Dear Editor,The COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has led to millions of lives lost worldwide. The trimeric spike protein(S) decorating the membrane sur...Dear Editor,The COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has led to millions of lives lost worldwide. The trimeric spike protein(S) decorating the membrane surface of the infectious virion is responsible for the attachment and entry by binding to the receptor angiotensin-converting enzyme 2(ACE2) in the early replication cycle(Zhou P. et al., 2020). Two subunits S1 and S2 are included in the trimeric glycoprotein.展开更多
Dear Editor,The ongoing coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has lasted for more than four years,resulting in an unprecedented global public h...Dear Editor,The ongoing coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has lasted for more than four years,resulting in an unprecedented global public health crisis.Progress in halting this pandemic seems slow due to the emergence of variants of concern,such as the B.1.1.7(Alpha),B.1.351(Beta),P.1(Gamma,also known as B.1.1.28.1),B.1.617.2(Delta),and B.1.1.529(Omicron),that appear to be high transmissible and more resistant to neutralizing antibodies(Wang et al.,2021g).New variants are thought to be responsible for re-infections(Hacisuleyman et al.,2021).A general decrease in immune protection against SARS-CoV-2 variants within 6–12 months after the primary infection or vaccination is also observed(Widge et al.,2021).However,not much is known about the immunogenic features of such a booster dose of a COVID-19 vaccine.展开更多
基金supported by funding from Beijing Natural Science Foundation-Haidian Primitive Innovation Joint fund(L192008)the National Key R&D Program(2020YFA0707500,2018YFA0900801,2021YFA1301400)the National Natural Science Foundation of China(31872730 and 32070947)
文摘Dear Editor,The COVID-19 pandemic, which is caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2), has led to millions of lives lost worldwide. The trimeric spike protein(S) decorating the membrane surface of the infectious virion is responsible for the attachment and entry by binding to the receptor angiotensin-converting enzyme 2(ACE2) in the early replication cycle(Zhou P. et al., 2020). Two subunits S1 and S2 are included in the trimeric glycoprotein.
基金supported by the Ministry of Science and Technology of China (CPL-1233 and SPRG22-003)CAS (YSBR-010)+2 种基金the National Science Foundation Grants (12034006,32325004 and T2394482)supported by National Science Fund for Distinguished Young Scholar (No. 32325004)the NSFS Innovative Research Group (No. 81921005)
文摘Dear Editor,The ongoing coronavirus disease 2019(COVID-19)pandemic caused by severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)has lasted for more than four years,resulting in an unprecedented global public health crisis.Progress in halting this pandemic seems slow due to the emergence of variants of concern,such as the B.1.1.7(Alpha),B.1.351(Beta),P.1(Gamma,also known as B.1.1.28.1),B.1.617.2(Delta),and B.1.1.529(Omicron),that appear to be high transmissible and more resistant to neutralizing antibodies(Wang et al.,2021g).New variants are thought to be responsible for re-infections(Hacisuleyman et al.,2021).A general decrease in immune protection against SARS-CoV-2 variants within 6–12 months after the primary infection or vaccination is also observed(Widge et al.,2021).However,not much is known about the immunogenic features of such a booster dose of a COVID-19 vaccine.
