AIM: To evaluate the efficacy of pegylated interferon in Iranian chronic hepatitis C patients in relation to interferon-λ(IFNL) polymorphisms. METHODS: This study enrolled patients with chronic hepatitis C referred t...AIM: To evaluate the efficacy of pegylated interferon in Iranian chronic hepatitis C patients in relation to interferon-λ(IFNL) polymorphisms. METHODS: This study enrolled patients with chronic hepatitis C referred to the Tehran Blood Transfusion Hepatitis Clinic in 2011. Patients were included in the study if they had no concomitant hepatic illness, were negative for human immunodeficiency virus antibodies, and had no prior history of treatment with any type ofpegylated interferon. Patients were treated with 180 μg pegylated interferon alpha-2a(Pegaferon®) weekly and 800-1200 mg ribavirin daily for 24 or 48 wk depending on weight and hepatitis C virus(HCV) genotype. Blood samples were collected from patients to obtain DNA for determination of IFNL rs12979860 and rs8099917 polymorphisms. The virologic response in patients was then evaluated and compared between the different IFNL genotypes.RESULTS: A total of 152 patients with a mean age of 41.9 ± 10.0 years were included in the study, of which 141/152 were men(92.8%). The most frequent HCV genotype was type-1, infecting 93/152(61.2%) patients. Sustained virologic response(SVR) was achieved in 81.9% of patients with HCV genotype-1 and 91.1% of patients with HCV genotype-3. Treatment success was achieved in 91.2%(52/57) of patients with the IFNL rs12979860 CC genotype and 82.1%(78/95) in those with other genotypes. Similar treatment response rates were also observed in patients with rs8099917 TT(39/45; 86.7%) and non-TT(61/68; 89.7%) genotypes. Univariate analyses identified the following factors which influenced treatment response for inclusion in a multivariate analysis: age, HCV RNA level, stage of liver fibrosis, rs12979860 CC genotype, and aspartate transaminase level. A logistic regression analysis revealed that only the rs12979860 CC genotype was significantly associated with achievement of SVR(OR = 6.2; 95%CI: 1.2-31.9; P = 0.03).CONCLUSION: The rs12979860 CC genotype was associated with SVR in patients receiving pegylated interferon plus ribavirin, however, the SVR rate in other rs12979860 genotypes was also relatively high.展开更多
The Energy Climate Package is the EU response to the Global Warming Challenge.Induction heating processes can contribute to the energy saving goal:20%saving within 2020.European induction manufacturer already propose ...The Energy Climate Package is the EU response to the Global Warming Challenge.Induction heating processes can contribute to the energy saving goal:20%saving within 2020.European induction manufacturer already propose many efficient solutions at industrial scale.To improve induction devices for an always better energy efficiency, EDF R&D set up a French cooperative project called ISIS with a financial support of the French National Research Agency.Its objective is to promote induction heating as Best Available Technology(BAT)and to develop innovative solutions to increase its efficiency.The ISIS innovations concern the electroheat conversion of induction devices(auto-adaptive multi-coil power supply,low losses coils)and the recovering of fatally lost energy.This paper shows the mid-term results of this project.Firsts control algorithms were successfully tested on a 100 kW 3-coil power supply.A homogenization technique is proposed to model a multi-strand coil.A heat recovery test bench is build and equipped with a PFC control loop to fit with the production fluctuations.展开更多
The EU H2020 ORCHYD project seeks to enhance drilling efficiency in hard rock environments,particularly for deep geothermal wells,by integrating innovative rock weakening techniques.In this context,3D finite element s...The EU H2020 ORCHYD project seeks to enhance drilling efficiency in hard rock environments,particularly for deep geothermal wells,by integrating innovative rock weakening techniques.In this context,3D finite element simulations of bit-rock interactions were performed to assess how combining high pressure water jetting(HPWJ)-induced groove and bottom-hole geometry can contribute to improve the down-hole percussive drilling performance.A Red Bohus granite rock was modelled using a continuum,elasto-visco-plastic,and damage-based model calibrated using Brazilian,uniaxial compression,and triaxial material tests as well as single insert impact tests.Bit-rock interaction with an HPWJ groove was studied through modelling of twelve different groove depths and bottom-hole configurations.Results demonstrate that deeper grooves significantly reduce impact loads by up to 35%and increase penetration up to 40%,leading to higher material removal(up to 240%).Groove depth also influences damage propagation between adjacent indents,with grooves facilitating a broader zone of fractured rock,particularly near the groove itself.Notably,the drilling efficiency benefits from HPWJ slotting are highly dependent on bit design:flat and concave bit profiles exhibit 70%greater improvement in drilling performance compared to other profiles.展开更多
基金Supported by Pooyesh Darou which is the local manufacturer of pegylated interferon alpha-2a in Iran(Pegaferon)
文摘AIM: To evaluate the efficacy of pegylated interferon in Iranian chronic hepatitis C patients in relation to interferon-λ(IFNL) polymorphisms. METHODS: This study enrolled patients with chronic hepatitis C referred to the Tehran Blood Transfusion Hepatitis Clinic in 2011. Patients were included in the study if they had no concomitant hepatic illness, were negative for human immunodeficiency virus antibodies, and had no prior history of treatment with any type ofpegylated interferon. Patients were treated with 180 μg pegylated interferon alpha-2a(Pegaferon®) weekly and 800-1200 mg ribavirin daily for 24 or 48 wk depending on weight and hepatitis C virus(HCV) genotype. Blood samples were collected from patients to obtain DNA for determination of IFNL rs12979860 and rs8099917 polymorphisms. The virologic response in patients was then evaluated and compared between the different IFNL genotypes.RESULTS: A total of 152 patients with a mean age of 41.9 ± 10.0 years were included in the study, of which 141/152 were men(92.8%). The most frequent HCV genotype was type-1, infecting 93/152(61.2%) patients. Sustained virologic response(SVR) was achieved in 81.9% of patients with HCV genotype-1 and 91.1% of patients with HCV genotype-3. Treatment success was achieved in 91.2%(52/57) of patients with the IFNL rs12979860 CC genotype and 82.1%(78/95) in those with other genotypes. Similar treatment response rates were also observed in patients with rs8099917 TT(39/45; 86.7%) and non-TT(61/68; 89.7%) genotypes. Univariate analyses identified the following factors which influenced treatment response for inclusion in a multivariate analysis: age, HCV RNA level, stage of liver fibrosis, rs12979860 CC genotype, and aspartate transaminase level. A logistic regression analysis revealed that only the rs12979860 CC genotype was significantly associated with achievement of SVR(OR = 6.2; 95%CI: 1.2-31.9; P = 0.03).CONCLUSION: The rs12979860 CC genotype was associated with SVR in patients receiving pegylated interferon plus ribavirin, however, the SVR rate in other rs12979860 genotypes was also relatively high.
基金Item Sponsored by French Research National Agency (ANR) Through "Efficacite Energetique et Reduction des Emissions de CO_2 Dans les Systemes Industriels" Program(Project ISIS n°ANR-09-EESI-004)
文摘The Energy Climate Package is the EU response to the Global Warming Challenge.Induction heating processes can contribute to the energy saving goal:20%saving within 2020.European induction manufacturer already propose many efficient solutions at industrial scale.To improve induction devices for an always better energy efficiency, EDF R&D set up a French cooperative project called ISIS with a financial support of the French National Research Agency.Its objective is to promote induction heating as Best Available Technology(BAT)and to develop innovative solutions to increase its efficiency.The ISIS innovations concern the electroheat conversion of induction devices(auto-adaptive multi-coil power supply,low losses coils)and the recovering of fatally lost energy.This paper shows the mid-term results of this project.Firsts control algorithms were successfully tested on a 100 kW 3-coil power supply.A homogenization technique is proposed to model a multi-strand coil.A heat recovery test bench is build and equipped with a PFC control loop to fit with the production fluctuations.
基金supported by the ORCHYD project,an EU Horizon 2020 research and innovation programme under grant agreement N101006752.
文摘The EU H2020 ORCHYD project seeks to enhance drilling efficiency in hard rock environments,particularly for deep geothermal wells,by integrating innovative rock weakening techniques.In this context,3D finite element simulations of bit-rock interactions were performed to assess how combining high pressure water jetting(HPWJ)-induced groove and bottom-hole geometry can contribute to improve the down-hole percussive drilling performance.A Red Bohus granite rock was modelled using a continuum,elasto-visco-plastic,and damage-based model calibrated using Brazilian,uniaxial compression,and triaxial material tests as well as single insert impact tests.Bit-rock interaction with an HPWJ groove was studied through modelling of twelve different groove depths and bottom-hole configurations.Results demonstrate that deeper grooves significantly reduce impact loads by up to 35%and increase penetration up to 40%,leading to higher material removal(up to 240%).Groove depth also influences damage propagation between adjacent indents,with grooves facilitating a broader zone of fractured rock,particularly near the groove itself.Notably,the drilling efficiency benefits from HPWJ slotting are highly dependent on bit design:flat and concave bit profiles exhibit 70%greater improvement in drilling performance compared to other profiles.
