The aim of the present work was to investigate the exposure to the medical and industrial toxic chemicals. The research was carried out on hair, nail and blood samples in a panel of 40 healthy volunteers aged 7 to 77 ...The aim of the present work was to investigate the exposure to the medical and industrial toxic chemicals. The research was carried out on hair, nail and blood samples in a panel of 40 healthy volunteers aged 7 to 77 with an average of 45 ± 19 years (18 women (45%) and 22 men (55%)). All of these individuals had not received medication for at least 1 year, including antibiotics and psychotropic. This study was realized from July 2013 to March 2014 in Beijing, China. The method for an accurate and reliable screening of medical and an industrial toxic chemical was based on detection and assay by ultra-high performance liquid chromatography with UV detection type of diode arrays. Also more than 10,000 toxic molecules commonly found in western industrial countries were screened by coupling gas chromatography and mass spectrometry. The main results indicate that the molecules analyzed are mainly antibiotic (Gentamycine and Tobramycine), antidepressant (Amitriptylin and its metabolites), narcotic (MDMA and Clonitazene), ingredient in cosmetics (Benzenediol and Benzoic acid), insecticide (Carbamate derivative), ketamine, chlorhexidine and phthalate derivatives. There are no detailed documented baseline data of the analysis of medical and Industrial toxic pollutants in hair, nail and blood samples in Beijing;however, this study should be completed on samples from other provinces of China. This study is the first of its kind. Therefore, further studies should be conducted in other cities and provinces of China to be compared with each other.展开更多
Chlormequat is a quaternary ammonium and choline chlorinated derivated is used as plant growth regulating agent. There are very few documented cases of poisoning in humans. We reported a case of non-fatal suicide atte...Chlormequat is a quaternary ammonium and choline chlorinated derivated is used as plant growth regulating agent. There are very few documented cases of poisoning in humans. We reported a case of non-fatal suicide attempt by chlormequat in France. A 34-year-old woman was admitted to hospital after deliberate consumption of plant growth regulator, C5 SUN, containing chlormequat chloride (460 g/L) and choline chloride (320 g/L). Immediately, she developed symptoms of respiratory distress and a cardiac massage was begun by her father. In this case report, we described the method for an accurate and reliable screening of chlormequat which was based on the combination of Target Analysis powerful software and a high performance TOF-MS (Impact HD from Bruker). After forced diuresis, the kinetic of elimination of chlormequat is biphasic: vascular phase diffusion (half-life of 5.6 hr) followed by a phase of free elimination (half-life of 16.2 h). Although chlormequat poisoning is clinically similar to that observed with anticholinesterase compounds, chlormequat chloride is not an acetylcholinesterase inhibitor. Chlormequat seems to be a weak substrat competitor for cholinesterase leading to acetylcholine accumulation and prolonged depolarization in muscular junction. Cardiac massage, artificial respiration and forced diuresis have significantly improved the prognosis of our patient.展开更多
In this prospective study, we evaluated the use of PCT when collecting the body which was carried out. The chosen cut-off was set at 10 ng/mL because at this level, the PCT was associated to a multiorgan failure attri...In this prospective study, we evaluated the use of PCT when collecting the body which was carried out. The chosen cut-off was set at 10 ng/mL because at this level, the PCT was associated to a multiorgan failure attributable to a septic shock.For 90 cases, two groups were stratified by their final diagnosis: 33 of for non violent deaths and 57 of violent deaths. There was no significant elevation of procalcitonin rate (PCT) in the group of violent deaths. We noted 6 elevations of PCT rate above 10 ng/mL for non violent deaths (15.4%) and in 3 cases there wasan evidence for an infectious context (recent anti- infectious treatments, chemotherapy in progress).Control of CRP performed on blood samples found initial elevations above 10 mg/L in 3 of the 6 cases (including 2 of 3 cases associated with an infectious context). There is no evidence of PCT rate increase for intermediate PMI (post mortem interval), long PMI and undefined PMI. This study found a PPV (positive predictive value) and clinical specificity of 100% for a cut-off set at 10 ng/mL. By taking this threshold, no significant PCT increase was observed in presence of death cases related to a violent origin as well as a fatal multiorgan failure due to malignant hyperthermia syndrome induced by neuroleptic use. The PCT appears to remain stable over time and whatever the conservation conditions of the body.展开更多
文摘The aim of the present work was to investigate the exposure to the medical and industrial toxic chemicals. The research was carried out on hair, nail and blood samples in a panel of 40 healthy volunteers aged 7 to 77 with an average of 45 ± 19 years (18 women (45%) and 22 men (55%)). All of these individuals had not received medication for at least 1 year, including antibiotics and psychotropic. This study was realized from July 2013 to March 2014 in Beijing, China. The method for an accurate and reliable screening of medical and an industrial toxic chemical was based on detection and assay by ultra-high performance liquid chromatography with UV detection type of diode arrays. Also more than 10,000 toxic molecules commonly found in western industrial countries were screened by coupling gas chromatography and mass spectrometry. The main results indicate that the molecules analyzed are mainly antibiotic (Gentamycine and Tobramycine), antidepressant (Amitriptylin and its metabolites), narcotic (MDMA and Clonitazene), ingredient in cosmetics (Benzenediol and Benzoic acid), insecticide (Carbamate derivative), ketamine, chlorhexidine and phthalate derivatives. There are no detailed documented baseline data of the analysis of medical and Industrial toxic pollutants in hair, nail and blood samples in Beijing;however, this study should be completed on samples from other provinces of China. This study is the first of its kind. Therefore, further studies should be conducted in other cities and provinces of China to be compared with each other.
文摘Chlormequat is a quaternary ammonium and choline chlorinated derivated is used as plant growth regulating agent. There are very few documented cases of poisoning in humans. We reported a case of non-fatal suicide attempt by chlormequat in France. A 34-year-old woman was admitted to hospital after deliberate consumption of plant growth regulator, C5 SUN, containing chlormequat chloride (460 g/L) and choline chloride (320 g/L). Immediately, she developed symptoms of respiratory distress and a cardiac massage was begun by her father. In this case report, we described the method for an accurate and reliable screening of chlormequat which was based on the combination of Target Analysis powerful software and a high performance TOF-MS (Impact HD from Bruker). After forced diuresis, the kinetic of elimination of chlormequat is biphasic: vascular phase diffusion (half-life of 5.6 hr) followed by a phase of free elimination (half-life of 16.2 h). Although chlormequat poisoning is clinically similar to that observed with anticholinesterase compounds, chlormequat chloride is not an acetylcholinesterase inhibitor. Chlormequat seems to be a weak substrat competitor for cholinesterase leading to acetylcholine accumulation and prolonged depolarization in muscular junction. Cardiac massage, artificial respiration and forced diuresis have significantly improved the prognosis of our patient.
文摘In this prospective study, we evaluated the use of PCT when collecting the body which was carried out. The chosen cut-off was set at 10 ng/mL because at this level, the PCT was associated to a multiorgan failure attributable to a septic shock.For 90 cases, two groups were stratified by their final diagnosis: 33 of for non violent deaths and 57 of violent deaths. There was no significant elevation of procalcitonin rate (PCT) in the group of violent deaths. We noted 6 elevations of PCT rate above 10 ng/mL for non violent deaths (15.4%) and in 3 cases there wasan evidence for an infectious context (recent anti- infectious treatments, chemotherapy in progress).Control of CRP performed on blood samples found initial elevations above 10 mg/L in 3 of the 6 cases (including 2 of 3 cases associated with an infectious context). There is no evidence of PCT rate increase for intermediate PMI (post mortem interval), long PMI and undefined PMI. This study found a PPV (positive predictive value) and clinical specificity of 100% for a cut-off set at 10 ng/mL. By taking this threshold, no significant PCT increase was observed in presence of death cases related to a violent origin as well as a fatal multiorgan failure due to malignant hyperthermia syndrome induced by neuroleptic use. The PCT appears to remain stable over time and whatever the conservation conditions of the body.
