Objectives This study aimed to examine the associations between depression,resilience,and fatigue in patients with multivessel coronary disease and verify their causal relationships.Methods Between October 2023 and Ju...Objectives This study aimed to examine the associations between depression,resilience,and fatigue in patients with multivessel coronary disease and verify their causal relationships.Methods Between October 2023 and June 2024,316 patients with multivessel coronary disease were recruited from three tertiary hospitals in Tangshan,China.The Patient Health Questionnaire,Connor-Davidson Resilience Scale,and the Multidimensional Fatigue Inventory were administered to the patients on the third day of admission(T1),one month after discharge(T2),and three months after discharge(T3).Pearson correlation analysis was conducted to examine the relationships among depression,resilience,and fatigue in patients with multivessel coronary disease,and cross-lagged analysis to explore the temporal causal relationships.Results In patients with multivessel coronary disease,levels of depression and fatigue decreased from T1 to T3,while resilience scores increased during the same period.The correlation analysis revealed significant relationships among depression,resilience,and fatigue at T1,T2,and T3(P<0.01).The autoregressive paths indicated high stability over time for depression,medium stability for resilience,and low stability for fatigue.Cross-lagged paths demonstrated that depression at T1 significantly predicted fatigue at T2(β=0.461,P<0.001),and depression at T2 significantly predicted fatigue at T3(β=0.957,P<0.001).And resilience at T1 significantly predicted fatigue at T2(β=−0.271,P<0.001),and resilience at T2 significantly predicted fatigue at T3(β=−0.176,P<0.001).Additionally,resilience had a moderating effect on the relationship between depression and fatigue(β=−0.760,P<0.001).Conclusions Our study confirmed that depression and resilience predicted fatigue in patients with multivessel coronary disease.To prevent and mitigate fatigue,alleviating depressive symptoms and enhancing resilience levels in patients at an early stage is essential.展开更多
Objectives:The study aimed to explore social alienation types in patients with inflammatorybowel diseases(IBD)and identify influencingfactors.Methods:This cross-sectional study was conducted using purposive sampling a...Objectives:The study aimed to explore social alienation types in patients with inflammatorybowel diseases(IBD)and identify influencingfactors.Methods:This cross-sectional study was conducted using purposive sampling among patients with IBD from July 2022 to July 2023.Patients were assessed using the Generalized Social Alienation Scale(GSAS),the Brief Illness Perception Questionnaire(B-IPQ),the Hospital Anxiety and Depression Scale(HADS),and the Medical Coping Modes Questionnaire(MCMQ).Demographic and disease-related characteristics were also collected.Latent profileanalysis(LPA)was used to identify potential subgroups of social alienation.Univariate analysis and multicollinearity analysis were conducted to explore the influencing factors,followed by multiple regression analysis to evaluate the effect of influencingfactors on social alienation.Results:Three distinct profilesof social alienation were identified:integrated-low alienation group(n=61,20.20%),accommodative-moderate alienation group(n=195,64.57%),and maladaptive-high alienation group(n=46,15.23%).Seven characteristics were associated with the profile’smembership:self-perceived financialstress,malnutrition risk,disease duration,illness comprehensibility,anxiety,depression,and acceptance-resignation coping mode.Conclusions:Patients with IBD were categorized into three subgroups based on social alienation levels.Financial stress,malnutrition risk,disease duration,illness comprehensibility,anxiety,depression,and acceptance-resignation coping mode were key predictors of the subgroup membership.Targeted interventions should be developed to mitigate the negative effects of social alienation,with a focus on improving illness perception,alleviating anxiety and depression,and promoting effective coping strategies.展开更多
Objective:This study aimed to evaluate the clinical utility of[^(68)Ga]Ga-RM2 positron emission tomography/computed tomography(PET/CT),in comparison with^(18)F-fluorodeoxyglucose([^(18)F]FDG)PET/CT,for staging and pro...Objective:This study aimed to evaluate the clinical utility of[^(68)Ga]Ga-RM2 positron emission tomography/computed tomography(PET/CT),in comparison with^(18)F-fluorodeoxyglucose([^(18)F]FDG)PET/CT,for staging and prognosis in patients with estrogen receptor-positive(ER+)breast cancer.Methods:This prospective study enrolled nine female patients with breast cancer(mean age 45.5±11.5 years).Eight patients were confirmed to have ER+disease.All participant underwent both[^(68)Ga]Ga-RM2 PET/CT and[^(18)F]FDG PET/CT scans within a one-week interval.The maximum standardized uptake values(SUV_(max))was measured for primary tumors,lymph nodes,and metastatic lesions.The physiological distribution of[^(68)Ga]GaRM2 was also evaluated.Results:No adverse events were observed.Metastatic were identified in lymph nodes(n=29 lesions),bone(n=19),liver(n=7),brain(n=3),and multiple other sites.[^(68)Ga]Ga-RM2 demonstrated a significantly higher median SUV_(max)than[^(18)F]FDG across all lesions[7.5(interquartile range,IQR,3.4-14.0)vs.4.0(IQR,2.3-6.1);P<0.001].Similarly,the tumor-to-background ratio(TBR)was significantly superior with[^(68)Ga]Ga-RM2 for all type of lesions:primary tumors[12.3(IQR,10.4-18.3)vs.7.0(IQR,6.0-10.0);P<0.001],lymph node metastases[17.8(IQR,4.4-39.0)vs.4.7(IQR,2.7-10.2);P<0.001],hepatic metastases[5.4(IQR,3.7-8.3)vs.1.0(IQR,0.9-1.5);P<0.001],and osseous metastases[13.9(IQR,7.3-18.0)vs.4.3(IQR,1.6-5.9);P<0.001].Physiological uptake of[^(68)Ga]Ga-RM2 was the highest in the pancreas(SUV_(max),77.82±22.64),with moderate uptake in the kidneys(2.82±0.62),heart(1.83±0.29),and liver(1.33±0.41).Conclusions:[^(68)Ga]Ga-RM2 PET/CT demonstrates superior uptake metrics for the detection of metastatic lesions,particularly in the brain and breast,suggesting its potential as a valuable complementary imaging modality to[^(18)F]FDG PET/CT.These promising foundings warrant further validation in larger cohorts to confirm their clinical impact and to standardize imaging protocols.展开更多
Artificial intelligence(AI)-driven data-centric paradigms are catalyzing a paradigm shift in radiopharmaceutical development and molecular imaging,two pivotal technologies that underpin precision nuclear medicine.This...Artificial intelligence(AI)-driven data-centric paradigms are catalyzing a paradigm shift in radiopharmaceutical development and molecular imaging,two pivotal technologies that underpin precision nuclear medicine.This review focuses on the cutting-edge applications of AI in radiopharmaceutical discovery and molecular image analytics,and systematically investigates the technical principles and typical cases of Deep Learning algorithms(e.g.,Graph Neural Networks(GNNs),Generative Adversarial Networks(GANs),and Transformer Models)in target identification,ligand design,pharmacokinetic optimization,and image reconstruction and enhancement.By integrating multi-omics data and 3D structural information,AI can significantly improve the accuracy of target affinity prediction for radiopharmaceuticals and accelerate the design of novel ligands.In the field of molecular imaging,AI-driven low-dose single-photon emission computed tomography(SPECT)and positron emission tomography(PET)image reconstruction,tumor segmentation,and quantitative analysis techniques have significantly improved the diagnostic efficiency and accuracy,providing a reliable basis for individualized treatment.In addition,the paper discusses data privacy,model generalization,and ethical challenges faced by AI in clinical translation,and looks forward to the future direction of multidisciplinary integration(e.g.,combining AI with radiochemistry and nuclear medicine)and technological innovations,which will help precision medicine leap from theory to practice.展开更多
The kinetics of reductive leaching of manganese from low grade pyrolusite in dilute sulfuric acid in the presence of molasses alcohol wastewater was investigated. The shrinking core model was applied to quantify the e...The kinetics of reductive leaching of manganese from low grade pyrolusite in dilute sulfuric acid in the presence of molasses alcohol wastewater was investigated. The shrinking core model was applied to quantify the effects of reaction parameters on leaching rate. The leaching rate increases with reaction temperature, concentrations of H 2 SO 4 and organic matter in molasses alcohol wastewater increase and ore particle size decreases. The leaching process follows the kinetics of a shrinking core model and the apparent activation energy is 57.5 kJ·mol –1 . The experimental results indicate a reaction order of 0.52 for H2SO4 concentration and 0.90 for chemical oxygen demand (COD) of molasses alcohol wastewater. It is concluded that the reductive leaching of pyrolusite with molasses alcohol wastewater is controlled by the diffusion through the ash/inert layer composed of the associated minerals.展开更多
BACKGROUND: Currently, no documentation is available regarding Chinese children with acute liver failure(ALF). This study was undertaken to investigate etiologies and outcomes of Chinese children with ALF.METHODS: We ...BACKGROUND: Currently, no documentation is available regarding Chinese children with acute liver failure(ALF). This study was undertaken to investigate etiologies and outcomes of Chinese children with ALF.METHODS: We retrospectively enrolled 32 pediatric patients with ALF admitted in five hospitals in different areas of China from January 2007 to December 2012. The coagulation indices, serum creatinine, serum lactate dehydrogenase,blood ammonia and prothrombin activity were analyzed; the relationship between these indices and mortality was evaluated by multivariate analysis.RESULTS: The most common causes of Chinese children with ALF were indeterminate etiology(15/32), drug toxicity(8/32),and acute cytomegalovirus hepatitis(6/32). Only 1 patient(3.13%)received liver transplantation and the spontaneous mortality of Chinese children with ALF was 58.06%(18/31). Patients who eventually died had higher baseline levels of international normalized ratio(P=0.01), serum creatinine(P=0.04), serum lactate dehydrogenase(P=0.01), blood ammonia(P<0.01) and lower prothrombin activity(P=0.01) than those who survived.Multivariate analysis showed that the entry blood ammonia was the only independent factor significantly associated with mortality(odds ratio=1.069, 95% confidence interval 1.023-1.117,P<0.01) and it had a sensitivity of 94.74%, a specificity of 84.62%and an accuracy of 90.63% for predicting the death. Based on the established model, with an increase of blood ammonia level,the risk of mortality would increase by 6.9%.CONCLUSIONS: The indeterminate causes predominated in the etiologies of ALF in Chinese children. The spontaneous mortality of pediatric patients with ALF was high, whereas the proportion of patients undergoing liver transplantation was significantly low. Entry blood ammonia was a reliable predictor for the death of pediatric patients with ALF.展开更多
Transfer station(TS)is an integral part of present-day municipal solid waste(MSW)management systems.To provide information for the incorporation of waste facilities within the current integrated waste management syste...Transfer station(TS)is an integral part of present-day municipal solid waste(MSW)management systems.To provide information for the incorporation of waste facilities within the current integrated waste management system,the authors measured the existing environmental quality at five MSW TSs.Discharged wastewater,air,and noise were monitored and assayed at the five TSs in Beijing in 2001-2006 during rainy seasons(RSs)and dry seasons(DSs).Except Ammonia(NH_3)and hydrogen sulfide(H_2S),the analytical results of...展开更多
Objective: Physical restraint is frequently used in medical services,such as in mental health settings,intensive care units and nursing homes,but its nature varies in different institutions.By reviewing related litera...Objective: Physical restraint is frequently used in medical services,such as in mental health settings,intensive care units and nursing homes,but its nature varies in different institutions.By reviewing related literature,this study aims to clarify the concept of physical restraint in mental health nursing.Method: Three databases (PubMed,PsyclNFO and CINAHL) were retrieved,and Walker and Avant's concept analysis method was used to analyze the concept of physical restraint in mental health nursing.Results: Physical restraint is a coercive approach that enables the administration of necessary treatment by safely reducing the patient's physical movement.It should be the last option used by qualified personnel.Antecedents of physical restraint are improper behavior (violence and disturbance) of patients,medical assessment prior to implementation and legislation governing clinical usage.Consequences of physical restraint are alleviation of conflict,physical injury,mental trauma and invisible impact on the institution.Discussion: This study defined the characteristics of physical restraint in mental health nursing.The proposed concept analysis provided theoretical foundation for future studies.展开更多
Based on core description,thin section identification,X-ray diffraction analysis,scanning electron microscopy,low-temperature gas adsorption and high-pressure mercury intrusion porosimetry,the shale lithofacies of Sha...Based on core description,thin section identification,X-ray diffraction analysis,scanning electron microscopy,low-temperature gas adsorption and high-pressure mercury intrusion porosimetry,the shale lithofacies of Shan23 sub-member of Permian Shanxi Formation in the east margin of Ordos Basin was systematically analyzed in this study.The Shan23 sub-member has six lithofacies,namely,low TOC clay shale(C-L),low TOC siliceous shale(S-L),medium TOC siliceous shale(S-M),medium TOC hybrid shale(M-M),high TOC siliceous shale(S-H),and high TOC clay shale(C-H).Among them,S-H is the best lithofacies,S-M and M-M are the second best.The C-L and C-H lithofacies,mainly found in the upper part of Shan23 sub-member,generally developed in tide-dominated delta facies;the S-L,S-M,S-H and M-M shales occurring in the lower part of Shan23 sub-member developed in tide-dominated estuarine bay facies.The S-H,S-M and M-M shales have good pore struc-ture and largely organic matter pores and mineral interparticle pores,including interlayer pore in clay minerals,pyrite inter-crystalline pore,and mineral dissolution pore.C-L and S-L shales have mainly mineral interparticle pores and clay mineral in-terlayer pores,and a small amount of organic matter pores,showing poorer pore structure.The C-H shale has organic mi-cro-pores and a small number of interlayer fissures of clay minerals,showing good micro-pore structure,and poor meso-pore and macro-pore structure.The formation of favorable lithofacies is jointly controlled by depositional environment and diagen-esis.Shallow bay-lagoon depositional environment is conducive to the formation of type II2 kerogen which can produce a large number of organic cellular pores.Besides,the rich biogenic silica is conducive to the preservation of primary pores and en-hances the fracability of the shale reservoir.展开更多
Objectives:This systematic review was conducted to explore whether nutritional supplement can improve the benefits of exercise intervention on sarcopenia in the elderly.Methods:Databases,including PubMed,Embase,Cochra...Objectives:This systematic review was conducted to explore whether nutritional supplement can improve the benefits of exercise intervention on sarcopenia in the elderly.Methods:Databases,including PubMed,Embase,Cochrane Library,Web of Science,CINAHL,CBM,CNKI,WANFANG,and VIP,were searched.All related papers with randomized controlled trials(RCT)meth-odology that were included in the databases from inception to 19 July 2016 were selected for the study.The tool"assessing risk of bias"from Cochrane Handbook 5.10 was used to evaluate the quality of included papers.A meta-analysis of eligible studies was performed using Stata12.0.Data that we were unable to convene or merge were subjected to descriptive analysis.Results:Six trials were included in our study,which included 429 elderly patients with sarcopenia.The overall methodological quality of the trials was moderate.Compared with the exercise group,patients who were given nutritional supplements gained a bigger boost in fat-free mass(standard mean differ-ence(SMD)=5.78,95%CI:5.17 to 6.40,P=0.000)and muscle mass(SMD=2.048,95%CI:0.907 to 3.189,P=0.000),as well as showed enhancement of keen extension strength(SMD=1.08,95%CI:0.71 to 1.45,P=0.000)and usual walk speed(SMD=0.570,95%CI:0.19 to 0.95,P=0.003).Conclusion:Nutritional supplementation may magnify the effect of exercise intervention on sarcopenia elderly in terms of muscle mass,muscle strength,and physical performance.Inconsistencies were pre-sent among research studies.More robust studies are needed to determine the most suitable type of nutrient and target population and to explore the actual role of combined intervention in managing sarcopenia in the elderly.展开更多
Objectives:This study aimed to understand the resilience experiences in patients with inflammatory bowel disease(IBD)and develop the resilience framework for them.Methods:Semistructured interviews were conducted with ...Objectives:This study aimed to understand the resilience experiences in patients with inflammatory bowel disease(IBD)and develop the resilience framework for them.Methods:Semistructured interviews were conducted with 15 patients with IBD who were purposefully recruited from the gastroenterology department of two hospitals in Jiangsu,China to gain diversity in the demographic and clinical characteristics.The data were analyzed using a directed content analysis approach based on the Kumpfer's resilience framework.Results:The resilience framework for patients with IBD was formed from the analysis.This framework was composed of four themes,as follows:(1)complicated factors in the environment,(2)change the environment into a protective one,(3)personality traits,and(4)resilience-related coping.Conclusions:The resilience framework for patients with IBD can effectively characterize the resilience experience of patients during the disease and assist healthcare professionals to understand how patients recover from the disease.More quantitative studies are needed to further explore the influencing factors of resilience and improve resilience in patient with inflammatory Bowel Disease.展开更多
Objectives:This study aimed to investigate the effect of motivational interviewing on the self-care behaviours in patients with chronic heart failure.Methods:Sixty-two hospitalized patients with chronic heart failure ...Objectives:This study aimed to investigate the effect of motivational interviewing on the self-care behaviours in patients with chronic heart failure.Methods:Sixty-two hospitalized patients with chronic heart failure were recruited in this study from April 2014 to April 2015 from a hospital.Twenty-nine patients were in the intervention group,and 33 patients were in the control group.Patients in the intervention group received four sessions of motivational interviewing,whereas those in the control group received traditional health education.At 2,4,and 8 weeks post-discharge,the intervention group underwent telephone follow-up based on motivational interviewing,whereas the control group underwent routine telephone follow-up.Primary outcome was measured using the Self-care of Heart Failure Index at baseline and at 2 months postdischarge.Results:Before intervention,the self-care behaviours scores were 79.00±48.80 in the intervention group and 88.68±29.26in the control group.No statistically significant differences were found between two groups in scores for each subscale and total scale(P>0.05).After intervention,the scores of self-care behaviours in the two groups were both improved at 155.13±35.65 for the intervention group and 115.44±22.82 for the control group with statistically significance(P<0.01).The score of self-care behaviours increased by 76.13 point in the intervention group on average,whereas 26.76 point in the control group.There was significant difference between increases in scores of self-care behaviours in two groups(P<0.01).Conclusions:The self-care behaviours of patients with chronic heart failure could be improved effectively through motivational interviewing.展开更多
Objective To explore the risk factors of low back pain among the Chinese occupational population in several major industries. Methods A total of 7200 subjects （3600 cases and 3600 controls） were randomly sampled fro...Objective To explore the risk factors of low back pain among the Chinese occupational population in several major industries. Methods A total of 7200 subjects （3600 cases and 3600 controls） were randomly sampled from a cross-sectional study, and they were investigated for individual and occupational factors of low back pain. The potential risk factors were first selected by using chi-square tests. Secondly, collinearity diagnosis proceeded by using the Kendall＇s rank correlation. Finally, binary logistic regression model was used for multi-factor analysis. Results Collinearity diagnosis showed that there was a severe collinearity problem among the potential risk factors of low back pain. Logistic regression model included 20 variables with statistical significance. Bending neck forward or holding neck in a forward posturefor long periods （0R=1.408） was the most important risk factor inducing low back pain in this study, followed by bending heavily with the trunk （0R=1.402）, carrying out identical work almost for the whole day （0R=1.340）. Additionally, suHicient normal break was a protective factor of low back pain. Conclusion Low back pain among the Chinese occupational population was associated with body height, occupation, work organization, physical work, working posture, and others. All these risk factors could be regarded as the indicators of low back pain, and some relevant preventive measures should be taken to reduce low back pain risk.展开更多
Fine-grained sedimentary rocks have become a research focus as important reservoirs and source rocks for tight and shale oil and gas.Laminae development determines the accumulation and production of tight and shale oi...Fine-grained sedimentary rocks have become a research focus as important reservoirs and source rocks for tight and shale oil and gas.Laminae development determines the accumulation and production of tight and shale oil and gas in fine-grained rocks.However,due to the resolution limit of conventional logs,it is challenging to recognize the features of centimeter-scale laminae.To close this gap,complementary studies,including core observation,thin section,X-ray diffraction(XRD),conventional log analysis,and slabs of image logs,were conducted to unravel the centimeter-scale laminae.The laminae recognition models were built using well logs.The fine-grained rocks can be divided into laminated rocks(lamina thickness of<0.01 m),layered rocks(0.01-0.1 m),and massive rocks(no layer or layer spacing of>0.1 m)according to the laminae scale from core observations.According to the mineral superposition assemblages from thin-section observations,the laminated rocks can be further divided into binary,ternary,and multiple structures.The typical mineral components,slabs,and T2spectrum distributions of various lamina types are unraveled.The core can identify the centimeter-millimeter-scale laminae,and the thin section can identify the millimeter-micrometer-scale laminae.Furthermore,they can detect mineral types and their superposition sequence.Conventional logs can identify the meter-scale layers,whereas image logs and related slabs can identify the laminae variations at millimeter-centimeter scales.Therefore,the slab of image logs combined with thin sections can identify laminae assemblage characteristics,including the thickness and vertical assemblage.The identification and classification of lamina structure of various scales on a single well can be predicted using conventional logs,image logs,and slabs combined with thin sections.The layered rocks have better reservoir quality and oil-bearing potential than the massive and laminated rocks.The laminated rocks’binary lamina is better than the ternary and multiple layers due to the high content of felsic minerals.The abovementioned results build the prediction model for multiscale laminae structure using well logs,helping sweet spots prediction in the Permian Lucaogou Formation in the Jimusar Sag and fine-grained sedimentary rocks worldwide.展开更多
AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to infl...AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H pylori.METHODS: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease assay.RESULTS: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically significant.CONCLUSION: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine polymorphisms and gene-environmental interactions on H pylori infection.展开更多
Serious soil erosion is one of the major issues threatening sustainable land use in semiarid areas, especially in the Loess Plateau of China. Understanding the effects of land use on soil and water loss is important f...Serious soil erosion is one of the major issues threatening sustainable land use in semiarid areas, especially in the Loess Plateau of China. Understanding the effects of land use on soil and water loss is important for sustainable land use strategy. Two sub-catchments： catchment A （CA） and catchment B （CB） with distinct land uses were selected to measure soil moisture, runoff and soil nutrient loss in Da Nangou catchment of the Loess Plateau of China. The effects of land use patterns on runoff and nutrient losses were analyzed based on soil moisture pattern by kriging and soil nutrients using multiple regression model. The results indicated that there were significant differences in runoff yield and soil nutrient losses between the two sub-catchments. With similar land uses, the CA produced an average sediment yield of 49 kg ha^-1 and 22.27 kg ha^-1 during two storm events. Meanwhile, there was almost no runoff in the CB with dissimilar land uses during the same events. Buffer zones should be established to re-absorb runoff and to trap sediments in catchment with similar land use structure such as the CA. Moreover, land use management strategy aiming to increase the infiltration threshold of hydrological response units could decrease the frequency of runoff occurrence on a slope and catchment scale.展开更多
As a new kind of air-hardening soil reinforcement material,polymer is being widely applied in river-bank slope reinforcement and ecological slope protection area.Thus,more attention should be paid to study the charact...As a new kind of air-hardening soil reinforcement material,polymer is being widely applied in river-bank slope reinforcement and ecological slope protection area.Thus,more attention should be paid to study the characteristics of reinforced soil after immersion.In this study,water-induced changes in strength characteristics of sand reinforced with polymer and fibers were reported.Several factors,including polymer content(1%,2%,3%and 4%by weight of dry sand),immersion time(6,12,24 and 48 h),dry density(1.40,1.45,1.50,1.55 and 1.60 g/cm^(3),)and fiber content(0.2%,0.4%,0.6%and 0.8%by weight of dry sand)which may influence the strength characteristics of reinforced sand after immersion were analyzed.The microstructure of reinforced sand was analyzed with nuclear magnetic resonance(NMR)and scanning electron microscope(SEM).Experimental results indicate that the compressive strength increases with the increase of polymer content and decreases with the increase of immersion time;the softening coefficients decrease with the increase of the polymer content and immersion time and increase with an increment in density and fiber content.Fiber plays an active role in reducing water-induced loss of strength at 0.6%content.展开更多
Alcohol liver disease(ALD)has become a global threat to human health.It is associated with a wide range of liver diseases including alcohol fatty liver,steatosis,fibrosis and cirrhosis,and finally leads to liver cance...Alcohol liver disease(ALD)has become a global threat to human health.It is associated with a wide range of liver diseases including alcohol fatty liver,steatosis,fibrosis and cirrhosis,and finally leads to liver cancer and even death.Centranthera grandiflora is a traditional Chinese medicinal herb commonly used to treat ALD,but no research about its mechanism is available.This study evaluated the hepatoprotective effect and mechanism of C.grandiflora against alcohol-induced liver injury in mice.We found that the ethanol extracts of C.grandiflora(CgW)alleviated the alcohol-induced liver injury,enhanced the levels of antioxidant enzymes,and reduced the amount of lipid peroxides.CgW also affected cell apoptosis by inhibiting the activity of Bax,cleaved-caspase 3 and cleaved-caspase 9,and increasing the activity of Bcl-2.In conclusion,the results showed that CgW can effectively improve ALD through alleviating oxidative stress and inhibiting cell apoptosis for the first time.This study suggested that C.grandiflora is a promising herbal medicine for ALD treatment.展开更多
Complex interactions within a microbial consortium can induce severe corrosion in oil pipelines.This study investigated the mechanism of microbiologically influenced corrosion(MIC)that led to failure of X52 steel pipe...Complex interactions within a microbial consortium can induce severe corrosion in oil pipelines.This study investigated the mechanism of microbiologically influenced corrosion(MIC)that led to failure of X52 steel pipelines after hydrostatic testing.Laboratory hydrostatic testing with untreated lake water and underground water were used to simulate and study the events that led to the actual corrosion.Biofilm analysis,weight loss,and several electrochemical measurements demonstrated rapid corrosion rates after hydrostatic testing.Analysis of microbial community structures revealed that methanogenic archaea and sulfate reducing bacteria(SRB),introduced by the hydrotest water,formed corrosive biofilms on X52 steel coupon surfaces that induced severe pitting.展开更多
基金supported by the Medical Science Research Project of Hebei(No.20241512).
文摘Objectives This study aimed to examine the associations between depression,resilience,and fatigue in patients with multivessel coronary disease and verify their causal relationships.Methods Between October 2023 and June 2024,316 patients with multivessel coronary disease were recruited from three tertiary hospitals in Tangshan,China.The Patient Health Questionnaire,Connor-Davidson Resilience Scale,and the Multidimensional Fatigue Inventory were administered to the patients on the third day of admission(T1),one month after discharge(T2),and three months after discharge(T3).Pearson correlation analysis was conducted to examine the relationships among depression,resilience,and fatigue in patients with multivessel coronary disease,and cross-lagged analysis to explore the temporal causal relationships.Results In patients with multivessel coronary disease,levels of depression and fatigue decreased from T1 to T3,while resilience scores increased during the same period.The correlation analysis revealed significant relationships among depression,resilience,and fatigue at T1,T2,and T3(P<0.01).The autoregressive paths indicated high stability over time for depression,medium stability for resilience,and low stability for fatigue.Cross-lagged paths demonstrated that depression at T1 significantly predicted fatigue at T2(β=0.461,P<0.001),and depression at T2 significantly predicted fatigue at T3(β=0.957,P<0.001).And resilience at T1 significantly predicted fatigue at T2(β=−0.271,P<0.001),and resilience at T2 significantly predicted fatigue at T3(β=−0.176,P<0.001).Additionally,resilience had a moderating effect on the relationship between depression and fatigue(β=−0.760,P<0.001).Conclusions Our study confirmed that depression and resilience predicted fatigue in patients with multivessel coronary disease.To prevent and mitigate fatigue,alleviating depressive symptoms and enhancing resilience levels in patients at an early stage is essential.
基金supported by the“333 High-Level Talents Training Project”of Jiangsu province(No.BRA2020069)。
文摘Objectives:The study aimed to explore social alienation types in patients with inflammatorybowel diseases(IBD)and identify influencingfactors.Methods:This cross-sectional study was conducted using purposive sampling among patients with IBD from July 2022 to July 2023.Patients were assessed using the Generalized Social Alienation Scale(GSAS),the Brief Illness Perception Questionnaire(B-IPQ),the Hospital Anxiety and Depression Scale(HADS),and the Medical Coping Modes Questionnaire(MCMQ).Demographic and disease-related characteristics were also collected.Latent profileanalysis(LPA)was used to identify potential subgroups of social alienation.Univariate analysis and multicollinearity analysis were conducted to explore the influencing factors,followed by multiple regression analysis to evaluate the effect of influencingfactors on social alienation.Results:Three distinct profilesof social alienation were identified:integrated-low alienation group(n=61,20.20%),accommodative-moderate alienation group(n=195,64.57%),and maladaptive-high alienation group(n=46,15.23%).Seven characteristics were associated with the profile’smembership:self-perceived financialstress,malnutrition risk,disease duration,illness comprehensibility,anxiety,depression,and acceptance-resignation coping mode.Conclusions:Patients with IBD were categorized into three subgroups based on social alienation levels.Financial stress,malnutrition risk,disease duration,illness comprehensibility,anxiety,depression,and acceptance-resignation coping mode were key predictors of the subgroup membership.Targeted interventions should be developed to mitigate the negative effects of social alienation,with a focus on improving illness perception,alleviating anxiety and depression,and promoting effective coping strategies.
基金supported by the National Natural Science Foundation of China(No.82372001,82171973,82171980)the Youth Talent Support Program(No.A002863)Scientific Research Foundation of Peking University Cancer Hospital(No.BJCH2024CZ02)。
文摘Objective:This study aimed to evaluate the clinical utility of[^(68)Ga]Ga-RM2 positron emission tomography/computed tomography(PET/CT),in comparison with^(18)F-fluorodeoxyglucose([^(18)F]FDG)PET/CT,for staging and prognosis in patients with estrogen receptor-positive(ER+)breast cancer.Methods:This prospective study enrolled nine female patients with breast cancer(mean age 45.5±11.5 years).Eight patients were confirmed to have ER+disease.All participant underwent both[^(68)Ga]Ga-RM2 PET/CT and[^(18)F]FDG PET/CT scans within a one-week interval.The maximum standardized uptake values(SUV_(max))was measured for primary tumors,lymph nodes,and metastatic lesions.The physiological distribution of[^(68)Ga]GaRM2 was also evaluated.Results:No adverse events were observed.Metastatic were identified in lymph nodes(n=29 lesions),bone(n=19),liver(n=7),brain(n=3),and multiple other sites.[^(68)Ga]Ga-RM2 demonstrated a significantly higher median SUV_(max)than[^(18)F]FDG across all lesions[7.5(interquartile range,IQR,3.4-14.0)vs.4.0(IQR,2.3-6.1);P<0.001].Similarly,the tumor-to-background ratio(TBR)was significantly superior with[^(68)Ga]Ga-RM2 for all type of lesions:primary tumors[12.3(IQR,10.4-18.3)vs.7.0(IQR,6.0-10.0);P<0.001],lymph node metastases[17.8(IQR,4.4-39.0)vs.4.7(IQR,2.7-10.2);P<0.001],hepatic metastases[5.4(IQR,3.7-8.3)vs.1.0(IQR,0.9-1.5);P<0.001],and osseous metastases[13.9(IQR,7.3-18.0)vs.4.3(IQR,1.6-5.9);P<0.001].Physiological uptake of[^(68)Ga]Ga-RM2 was the highest in the pancreas(SUV_(max),77.82±22.64),with moderate uptake in the kidneys(2.82±0.62),heart(1.83±0.29),and liver(1.33±0.41).Conclusions:[^(68)Ga]Ga-RM2 PET/CT demonstrates superior uptake metrics for the detection of metastatic lesions,particularly in the brain and breast,suggesting its potential as a valuable complementary imaging modality to[^(18)F]FDG PET/CT.These promising foundings warrant further validation in larger cohorts to confirm their clinical impact and to standardize imaging protocols.
基金supported by the Major Research Plan of NSFC project(No.92359203,China)Youth Beijing Scholar 2024(No.113,China)+1 种基金Youth Talent Support Program A002863(China)Science Foundation of Peking University Cancer Hospital BJCH2025BJ02.
文摘Artificial intelligence(AI)-driven data-centric paradigms are catalyzing a paradigm shift in radiopharmaceutical development and molecular imaging,two pivotal technologies that underpin precision nuclear medicine.This review focuses on the cutting-edge applications of AI in radiopharmaceutical discovery and molecular image analytics,and systematically investigates the technical principles and typical cases of Deep Learning algorithms(e.g.,Graph Neural Networks(GNNs),Generative Adversarial Networks(GANs),and Transformer Models)in target identification,ligand design,pharmacokinetic optimization,and image reconstruction and enhancement.By integrating multi-omics data and 3D structural information,AI can significantly improve the accuracy of target affinity prediction for radiopharmaceuticals and accelerate the design of novel ligands.In the field of molecular imaging,AI-driven low-dose single-photon emission computed tomography(SPECT)and positron emission tomography(PET)image reconstruction,tumor segmentation,and quantitative analysis techniques have significantly improved the diagnostic efficiency and accuracy,providing a reliable basis for individualized treatment.In addition,the paper discusses data privacy,model generalization,and ethical challenges faced by AI in clinical translation,and looks forward to the future direction of multidisciplinary integration(e.g.,combining AI with radiochemistry and nuclear medicine)and technological innovations,which will help precision medicine leap from theory to practice.
基金Supported by the National Natural Science Foundation of China （20866001） the Natural Science Foundation of GuangxiProvince （0832035）
文摘The kinetics of reductive leaching of manganese from low grade pyrolusite in dilute sulfuric acid in the presence of molasses alcohol wastewater was investigated. The shrinking core model was applied to quantify the effects of reaction parameters on leaching rate. The leaching rate increases with reaction temperature, concentrations of H 2 SO 4 and organic matter in molasses alcohol wastewater increase and ore particle size decreases. The leaching process follows the kinetics of a shrinking core model and the apparent activation energy is 57.5 kJ·mol –1 . The experimental results indicate a reaction order of 0.52 for H2SO4 concentration and 0.90 for chemical oxygen demand (COD) of molasses alcohol wastewater. It is concluded that the reductive leaching of pyrolusite with molasses alcohol wastewater is controlled by the diffusion through the ash/inert layer composed of the associated minerals.
文摘BACKGROUND: Currently, no documentation is available regarding Chinese children with acute liver failure(ALF). This study was undertaken to investigate etiologies and outcomes of Chinese children with ALF.METHODS: We retrospectively enrolled 32 pediatric patients with ALF admitted in five hospitals in different areas of China from January 2007 to December 2012. The coagulation indices, serum creatinine, serum lactate dehydrogenase,blood ammonia and prothrombin activity were analyzed; the relationship between these indices and mortality was evaluated by multivariate analysis.RESULTS: The most common causes of Chinese children with ALF were indeterminate etiology(15/32), drug toxicity(8/32),and acute cytomegalovirus hepatitis(6/32). Only 1 patient(3.13%)received liver transplantation and the spontaneous mortality of Chinese children with ALF was 58.06%(18/31). Patients who eventually died had higher baseline levels of international normalized ratio(P=0.01), serum creatinine(P=0.04), serum lactate dehydrogenase(P=0.01), blood ammonia(P<0.01) and lower prothrombin activity(P=0.01) than those who survived.Multivariate analysis showed that the entry blood ammonia was the only independent factor significantly associated with mortality(odds ratio=1.069, 95% confidence interval 1.023-1.117,P<0.01) and it had a sensitivity of 94.74%, a specificity of 84.62%and an accuracy of 90.63% for predicting the death. Based on the established model, with an increase of blood ammonia level,the risk of mortality would increase by 6.9%.CONCLUSIONS: The indeterminate causes predominated in the etiologies of ALF in Chinese children. The spontaneous mortality of pediatric patients with ALF was high, whereas the proportion of patients undergoing liver transplantation was significantly low. Entry blood ammonia was a reliable predictor for the death of pediatric patients with ALF.
文摘Transfer station(TS)is an integral part of present-day municipal solid waste(MSW)management systems.To provide information for the incorporation of waste facilities within the current integrated waste management system,the authors measured the existing environmental quality at five MSW TSs.Discharged wastewater,air,and noise were monitored and assayed at the five TSs in Beijing in 2001-2006 during rainy seasons(RSs)and dry seasons(DSs).Except Ammonia(NH_3)and hydrogen sulfide(H_2S),the analytical results of...
基金We acknowledge this paper was supported by the program of Key Specialty of TCM Nursing of Guangzhou City,which aims to enrich theoretical content of mental health nursing
文摘Objective: Physical restraint is frequently used in medical services,such as in mental health settings,intensive care units and nursing homes,but its nature varies in different institutions.By reviewing related literature,this study aims to clarify the concept of physical restraint in mental health nursing.Method: Three databases (PubMed,PsyclNFO and CINAHL) were retrieved,and Walker and Avant's concept analysis method was used to analyze the concept of physical restraint in mental health nursing.Results: Physical restraint is a coercive approach that enables the administration of necessary treatment by safely reducing the patient's physical movement.It should be the last option used by qualified personnel.Antecedents of physical restraint are improper behavior (violence and disturbance) of patients,medical assessment prior to implementation and legislation governing clinical usage.Consequences of physical restraint are alleviation of conflict,physical injury,mental trauma and invisible impact on the institution.Discussion: This study defined the characteristics of physical restraint in mental health nursing.The proposed concept analysis provided theoretical foundation for future studies.
基金China National Science and Technology Major Project(2017ZX05035).
文摘Based on core description,thin section identification,X-ray diffraction analysis,scanning electron microscopy,low-temperature gas adsorption and high-pressure mercury intrusion porosimetry,the shale lithofacies of Shan23 sub-member of Permian Shanxi Formation in the east margin of Ordos Basin was systematically analyzed in this study.The Shan23 sub-member has six lithofacies,namely,low TOC clay shale(C-L),low TOC siliceous shale(S-L),medium TOC siliceous shale(S-M),medium TOC hybrid shale(M-M),high TOC siliceous shale(S-H),and high TOC clay shale(C-H).Among them,S-H is the best lithofacies,S-M and M-M are the second best.The C-L and C-H lithofacies,mainly found in the upper part of Shan23 sub-member,generally developed in tide-dominated delta facies;the S-L,S-M,S-H and M-M shales occurring in the lower part of Shan23 sub-member developed in tide-dominated estuarine bay facies.The S-H,S-M and M-M shales have good pore struc-ture and largely organic matter pores and mineral interparticle pores,including interlayer pore in clay minerals,pyrite inter-crystalline pore,and mineral dissolution pore.C-L and S-L shales have mainly mineral interparticle pores and clay mineral in-terlayer pores,and a small amount of organic matter pores,showing poorer pore structure.The C-H shale has organic mi-cro-pores and a small number of interlayer fissures of clay minerals,showing good micro-pore structure,and poor meso-pore and macro-pore structure.The formation of favorable lithofacies is jointly controlled by depositional environment and diagen-esis.Shallow bay-lagoon depositional environment is conducive to the formation of type II2 kerogen which can produce a large number of organic cellular pores.Besides,the rich biogenic silica is conducive to the preservation of primary pores and en-hances the fracability of the shale reservoir.
文摘Objectives:This systematic review was conducted to explore whether nutritional supplement can improve the benefits of exercise intervention on sarcopenia in the elderly.Methods:Databases,including PubMed,Embase,Cochrane Library,Web of Science,CINAHL,CBM,CNKI,WANFANG,and VIP,were searched.All related papers with randomized controlled trials(RCT)meth-odology that were included in the databases from inception to 19 July 2016 were selected for the study.The tool"assessing risk of bias"from Cochrane Handbook 5.10 was used to evaluate the quality of included papers.A meta-analysis of eligible studies was performed using Stata12.0.Data that we were unable to convene or merge were subjected to descriptive analysis.Results:Six trials were included in our study,which included 429 elderly patients with sarcopenia.The overall methodological quality of the trials was moderate.Compared with the exercise group,patients who were given nutritional supplements gained a bigger boost in fat-free mass(standard mean differ-ence(SMD)=5.78,95%CI:5.17 to 6.40,P=0.000)and muscle mass(SMD=2.048,95%CI:0.907 to 3.189,P=0.000),as well as showed enhancement of keen extension strength(SMD=1.08,95%CI:0.71 to 1.45,P=0.000)and usual walk speed(SMD=0.570,95%CI:0.19 to 0.95,P=0.003).Conclusion:Nutritional supplementation may magnify the effect of exercise intervention on sarcopenia elderly in terms of muscle mass,muscle strength,and physical performance.Inconsistencies were pre-sent among research studies.More robust studies are needed to determine the most suitable type of nutrient and target population and to explore the actual role of combined intervention in managing sarcopenia in the elderly.
基金This work was supported by the Special Project of Philosophy and Social Science Development of Nanjing Medical University (grant no.2017ZSZ007)
文摘Objectives:This study aimed to understand the resilience experiences in patients with inflammatory bowel disease(IBD)and develop the resilience framework for them.Methods:Semistructured interviews were conducted with 15 patients with IBD who were purposefully recruited from the gastroenterology department of two hospitals in Jiangsu,China to gain diversity in the demographic and clinical characteristics.The data were analyzed using a directed content analysis approach based on the Kumpfer's resilience framework.Results:The resilience framework for patients with IBD was formed from the analysis.This framework was composed of four themes,as follows:(1)complicated factors in the environment,(2)change the environment into a protective one,(3)personality traits,and(4)resilience-related coping.Conclusions:The resilience framework for patients with IBD can effectively characterize the resilience experience of patients during the disease and assist healthcare professionals to understand how patients recover from the disease.More quantitative studies are needed to further explore the influencing factors of resilience and improve resilience in patient with inflammatory Bowel Disease.
文摘Objectives:This study aimed to investigate the effect of motivational interviewing on the self-care behaviours in patients with chronic heart failure.Methods:Sixty-two hospitalized patients with chronic heart failure were recruited in this study from April 2014 to April 2015 from a hospital.Twenty-nine patients were in the intervention group,and 33 patients were in the control group.Patients in the intervention group received four sessions of motivational interviewing,whereas those in the control group received traditional health education.At 2,4,and 8 weeks post-discharge,the intervention group underwent telephone follow-up based on motivational interviewing,whereas the control group underwent routine telephone follow-up.Primary outcome was measured using the Self-care of Heart Failure Index at baseline and at 2 months postdischarge.Results:Before intervention,the self-care behaviours scores were 79.00±48.80 in the intervention group and 88.68±29.26in the control group.No statistically significant differences were found between two groups in scores for each subscale and total scale(P>0.05).After intervention,the scores of self-care behaviours in the two groups were both improved at 155.13±35.65 for the intervention group and 115.44±22.82 for the control group with statistically significance(P<0.01).The score of self-care behaviours increased by 76.13 point in the intervention group on average,whereas 26.76 point in the control group.There was significant difference between increases in scores of self-care behaviours in two groups(P<0.01).Conclusions:The self-care behaviours of patients with chronic heart failure could be improved effectively through motivational interviewing.
基金supported by the Research Fund from National Science and Technology Infrastructure Program of the People's Republic of China, 2006BA106B08
文摘Objective To explore the risk factors of low back pain among the Chinese occupational population in several major industries. Methods A total of 7200 subjects （3600 cases and 3600 controls） were randomly sampled from a cross-sectional study, and they were investigated for individual and occupational factors of low back pain. The potential risk factors were first selected by using chi-square tests. Secondly, collinearity diagnosis proceeded by using the Kendall＇s rank correlation. Finally, binary logistic regression model was used for multi-factor analysis. Results Collinearity diagnosis showed that there was a severe collinearity problem among the potential risk factors of low back pain. Logistic regression model included 20 variables with statistical significance. Bending neck forward or holding neck in a forward posturefor long periods （0R=1.408） was the most important risk factor inducing low back pain in this study, followed by bending heavily with the trunk （0R=1.402）, carrying out identical work almost for the whole day （0R=1.340）. Additionally, suHicient normal break was a protective factor of low back pain. Conclusion Low back pain among the Chinese occupational population was associated with body height, occupation, work organization, physical work, working posture, and others. All these risk factors could be regarded as the indicators of low back pain, and some relevant preventive measures should be taken to reduce low back pain risk.
基金National Natural Science Foundation of China(Grant No.42002133,42072150)Science Foundation of China University of Petroleum,Beijing(No.2462021YXZZ003)the Strategic Cooperation Technology Projects of CNPC and CUPB(ZLZX2020-01-06)for the financial supports and permissions to publish this paper
文摘Fine-grained sedimentary rocks have become a research focus as important reservoirs and source rocks for tight and shale oil and gas.Laminae development determines the accumulation and production of tight and shale oil and gas in fine-grained rocks.However,due to the resolution limit of conventional logs,it is challenging to recognize the features of centimeter-scale laminae.To close this gap,complementary studies,including core observation,thin section,X-ray diffraction(XRD),conventional log analysis,and slabs of image logs,were conducted to unravel the centimeter-scale laminae.The laminae recognition models were built using well logs.The fine-grained rocks can be divided into laminated rocks(lamina thickness of<0.01 m),layered rocks(0.01-0.1 m),and massive rocks(no layer or layer spacing of>0.1 m)according to the laminae scale from core observations.According to the mineral superposition assemblages from thin-section observations,the laminated rocks can be further divided into binary,ternary,and multiple structures.The typical mineral components,slabs,and T2spectrum distributions of various lamina types are unraveled.The core can identify the centimeter-millimeter-scale laminae,and the thin section can identify the millimeter-micrometer-scale laminae.Furthermore,they can detect mineral types and their superposition sequence.Conventional logs can identify the meter-scale layers,whereas image logs and related slabs can identify the laminae variations at millimeter-centimeter scales.Therefore,the slab of image logs combined with thin sections can identify laminae assemblage characteristics,including the thickness and vertical assemblage.The identification and classification of lamina structure of various scales on a single well can be predicted using conventional logs,image logs,and slabs combined with thin sections.The layered rocks have better reservoir quality and oil-bearing potential than the massive and laminated rocks.The laminated rocks’binary lamina is better than the ternary and multiple layers due to the high content of felsic minerals.The abovementioned results build the prediction model for multiscale laminae structure using well logs,helping sweet spots prediction in the Permian Lucaogou Formation in the Jimusar Sag and fine-grained sedimentary rocks worldwide.
基金a Grant-in-Aid for Young Scientists from the Ministry of Education,Culture,Sports,Science and Technology of Japana Grant-in-Aid for Scientific Research from the Ministry of Health,Labour and Welfare of Japan
文摘AIM: To investigate whether the pro- and anti-inflammatory cytokine gene polymorphisms, IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G, interact with smoking and drinking habits to influence infection with H pylori.METHODS: The subjects were 410 Japanese transit company employees. C-reactive protein and conventional cardiovascular risk factors were evaluated. Serum anti-H pylori antibodies were measured. The genotypes of IL1B-511C/T, IL1B-31C/T, IL6-634C/G, TNF-1031T/C, TNF-857C/T, and IL10-1082A/G polymorphisms were determined by allelic discrimination using fluorogenic probes and a 5′nuclease assay.RESULTS: In gender- and age-adjusted logistic analyses, the subjects with TNF-857T/T had a significantly lower odds ratio (OR) for H pylori seropositivity (reference -857C/C; OR = 0.15, 95% CI: 0.03-0.59, P = 0.007). After stratification according to smoking and drinking status, among never-smokers, the subjects with IL1B-511C/T had a significantly lower OR (reference -511C/C; OR = 0.30, 95% CI: 0.10-0.90, P = 0.032). Among drinkers in the 1-5 times/wk category, the subjects with IL1B-511T/T had a significantly lower OR (reference C/C; OR = 0.38, 95% CI: 0.16-0.95, P = 0.039), and the subjects with IL1B-31C/T and T/T had a significantly higher OR (reference C/C; C/T: OR = 2.59, 95% CI, P = 0.042: 1.04-6.47; C/C: OR = 3.17, 95% CI: 1.23-8.14, P = 0.017). Among current smokers, the subjects withIL6-634C/G had a significantly higher OR (reference C/C; OR = 2.28, 95% CI: 1.13-4.58, P = 0.021). However, the interactions terms between the aforementioned genotypes and lifestyles were not statistically significant.CONCLUSION: Contrary to previous findings, the results herein suggest that the TNF-857T/T genotype may be protective against chronic infection with H pylori. Drinking and smoking habits may influence the effect of cytokine gene polymorphisms. Further studies are required to clarify the effects of the pro- and anti-inflammatory cytokine polymorphisms and gene-environmental interactions on H pylori infection.
基金National Natural Science Foundation of China, No.40401001 No.40201003 Programme of Excellent YoungScientistsoftheM inistry ofLand and Resources
文摘Serious soil erosion is one of the major issues threatening sustainable land use in semiarid areas, especially in the Loess Plateau of China. Understanding the effects of land use on soil and water loss is important for sustainable land use strategy. Two sub-catchments： catchment A （CA） and catchment B （CB） with distinct land uses were selected to measure soil moisture, runoff and soil nutrient loss in Da Nangou catchment of the Loess Plateau of China. The effects of land use patterns on runoff and nutrient losses were analyzed based on soil moisture pattern by kriging and soil nutrients using multiple regression model. The results indicated that there were significant differences in runoff yield and soil nutrient losses between the two sub-catchments. With similar land uses, the CA produced an average sediment yield of 49 kg ha^-1 and 22.27 kg ha^-1 during two storm events. Meanwhile, there was almost no runoff in the CB with dissimilar land uses during the same events. Buffer zones should be established to re-absorb runoff and to trap sediments in catchment with similar land use structure such as the CA. Moreover, land use management strategy aiming to increase the infiltration threshold of hydrological response units could decrease the frequency of runoff occurrence on a slope and catchment scale.
基金Project(41472241)supported by the National Natural Science Foundation of ChinaProject(KJXM2019028)supported by the Natural Resources Science and Technology Project of Jiangsu Province,ChinaProject(2019B17314)supported by the Fundamental Research Funds for the Central Universities,China。
文摘As a new kind of air-hardening soil reinforcement material,polymer is being widely applied in river-bank slope reinforcement and ecological slope protection area.Thus,more attention should be paid to study the characteristics of reinforced soil after immersion.In this study,water-induced changes in strength characteristics of sand reinforced with polymer and fibers were reported.Several factors,including polymer content(1%,2%,3%and 4%by weight of dry sand),immersion time(6,12,24 and 48 h),dry density(1.40,1.45,1.50,1.55 and 1.60 g/cm^(3),)and fiber content(0.2%,0.4%,0.6%and 0.8%by weight of dry sand)which may influence the strength characteristics of reinforced sand after immersion were analyzed.The microstructure of reinforced sand was analyzed with nuclear magnetic resonance(NMR)and scanning electron microscope(SEM).Experimental results indicate that the compressive strength increases with the increase of polymer content and decreases with the increase of immersion time;the softening coefficients decrease with the increase of the polymer content and immersion time and increase with an increment in density and fiber content.Fiber plays an active role in reducing water-induced loss of strength at 0.6%content.
基金supported by the National Science and Technology Major Projects of New Drugs(Nos.2019ZX09301124,2019ZX09201001 and 2019ZX09301-110)the Project Program of the State Key Laboratory of Natural Medicines(No.SKLNMZZCX201821)+3 种基金the Natural Science Foundation of Jiangsu Province,China(No.BK20180569)the Open Project of State Key Laboratory of Natural Medicines(No.SKLNMKF202008)the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)and the“Double First-Class”University Project(Nos.CPU2018GY13 and CPU2018PZH03)。
文摘Alcohol liver disease(ALD)has become a global threat to human health.It is associated with a wide range of liver diseases including alcohol fatty liver,steatosis,fibrosis and cirrhosis,and finally leads to liver cancer and even death.Centranthera grandiflora is a traditional Chinese medicinal herb commonly used to treat ALD,but no research about its mechanism is available.This study evaluated the hepatoprotective effect and mechanism of C.grandiflora against alcohol-induced liver injury in mice.We found that the ethanol extracts of C.grandiflora(CgW)alleviated the alcohol-induced liver injury,enhanced the levels of antioxidant enzymes,and reduced the amount of lipid peroxides.CgW also affected cell apoptosis by inhibiting the activity of Bax,cleaved-caspase 3 and cleaved-caspase 9,and increasing the activity of Bcl-2.In conclusion,the results showed that CgW can effectively improve ALD through alleviating oxidative stress and inhibiting cell apoptosis for the first time.This study suggested that C.grandiflora is a promising herbal medicine for ALD treatment.
基金financially supported by the National Natural Science Foundation of China(No.51871050)the Natural Science Foundation of Liaoning Province(No.20180510041)+1 种基金the Liaoning Revitalization Talents Program(No.XLYC1907158)the Fundamental Research Funds for the Central Universities of the Ministry of Education of China(N180205021 and N180203019)。
文摘Complex interactions within a microbial consortium can induce severe corrosion in oil pipelines.This study investigated the mechanism of microbiologically influenced corrosion(MIC)that led to failure of X52 steel pipelines after hydrostatic testing.Laboratory hydrostatic testing with untreated lake water and underground water were used to simulate and study the events that led to the actual corrosion.Biofilm analysis,weight loss,and several electrochemical measurements demonstrated rapid corrosion rates after hydrostatic testing.Analysis of microbial community structures revealed that methanogenic archaea and sulfate reducing bacteria(SRB),introduced by the hydrotest water,formed corrosive biofilms on X52 steel coupon surfaces that induced severe pitting.
