Intracortical microelectrodes are used for recording activity from individual neurons,providing both a valuable neuroscience tool and an enabling medical technology for individuals with motor disabilities.Standard neu...Intracortical microelectrodes are used for recording activity from individual neurons,providing both a valuable neuroscience tool and an enabling medical technology for individuals with motor disabilities.Standard neural probes carrying the microelectrodes are rigid silicon-based structures that can penetrate the brain parenchyma to interface with the targeted neurons.Unfortunately,within weeks after implantation,neural recording quality from microelectrodes degrades,owing largely to a neuroinflammatory response.Key contributors to the neuroinflammatory response include mechanical mismatch at the device-tissue interface and oxidative stress.We developed a mechanically-adaptive,resveratrol-eluting(MARE)neural probe to mitigate both mechanical mismatch and oxidative stress and thereby promote improved neural recording quality and longevity.In this work,we demonstrate that compared to rigid silicon controls,highly-flexible MARE probes exhibit improved recording performance,more stable impedance,and a healing tissue response.With further optimization,MARE probes can serve as long-term,robust neural probes for brain-machine interface applications.展开更多
基金funded by Merit Review Award#I01RX003083(A.H.-D./J.R.C.)and a Research Career Scientist Award Grant#12635707(J.R.C.)from the United States Department of Veterans Affairs Rehabilitation Research and Development Servicesupport was provided in a pre-doctoral fellowship to N.N.M.from the Department of Defense National Defense Science and Engineering Fellowship Program。
文摘Intracortical microelectrodes are used for recording activity from individual neurons,providing both a valuable neuroscience tool and an enabling medical technology for individuals with motor disabilities.Standard neural probes carrying the microelectrodes are rigid silicon-based structures that can penetrate the brain parenchyma to interface with the targeted neurons.Unfortunately,within weeks after implantation,neural recording quality from microelectrodes degrades,owing largely to a neuroinflammatory response.Key contributors to the neuroinflammatory response include mechanical mismatch at the device-tissue interface and oxidative stress.We developed a mechanically-adaptive,resveratrol-eluting(MARE)neural probe to mitigate both mechanical mismatch and oxidative stress and thereby promote improved neural recording quality and longevity.In this work,we demonstrate that compared to rigid silicon controls,highly-flexible MARE probes exhibit improved recording performance,more stable impedance,and a healing tissue response.With further optimization,MARE probes can serve as long-term,robust neural probes for brain-machine interface applications.
