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Patisiran脂质体ONPATTRO发展及临床应用 被引量:1
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作者 李和文 潘弘 甘莉 《中国处方药》 2021年第1期24-27,共4页
获得诺贝尔奖的RNA干扰技术无疑是令人兴奋的重大发现,但RNA类药物存在诸如稳定性差、难以靶向递送等问题限制了其应用。美国Alnylam制药和赛诺菲共同开发的新药patisiran脂质复合物注射液于2018年获批上市治疗遗传性转甲状腺素蛋白淀... 获得诺贝尔奖的RNA干扰技术无疑是令人兴奋的重大发现,但RNA类药物存在诸如稳定性差、难以靶向递送等问题限制了其应用。美国Alnylam制药和赛诺菲共同开发的新药patisiran脂质复合物注射液于2018年获批上市治疗遗传性转甲状腺素蛋白淀粉样病变,成为首个siRNA药物的成功临床应用。本文从该产品的处方、作用机制、临床试验及市场等方面进行分析,对ONPATTRO的开发及药效做一简要综述。 展开更多
关键词 siRNA脂质体 Onpattro 阳离子脂质辅料 遗传性转甲状腺素蛋白淀粉样病变
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Modeling of shear induced coarsening effects in semi-solid alloys
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作者 M.MODIGEL L A.POLA 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2010年第9期1696-1701,共6页
In long-term rheological shear experiments with semi-solid alloys, coarsening of the particles will falsify the interpretation of the experimental results.The coarsening is intensified by the shear induced convection ... In long-term rheological shear experiments with semi-solid alloys, coarsening of the particles will falsify the interpretation of the experimental results.The coarsening is intensified by the shear induced convection and the mean size of the particles is changed significantly during the experiments.A simple model has been set up which takes the influence of the convection into account.The resulting growth law has been simplified for diffusion and convection dominated growth.The growth law was verified with shear experiments in a Searl-rheometer with A356 and tin-lead alloys.The experiments demonstrated that under convection the growth follows a linear time law and that the rate constant depends on the root of the shear rate.The correction of experimental results to gain the true viscosity function is demonstrated for a shear jump experiment with A356. 展开更多
关键词 MICROSTRUCTURE COARSENING Ostwald ripening flow function VISCOSITY RHEOLOGY semi-solid alloys
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L64020单片DVD解码芯片
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《世界电子元器件》 1998年第9期56-57,共2页
L64020是美国LSI Logic公司推出的单片DVD解码芯片方案。该芯片功能强大,低成本,低功耗,它的高集成度、优异性能和具有竞争力的价格,使其在众多的DVD方案中独具优势,已被国外众多公司所采用。
关键词 DVD 解码芯片 影碟机 L64020
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