Union and the Clean Hydrogen Joint Undertaking(Grant no.101112055).
文摘The global drive for sustainable energy solutions intensified interest in anion exchange membrane water electrolysis(AEMWE),as a promising hydrogen production pathway,leveraging renewable energy sources.However,widespread adoption is hindered by the high cost and non-optimised design of crucial components,such as porous transport layers(PTL)and flow fields.This study comprehensively investigates the interplay between structure,mechanics,and electrochemical performance of a low-cost knitted wire mesh PTL,focusing on its potential to enhance cell assembly and operation.Electrochemical characterisation was performed on a single 4 cm^(2)cell,using 1M KOH at 60℃.Knitted wire mesh PTL,characterised by approximately 70%porosity,2mm thickness,and 1.098 tortuosity,delivered a 33%improvement in current density compared to the standard cell configuration.Introducing a knitted PTL interlayer reduced cell voltage by 74 mV at 2 A cm^(−2)by improving compression force distribution across the active area,enhancing gas transport and maintaining optimal electrical and thermal conductivity.These findings highlight the significant potential of innovative PTL designs in AEMWE to improve mechanical and operational efficiency without increasing the cost.
基金supported by the National Key Research&Development Program of China(Nos.2021YFC2302400,2021YFA1201000,2023YFC2606004)the Fundamental Research Funds for the Central Universities(No.2022CX01013)。
文摘Linear mRNA vaccines are constrained by exonuclease susceptibility and instability,leading to compromised antigen expression.Circular RNA(circRNA) lacking canonical 5' and 3' untranslated regions demonstrates intrinsic exonuclease resistance.Current circularization strategies face three principal limitations:chemical methods produce non-native 2',5'-phosphodiester bonds;ribozyme-mediated approaches are restricted to RNA fragments shorter than 500 nucleotides;the Anabaena Group I intron system retains immunogenic exon sequences.In contrast,the self-splicing Group I intron ribozyme from Tetrahymena enables precisely controlled circularization through autonomous structural rearrangement,yielding exonfree constructs.Through optimized purification protocols,historical scalability challenges are systematically addressed.This Perspective establishes the mechanistic rationale and therapeutic superiority of this engineered RNA circularization platform.
基金Supported by the Hebei Natural Science Foundation,No.H2023206042Medical Science Research Project of Hebei,No.20230670。
文摘BACKGROUND Acute-on-chronic liver failure(ACLF)is characterized by severe metabolic disturbances;however,the specific metabolomic features and their predictive value on 90-day prognosis remain unclear.AIM To identify serum metabolomic changes in patients with ACLF with different prognoses to support clinical prediction of outcomes and treatment decisions.METHODS This non-interventional,observational case-control study enrolled 58 patients with ACLF.Fasting venous blood samples were analyzed using targeted metabolomics.Univariate and multivariate statistical analyses identified differential metabolites among 18 amino acids,11 fatty acids,5 gut microbiota-related metabolites,and 4 bile acid metabolites.Binary logistic regression identified independent mortality risk factors,visualized via forest plots and receiver operating characteristic curves.RESULTS Significant differences(P<0.05)were observed between the death and survival groups in baseline age,model for end-stage liver disease score,model for end-stage liver disease with sodium,neutrophil-to-lymphocyte ratio(NLR),total bilirubin,serum creatinine,blood urea nitrogen,and platelet count.Metabolites,including L-carnitine,creatinine,alanine,arginine(Arg),proline,choline,and oleic acid,also showed statistically significant differences between the groups.Multivariate analysis identified age,NLR,and Arg as independent risk factors for 90-day mortality in patients with ACLF.The predictive model,age-NLR-Arg=-15.481+0.135×age+0.156×NLR+0.203×Arg,with a cutoff of 0.759,achieved an area under the receiver operating characteristic curve of 0.945 with sensitivity of 84.0%and specificity of 87.9%.CONCLUSION The age-NLR-Arg model demonstrates a strong predictive value for 90-day mortality risk in patients with ACLF.
基金supported by 40th DLR Parabolic Flight Campaign and within the project"Powder based Additive Manufacturing at reduced Gravitation"(Grant No.FKZ:50WM2068)European Space Agency,OSIP Off-Earth Manufacturing and Construction Campaign(Grant No.4000134280/21/NL/GLC/mk)。
文摘In order to increase the sustainability of future lunar missions,techniques for in-situ resource utilization(ISRU)must be developed.In this context,the local melting of lunar dust(regolith)by laser radiation for the production of parts and larger structures was investigated in detail.With different experimental setups in normal and microgravity,laser spots with diameters from 5 mm to 100 mm were realized to melt the regolith simulant EAC-1A and an 80%/20%mixture of TUBS-T and TUBS-M,which are used as a substitute for the actual lunar soil.In the experiments performed,the critical parameters are the size of the laser spot,the velocity of the laser spot on the surface of the powder bed,the gravity and the wettability of the powder bed by the melt.The stability of the melt pool as a function of these parameters was investigated and it was found that the formation of a stable melt pool is determined by gravity for large melt pool sizes in the range of 50 mm and by surface tension for small melt pool sizes in the range of a few mm.
基金financially supported by the Federal Ministry for Education and Research of Germany(Bundesminis-terium für Bildung und Forschung,BMBF)and the European Commission within the projects“MagSiMal”(03XP0208)“E-MAGIC”(824066),respectively。
文摘The development of magnesium batteries strongly relies on the use of a Mg metal anode and its benefits of high volumetric capacity,reduction potential,low cost and improved safety,however,to date,it still lacks sufficient cycling stability and reversibility.Along with the electrolyte selection,the interfacial processes can be affected by the anode itself applying electrode engineering strategies.In this study,six different Mg anode approaches–namely bare Mg metal,Mg foil with an organic and inorganic artificial solid electrolyte interphase,Mg alloy,Mg pellet and a tape-casted Mg slurry–are selected to be investigated by means of electrochemical impedance spectroscopy in Mg|Mg and Mg|S cells.While a plating/stripping overpotential asymmetry was observed and assigned to the desolvation during Mg plating,the impedance spectra of stripping and plating hardly differ for all applied anodes.In contrast,the sulfur species significantly influence the impedance response by altering the surface layer composition.By systematic process assignment of the gained spectra in Mg|Mg and Mg|S cells,specific equivalent circuit models for different anodes and cell conditions are derived.Overall,the study aims to give valuable insights into the interfacial processes of Mg anodes to support their further development toward long-lasting Mg batteries.
文摘Background:Due to its high relevance in sports and rehabilitation,the exploration of interventions to further optimize flexibility becomes paramount.While stretching might be the most common way to enhance range of motion,these increases could be optimized by imposing an additional activation of the muscle,such as mechanical vibratory stimulation.While several original articles provide promising findings,contradictory results on flexibility and underlying mechanisms(e.g.,stiffness),reasonable effect size(ES)pooling remains scarce.With this work we systematically reviewed the available literature to explore the possibility of potentiating flexibility,stiffness,and passive torque adaptations by superimposing mechanical vibration stimulation.Methods:A systematic search of 4 databases(Web of Science,MEDLINE,Scopus,and Cochrane Public Library)was conducted until December2023 to identify studies comparing mechanical vibratory interventions with passive controls or the same intervention without vibration(sham)on range of motion and passive muscle stiffness in acute(immediate effects after single session)and chronic conditions(multiple sessions over a period of time).ES pooling was conducted using robust variance estimation via R to account for multiple study outcomes.Potential moderators of effects were analyzed using meta regression.Results:Overall,65 studies(acute:1162 participants,chronic:788 participants)were included.There was moderate certainty of evidence for acute flexibility(ES=0.71,p<0.001)and stiffness(ES=-0.89,p=0.006)effects of mechanical vibration treatments vs.passive controls without meaningful results against the sham condition(flexibility:ES=0.20,p<0.001;stiffness:ES=-0.19,p=0.076).Similarly,moderate certainty of evidence was found for chronic vibration effects on flexibility(control:ES=0.64,p=0.043;sham:ES=0.65,p<0.001).Lack of studies and large outcome heterogeneity prevented ES pooling for underlying mechanisms.Conclusion:Vibration improved flexibility in acute and chronic interventions compared to the stand-alone intervention,which can possibly be attributed to an accumulated mechanical stimulus through vibration.However,studies on biological mechanisms are needed to explain flexibility and stiffness effects in response to specific vibration modalities and timing.
基金supported by grants from the National Key Research and Development Program of China(2023YFA1801804,2022YFA0807000,2021YFA1101300,2021YFA1101800,and 2020YFA0112503)the National Natural Science Foundation of China(82171149,82371166,81970892,82330033,82030029,92149304,82071053,and 82171144)+5 种基金the Shenzhen Science and Technology Program(JCYJ20230807114700001,JCYJ20210324125608022,and JCYJ20190814093401920)the Guangdong Basic and Applied Basic Research Foundation(2024A1515010548)the Science and Technology Department of Sichuan Province(2021YFS0371)the Jiangsu Provincial Scientific Research Center of Applied Mathematics(BK20233002)the Open Research Fund of Guangdong Academy of Medical Sciences(YKY‐KF202201)the Taishan Scholars Project-Young Experts Program of Shandong Province(tsqn202211357).
文摘Sensorineural hearing loss(SNHL),the most commonly-occurring form of hearing loss,is caused mainly by injury to or the loss of hair cells and spiral ganglion neurons in the cochlea.Numerous environmental and physiological factors have been shown to cause acquired SNHL,such as ototoxic drugs,noise exposure,aging,infections,and diseases.Several programmed cell death(PCD)pathways have been reported to be involved in SNHL,especially some novel PCD pathways that have only recently been reported,such as ferroptosis,necroptosis,and pyroptosis.Here we summarize these PCD pathways and their roles and mechanisms in SNHL,aiming to provide new insights and potential therapeutic strategies for SNHL by targeting these PCD pathways.
文摘Concentrated solar power(CSP)plants with thermal energy storage(TES)system are emerging as one kind of the most promising power plants in the future renewable energy system,since they can supply dispatchable and low-cost electricity with abundant but intermittent solar energy.In order to significantly reduce the levelized cost of electricity(LCOE)of the present commercial CSP plants,the next generation CSP technology with higher process temperature and energy efficiency is being developed.The TES system in the next generation CSP plants works with new TES materials at higher temperatures(>565℃)compared to that with the commercial nitrate salt mixtures.This paper reviews recent progressin research and development of the next generation CSP and TES technology.Emphasis is given on theadvanced'TES technology based on molten chloride salt mixtures such as MgCl_(2)/NaCl/KCl which hassimilar thermo-physical properties as the commercial nitrate salt mixtures,higher thermal stability(>800℃),and lower costs(<0.35USD·kg^(-1)).Recent progress in the selection/optimization of chloridesalts,determination of molten chloride salt properties,and corrosion control of construction materials(eg.,alloys)in molten chlorides is reviewed.
基金Supported by the State Key Laboratory of Pathogen and Biosecurity(Academy of Military Medical Science)No.SKLPBS1442the Youth Talent Support Program of the School of Public Health,Peking University
文摘AIM To explore the association between Helicobacter pylori(H. pylori) infection and obesity/weight gain in a Chinese population.METHODS Our primary outcome was the change in body mass index(BMI). The generalized linear models were used to explore the association between H. pylori infection and the change of BMI, and the logistic regression models were used to explore the association between H. pylori infection and obesity.RESULTS A total of 3039 subjects were recruited and analyzed, of which 12.8% were obese. The prevalence of H. pylori infection was 53.9%(1639/3039) overall and 54.6%(212/388) in the obese subjects. The change of BMI in the H. pylori(+) group was not significantly higher than that in the H. pylori(-) group after adjustment for potential confounding factors [RR = 0.988, 95%CI:0.924-1.057, P = 0.729]. The prevalence of obesity decreased 1.1% in the H. pylori(+) group and 0.5% in the H. pylori(-) group. The RR of H. pylori infection for obesity was 0.831(95%CI: 0.577-1.197, P = 0.321) after the adjustment.CONCLUSION H. pylori infection was not associated with overweight/obesity observed from the retrospective study in this Chinese population.
基金We would like to acknowledge the efforts of the MGEX station operators,data,and analysis centers,as well as the ILRS for providing SLR normal points.
文摘The analysis centers of the Multi-GNSS Pilot Project of the International GNSS Service provide orbit and clock products for the global navigation satellite systems(GNSSs)Global Positioning System(GPS),GLONASS,Galileo,and BeiDou,as well as for the Japanese regional Quasi-Zenith Satellite System(QZSS).Due to improved solar radiation pressure modeling and other more sophisticated models,the consistency of these products has improved in recent years.The current orbit consistency between different analysis centers is on the level of a few centimeters for GPS,around one decimeter for GLONASS and Galileo,a few decimeters for BeiDou-2,and several decimeters for QZSS.The clock consistency is about 2 cm for GPS,5 cm for GLONASS and Galileo,and 10 cm for BeiDou-2.In terms of carrier phase modeling error for precise point positioning,the various products exhibit consistencies of 2–3 cm for GPS,6–14 cm for GLONASS,3–10 cm for Galileo,and 10–17 cm for BeiDou-2.
