In this editorial,we comment on the recent article by Fei et al exploring the field of near-infrared spectroscopy(NIRS)research in schizophrenia from a bibliometrics perspective.In recent years,NIRS has shown unique a...In this editorial,we comment on the recent article by Fei et al exploring the field of near-infrared spectroscopy(NIRS)research in schizophrenia from a bibliometrics perspective.In recent years,NIRS has shown unique advantages in the auxiliary diagnosis of schizophrenia,and the introduction of bibliometrics has provided a macro perspective for research in this field.Despite the opportunities brought about by these technological developments,remaining challenges require multidi-sciplinary approach to devise a reliable and accurate diagnosis system for schizo-phrenia.Nonetheless,NIRS-assisted technology is expected to contribute to the division of methods for early intervention and treatment of schizophrenia.展开更多
Objectives:College students face increasing mental health challenges.Although Acceptance and CommitmentTherapy(ACT)is effective,the efficacy of Internet-based ACT(iACT)needs further exploration.Methods:This study exam...Objectives:College students face increasing mental health challenges.Although Acceptance and CommitmentTherapy(ACT)is effective,the efficacy of Internet-based ACT(iACT)needs further exploration.Methods:This study examines the efficacy of iACT on college students’mental health through a randomized controlled trial.We recruited 90 college students(19.16±1.02 years old)and randomly divided them into the iACT group,face-to-face ACT group,and control group.The effects of the interventions were evaluated using the comprehensive assessment of ACT processes(CompACT)and the Depression Anxiety Stress Scales(DASS-21).Results:Two-factor repeated measures ANOVA revealed a significant time main effect of iACT.Face-to-face ACT and iACT effectively improved college students’psychological flexibility[F(2,83)=18.78,p<0.001,η^(2)=0.18]and alleviated their negative emotions[F(2,82)=41.17,p<0.001,η^(2)=0.36].Face-to-face ACT exhibited sustained effects on improving participants’psychological flexibility and alleviating their negative emotions(p<0.001),while iACT showed no sustained effect on improving participants’psychological flexibility(p>0.05).Conclusion:While iACT and face-to-face ACT are effective shortterm interventions,face-to-face ACT demonstrates superior sustainability.Integrating guided sessions into iACT may enhance long-term outcomes.These findings advocate for blended interventions to address college students’mental health needs,particularly in resource-limited settings.展开更多
Brown planthopper(BPH)is a highly destructive pest that presents a significant challenge to rice production,particularly in the Asia-Pacific region.Numerous BPH-resistant rice varieties have been successfully bred and...Brown planthopper(BPH)is a highly destructive pest that presents a significant challenge to rice production,particularly in the Asia-Pacific region.Numerous BPH-resistant rice varieties have been successfully bred and released for commercial cultivation across diverse rice-growing ecosystems.However,resistance breakdown in several varieties carrying major resistance genes has been reported,highlighting the urgent need for the development of novel,genetically diverse,and broad-spectrum resistant varieties.To date,more than 45 resistance loci have been identified and mapped from both cultivated and wild rice species.Among these,a subset of genes(including Bph1,Bph3,Bph6,Bph7,Bph9,Bph10,Bph14,Bph15,Bph18,Bph21,Bph26/2,bph29,Bph32,Bph37,and Bph30/Bph40)have been positionally cloned.Most of these genes encode coiled-coil nucleotide-binding leucine-rich repeat proteins,which are central to plant immune responses,along with a few signaling molecules playing pivotal roles.In addition to these core resistance genes,various other genetic components,including miRNAs,protein kinases,and transcription factors,have been functionally characterized for their roles in mediating BPH resistance.The advent of post-genomic tools such as RNA sequencing and single-cell sequencing,along with cutting-edge genomic technologies like CRISPR/Cas gene editing,has significantly accelerated resistance breeding programs.In this context,we provide an overview of genetics,mapping,isolation,and functional characterization of BPH resistance,along with strategies for incorporating resistance using advanced genomics-assisted breeding tools.Furthermore,we present a snapshot of how the integration of genomics and novel breeding technologies holds great promise for dissecting the genetic architecture of pest resistance and accelerating crop improvement.展开更多
Objectives:The aim of this study was to verify the causal relationship between trait aggressiveness(TA)and moral disengagement(MD),know more about the growth trajectory of MD,and explore the effects of gender and TA o...Objectives:The aim of this study was to verify the causal relationship between trait aggressiveness(TA)and moral disengagement(MD),know more about the growth trajectory of MD,and explore the effects of gender and TA on the growth trajectory.Methods:We used the Buss-Perry Aggression Questionnaire and Moral Disengagement Scale to survey 433 Chinese junior high school students longitudinally three times.Results:The results of the random intercept cross-lagged panel model(RI-CLPM)analysis indicated that TA positively predicted MD,while MD did not predict TA at the within-person level.Thus,TA could be considered an antecedent variable of MD.Furthermore,the unconditional latent growth linear model analysis revealed that MD among junior high school students exhibited an upward trend,characterized by an increasing rate of growth over time.In the conditional latent growth linear model analysis,we found that gender influenced only the initial level of MD but had no effect on its growth rate.Conversely,TA demonstrated both delayed and immediate positive effects on the growth of MD.Conclusions:Our findings suggested a one-way cross-lag effect between TA and MD.Additionally,the growth trajectory of MD among junior high school students was found to be ascending.This growth trajectory was influenced by gender and TA,offering valuable insights for the prevention and intervention of behavioral problems in junior high school students.展开更多
Objective To investigate the association between long-term glycemic control and cerebral infarction risk in patients with diabetes through a large-scale cohort study.Methods This prospective,community-based cohort stu...Objective To investigate the association between long-term glycemic control and cerebral infarction risk in patients with diabetes through a large-scale cohort study.Methods This prospective,community-based cohort study included 12,054 patients with diabetes.From 2006 to 2012,38,272 fasting blood glucose(FBG)measurements were obtained from these participants.FBG trajectory patterns were generated using latent mixture modelling.Cox proportional hazards models were applied to assess the subsequent risk of cerebral infarction associated with different FBG trajectory patterns.Results At baseline,the mean age of the participants was 55.2 years.Four distinct FBG trajectories were identified based on FBG concentrations and their changes over the 6-year follow-up period.After a median follow-up of 6.9 years,786 cerebral infarction events were recorded.Different trajectory patterns were associated with significantly varied outcome risks(Log-Rank P<0.001).Compared with the low-stability group,Hazard Ratio(HR)adjusted for potential confounders were 1.37 for the moderate-increasing group,1.23 for the elevated-decreasing group,and 2.08 for the elevated-stable group.Conclusion Sustained high FBG levels were found to play a critical role in the development of ischemic stroke among patients with diabetes.Controlling FBG levels may reduce the risk of cerebral infarction.展开更多
Objective Acute aortic dissection （AAD） is a catastrophic event with high early mortality rate, but to date, no data on the incidence of AAD in China's Mainland is available. This study aimed to estimate the inc...Objective Acute aortic dissection （AAD） is a catastrophic event with high early mortality rate, but to date, no data on the incidence of AAD in China's Mainland is available. This study aimed to estimate the incidence of AAD in China and characterize the clinical profile, management and in-hospital outcomes of this vascular event. Methods We used the China Health Insurance Research Data （the CHIRA Data） 2011 which comprises all inpatient hospital records （300,886） during the period of Jan. 1st 2011 to Dec. 31 2011 of 3,335,000 randomly sampled beneficiaries （1,718,500 men and 1,616,500 women） from 25 cities and counties in different economic-geographic regions of China's Mainland. Patients with acute aortic dissection were identified according to International Classification of Disease 10m Revision （ICD-10） of I71.0, The estimated incidence of AAD was calculated using the equation： estimated incidence = 2.0 × （40% × hospital admission rate） ＋ 60% × hospital admission rate. Results The hospital admission rate was 2.0/100,000 （65/3,325,000, 95% CI： 1.2-2.8）. The estimated annual incidence of AAD was 2.8/100,000 （95% CI： 1.9-3.6） and was higher in male than in female （3.7 vs. 1.5, P 〈 0.001）. The mean age was 58.9 ± 13.4 years. During the mean hospital stay of 23 ±6 days, the overall in-hospital mortality was 13.9% （9/65）. Conclusions Our study showed relatively lower but not negligible incidence and in-hospital mortality of AAD in the mainland of China. The mean age of patients with AAD in Chinese was younger than that reported by researches from west countries, while the male to female incidence ratio is similar to those reported by other studies.展开更多
The purpose of this work is to study the effect of a type of water-saving irrigation （WSI） on nutrient runoff of paddy field. The volume of surface drainage was maintained low by WSI. In particular, WSI effectively ...The purpose of this work is to study the effect of a type of water-saving irrigation （WSI） on nutrient runoff of paddy field. The volume of surface drainage was maintained low by WSI. In particular, WSI effectively reduced surface drainage in rain events. Model simulation indicated that net runoff load of total nitrogen （TN） from the paddy field was increased by WSI. Meanwhile, net runoff loads of total phosphorus （TP） and total organic carbon （TOC） from the paddy field was decreased by WSI. Because ponding waters of the study fields were enriched with TP and TOC, WSI reduced runoff of these nutrients by controlling the volume of surface drainage. WSI could be considered an efficient method for reducing runoff loads and could conserve water quality in an agricultural watershed.展开更多
In this study,we used remotely sensed data,GIS modeling,and statistical methods to evaluate the damage caused by the Wenchuan Earthquake (May 12,2008) to the giant panda (Ailuropoda melanoleuca) habitat in the World N...In this study,we used remotely sensed data,GIS modeling,and statistical methods to evaluate the damage caused by the Wenchuan Earthquake (May 12,2008) to the giant panda (Ailuropoda melanoleuca) habitat in the World Nature Heritage Sichuan Giant Panda Sanctuary (WHSGPS) in China.A landscape ecological analysis found increases of landscape heterogeneity,complexity,and fragmentation in the giant panda habitat after the earthquake.A terrain analysis found that slope and elevation are directly associated with the distribution of the damaged areas.As slope and elevation increase,the size of the damaged area keeps increase until to a peak,and then starts to drop.The total area of the damaged vegetation in our study area is 114.26 km 2,accounting for 3.78% of the study area;30.46% of that 114.26 km 2 is located in the Core Zone of WHSGPS.There are 18.57km 2 of the damaged vegetation located in the identified suitable giant panda habitat,accounting for 1.75% of the total area of suitable giant panda habitats in the study area.Based on these findings,we conclude that the Wenchuan Earthquake does not have significant impact on the WHSGPS as a whole.展开更多
Objective:To examine the effects of modified Shenmai Yin on invigorating vital energy, promoting blood flow, and protection against neural impairment in an endotoxin-induced shock rat model. Methods: Ninety-six SD rat...Objective:To examine the effects of modified Shenmai Yin on invigorating vital energy, promoting blood flow, and protection against neural impairment in an endotoxin-induced shock rat model. Methods: Ninety-six SD rats were randomly divided into four groups: sham operation (saline 20 ml/kg), shock model (lipopolysaccharide, LPS, 8 mg/kg), Reformed Shengmai Yin (加味生脉饮 Pulse-activating Decoction) (LPS 8 mg/kg + reformed Shengmai Yin Injection 10 ml/kg), and dexamethasone (LPS 8 mg/kg + dexamethasone 5 mg/kg) groups. Each group was subdivided into 1 h, 2 h, 3 h, and 6 h time points for observation. The carotid artery was separated and connected with a biological functional system to monitor mean arterial pressure (MAP). Brain water levels, malonaldehyde (MDA) content, and superoxide dismutase (SOD) activity were also determined. Results: In the shock model group, MAP was progressively decreased after injection of LPS, brain water and MDA contents were increased, brain SOD activity was decreased, and capillary vessel edema in brain tissue was also observed. All these parameters were improved significantly in both treatment groups, although the effects were more marked with Shengmai Yin than with dexamethasone. Conclusion: Modified Shengmai Yin exhibits strong anti-shock and neuroprotective effects against Endotoxininduced shock.展开更多
Ag/AgCl electrode has been prepared using pressed powder techniques. In order to verify the feasibility of this type of electrode used as detecting electric field generated by vessels in seawater, its characteristics ...Ag/AgCl electrode has been prepared using pressed powder techniques. In order to verify the feasibility of this type of electrode used as detecting electric field generated by vessels in seawater, its characteristics of DC resistance, low frequency AC impedance, and receiving impedance in artificial seawater have been studied by polarization measurements, low frequency electrochemical impedance spectra, the open and short circuit cell conditions. The results show that the electrode can keep a low resistance when it responses the weak electrostatic field in seawater. The AC impedance of the electrode decreases as the frequency of the signal increasing. The receiving impedance decreases when the frequency of external field increases too. The valid detection bandwidth is determined by the properties of the impedance and the reactions occurring on the surface of the electrode.展开更多
Objectives:To describe and compare fear of childbirth and in-labor pain intensity between primiparas and multiparas and explore the association between the amount of actual pain relief and fear of childbirth.Methods:A...Objectives:To describe and compare fear of childbirth and in-labor pain intensity between primiparas and multiparas and explore the association between the amount of actual pain relief and fear of childbirth.Methods:A convenience sampling method was used.A total of 260 women undergoing spontaneous or induced labor,including 97 primiparas and 163 multiparas,were recruited in a large academic specialized hospital in Guangzhou,China,from February 2018 to August 2019.The clinical data of maternal and neonatal were extracted from a structured electronic medical record system.Other demographic information,such as employment and family monthly income,was collected by a questionnaire.The Numeric Rating Scale(NRS)and the Chinese version of the Childbirth Attitude Questionnaire(C-CAQ)were applied to assess maternal in-labor pain intensity and fear of childbirth.The analgesic consumption and the frequency of manual boluses as rescue analgesia were stored and collected from the analgesia pump.Results:Eighty-two(84.5%)primiparas and ninety-nine(60.7%)multiparas received epidural analgesia(P<0.001).In the epidural subgroup,the primiparous average fear of childbirth(36.46±10.93)was higher than that of the multiparas(32.06±10.23)(P¼0.007).However,multiparas reported more intense in-labor pain[8.0(8.0,9.0)vs.8.0(7.0,8.0)],had more successful manual boluses per hour[2.68(1.65,3.85)vs.1.77(0.90,2.47)],more hourly analgesic consumption[23.00(16.00,28.25)vs.17.24(11.52,21.36)mL]and more average analgesic consumption[0.35(0.24,0.45)vs.0.26(0.19,0.35)mL/(h$kg)]than the primiparas(P<0.05).Spearman’s correlation analysis showed that the maximum in-labor pain was weakly positively correlated with fear of childbirth(r¼0.09)(P<0.05),hourly analgesic consumption(r¼0.16)(P<0.01)and average analgesic consumption(r¼0.17)(P<0.05).No statistically significant association was uncovered between analgesic consumption and maternal fear of childbirth.Conclusions:Fear of childbirth is a potential predictor of labor pain intensity.Further study is needed to explore its role and value in pain management during delivery.Parity is not a determinant of pain relief use and should not be a preconceived preference of obstetric care team members to determine the distribution of epidural analgesia,especially when analgesia resources are insufficient.展开更多
Experiments were conducted to evaluate the physiological and the biochemical characteristics of waxy wheat seeds under accelerated aging conditions. Five waxy wheat lines, which were Waxy 1, Waxy 4, Waxy 8, Waxy 9, an...Experiments were conducted to evaluate the physiological and the biochemical characteristics of waxy wheat seeds under accelerated aging conditions. Five waxy wheat lines, which were Waxy 1, Waxy 4, Waxy 8, Waxy 9, and Waxy 15; and five non-waxy wheat lines： S-39, 04J89, Jan-81, III42-4, and II110 were studied. The seeds were subjected to accelerated aging at 40℃, 45℃, 50℃, 55℃, and 60℃, and 90% relative humidity for 0, 2, 4, 6, and 8 days, respectively. The results showed a gradual increase in conductivity and decrease in germination rate during accelerated aging. SOD, POD and CAT activities increased at lowgrade treatment, but decreased at severe treatment. On the other hand, the soluble protein content decreased at 45 ℃, but successively increased, then decreased 50℃. From the above study, it showed that 90% RH at 55℃ was the best accelerated aging condition for optimum efficiency in a shorter period.展开更多
The study aims to compare the differences of macrofauna communities of wetlands at 3-year-forest- age, 5-year-forest-age Sonneratia apetala artificial mangroves, 5-year-forest-age Kandelia candel ar- tificial mangrove...The study aims to compare the differences of macrofauna communities of wetlands at 3-year-forest- age, 5-year-forest-age Sonneratia apetala artificial mangroves, 5-year-forest-age Kandelia candel ar- tificial mangroves with the same restoration background, and the naked tidal flat in the Qi’ao Island Mangrove Nature Reserve of Zhuhai, Guangdong Province. The results show that there were signif- icant structural differences in macrofauna communities among four kinds of habitats. The increase of biomass and species diversity of macrofauna at 3-year-forest-age S. apetala artificial mangroves was obviously faster than that at 5-year-forest-age K. candel artificial mangroves whose average tree height was close to that of 3-year-forest-age S. apetala artificial mangroves. The BIOENV analysis shows that it was related to the rapid growth of S. apetala, which rapidly changed the light level and shading conditions in the forests. The 5-year-forest-age S. apetala artificial mangroves had lower macrofauna species diversity but higher density and biomass than K. candel artificial mangroves with the same forest age. This was due to the rapid changes of physical and chemical properties of habitat soil by the ecological restoration of S. apetala artificial mangroves as well as the changed food sources possibly caused by the leaf-litter of such non-indigenous mangrove species S. apetala. However, further survey should be conducted on whether there are any negative ecological impacts of large-scale cultivation of S. apetala on macrofauna communities, so as to evaluate correctly S. apetala’s role in the restoration of coastal mangrove ecosystems.展开更多
Wastewater, which involves easy-soluble reactive dyes, especially non-degradable dyes, is very difficult to decolor efficiently by normal processes such as coagulation process and biological treatment. The high chroma...Wastewater, which involves easy-soluble reactive dyes, especially non-degradable dyes, is very difficult to decolor efficiently by normal processes such as coagulation process and biological treatment. The high chromaticity se- riously hinders the reuse of reactive dye waste water. In this paper, a new method by bentonite adsorption and coagulation (PAC) is employed for removing color from synthetic dye waste water which contains reactive red K-2G, K-RN blue, K-GR blue, X-3B red, K-GN orange, KB-3G yellow, K-2BP red, K-RN yellow and K-6G yellow. Bentonite pre- treated by 4% CTMAB and milled to 160 order screen is proven to the best decoloring agent. For a 100 mL reactive red K-2G sample (CODcr 400 mg/L, 25 000 chromaticity color), 0.5 g bentonite pretreated and 2.5 mL PAC is enough to decolor wastewater up to 99.92% and the sediment time is short. Non-degradable dyes such as active red X-3B and K-GN orange are declored completely as well. Raw sewage (low chromaticity color) is decolored completely at a ben-tonite dosage of 0.001g. More researches prove the high practical value of this process.展开更多
Forest volume, the major component of forest biomass, is an important issue in forest resource monitoring.It is estimated from tree volume tables or equations. Based on tree volume data of 1840 sample trees from Chine...Forest volume, the major component of forest biomass, is an important issue in forest resource monitoring.It is estimated from tree volume tables or equations. Based on tree volume data of 1840 sample trees from Chinese fir （Cunninghamia lanceolata） plantations in Guizhou Province in southwestern China, parallel one- and two-variable tree volume tables and tree height curves for central and other areas were constructed using an error-in-variable modeling method. The results show that, although the one-variable tree volume equations and height curves between the central and other areas were significantly different, the two-variable volume equations were sufficiently close, so that a generalized two-variable tree volume equation could be established for the entire province.展开更多
Three stochastic mathematical models for calculation of the reservoir flood regulation process, river course flood release, and flood risk rate under flood control were established based on the theory of stochastic di...Three stochastic mathematical models for calculation of the reservoir flood regulation process, river course flood release, and flood risk rate under flood control were established based on the theory of stochastic differential equations and features of flood control systems in the middle reach of the Huaihe River from Xixian to the Bengbu floodgate, comprehensively considering uncertain factors of hydrology, hydraulics, and engineering control. They were used to calculate the flood risk rate with flood regulation of five key reservoirs, including the Meishan, Xianghongdian, Nianyushan, Mozitan, and Foziling reservoirs in the middle reach of the Huaihe River under different flood frequencies, the flood risk rate with river course flood release under design and check floods for the trunk of the Huaihe River in conjunction with relevant flood storage areas, and the flood risk rate with operation of the Linhuaigang Project under design and check floods. The calculated results show that （l） the five reservoirs can withstand design floods, but the Xianghongdian and Foziling reservoirs will suffer overtopping accidents under check floods; （2） considering the service of flood storage areas under the design flood conditions of the Huaihe River, the mean flood risk rate with flood regulation of dykes and dams from Xixian to the Bengbu floodgate is about 0.2, and the trunk of the Huaihe River can generally withstand design floods; and （3） under a check flood with the flood return period of 1 000 years, the risk rate of overtopping accidents of the Linhuaigang Project is not larger than 0.15, indicating that it has a high flood regulation capacity. Through regulation and application of the flood control system of the Linhuigang Project, the Huaihe River Basin can withstand large floods, and the safety of the protected area can be ensured.展开更多
China implemented the public hospital reform in 2012. This study utilized bootstrapping data envelopment analysis（DEA） to evaluate the technical efficiency（TE） and productivity of county public hospitals in Easter...China implemented the public hospital reform in 2012. This study utilized bootstrapping data envelopment analysis（DEA） to evaluate the technical efficiency（TE） and productivity of county public hospitals in Eastern, Central, and Western China after the 2012 public hospital reform. Data from 127 county public hospitals（39, 45, and 43 in Eastern, Central, and Western China, respectively） were collected during 2012–2015. Changes of TE and productivity over time were estimated by bootstrapping DEA and bootstrapping Malmquist. The disparities in TE and productivity among public hospitals in the three regions of China were compared by Kruskal–Wallis H test and Mann–Whitney U test. The average bias-corrected TE values for the four-year period were 0.6442, 0.5785, 0.6099, and 0.6094 in Eastern, Central, and Western China, and the entire country respectively, with average non-technical efficiency, low pure technical efficiency（PTE）, and high scale efficiency found. Productivity increased by 8.12%, 0.25%, 12.11%, and 11.58% in China and its three regions during 2012–2015, and such increase in productivity resulted from progressive technological changes by 16.42%, 6.32%, 21.08%, and 21.42%, respectively. The TE and PTE of the county hospitals significantly differed among the three regions of China. Eastern and Western China showed significantly higher TE and PTE than Central China. More than 60% of county public hospitals in China and its three areas operated at decreasing return scales. There was a considerable space for TE improvement in county hospitals in China and its three regions. During 2012–2015, the hospitals experienced progressive productivity; however, the PTE changed adversely. Moreover, Central China continuously achieved a significantly lower efficiency score than Eastern and Western China. Decision makers and administrators in China should identify the causes of the observed inefficiencies and take appropriate measures to increase the efficiency of county public hospitals in the three areas of China, especially in Central China.展开更多
The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid（CSF） T‐SPOT.TB test for the diagnosis of TB meningitis（TBM）. A retrospective analysis of 96 patients with manifested meningiti...The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid（CSF） T‐SPOT.TB test for the diagnosis of TB meningitis（TBM）. A retrospective analysis of 96 patients with manifested meningitis was conducted; T‐SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value（PPV）, and negative predictive value（NPV）. A receiver operating characteristic（ROC） curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T‐SPOT.TB test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients（54.2%） of the 96 enrolled patients. The area under the curve（AUC） was 0.910, and the sensitivities of CSF T‐SPOT.TB for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T‐SPOT.TB test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.展开更多
The dependence of tumor growth on neovascularization has become an important aspect of cancer biology.Tumor angiogenesis is one of the key mechanisms of tumorigenesis,growth and metastasis.The key events involved in t...The dependence of tumor growth on neovascularization has become an important aspect of cancer biology.Tumor angiogenesis is one of the key mechanisms of tumorigenesis,growth and metastasis.The key events involved in this process are endothelial cell proliferation,migration,and vascular formation.Recent studies have revealed the importance of tumor-associated endothelial cells(TECs)in the development and progression of colorectal cancer(CRC),including epithelial proliferation,stem cell maintenance,angiogenesis,and immune remodeling.Decades of research have identified that the molecular basis of tumor angiogenesis includes vascular endothelial growth factors(VEGFs)and their receptor family,which are the main targets of antiangiogenesis therapy.VEGFs and their receptors play key roles in the pathology of angiogenesis,and their overexpression indicates poor prognosis in CRC.This article reviews the characteristics of the tumor vasculature and the role of TECs in different stages of CRC and immune remodeling.We also discuss the biological effects of VEGFs and their receptor family as angiogenesis regulators and emphasize the clinical implications of TECs in clinical treatment.展开更多
The coast of the Dapeng Peninsula has been honored as one of “the eight most beautiful coasts in China”. The most precious tourism resource for the peninsula is headland bay beaches, among which the beach at Xichong...The coast of the Dapeng Peninsula has been honored as one of “the eight most beautiful coasts in China”. The most precious tourism resource for the peninsula is headland bay beaches, among which the beach at Xichong on the southern coast of the peninsula is the longest and the most important one. The information of the stability, sedimentary source and shape change of the beach is very important for maintaining the beach in terms of sustainable development of the peninsula. Heavy minerals in the sand of the beach and the inland stream at Xichong are compared with those of a nearby beach on the same coast to determine the beach sand source; with help of a computer software, MEPBAY, the equilibrium planforms of the beaches on the peninsula are compared with those of an island without rivers to evaluate the stream＇s effects on the beach stability; cross shore profiles along the Xichong beach are also surveyed in different seasons of a year to assess the annual shore normal beach changes affected by the stream input, and the relation between the equilibrium planform state and cross shore changes of the beach. It is shown that （1） stream is the main sedimentary source of the beach and the weathering materials of the rocky headlands on both sides of the bay transported by waves are the second source for the beach but it is limited, sand from an inner shelf is not the sedimentary source for the beach at present and was not even during the Holocene transgression; （2） the Xichong beach cannot reach static equilibrium around the entire bay shoreline, the segment of the shore-line where a stream outlet is located is in dynamic equilibrium, and the unstable section occurs in the wave shadow region in the lee of an offshore island; （3） no matter whether the section of the beach shoreline at Xichong is in an equilibrium state or not, it is eroded in the typhoon season and recovered after the season, the maximum change in erosion and accretion occurs in the unstable segment; （4） the Xichong beach can only have small sand body since it is supplied with sand mainly form inland streams, resulting in a possible danger in which sand loss induced by human activities or huge storms cannot be replenished naturally.展开更多
文摘In this editorial,we comment on the recent article by Fei et al exploring the field of near-infrared spectroscopy(NIRS)research in schizophrenia from a bibliometrics perspective.In recent years,NIRS has shown unique advantages in the auxiliary diagnosis of schizophrenia,and the introduction of bibliometrics has provided a macro perspective for research in this field.Despite the opportunities brought about by these technological developments,remaining challenges require multidi-sciplinary approach to devise a reliable and accurate diagnosis system for schizo-phrenia.Nonetheless,NIRS-assisted technology is expected to contribute to the division of methods for early intervention and treatment of schizophrenia.
基金funded by the Education and Teaching Reform Research Major Project of Anhui Province(2022xqhz023)(2023sx170).
文摘Objectives:College students face increasing mental health challenges.Although Acceptance and CommitmentTherapy(ACT)is effective,the efficacy of Internet-based ACT(iACT)needs further exploration.Methods:This study examines the efficacy of iACT on college students’mental health through a randomized controlled trial.We recruited 90 college students(19.16±1.02 years old)and randomly divided them into the iACT group,face-to-face ACT group,and control group.The effects of the interventions were evaluated using the comprehensive assessment of ACT processes(CompACT)and the Depression Anxiety Stress Scales(DASS-21).Results:Two-factor repeated measures ANOVA revealed a significant time main effect of iACT.Face-to-face ACT and iACT effectively improved college students’psychological flexibility[F(2,83)=18.78,p<0.001,η^(2)=0.18]and alleviated their negative emotions[F(2,82)=41.17,p<0.001,η^(2)=0.36].Face-to-face ACT exhibited sustained effects on improving participants’psychological flexibility and alleviating their negative emotions(p<0.001),while iACT showed no sustained effect on improving participants’psychological flexibility(p>0.05).Conclusion:While iACT and face-to-face ACT are effective shortterm interventions,face-to-face ACT demonstrates superior sustainability.Integrating guided sessions into iACT may enhance long-term outcomes.These findings advocate for blended interventions to address college students’mental health needs,particularly in resource-limited settings.
文摘Brown planthopper(BPH)is a highly destructive pest that presents a significant challenge to rice production,particularly in the Asia-Pacific region.Numerous BPH-resistant rice varieties have been successfully bred and released for commercial cultivation across diverse rice-growing ecosystems.However,resistance breakdown in several varieties carrying major resistance genes has been reported,highlighting the urgent need for the development of novel,genetically diverse,and broad-spectrum resistant varieties.To date,more than 45 resistance loci have been identified and mapped from both cultivated and wild rice species.Among these,a subset of genes(including Bph1,Bph3,Bph6,Bph7,Bph9,Bph10,Bph14,Bph15,Bph18,Bph21,Bph26/2,bph29,Bph32,Bph37,and Bph30/Bph40)have been positionally cloned.Most of these genes encode coiled-coil nucleotide-binding leucine-rich repeat proteins,which are central to plant immune responses,along with a few signaling molecules playing pivotal roles.In addition to these core resistance genes,various other genetic components,including miRNAs,protein kinases,and transcription factors,have been functionally characterized for their roles in mediating BPH resistance.The advent of post-genomic tools such as RNA sequencing and single-cell sequencing,along with cutting-edge genomic technologies like CRISPR/Cas gene editing,has significantly accelerated resistance breeding programs.In this context,we provide an overview of genetics,mapping,isolation,and functional characterization of BPH resistance,along with strategies for incorporating resistance using advanced genomics-assisted breeding tools.Furthermore,we present a snapshot of how the integration of genomics and novel breeding technologies holds great promise for dissecting the genetic architecture of pest resistance and accelerating crop improvement.
基金supported by the National Natural Science Foundation of China(72164018)Humanities and Social Sciences Research Planning Foundation of the Ministry of Education(22YJA190012)+1 种基金Jiangxi Universities Key Research Base Project of Humanities and Social Sciences(JD23071)Jiangxi Provincial Colleges and Universities Ideological and Political Education Research Association Project(XSGZ24239).
文摘Objectives:The aim of this study was to verify the causal relationship between trait aggressiveness(TA)and moral disengagement(MD),know more about the growth trajectory of MD,and explore the effects of gender and TA on the growth trajectory.Methods:We used the Buss-Perry Aggression Questionnaire and Moral Disengagement Scale to survey 433 Chinese junior high school students longitudinally three times.Results:The results of the random intercept cross-lagged panel model(RI-CLPM)analysis indicated that TA positively predicted MD,while MD did not predict TA at the within-person level.Thus,TA could be considered an antecedent variable of MD.Furthermore,the unconditional latent growth linear model analysis revealed that MD among junior high school students exhibited an upward trend,characterized by an increasing rate of growth over time.In the conditional latent growth linear model analysis,we found that gender influenced only the initial level of MD but had no effect on its growth rate.Conversely,TA demonstrated both delayed and immediate positive effects on the growth of MD.Conclusions:Our findings suggested a one-way cross-lag effect between TA and MD.Additionally,the growth trajectory of MD among junior high school students was found to be ascending.This growth trajectory was influenced by gender and TA,offering valuable insights for the prevention and intervention of behavioral problems in junior high school students.
基金supported by the National Key R&D Program of China(2021YFC2500500)National Natural Science Foundation of China(Grant Nos.81973112,92049302,and U22A20364).
文摘Objective To investigate the association between long-term glycemic control and cerebral infarction risk in patients with diabetes through a large-scale cohort study.Methods This prospective,community-based cohort study included 12,054 patients with diabetes.From 2006 to 2012,38,272 fasting blood glucose(FBG)measurements were obtained from these participants.FBG trajectory patterns were generated using latent mixture modelling.Cox proportional hazards models were applied to assess the subsequent risk of cerebral infarction associated with different FBG trajectory patterns.Results At baseline,the mean age of the participants was 55.2 years.Four distinct FBG trajectories were identified based on FBG concentrations and their changes over the 6-year follow-up period.After a median follow-up of 6.9 years,786 cerebral infarction events were recorded.Different trajectory patterns were associated with significantly varied outcome risks(Log-Rank P<0.001).Compared with the low-stability group,Hazard Ratio(HR)adjusted for potential confounders were 1.37 for the moderate-increasing group,1.23 for the elevated-decreasing group,and 2.08 for the elevated-stable group.Conclusion Sustained high FBG levels were found to play a critical role in the development of ischemic stroke among patients with diabetes.Controlling FBG levels may reduce the risk of cerebral infarction.
文摘Objective Acute aortic dissection （AAD） is a catastrophic event with high early mortality rate, but to date, no data on the incidence of AAD in China's Mainland is available. This study aimed to estimate the incidence of AAD in China and characterize the clinical profile, management and in-hospital outcomes of this vascular event. Methods We used the China Health Insurance Research Data （the CHIRA Data） 2011 which comprises all inpatient hospital records （300,886） during the period of Jan. 1st 2011 to Dec. 31 2011 of 3,335,000 randomly sampled beneficiaries （1,718,500 men and 1,616,500 women） from 25 cities and counties in different economic-geographic regions of China's Mainland. Patients with acute aortic dissection were identified according to International Classification of Disease 10m Revision （ICD-10） of I71.0, The estimated incidence of AAD was calculated using the equation： estimated incidence = 2.0 × （40% × hospital admission rate） ＋ 60% × hospital admission rate. Results The hospital admission rate was 2.0/100,000 （65/3,325,000, 95% CI： 1.2-2.8）. The estimated annual incidence of AAD was 2.8/100,000 （95% CI： 1.9-3.6） and was higher in male than in female （3.7 vs. 1.5, P 〈 0.001）. The mean age was 58.9 ± 13.4 years. During the mean hospital stay of 23 ±6 days, the overall in-hospital mortality was 13.9% （9/65）. Conclusions Our study showed relatively lower but not negligible incidence and in-hospital mortality of AAD in the mainland of China. The mean age of patients with AAD in Chinese was younger than that reported by researches from west countries, while the male to female incidence ratio is similar to those reported by other studies.
文摘The purpose of this work is to study the effect of a type of water-saving irrigation （WSI） on nutrient runoff of paddy field. The volume of surface drainage was maintained low by WSI. In particular, WSI effectively reduced surface drainage in rain events. Model simulation indicated that net runoff load of total nitrogen （TN） from the paddy field was increased by WSI. Meanwhile, net runoff loads of total phosphorus （TP） and total organic carbon （TOC） from the paddy field was decreased by WSI. Because ponding waters of the study fields were enriched with TP and TOC, WSI reduced runoff of these nutrients by controlling the volume of surface drainage. WSI could be considered an efficient method for reducing runoff loads and could conserve water quality in an agricultural watershed.
基金supported by Sichuan Foundation of Excellent Scientists (Grant No.2010JZ0002)the Directional Project of Chinese Academy of Sciences (Grant No.KZX2-YW-333)
文摘In this study,we used remotely sensed data,GIS modeling,and statistical methods to evaluate the damage caused by the Wenchuan Earthquake (May 12,2008) to the giant panda (Ailuropoda melanoleuca) habitat in the World Nature Heritage Sichuan Giant Panda Sanctuary (WHSGPS) in China.A landscape ecological analysis found increases of landscape heterogeneity,complexity,and fragmentation in the giant panda habitat after the earthquake.A terrain analysis found that slope and elevation are directly associated with the distribution of the damaged areas.As slope and elevation increase,the size of the damaged area keeps increase until to a peak,and then starts to drop.The total area of the damaged vegetation in our study area is 114.26 km 2,accounting for 3.78% of the study area;30.46% of that 114.26 km 2 is located in the Core Zone of WHSGPS.There are 18.57km 2 of the damaged vegetation located in the identified suitable giant panda habitat,accounting for 1.75% of the total area of suitable giant panda habitats in the study area.Based on these findings,we conclude that the Wenchuan Earthquake does not have significant impact on the WHSGPS as a whole.
基金supported by a grant from National Natural Science Foundation of China (No.30672737)
文摘Objective:To examine the effects of modified Shenmai Yin on invigorating vital energy, promoting blood flow, and protection against neural impairment in an endotoxin-induced shock rat model. Methods: Ninety-six SD rats were randomly divided into four groups: sham operation (saline 20 ml/kg), shock model (lipopolysaccharide, LPS, 8 mg/kg), Reformed Shengmai Yin (加味生脉饮 Pulse-activating Decoction) (LPS 8 mg/kg + reformed Shengmai Yin Injection 10 ml/kg), and dexamethasone (LPS 8 mg/kg + dexamethasone 5 mg/kg) groups. Each group was subdivided into 1 h, 2 h, 3 h, and 6 h time points for observation. The carotid artery was separated and connected with a biological functional system to monitor mean arterial pressure (MAP). Brain water levels, malonaldehyde (MDA) content, and superoxide dismutase (SOD) activity were also determined. Results: In the shock model group, MAP was progressively decreased after injection of LPS, brain water and MDA contents were increased, brain SOD activity was decreased, and capillary vessel edema in brain tissue was also observed. All these parameters were improved significantly in both treatment groups, although the effects were more marked with Shengmai Yin than with dexamethasone. Conclusion: Modified Shengmai Yin exhibits strong anti-shock and neuroprotective effects against Endotoxininduced shock.
文摘Ag/AgCl electrode has been prepared using pressed powder techniques. In order to verify the feasibility of this type of electrode used as detecting electric field generated by vessels in seawater, its characteristics of DC resistance, low frequency AC impedance, and receiving impedance in artificial seawater have been studied by polarization measurements, low frequency electrochemical impedance spectra, the open and short circuit cell conditions. The results show that the electrode can keep a low resistance when it responses the weak electrostatic field in seawater. The AC impedance of the electrode decreases as the frequency of the signal increasing. The receiving impedance decreases when the frequency of external field increases too. The valid detection bandwidth is determined by the properties of the impedance and the reactions occurring on the surface of the electrode.
文摘Objectives:To describe and compare fear of childbirth and in-labor pain intensity between primiparas and multiparas and explore the association between the amount of actual pain relief and fear of childbirth.Methods:A convenience sampling method was used.A total of 260 women undergoing spontaneous or induced labor,including 97 primiparas and 163 multiparas,were recruited in a large academic specialized hospital in Guangzhou,China,from February 2018 to August 2019.The clinical data of maternal and neonatal were extracted from a structured electronic medical record system.Other demographic information,such as employment and family monthly income,was collected by a questionnaire.The Numeric Rating Scale(NRS)and the Chinese version of the Childbirth Attitude Questionnaire(C-CAQ)were applied to assess maternal in-labor pain intensity and fear of childbirth.The analgesic consumption and the frequency of manual boluses as rescue analgesia were stored and collected from the analgesia pump.Results:Eighty-two(84.5%)primiparas and ninety-nine(60.7%)multiparas received epidural analgesia(P<0.001).In the epidural subgroup,the primiparous average fear of childbirth(36.46±10.93)was higher than that of the multiparas(32.06±10.23)(P¼0.007).However,multiparas reported more intense in-labor pain[8.0(8.0,9.0)vs.8.0(7.0,8.0)],had more successful manual boluses per hour[2.68(1.65,3.85)vs.1.77(0.90,2.47)],more hourly analgesic consumption[23.00(16.00,28.25)vs.17.24(11.52,21.36)mL]and more average analgesic consumption[0.35(0.24,0.45)vs.0.26(0.19,0.35)mL/(h$kg)]than the primiparas(P<0.05).Spearman’s correlation analysis showed that the maximum in-labor pain was weakly positively correlated with fear of childbirth(r¼0.09)(P<0.05),hourly analgesic consumption(r¼0.16)(P<0.01)and average analgesic consumption(r¼0.17)(P<0.05).No statistically significant association was uncovered between analgesic consumption and maternal fear of childbirth.Conclusions:Fear of childbirth is a potential predictor of labor pain intensity.Further study is needed to explore its role and value in pain management during delivery.Parity is not a determinant of pain relief use and should not be a preconceived preference of obstetric care team members to determine the distribution of epidural analgesia,especially when analgesia resources are insufficient.
基金Supported by National Natural Science Foundation of China (31000712)National Natural Science Fund (31000712)Yunnan Provincial Education Department Scientific Research Program (08Y0166)
文摘Experiments were conducted to evaluate the physiological and the biochemical characteristics of waxy wheat seeds under accelerated aging conditions. Five waxy wheat lines, which were Waxy 1, Waxy 4, Waxy 8, Waxy 9, and Waxy 15; and five non-waxy wheat lines： S-39, 04J89, Jan-81, III42-4, and II110 were studied. The seeds were subjected to accelerated aging at 40℃, 45℃, 50℃, 55℃, and 60℃, and 90% relative humidity for 0, 2, 4, 6, and 8 days, respectively. The results showed a gradual increase in conductivity and decrease in germination rate during accelerated aging. SOD, POD and CAT activities increased at lowgrade treatment, but decreased at severe treatment. On the other hand, the soluble protein content decreased at 45 ℃, but successively increased, then decreased 50℃. From the above study, it showed that 90% RH at 55℃ was the best accelerated aging condition for optimum efficiency in a shorter period.
基金The Science and Technology Project of Guangdong under contract No. 2009B030600006National Science and Technology Support Program sub-topics under contract No. 2009BADB2B0401-02Appropriative Researching Fund for Professors and Doctors, Guangdong University of Education under contract No. 10ARF01
文摘The study aims to compare the differences of macrofauna communities of wetlands at 3-year-forest- age, 5-year-forest-age Sonneratia apetala artificial mangroves, 5-year-forest-age Kandelia candel ar- tificial mangroves with the same restoration background, and the naked tidal flat in the Qi’ao Island Mangrove Nature Reserve of Zhuhai, Guangdong Province. The results show that there were signif- icant structural differences in macrofauna communities among four kinds of habitats. The increase of biomass and species diversity of macrofauna at 3-year-forest-age S. apetala artificial mangroves was obviously faster than that at 5-year-forest-age K. candel artificial mangroves whose average tree height was close to that of 3-year-forest-age S. apetala artificial mangroves. The BIOENV analysis shows that it was related to the rapid growth of S. apetala, which rapidly changed the light level and shading conditions in the forests. The 5-year-forest-age S. apetala artificial mangroves had lower macrofauna species diversity but higher density and biomass than K. candel artificial mangroves with the same forest age. This was due to the rapid changes of physical and chemical properties of habitat soil by the ecological restoration of S. apetala artificial mangroves as well as the changed food sources possibly caused by the leaf-litter of such non-indigenous mangrove species S. apetala. However, further survey should be conducted on whether there are any negative ecological impacts of large-scale cultivation of S. apetala on macrofauna communities, so as to evaluate correctly S. apetala’s role in the restoration of coastal mangrove ecosystems.
文摘Wastewater, which involves easy-soluble reactive dyes, especially non-degradable dyes, is very difficult to decolor efficiently by normal processes such as coagulation process and biological treatment. The high chromaticity se- riously hinders the reuse of reactive dye waste water. In this paper, a new method by bentonite adsorption and coagulation (PAC) is employed for removing color from synthetic dye waste water which contains reactive red K-2G, K-RN blue, K-GR blue, X-3B red, K-GN orange, KB-3G yellow, K-2BP red, K-RN yellow and K-6G yellow. Bentonite pre- treated by 4% CTMAB and milled to 160 order screen is proven to the best decoloring agent. For a 100 mL reactive red K-2G sample (CODcr 400 mg/L, 25 000 chromaticity color), 0.5 g bentonite pretreated and 2.5 mL PAC is enough to decolor wastewater up to 99.92% and the sediment time is short. Non-degradable dyes such as active red X-3B and K-GN orange are declored completely as well. Raw sewage (low chromaticity color) is decolored completely at a ben-tonite dosage of 0.001g. More researches prove the high practical value of this process.
基金supported by the Agricultural Science and Technique Foundation of Guizhou Province, China (No. 2008-3059)the Research Funds of Forestry Administration of Guizhou Province, China (Nos. 2010-01-08, 2010-01, 200625)
文摘Forest volume, the major component of forest biomass, is an important issue in forest resource monitoring.It is estimated from tree volume tables or equations. Based on tree volume data of 1840 sample trees from Chinese fir （Cunninghamia lanceolata） plantations in Guizhou Province in southwestern China, parallel one- and two-variable tree volume tables and tree height curves for central and other areas were constructed using an error-in-variable modeling method. The results show that, although the one-variable tree volume equations and height curves between the central and other areas were significantly different, the two-variable volume equations were sufficiently close, so that a generalized two-variable tree volume equation could be established for the entire province.
基金supported by the National Natural Science Foundation of China(Grant No.51139001)
文摘Three stochastic mathematical models for calculation of the reservoir flood regulation process, river course flood release, and flood risk rate under flood control were established based on the theory of stochastic differential equations and features of flood control systems in the middle reach of the Huaihe River from Xixian to the Bengbu floodgate, comprehensively considering uncertain factors of hydrology, hydraulics, and engineering control. They were used to calculate the flood risk rate with flood regulation of five key reservoirs, including the Meishan, Xianghongdian, Nianyushan, Mozitan, and Foziling reservoirs in the middle reach of the Huaihe River under different flood frequencies, the flood risk rate with river course flood release under design and check floods for the trunk of the Huaihe River in conjunction with relevant flood storage areas, and the flood risk rate with operation of the Linhuaigang Project under design and check floods. The calculated results show that （l） the five reservoirs can withstand design floods, but the Xianghongdian and Foziling reservoirs will suffer overtopping accidents under check floods; （2） considering the service of flood storage areas under the design flood conditions of the Huaihe River, the mean flood risk rate with flood regulation of dykes and dams from Xixian to the Bengbu floodgate is about 0.2, and the trunk of the Huaihe River can generally withstand design floods; and （3） under a check flood with the flood return period of 1 000 years, the risk rate of overtopping accidents of the Linhuaigang Project is not larger than 0.15, indicating that it has a high flood regulation capacity. Through regulation and application of the flood control system of the Linhuigang Project, the Huaihe River Basin can withstand large floods, and the safety of the protected area can be ensured.
基金supported by the National Natural Science Foundation of China(No.71473099)
文摘China implemented the public hospital reform in 2012. This study utilized bootstrapping data envelopment analysis（DEA） to evaluate the technical efficiency（TE） and productivity of county public hospitals in Eastern, Central, and Western China after the 2012 public hospital reform. Data from 127 county public hospitals（39, 45, and 43 in Eastern, Central, and Western China, respectively） were collected during 2012–2015. Changes of TE and productivity over time were estimated by bootstrapping DEA and bootstrapping Malmquist. The disparities in TE and productivity among public hospitals in the three regions of China were compared by Kruskal–Wallis H test and Mann–Whitney U test. The average bias-corrected TE values for the four-year period were 0.6442, 0.5785, 0.6099, and 0.6094 in Eastern, Central, and Western China, and the entire country respectively, with average non-technical efficiency, low pure technical efficiency（PTE）, and high scale efficiency found. Productivity increased by 8.12%, 0.25%, 12.11%, and 11.58% in China and its three regions during 2012–2015, and such increase in productivity resulted from progressive technological changes by 16.42%, 6.32%, 21.08%, and 21.42%, respectively. The TE and PTE of the county hospitals significantly differed among the three regions of China. Eastern and Western China showed significantly higher TE and PTE than Central China. More than 60% of county public hospitals in China and its three areas operated at decreasing return scales. There was a considerable space for TE improvement in county hospitals in China and its three regions. During 2012–2015, the hospitals experienced progressive productivity; however, the PTE changed adversely. Moreover, Central China continuously achieved a significantly lower efficiency score than Eastern and Western China. Decision makers and administrators in China should identify the causes of the observed inefficiencies and take appropriate measures to increase the efficiency of county public hospitals in the three areas of China, especially in Central China.
文摘The aim of this study was to evaluate the diagnostic value of the cerebrospinal fluid（CSF） T‐SPOT.TB test for the diagnosis of TB meningitis（TBM）. A retrospective analysis of 96 patients with manifested meningitis was conducted; T‐SPOT.TB test was performed for diagnosing TBM to determine the diagnostic sensitivity, specificity, positive predictive value（PPV）, and negative predictive value（NPV）. A receiver operating characteristic（ROC） curve was also drawn to assess the diagnostic accuracy. The sensitivity, specificity, PPV, and NPV of CSF T‐SPOT.TB test were 97.8%, 78.0%, 80.3%, and 97.5%, respectively, for 52 patients（54.2%） of the 96 enrolled patients. The area under the curve（AUC） was 0.910, and the sensitivities of CSF T‐SPOT.TB for patients with stages I, II, and III of TBM were 96.7%, 97.2%, and 98.9%, respectively. CSF T‐SPOT.TB test is a rapid and accurate diagnostic method with higher sensitivity and specificity for diagnosing TBM.
基金Supported by the National Natural Science Foundation of China,No.81502564,No.81972598the Natural Science Foundation of Zhejiang Province,No.LY16H160018,No.LY18H160001the scholarship from China Scholarship Council(CSC)under the Grant CSC,No.201706325003
文摘The dependence of tumor growth on neovascularization has become an important aspect of cancer biology.Tumor angiogenesis is one of the key mechanisms of tumorigenesis,growth and metastasis.The key events involved in this process are endothelial cell proliferation,migration,and vascular formation.Recent studies have revealed the importance of tumor-associated endothelial cells(TECs)in the development and progression of colorectal cancer(CRC),including epithelial proliferation,stem cell maintenance,angiogenesis,and immune remodeling.Decades of research have identified that the molecular basis of tumor angiogenesis includes vascular endothelial growth factors(VEGFs)and their receptor family,which are the main targets of antiangiogenesis therapy.VEGFs and their receptors play key roles in the pathology of angiogenesis,and their overexpression indicates poor prognosis in CRC.This article reviews the characteristics of the tumor vasculature and the role of TECs in different stages of CRC and immune remodeling.We also discuss the biological effects of VEGFs and their receptor family as angiogenesis regulators and emphasize the clinical implications of TECs in clinical treatment.
基金Shenzhen Dapeng Peninsula National Geopark Project of China under contract No.340775the Natural Science Foundation of Guangdong Province of China unde contract No.S2012010008610the National Natural Science Foundation of China under contract No.40871020
文摘The coast of the Dapeng Peninsula has been honored as one of “the eight most beautiful coasts in China”. The most precious tourism resource for the peninsula is headland bay beaches, among which the beach at Xichong on the southern coast of the peninsula is the longest and the most important one. The information of the stability, sedimentary source and shape change of the beach is very important for maintaining the beach in terms of sustainable development of the peninsula. Heavy minerals in the sand of the beach and the inland stream at Xichong are compared with those of a nearby beach on the same coast to determine the beach sand source; with help of a computer software, MEPBAY, the equilibrium planforms of the beaches on the peninsula are compared with those of an island without rivers to evaluate the stream＇s effects on the beach stability; cross shore profiles along the Xichong beach are also surveyed in different seasons of a year to assess the annual shore normal beach changes affected by the stream input, and the relation between the equilibrium planform state and cross shore changes of the beach. It is shown that （1） stream is the main sedimentary source of the beach and the weathering materials of the rocky headlands on both sides of the bay transported by waves are the second source for the beach but it is limited, sand from an inner shelf is not the sedimentary source for the beach at present and was not even during the Holocene transgression; （2） the Xichong beach cannot reach static equilibrium around the entire bay shoreline, the segment of the shore-line where a stream outlet is located is in dynamic equilibrium, and the unstable section occurs in the wave shadow region in the lee of an offshore island; （3） no matter whether the section of the beach shoreline at Xichong is in an equilibrium state or not, it is eroded in the typhoon season and recovered after the season, the maximum change in erosion and accretion occurs in the unstable segment; （4） the Xichong beach can only have small sand body since it is supplied with sand mainly form inland streams, resulting in a possible danger in which sand loss induced by human activities or huge storms cannot be replenished naturally.
