ABSTRACT Melt electrowriting(MEW)enables the precise deposition of polymeric fibers at micro-/nanoscale,allowing for the fabrication of 3D biomimetic scaffolds.By incorporating stimuli-responsive polymers and/or funct...ABSTRACT Melt electrowriting(MEW)enables the precise deposition of polymeric fibers at micro-/nanoscale,allowing for the fabrication of 3D biomimetic scaffolds.By incorporating stimuli-responsive polymers and/or functional fillers,MEW-based 4D printing creates scaffolds capable of undergoing controlled,reversible shape transformations in response to external stimuli over time.These dynamic 4D scaffolds can be tailored for minimally invasive delivery,remote actuation,and real-time responsiveness to physiological environments,making them highly relevant for biomedical applications.This review systematically elucidates the principles of MEW-based 4D printing,including material considerations,actuation methods,and structure design strategies,along with shape programming and morphing mechanisms.The versatility of MEW for rational fabrication of biomimetic scaffolds is firstly introduced.Subsequently,the critical elements underpinning MEW-based 4D printing process are overviewed,including an analysis of stimuli-responsive materials compatible with MEW,an evaluation of applicable external stimuli,and a discussion on the advancements in design strategies for 4D scaffolds.Recent progress of MEW 4D scaffolds for applications in tissue engineering,biomedical implants,and drug delivery systems are highlighted.Finally,key challenges and perspectives toward material innovation,fabrication optimization,and actuation control are discussed.This review aims to provide valuable insights for design and creation of multifunctional biomimetic dynamic scaffolds by MEW-based 4D printing.展开更多
On July 2^(nd),2025,32 scientists representing 15 countries gathered at Tartu,Estonia to make on-site endorsements for the Global ONCE(Ocean Negative Carbon Emissions)Program at the 12th INTECOL Wetlands Conference.Th...On July 2^(nd),2025,32 scientists representing 15 countries gathered at Tartu,Estonia to make on-site endorsements for the Global ONCE(Ocean Negative Carbon Emissions)Program at the 12th INTECOL Wetlands Conference.This marks a significant milestone for ONCE in establishing a systematic framework for coastal wetland carbon sequestration research and global collaboration(Figs.1,2).Coastal wetlands are critical transition zones linking terrestrial and marine ecosystems,yet they face severe degradation from anthropogenic land-based activities and sea level rise that propagate impacts to the ocean.As a UN Ocean Decade Program,the Global ONCE Program champions interdisciplinary and cross-regional collaboration to enhance carbon sequestration in the ocean and coastal wetlands through science and innovation.Aligned with the Tartu Declaration on Wetlands that includes resolutions to promote the rights of global wetlands(especially peatlands)and advance the discipline of wetland science based on facts,this initiative addresses key knowledge gaps in land-ocean interactions.The goal is to harness the full potential of coastal wetlands and ocean systems for climate mitigation,thereby laying a scientific foundation for international policy formulation and implementation.展开更多
Nitrogenous compounds(i.e.,amines,amides,nitriles,oximes,amino acids and nitrogen-heterocycles derivatives)are important building blocks for synthetic chemistry,pharmaceuticals,and functional materials.Conventional sy...Nitrogenous compounds(i.e.,amines,amides,nitriles,oximes,amino acids and nitrogen-heterocycles derivatives)are important building blocks for synthetic chemistry,pharmaceuticals,and functional materials.Conventional synthetic strategies involve the use of toxic organic nitrogenous precursors or expensive heterogeneous catalysts under elevated temperatures and pressurized oxygen.Heterogeneous electrocatalysis can initiate the activation of inorganic N sources(i.e.,NH_(3)and NO^(-)_(x))under ambient reactions in liquid phase by applying a small bias,thus allowing the synthesis of value?added nitrogenous compounds from carbonyls,alkenes,keto acids,and even carbon dioxide in a sustainable manner without the use of oxidants/reductants.This review outlines recent de-velopments in electrosynthesis of nitrogenous compounds using inorganic N sources,focusing on reaction mechanisms understanding,the design and optimization of efficient electrocatalysts,and the advances in cell configurations for various C‒N coupling reactions.The limitations and challenges in applications are also discussed.展开更多
In the quest for effective solutions to address Environ.Pollut.and meet the escalating energy demands,heterojunction photocatalysts have emerged as a captivating and versatile technology.These photocatalysts have garn...In the quest for effective solutions to address Environ.Pollut.and meet the escalating energy demands,heterojunction photocatalysts have emerged as a captivating and versatile technology.These photocatalysts have garnered significant interest due to their wideranging applications,including wastewater treatment,air purification,CO_(2) capture,and hydrogen generation via water splitting.This technique harnesses the power of semiconductors,which are activated under light illumination,providing the necessary energy for catalytic reactions.With visible light constituting a substantial portion(46%)of the solar spectrum,the development of visible-light-driven semiconductors has become imperative.Heterojunction photocatalysts offer a promising strategy to overcome the limitations associated with activating semiconductors under visible light.In this comprehensive review,we present the recent advancements in the field of photocatalytic degradation of contaminants across diverse media,as well as the remarkable progress made in renewable energy production.Moreover,we delve into the crucial role played by various operating parameters in influencing the photocatalytic performance of heterojunction systems.Finally,we address emerging challenges and propose novel perspectives to provide valuable insights for future advancements in this dynamic research domain.By unraveling the potential of heterojunction photocatalysts,this reviewcontributes to the broader understanding of their applications and paves the way for exciting avenues of exploration and innovation.展开更多
Background Post-weaning diarrhea(PWD)in piglets,often caused by F4^(+)enterotoxigenic Escherichia coli(ETEC),poses significant challenges in pig production.Traditional solutions like antibiotics and zinc oxide face in...Background Post-weaning diarrhea(PWD)in piglets,often caused by F4^(+)enterotoxigenic Escherichia coli(ETEC),poses significant challenges in pig production.Traditional solutions like antibiotics and zinc oxide face increasing restrictions due to growing concerns over antibiotic resistance and environmental sustainability.This study investigates the application of bivalent heavy chain variable domain(V_(H)H)constructs(BL1.2 and BL2.2)targeting ETEC virulence factors,administered in feed to mitigate ETEC-induced PWD in weaned piglets.Results The supplementation of BL1.2 and BL2.2 in both mash and pelleted feed significantly reduced the diarrhea incidence and fecal shedding of F4^(+)ETEC in challenged piglets.Pelleted feed containing V_(H)H constructs helped to preserve gut barrier integrity by maintaining levels of the tight junction protein occludin in the small intestine.Additionally,the constructs maintained blood granulocyte counts at a similar level to the non-challenged control group,including neutrophils,and ameliorated the acute phase protein response after challenge.Notably,even at low feed intake immediately after weaning,V_(H)H constructs helped maintain piglet health by mitigating ETEC-induced inflammation and the resulting diarrhea.Conclusions Our findings demonstrated that using V_(H)H constructs as feed additives could serve as an effective strategy to help manage ETEC-associated PWD,by reducing F4^(+)ETEC gut colonization and supporting gut barrier function of weaned piglets.The high stability of these V_(H)H constructs supports their incorporation into industrial feed manufacturing processes,offering a more sustainable preventive strategy compared to traditional antimicrobial interventions,which could contribute to sustainable farming practices.展开更多
The single-layer Ti_(3)C_(2)T_(x)/MXene has become a special electromagnetic wave absorber near the terahertz band because of its abundant surface groups and excellent conductivity.However,the macro-preparation of sin...The single-layer Ti_(3)C_(2)T_(x)/MXene has become a special electromagnetic wave absorber near the terahertz band because of its abundant surface groups and excellent conductivity.However,the macro-preparation of single-layer Ti_(3)C_(2)T_(x)/MXene shows significantly difficult to influence its application.The two-dimensional Ti_(3)C_(2)T_(x)is easily prepared to have high production,but its weak absorption ability due to high surface conductivity also restricts its application.To realize the strong electromagnetic wave absorption of two-dimensional Ti_(3)C_(2)T_(x)/MXene,a new strategy with magnetic FeNi nanoparticles decorating Ti_(3)C_(2)T_(x)/MXene composites(FeNi-Ti_(3)C_(2)T_(x))were proposed and the effective electromagnetic wave absorption features covering 170-220 GHz that means the absorption band width reach 50 GHz.With an absorber composite film thickness being only 0.6 mm,the absorptivity of the composite is enhanced with the increase of decorating FeNi nanoparticles and promote up to 75%when the FeNi nanoparticles loading content reaches 30 wt%.The improvement of absorption is attributed to the introduction of soft magnetic FeNi to adjust the high surface conductivity of MXene and improve the electromagnetic balance of the absorber.展开更多
The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young adulthood.Impaire...The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young adulthood.Impaired neurodevelopment can result in various neurological and psychiatric conditions,jointly named neurodevelopmental disorders(NDDs).展开更多
Dibromoethane is a widespread,persistent organic pollutant.Biochars are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous brom...Dibromoethane is a widespread,persistent organic pollutant.Biochars are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous bromide and ethylene.However,the critical characteristics that determine mediator functionality are lesser known.Fifteen biochar substrates were pyrolyzed at 600℃and 800℃,characterized by elemental analysis,X-ray photo spectrometry C and N surface speciation,X-ray powder diffraction,specific surface area analysis,and tested for mediation of reductive debromination of 1,2-dibromoethane by a green rust reductant under anoxic conditions.A statistical analysis was performed to determine the biochar properties,critical for debromination kinetics and total debromination extent.It was shown that selected plant based biochars can mediate debromination of 1,2-dibromoethane,that the highest first order rate constant was 0.082/hr,and the highest debromination extent was 27%in reactivity experiments with 0.1μmol(20μmol/L)1,2-dibromoethane,≈22 mmol/L Fe^(Ⅱ)GR,and 0.12 g/L soybean meal biochar(7 days).Contents of Ni,Zn,N,and P,and the relative contribution of quinone surface functional groups were significantly(p<0.05)positively correlated with 1,2-dibromoethane debromination,while adsorption,specific surface area,and the relative contribution of pyridinic N oxide surface groups were significantly negatively correlated with debromination.展开更多
Emerging new races of wheat stem rust(Puccinia graminis f.sp.tritici)are threatening global wheat(Triticum aestivum L.)production.Host resistance is the most effective and environmentally friendly method of controllin...Emerging new races of wheat stem rust(Puccinia graminis f.sp.tritici)are threatening global wheat(Triticum aestivum L.)production.Host resistance is the most effective and environmentally friendly method of controlling stem rust.The stem rust resistance gene Sr59 was previously identified within a T2DS 2RL wheat-rye whole arm translocation,providing broad-spectrum resistance to various stem rust races.Seedling evaluation,molecular marker analysis,and cytogenetic studies identified wheat-rye introgression line#284 containing a new translocation chromosome T2BL 2BS-2RL.This line has demonstrated broad-spectrum resistance to stem rust at the seedling stage.Seedling evaluation and cytogenetic analysis of three backcross populations between the line#284 and the adapted cultivars SLU-Elite,Navruz,and Linkert confirmed that Sr59 is located within the short distal 2RL translocation.This study aimed physical mapping of Sr59 in the 2RL introgression segment and develop a robust molecular marker for marker-assisted selection.Using genotyping-by-sequencing(GBS),GBS-derived SNPs were aligned with full-length annotated rye nucleotide-binding leucine-rich repeat(NLR)genes in the parental lines CS ph1b,SLU238,SLU-Elite,Navruz,and Linkert,as well as in 33 BC4F5progeny.Four NLR genes were identified on the 2R chromosome,with Chr2R_NLR_60 being tightly linked to the Sr59resistance gene.In-silico functional enrichment analysis of the translocated 2RL region(25,681,915 bp)identified 223 genes,with seven candidate genes associated with plant disease resistance and three linked to agronomic performance,contributing to oxidative stress response,protein kinase activity,and cellular homeostasis.These findings facilitate a better understanding of the genetic basis of stem rust resistance provided by Sr59.展开更多
Background Depression is a common comorbidity in Parkinson's disease(PD)and Lewy body dementia(LBD).However,studies examining the rate of incident depression in the period preceding and following the diagnosis of ...Background Depression is a common comorbidity in Parkinson's disease(PD)and Lewy body dementia(LBD).However,studies examining the rate of incident depression in the period preceding and following the diagnosis of PD and LBD are lacki ng in the literature.Aims To quantify the incidence of depression in the period preceding and following the diagnosis of PD and LBD.Methods We conducted a retrospective case-control study.Specifically,we used Danish registers to identify all patients with a diagnosis of PD or LBD in the period from 2007 to 2019.These patients were matched by age,calendar year of diagnosis and sex with up to three patients diagnosed with rheumatoid arthritis(RA),chronic kidney disease(CKD)or osteoporosis,respectively.The outcome was incident depression.The incidence of depression was assessed for up to 10 years before and up to 10 years after the diagnosis of PD or LBD.Hazard rates of incident depression for patients with PD or LBD,both before and after diagnosis,were compared with those for patients with RA,CKD or osteoporosis using a Coxproportional hazards model.Results We identified 17711 patients with PD or LBD.Their median age was 74.98(68.10-80.85)years,and39.92%were females.These patients were matched to 19556,40842 and 47809 patients with RA,CKD and osteoporosis,respectively.From 7 to 8 years before diagnosis to 5 years after diagnosis,patients with PD and LBD consistently had higher hazard rates of incident depression than all comparator groups.Conclusions These findings are compatible with depression being an early manifestation of the neurodegenerative changes eventually leading to PD and LBD and imply that incident depression at a late age should raise awareness of potential PD and LBD.展开更多
Accurate Global Horizontal Irradiance(GHI)forecasting has become vital for successfully integrating solar energy into the electrical grid because of the expanding demand for green power and the worldwide shift favouri...Accurate Global Horizontal Irradiance(GHI)forecasting has become vital for successfully integrating solar energy into the electrical grid because of the expanding demand for green power and the worldwide shift favouring green energy resources.Particularly considering the implications of the aggressive GHG emission targets,accurate GHI forecasting has become vital for developing,designing,and operational managing solar energy systems.This research presented the core concepts of modelling and performance analysis of the application of various forecasting models such as ARIMA(Autoregressive Integrated Moving Average),Elaman NN(Elman Neural Network),RBFN(Radial Basis Function Neural Network),SVM(Support Vector Machine),LSTM(Long Short-Term Memory),Persistent,BPN(Back Propagation Neural Network),MLP(Multilayer Perceptron Neural Network),RF(Random Forest),and XGBoost(eXtreme Gradient Boosting)for assessing multi-seasonal forecasting of GHI.Used the India region data to evaluate the models’performance and forecasting ability.Research using forecasting models for seasonal Global Horizontal Irradiance(GHI)forecasting in winter,spring,summer,monsoon,and autumn.Substantiated performance effectiveness through evaluation metrics,such as Mean Absolute Error(MAE),Root Mean Squared Error(RMSE),and R-squared(R^(2)),coded using Python programming.The performance experimentation analysis inferred that the most accurate forecasts in all the seasons compared to the other forecasting models the Random Forest and eXtreme Gradient Boosting,are the superior and competing models that yield Winter season-based forecasting XGBoost is the best forecasting model with MAE:1.6325,RMSE:4.8338,and R^(2):0.9998.Spring season-based forecasting XGBoost is the best forecasting model with MAE:2.599599,RMSE:5.58539,and R^(2):0.999784.Summer season-based forecasting RF is the best forecasting model with MAE:1.03843,RMSE:2.116325,and R^(2):0.999967.Monsoon season-based forecasting RF is the best forecasting model with MAE:0.892385,RMSE:2.417587,and R^(2):0.999942.Autumn season-based forecasting RF is the best forecasting model with MAE:0.810462,RMSE:1.928215,and R^(2):0.999958.Based on seasonal variations and computing constraints,the findings enable energy system operators to make helpful recommendations for choosing the most effective forecasting models.展开更多
Dendrobium officinale is an orchid herb distinguished by its exceptional drought resistance capabilities.The remarkable drought tolerance of D.officinale stems from its structural and compositional features,including ...Dendrobium officinale is an orchid herb distinguished by its exceptional drought resistance capabilities.The remarkable drought tolerance of D.officinale stems from its structural and compositional features,including thick leaves and stems containing abundant polysaccharides and colloidal substances.Despite these adaptations,the underlying molecular mechanisms responsible for enhanced drought tolerance remain inadequately understood.This study subjected D.officinale to water restriction for periods ranging from 1 to 6 months,conducting physiological and RNA sequencing analyses to elucidate its long-term dehydration response mechanisms and identify drought-protective genes.Following 6 months of dehydration,D.officinale maintained viability,demonstrated by rapid growth resumption after merely 2 d of rehydration.Transcriptome analysis of D.officinale plants under 1-month dehydration revealed differential gene expression across various processes,predominantly in stress responses,photosynthesis,phytohormone signaling,carbon metabolism,and fructose/mannose pathways.Among these,PEROXIDASE4(POD4)and NAC37 showed significant upregulation and were selected for further investigation of their roles in drought protection.Transgenic tomato plants overexpressing D.officinale’s POD4 and NAC37 genes exhibited superior drought tolerance compared to controls,displaying enhanced vigor,increased fruit production,higher respiration rates,elevated chlorophyll levels,and reduced oxidative damage.This research demonstrates the value of exploring underutilized species for drought-tolerance genes and identifies POD4 and NAC37 as promising candidates for improving drought tolerance through breeding programs.展开更多
Metabolomics utilizes advanced analytical profiling techniques to comprehensively measure small molecules in cells,tissues,and biological fluids.Nutritional metabolomics studies in pigs have reported changes in hundre...Metabolomics utilizes advanced analytical profiling techniques to comprehensively measure small molecules in cells,tissues,and biological fluids.Nutritional metabolomics studies in pigs have reported changes in hundreds of metabolites across various sample types,including plasma,serum,urine,digesta,and feces,following dietary interventions.These findings can help identify biomarkers of gastrointestinal functionality and beyond,as well as investigate mechanistic interactions between diet,host,microbiome,and metabolites.This review aims to summarize the current literature on nutritional metabolomics in pigs and its use to investigate how different dietary approaches impact the gut health of pigs.Here,we critically assessed and categorized the impact of the main macronutrients-carbohydrates,proteins,and fats—along with feed additives such as amino acids,bile acids,and probiotics,as well as feeding strategies like creep feeding,milk replacer introduction,and time-restricted feeding,on the pig metabolome.Additionally,we discuss the potential modes of action of the key affected metabolites on pig gut health.展开更多
Understanding how renewable energy generation affects electricity prices is essential for designing efficient and sustainable electricity markets.However,most existing studies rely on regression-based approaches that ...Understanding how renewable energy generation affects electricity prices is essential for designing efficient and sustainable electricity markets.However,most existing studies rely on regression-based approaches that capture correlations but fail to identify causal relationships,particularly in the presence of non-linearities and confounding factors.This limits their value for informing policy and market design in the context of the energy transition.To address this gap,we propose a novel causal inference framework based on local partially linear double machine learning(DML).Our method isolates the true impact of predicted wind and solar power generation on electricity prices by controlling for high-dimensional confounders and allowing for non-linear,context-dependent effects.This represents a substantial methodological advancement over standard econometric techniques.Applying this framework to the UK electricity market over the period 2018-2024,we produce the first robust causal estimates of how renewables affect dayahead wholesale electricity prices.We find that wind power exerts a U-shaped causal effect:at low penetration levels,a 1 GWh increase reduces prices by up to£7/MWh,the effect weakens at mid-levels,and intensifies again at higher penetration.Solar power consistently reduces prices at low penetration levels,up to£9/MWh per additional GWh,but its marginal effect diminishes quickly.Importantly,the magnitude of these effects has increased over time,reflecting the growing influence of renewables on price formation as their share in the energy mix rises.These findings offer a sound empirical basis for improving the design of support schemes,refining capacity planning,and enhancing electricity market efficiency.By providing a robust causal understanding of renewable impacts,our study contributes both methodological innovation and actionable insights to guide future energy policy.展开更多
The caries-preventive effects of arginine have been attributed to its impact on biofilm composition and pH.Recent in vitro studies suggest that arginine also affects the production of biofilm matrix components that co...The caries-preventive effects of arginine have been attributed to its impact on biofilm composition and pH.Recent in vitro studies suggest that arginine also affects the production of biofilm matrix components that contribute to virulence,but this mechanism has not been investigated clinically.This randomized,placebo-controlled,triple-blind,split-mouth in situ trial assessed arginine's impact on the microbial composition,matrix architecture,and microscale pH of biofilms from caries-active patients(N=10).We also examined whether individual differences in the pH response to arginine were related to biofilm composition and matrix structure.Biofilms were grown for four days on carriers attached to intraoral splints.Three times daily,the biofilms were treated extraorally with sucrose(5 min),followed by arginine or placebo(30 min),in a split-mouth design.After growth,the microscale biofilm p H response to sucrose was monitored by pH ratiometry.Microbial biofilm composition and carbohydrate matrix architecture were analyzed by 16S rRNA gene sequencing and fluorescence lectin-binding analysis,respectively.Arginine treatment significantly mitigated sucrose-induced pH drops,reduced total carbohydrate matrix production,and altered the spatial distribution of fucoseand galactose-containing carbohydrates.Both arginine-and placebo-treated biofilms were dominated by streptococci and Veillonella spp.Paired analyses showed a significant reduction in mitis/oralis group streptococci and a non-significant increase in several arginine metabolizers in arginine-treated biofilms.Individual pH responses were not significantly associated with the abundance of specific bacterial taxa or carbohydrate matrix components.In conclusion,arginine reduced the virulence of biofilms from caries-active patients through multiple mechanisms,including suppressing matrix carbohydrate production.展开更多
PbSe materials,with their narrow bandgap,excellent optical absorption and outstanding optical response,are ideal for infrared photodetectors,exhibiting unique advantages in optical communication,infrared imaging and t...PbSe materials,with their narrow bandgap,excellent optical absorption and outstanding optical response,are ideal for infrared photodetectors,exhibiting unique advantages in optical communication,infrared imaging and thermal detection.Nevertheless,PbSe typically has a non-layered crystal structure and inherent isotropy,making the synthesis of low-dimensional nanomaterials challenging.Besides,PbSe photoconductive detectors suffer from high dark current due to intrinsic defects and thermally excited carriers,which is detrimental to device performance.Here,we utilized physical vapor deposition(PVD)method to grow high-quality PbSe nanosheets and combined them with two-dimensional(2D)transition metal dichalcogenides(TMDs)material WSe_(2)to fabricate a self-powered PbSe/WSe_(2)p-n heterostructure photodetector.Under illumination with a 650 nm laser at a power density of 128.97 mW/cm^(2)and 0 V bias,the PbSe/WSe_(2)heterojunction device exhibited significant photovoltaic characteristics and generated a short-circuit current of 161.7 nA.Furthermore,under 0.02 mW/cm^(2)of 650 nm laser illumination at 0 V bias,the device achieved an excellent responsivity(R)of 15.6 A/W and a specific detectivity(D^(*))of 1.08×10^(11)Jones.And the response speed of the heterojunction device at 0 V(511µs/74µs)was three orders of magnitude faster than that of PbSe nanosheets(93 ms/104 ms).The device also demonstrated broadband detection capabilities from 405 nm to 1550 nm and excellent imaging performance in the near-infrared region at 0 V bias.In summary,the outstanding photoelectric detection performance and imaging capabilities of the PbSe/WSe_(2)heterojunction nanosheet detector indicate its significant potential for applications in miniaturized,low-noise,broadband,high-speed and high-performance photodetectors.展开更多
Introduction This study aimed to either identify or develop and validate a patient-reported outcome measure(PROM)to assess treatment burden related to general practice for patients with multimorbidity,which can be use...Introduction This study aimed to either identify or develop and validate a patient-reported outcome measure(PROM)to assess treatment burden related to general practice for patients with multimorbidity,which can be used alongside the MultiMorbidity Questionnaire part 1(MMQ1)without overwhelming the target population with redundant items.Methods We conducted a systematic literature review to identify all existing PROMs measuring treatment burden.If no suitable PROM was found,our plan was to:(1)develop a draft PROM using items from existing instruments,(2)carry out group and individual interviews with patients with multimorbidity to ensure the PROM’s understandability,clarity,completeness and relevance and(3)undertake psychometric validation with a diverse sample of primary care patients with chronic conditions.Results We did not identify an eligible PROM in the literature review.The draft PROM consisted of 30 items divided into six domains;Information about treatment,Challenges with medication,Medical appointments,Self-monitoring,Health behaviour and Challenges in the contact to the health system.In the psychometric validation,neither these domains nor any other theoretical constellation of items had adequate psychometric properties.Individual items had good criterion validity and sensitivity to change.Conclusions In this study,we developed a 30-item PROM with high content validity where various individual items showed adequate criterion validity and sensitivity to change,making these items useful as a supplemental measure to the MMQ1.Trial registration number NCT05676541 Registration Date:16 December 2022.展开更多
Microneedle(MN)patches could be a promising treatment for diabetic foot ulcers that plague thousands of people worldwide.While reducing skin resistance or increasing driving force can accelerate the efficiency of tran...Microneedle(MN)patches could be a promising treatment for diabetic foot ulcers that plague thousands of people worldwide.While reducing skin resistance or increasing driving force can accelerate the efficiency of transdermal drug delivery with conventional MN patches,it can create toxic chemical residues or require the help of additional devices.Herein,a thermo-responsive microneedles patch(TMN)with high biocompatibility without additional equipment is proposed.The TMN consisted of a bilayer microneedles composed of sodium alginate(SA)-g-poly(N-isopropylacrylamide)layer(SA-g-PNIPAM)loaded with sucrose octasulfate sodium salt(SOS)and hyaluronic acid layer and a polycaprolactone/chitosan nanofiber membrane loading with tetracycline hydrochloride(TH)and SOS.PNIPAM accelerates drug release by extruding the drug through a volumetric phase transition in response to temperature changes,and TH and SOS promote wound healing by inhibiting bacterial growth and promoting vascular regeneration and epithelial formation.The results showed that the drug release of TMN was significantly faster,with the drug release rate of more than 80% in the 10th h,and the antibacterial rate of TMN could reach 800%.In addition,TMN had good biocompatibility and good healing effects in vivo,which may be helpful for the design of multifunctional dressings in the future.展开更多
基金supported by the National Natural Science Foundation of China(Grant No.12302422,12572342)Marie Sklodowska-Curie grant agreement ENSIGN(101086226),NanoRam(101120146)and L4DNANO(101086227).
文摘ABSTRACT Melt electrowriting(MEW)enables the precise deposition of polymeric fibers at micro-/nanoscale,allowing for the fabrication of 3D biomimetic scaffolds.By incorporating stimuli-responsive polymers and/or functional fillers,MEW-based 4D printing creates scaffolds capable of undergoing controlled,reversible shape transformations in response to external stimuli over time.These dynamic 4D scaffolds can be tailored for minimally invasive delivery,remote actuation,and real-time responsiveness to physiological environments,making them highly relevant for biomedical applications.This review systematically elucidates the principles of MEW-based 4D printing,including material considerations,actuation methods,and structure design strategies,along with shape programming and morphing mechanisms.The versatility of MEW for rational fabrication of biomimetic scaffolds is firstly introduced.Subsequently,the critical elements underpinning MEW-based 4D printing process are overviewed,including an analysis of stimuli-responsive materials compatible with MEW,an evaluation of applicable external stimuli,and a discussion on the advancements in design strategies for 4D scaffolds.Recent progress of MEW 4D scaffolds for applications in tissue engineering,biomedical implants,and drug delivery systems are highlighted.Finally,key challenges and perspectives toward material innovation,fabrication optimization,and actuation control are discussed.This review aims to provide valuable insights for design and creation of multifunctional biomimetic dynamic scaffolds by MEW-based 4D printing.
文摘On July 2^(nd),2025,32 scientists representing 15 countries gathered at Tartu,Estonia to make on-site endorsements for the Global ONCE(Ocean Negative Carbon Emissions)Program at the 12th INTECOL Wetlands Conference.This marks a significant milestone for ONCE in establishing a systematic framework for coastal wetland carbon sequestration research and global collaboration(Figs.1,2).Coastal wetlands are critical transition zones linking terrestrial and marine ecosystems,yet they face severe degradation from anthropogenic land-based activities and sea level rise that propagate impacts to the ocean.As a UN Ocean Decade Program,the Global ONCE Program champions interdisciplinary and cross-regional collaboration to enhance carbon sequestration in the ocean and coastal wetlands through science and innovation.Aligned with the Tartu Declaration on Wetlands that includes resolutions to promote the rights of global wetlands(especially peatlands)and advance the discipline of wetland science based on facts,this initiative addresses key knowledge gaps in land-ocean interactions.The goal is to harness the full potential of coastal wetlands and ocean systems for climate mitigation,thereby laying a scientific foundation for international policy formulation and implementation.
基金the NSFC(No.22472112)the Suzhou Foreign Academician Workstation(No.SWY2022001)for financial supportsthe Soochow Municipal Laboratory for Low Carbon Technologies and Industries.
文摘Nitrogenous compounds(i.e.,amines,amides,nitriles,oximes,amino acids and nitrogen-heterocycles derivatives)are important building blocks for synthetic chemistry,pharmaceuticals,and functional materials.Conventional synthetic strategies involve the use of toxic organic nitrogenous precursors or expensive heterogeneous catalysts under elevated temperatures and pressurized oxygen.Heterogeneous electrocatalysis can initiate the activation of inorganic N sources(i.e.,NH_(3)and NO^(-)_(x))under ambient reactions in liquid phase by applying a small bias,thus allowing the synthesis of value?added nitrogenous compounds from carbonyls,alkenes,keto acids,and even carbon dioxide in a sustainable manner without the use of oxidants/reductants.This review outlines recent de-velopments in electrosynthesis of nitrogenous compounds using inorganic N sources,focusing on reaction mechanisms understanding,the design and optimization of efficient electrocatalysts,and the advances in cell configurations for various C‒N coupling reactions.The limitations and challenges in applications are also discussed.
基金supported by the National Natural Science Foundation of China (Nos.52072152 and 51802126)Jiangsu University Jinshan Professor Fund,Jiangsu Specially-Appointed Professor Fund,the Open Fund from Guangxi Key Laboratory of Electrochemical Energy Materials,Zhenjiang“Jinshan Talents”Project 2021,China PostDoctoral Science Foundation (No.2022M721372)+1 种基金the“Doctor of Entrepreneurship and Innovation”in Jiangsu Province (No.JSSCBS20221197)the Postgraduate Research&Practice Innovation Program of Jiangsu Province (No.KYCX22_3645).
文摘In the quest for effective solutions to address Environ.Pollut.and meet the escalating energy demands,heterojunction photocatalysts have emerged as a captivating and versatile technology.These photocatalysts have garnered significant interest due to their wideranging applications,including wastewater treatment,air purification,CO_(2) capture,and hydrogen generation via water splitting.This technique harnesses the power of semiconductors,which are activated under light illumination,providing the necessary energy for catalytic reactions.With visible light constituting a substantial portion(46%)of the solar spectrum,the development of visible-light-driven semiconductors has become imperative.Heterojunction photocatalysts offer a promising strategy to overcome the limitations associated with activating semiconductors under visible light.In this comprehensive review,we present the recent advancements in the field of photocatalytic degradation of contaminants across diverse media,as well as the remarkable progress made in renewable energy production.Moreover,we delve into the crucial role played by various operating parameters in influencing the photocatalytic performance of heterojunction systems.Finally,we address emerging challenges and propose novel perspectives to provide valuable insights for future advancements in this dynamic research domain.By unraveling the potential of heterojunction photocatalysts,this reviewcontributes to the broader understanding of their applications and paves the way for exciting avenues of exploration and innovation.
基金financially supported by the Green Development and Demonstration Programme(GUDP)(case number 34009-19-1585)。
文摘Background Post-weaning diarrhea(PWD)in piglets,often caused by F4^(+)enterotoxigenic Escherichia coli(ETEC),poses significant challenges in pig production.Traditional solutions like antibiotics and zinc oxide face increasing restrictions due to growing concerns over antibiotic resistance and environmental sustainability.This study investigates the application of bivalent heavy chain variable domain(V_(H)H)constructs(BL1.2 and BL2.2)targeting ETEC virulence factors,administered in feed to mitigate ETEC-induced PWD in weaned piglets.Results The supplementation of BL1.2 and BL2.2 in both mash and pelleted feed significantly reduced the diarrhea incidence and fecal shedding of F4^(+)ETEC in challenged piglets.Pelleted feed containing V_(H)H constructs helped to preserve gut barrier integrity by maintaining levels of the tight junction protein occludin in the small intestine.Additionally,the constructs maintained blood granulocyte counts at a similar level to the non-challenged control group,including neutrophils,and ameliorated the acute phase protein response after challenge.Notably,even at low feed intake immediately after weaning,V_(H)H constructs helped maintain piglet health by mitigating ETEC-induced inflammation and the resulting diarrhea.Conclusions Our findings demonstrated that using V_(H)H constructs as feed additives could serve as an effective strategy to help manage ETEC-associated PWD,by reducing F4^(+)ETEC gut colonization and supporting gut barrier function of weaned piglets.The high stability of these V_(H)H constructs supports their incorporation into industrial feed manufacturing processes,offering a more sustainable preventive strategy compared to traditional antimicrobial interventions,which could contribute to sustainable farming practices.
基金supported by the National Key R&D Program of China(Nos.2023YFF0718303 and 2022YFB3504804)the National Natural Science Foundation of China(Nos.51871219,52031014 and 52401255)the Science and Technology Project of Shenyang City(No.22-101-0-27).
文摘The single-layer Ti_(3)C_(2)T_(x)/MXene has become a special electromagnetic wave absorber near the terahertz band because of its abundant surface groups and excellent conductivity.However,the macro-preparation of single-layer Ti_(3)C_(2)T_(x)/MXene shows significantly difficult to influence its application.The two-dimensional Ti_(3)C_(2)T_(x)is easily prepared to have high production,but its weak absorption ability due to high surface conductivity also restricts its application.To realize the strong electromagnetic wave absorption of two-dimensional Ti_(3)C_(2)T_(x)/MXene,a new strategy with magnetic FeNi nanoparticles decorating Ti_(3)C_(2)T_(x)/MXene composites(FeNi-Ti_(3)C_(2)T_(x))were proposed and the effective electromagnetic wave absorption features covering 170-220 GHz that means the absorption band width reach 50 GHz.With an absorber composite film thickness being only 0.6 mm,the absorptivity of the composite is enhanced with the increase of decorating FeNi nanoparticles and promote up to 75%when the FeNi nanoparticles loading content reaches 30 wt%.The improvement of absorption is attributed to the introduction of soft magnetic FeNi to adjust the high surface conductivity of MXene and improve the electromagnetic balance of the absorber.
基金supported by Danish National Research Foundation(#DNRF133)(to AN)。
文摘The formation of the mammalian nervous system and its maturation into sensory,motor,cognitive,and behavioral circuits is a complex process that begins during early embryogenesis and lasts until young adulthood.Impaired neurodevelopment can result in various neurological and psychiatric conditions,jointly named neurodevelopmental disorders(NDDs).
文摘Dibromoethane is a widespread,persistent organic pollutant.Biochars are known mediators of reductive dehalogenation by layered Fe^(Ⅱ)-Fe^(Ⅲ)hydroxides(green rust),which can reduce 1,2-dibromoethane to innocuous bromide and ethylene.However,the critical characteristics that determine mediator functionality are lesser known.Fifteen biochar substrates were pyrolyzed at 600℃and 800℃,characterized by elemental analysis,X-ray photo spectrometry C and N surface speciation,X-ray powder diffraction,specific surface area analysis,and tested for mediation of reductive debromination of 1,2-dibromoethane by a green rust reductant under anoxic conditions.A statistical analysis was performed to determine the biochar properties,critical for debromination kinetics and total debromination extent.It was shown that selected plant based biochars can mediate debromination of 1,2-dibromoethane,that the highest first order rate constant was 0.082/hr,and the highest debromination extent was 27%in reactivity experiments with 0.1μmol(20μmol/L)1,2-dibromoethane,≈22 mmol/L Fe^(Ⅱ)GR,and 0.12 g/L soybean meal biochar(7 days).Contents of Ni,Zn,N,and P,and the relative contribution of quinone surface functional groups were significantly(p<0.05)positively correlated with 1,2-dibromoethane debromination,while adsorption,specific surface area,and the relative contribution of pyridinic N oxide surface groups were significantly negatively correlated with debromination.
基金the financial support from FORMAS(2018-01029)the Swedish Institute(01132-2022)for supporting Ivan Motsnyi’s visit and research at Swedish University of Agricultural Sciences。
文摘Emerging new races of wheat stem rust(Puccinia graminis f.sp.tritici)are threatening global wheat(Triticum aestivum L.)production.Host resistance is the most effective and environmentally friendly method of controlling stem rust.The stem rust resistance gene Sr59 was previously identified within a T2DS 2RL wheat-rye whole arm translocation,providing broad-spectrum resistance to various stem rust races.Seedling evaluation,molecular marker analysis,and cytogenetic studies identified wheat-rye introgression line#284 containing a new translocation chromosome T2BL 2BS-2RL.This line has demonstrated broad-spectrum resistance to stem rust at the seedling stage.Seedling evaluation and cytogenetic analysis of three backcross populations between the line#284 and the adapted cultivars SLU-Elite,Navruz,and Linkert confirmed that Sr59 is located within the short distal 2RL translocation.This study aimed physical mapping of Sr59 in the 2RL introgression segment and develop a robust molecular marker for marker-assisted selection.Using genotyping-by-sequencing(GBS),GBS-derived SNPs were aligned with full-length annotated rye nucleotide-binding leucine-rich repeat(NLR)genes in the parental lines CS ph1b,SLU238,SLU-Elite,Navruz,and Linkert,as well as in 33 BC4F5progeny.Four NLR genes were identified on the 2R chromosome,with Chr2R_NLR_60 being tightly linked to the Sr59resistance gene.In-silico functional enrichment analysis of the translocated 2RL region(25,681,915 bp)identified 223 genes,with seven candidate genes associated with plant disease resistance and three linked to agronomic performance,contributing to oxidative stress response,protein kinase activity,and cellular homeostasis.These findings facilitate a better understanding of the genetic basis of stem rust resistance provided by Sr59.
文摘Background Depression is a common comorbidity in Parkinson's disease(PD)and Lewy body dementia(LBD).However,studies examining the rate of incident depression in the period preceding and following the diagnosis of PD and LBD are lacki ng in the literature.Aims To quantify the incidence of depression in the period preceding and following the diagnosis of PD and LBD.Methods We conducted a retrospective case-control study.Specifically,we used Danish registers to identify all patients with a diagnosis of PD or LBD in the period from 2007 to 2019.These patients were matched by age,calendar year of diagnosis and sex with up to three patients diagnosed with rheumatoid arthritis(RA),chronic kidney disease(CKD)or osteoporosis,respectively.The outcome was incident depression.The incidence of depression was assessed for up to 10 years before and up to 10 years after the diagnosis of PD or LBD.Hazard rates of incident depression for patients with PD or LBD,both before and after diagnosis,were compared with those for patients with RA,CKD or osteoporosis using a Coxproportional hazards model.Results We identified 17711 patients with PD or LBD.Their median age was 74.98(68.10-80.85)years,and39.92%were females.These patients were matched to 19556,40842 and 47809 patients with RA,CKD and osteoporosis,respectively.From 7 to 8 years before diagnosis to 5 years after diagnosis,patients with PD and LBD consistently had higher hazard rates of incident depression than all comparator groups.Conclusions These findings are compatible with depression being an early manifestation of the neurodegenerative changes eventually leading to PD and LBD and imply that incident depression at a late age should raise awareness of potential PD and LBD.
文摘Accurate Global Horizontal Irradiance(GHI)forecasting has become vital for successfully integrating solar energy into the electrical grid because of the expanding demand for green power and the worldwide shift favouring green energy resources.Particularly considering the implications of the aggressive GHG emission targets,accurate GHI forecasting has become vital for developing,designing,and operational managing solar energy systems.This research presented the core concepts of modelling and performance analysis of the application of various forecasting models such as ARIMA(Autoregressive Integrated Moving Average),Elaman NN(Elman Neural Network),RBFN(Radial Basis Function Neural Network),SVM(Support Vector Machine),LSTM(Long Short-Term Memory),Persistent,BPN(Back Propagation Neural Network),MLP(Multilayer Perceptron Neural Network),RF(Random Forest),and XGBoost(eXtreme Gradient Boosting)for assessing multi-seasonal forecasting of GHI.Used the India region data to evaluate the models’performance and forecasting ability.Research using forecasting models for seasonal Global Horizontal Irradiance(GHI)forecasting in winter,spring,summer,monsoon,and autumn.Substantiated performance effectiveness through evaluation metrics,such as Mean Absolute Error(MAE),Root Mean Squared Error(RMSE),and R-squared(R^(2)),coded using Python programming.The performance experimentation analysis inferred that the most accurate forecasts in all the seasons compared to the other forecasting models the Random Forest and eXtreme Gradient Boosting,are the superior and competing models that yield Winter season-based forecasting XGBoost is the best forecasting model with MAE:1.6325,RMSE:4.8338,and R^(2):0.9998.Spring season-based forecasting XGBoost is the best forecasting model with MAE:2.599599,RMSE:5.58539,and R^(2):0.999784.Summer season-based forecasting RF is the best forecasting model with MAE:1.03843,RMSE:2.116325,and R^(2):0.999967.Monsoon season-based forecasting RF is the best forecasting model with MAE:0.892385,RMSE:2.417587,and R^(2):0.999942.Autumn season-based forecasting RF is the best forecasting model with MAE:0.810462,RMSE:1.928215,and R^(2):0.999958.Based on seasonal variations and computing constraints,the findings enable energy system operators to make helpful recommendations for choosing the most effective forecasting models.
基金supported by the Hubei Provincial Natural Science Foundation,China(2022CFB009)the National Natural Science Foundation of China(31900242).
文摘Dendrobium officinale is an orchid herb distinguished by its exceptional drought resistance capabilities.The remarkable drought tolerance of D.officinale stems from its structural and compositional features,including thick leaves and stems containing abundant polysaccharides and colloidal substances.Despite these adaptations,the underlying molecular mechanisms responsible for enhanced drought tolerance remain inadequately understood.This study subjected D.officinale to water restriction for periods ranging from 1 to 6 months,conducting physiological and RNA sequencing analyses to elucidate its long-term dehydration response mechanisms and identify drought-protective genes.Following 6 months of dehydration,D.officinale maintained viability,demonstrated by rapid growth resumption after merely 2 d of rehydration.Transcriptome analysis of D.officinale plants under 1-month dehydration revealed differential gene expression across various processes,predominantly in stress responses,photosynthesis,phytohormone signaling,carbon metabolism,and fructose/mannose pathways.Among these,PEROXIDASE4(POD4)and NAC37 showed significant upregulation and were selected for further investigation of their roles in drought protection.Transgenic tomato plants overexpressing D.officinale’s POD4 and NAC37 genes exhibited superior drought tolerance compared to controls,displaying enhanced vigor,increased fruit production,higher respiration rates,elevated chlorophyll levels,and reduced oxidative damage.This research demonstrates the value of exploring underutilized species for drought-tolerance genes and identifies POD4 and NAC37 as promising candidates for improving drought tolerance through breeding programs.
基金the PIG-PARADIGM project,funded by the Novo Nordisk Foundation(Grant No.NNFSA210073688).
文摘Metabolomics utilizes advanced analytical profiling techniques to comprehensively measure small molecules in cells,tissues,and biological fluids.Nutritional metabolomics studies in pigs have reported changes in hundreds of metabolites across various sample types,including plasma,serum,urine,digesta,and feces,following dietary interventions.These findings can help identify biomarkers of gastrointestinal functionality and beyond,as well as investigate mechanistic interactions between diet,host,microbiome,and metabolites.This review aims to summarize the current literature on nutritional metabolomics in pigs and its use to investigate how different dietary approaches impact the gut health of pigs.Here,we critically assessed and categorized the impact of the main macronutrients-carbohydrates,proteins,and fats—along with feed additives such as amino acids,bile acids,and probiotics,as well as feeding strategies like creep feeding,milk replacer introduction,and time-restricted feeding,on the pig metabolome.Additionally,we discuss the potential modes of action of the key affected metabolites on pig gut health.
文摘Understanding how renewable energy generation affects electricity prices is essential for designing efficient and sustainable electricity markets.However,most existing studies rely on regression-based approaches that capture correlations but fail to identify causal relationships,particularly in the presence of non-linearities and confounding factors.This limits their value for informing policy and market design in the context of the energy transition.To address this gap,we propose a novel causal inference framework based on local partially linear double machine learning(DML).Our method isolates the true impact of predicted wind and solar power generation on electricity prices by controlling for high-dimensional confounders and allowing for non-linear,context-dependent effects.This represents a substantial methodological advancement over standard econometric techniques.Applying this framework to the UK electricity market over the period 2018-2024,we produce the first robust causal estimates of how renewables affect dayahead wholesale electricity prices.We find that wind power exerts a U-shaped causal effect:at low penetration levels,a 1 GWh increase reduces prices by up to£7/MWh,the effect weakens at mid-levels,and intensifies again at higher penetration.Solar power consistently reduces prices at low penetration levels,up to£9/MWh per additional GWh,but its marginal effect diminishes quickly.Importantly,the magnitude of these effects has increased over time,reflecting the growing influence of renewables on price formation as their share in the energy mix rises.These findings offer a sound empirical basis for improving the design of support schemes,refining capacity planning,and enhancing electricity market efficiency.By providing a robust causal understanding of renewable impacts,our study contributes both methodological innovation and actionable insights to guide future energy policy.
基金supported by the Faculty of Health,Aarhus University,Denmark。
文摘The caries-preventive effects of arginine have been attributed to its impact on biofilm composition and pH.Recent in vitro studies suggest that arginine also affects the production of biofilm matrix components that contribute to virulence,but this mechanism has not been investigated clinically.This randomized,placebo-controlled,triple-blind,split-mouth in situ trial assessed arginine's impact on the microbial composition,matrix architecture,and microscale pH of biofilms from caries-active patients(N=10).We also examined whether individual differences in the pH response to arginine were related to biofilm composition and matrix structure.Biofilms were grown for four days on carriers attached to intraoral splints.Three times daily,the biofilms were treated extraorally with sucrose(5 min),followed by arginine or placebo(30 min),in a split-mouth design.After growth,the microscale biofilm p H response to sucrose was monitored by pH ratiometry.Microbial biofilm composition and carbohydrate matrix architecture were analyzed by 16S rRNA gene sequencing and fluorescence lectin-binding analysis,respectively.Arginine treatment significantly mitigated sucrose-induced pH drops,reduced total carbohydrate matrix production,and altered the spatial distribution of fucoseand galactose-containing carbohydrates.Both arginine-and placebo-treated biofilms were dominated by streptococci and Veillonella spp.Paired analyses showed a significant reduction in mitis/oralis group streptococci and a non-significant increase in several arginine metabolizers in arginine-treated biofilms.Individual pH responses were not significantly associated with the abundance of specific bacterial taxa or carbohydrate matrix components.In conclusion,arginine reduced the virulence of biofilms from caries-active patients through multiple mechanisms,including suppressing matrix carbohydrate production.
基金supported financially by National Key Research and Development Program of China(No.2023YFB3611400)National Natural Science Foundation of China(Nos.62175026,62305047)+4 种基金China National Postdoctoral Program for Innovative Talents(No.BX20230059)China Postdoctoral Science Foundation(No.2023M740509)Guangdong Basic and Applied Basic Research Foundation(No.2024A1515010005)National Key Laboratory of Intense Pulsed Radiation Simulation and Effect Research Foundation(No.NKLIPR2315)Natural Science Foundation of Sichuan Province(No.24NSFSC1465).
文摘PbSe materials,with their narrow bandgap,excellent optical absorption and outstanding optical response,are ideal for infrared photodetectors,exhibiting unique advantages in optical communication,infrared imaging and thermal detection.Nevertheless,PbSe typically has a non-layered crystal structure and inherent isotropy,making the synthesis of low-dimensional nanomaterials challenging.Besides,PbSe photoconductive detectors suffer from high dark current due to intrinsic defects and thermally excited carriers,which is detrimental to device performance.Here,we utilized physical vapor deposition(PVD)method to grow high-quality PbSe nanosheets and combined them with two-dimensional(2D)transition metal dichalcogenides(TMDs)material WSe_(2)to fabricate a self-powered PbSe/WSe_(2)p-n heterostructure photodetector.Under illumination with a 650 nm laser at a power density of 128.97 mW/cm^(2)and 0 V bias,the PbSe/WSe_(2)heterojunction device exhibited significant photovoltaic characteristics and generated a short-circuit current of 161.7 nA.Furthermore,under 0.02 mW/cm^(2)of 650 nm laser illumination at 0 V bias,the device achieved an excellent responsivity(R)of 15.6 A/W and a specific detectivity(D^(*))of 1.08×10^(11)Jones.And the response speed of the heterojunction device at 0 V(511µs/74µs)was three orders of magnitude faster than that of PbSe nanosheets(93 ms/104 ms).The device also demonstrated broadband detection capabilities from 405 nm to 1550 nm and excellent imaging performance in the near-infrared region at 0 V bias.In summary,the outstanding photoelectric detection performance and imaging capabilities of the PbSe/WSe_(2)heterojunction nanosheet detector indicate its significant potential for applications in miniaturized,low-noise,broadband,high-speed and high-performance photodetectors.
基金supported by the public agreement between the Danish Regions and the General Practitioners’Organization 2022–2024.
文摘Introduction This study aimed to either identify or develop and validate a patient-reported outcome measure(PROM)to assess treatment burden related to general practice for patients with multimorbidity,which can be used alongside the MultiMorbidity Questionnaire part 1(MMQ1)without overwhelming the target population with redundant items.Methods We conducted a systematic literature review to identify all existing PROMs measuring treatment burden.If no suitable PROM was found,our plan was to:(1)develop a draft PROM using items from existing instruments,(2)carry out group and individual interviews with patients with multimorbidity to ensure the PROM’s understandability,clarity,completeness and relevance and(3)undertake psychometric validation with a diverse sample of primary care patients with chronic conditions.Results We did not identify an eligible PROM in the literature review.The draft PROM consisted of 30 items divided into six domains;Information about treatment,Challenges with medication,Medical appointments,Self-monitoring,Health behaviour and Challenges in the contact to the health system.In the psychometric validation,neither these domains nor any other theoretical constellation of items had adequate psychometric properties.Individual items had good criterion validity and sensitivity to change.Conclusions In this study,we developed a 30-item PROM with high content validity where various individual items showed adequate criterion validity and sensitivity to change,making these items useful as a supplemental measure to the MMQ1.Trial registration number NCT05676541 Registration Date:16 December 2022.
基金supported by the Joint Funds of National Natural Science Foundation of China(No.U22A20162)the Natural Science Foundation of Hebei Province of China(No.C2021202002)+1 种基金the National Natural Science Foundation of China(No.52271245),the Natural Science Foundation of Tianjin(No.21JCQNJC01280)the financial support from the Danish Council for Independent Research(9040-00219B),European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement ENSIGN(Project ID:101086226),L4DNANO(Project ID:101086227).
文摘Microneedle(MN)patches could be a promising treatment for diabetic foot ulcers that plague thousands of people worldwide.While reducing skin resistance or increasing driving force can accelerate the efficiency of transdermal drug delivery with conventional MN patches,it can create toxic chemical residues or require the help of additional devices.Herein,a thermo-responsive microneedles patch(TMN)with high biocompatibility without additional equipment is proposed.The TMN consisted of a bilayer microneedles composed of sodium alginate(SA)-g-poly(N-isopropylacrylamide)layer(SA-g-PNIPAM)loaded with sucrose octasulfate sodium salt(SOS)and hyaluronic acid layer and a polycaprolactone/chitosan nanofiber membrane loading with tetracycline hydrochloride(TH)and SOS.PNIPAM accelerates drug release by extruding the drug through a volumetric phase transition in response to temperature changes,and TH and SOS promote wound healing by inhibiting bacterial growth and promoting vascular regeneration and epithelial formation.The results showed that the drug release of TMN was significantly faster,with the drug release rate of more than 80% in the 10th h,and the antibacterial rate of TMN could reach 800%.In addition,TMN had good biocompatibility and good healing effects in vivo,which may be helpful for the design of multifunctional dressings in the future.
