Ribavirin has been used in urgency to treat SARS patients recently.In order to study its antiviral mechanism by photolabeling approach,we have synthesized and characterized 5-azido-1-β-D-ribofuranosyl-1,2,4-triazole-...Ribavirin has been used in urgency to treat SARS patients recently.In order to study its antiviral mechanism by photolabeling approach,we have synthesized and characterized 5-azido-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxiamide 1 as a photolabeling probe of ribavirin.The azidotriazole nucleoside showed rapid and clean photochemical reaction,suggesting that l is a promising probe to study the antiviral mechanism of ribarivin by photolabeling.展开更多
We synthesized and characterized photoactivatable phospholipidic probes 1-3.These probes have the perfluorinated aryl azide function at the polar head of phospholipid.They are stable in dark and become highly reactive...We synthesized and characterized photoactivatable phospholipidic probes 1-3.These probes have the perfluorinated aryl azide function at the polar head of phospholipid.They are stable in dark and become highly reactive upon photoirradiation.The preliminary results suggest that they are promising tools to study the topology of membrane proteins and protein-lipid interactions using photolabeling approach.展开更多
基金Financial support from Wuhan University,Cheung Kong Scholar Foundation and the CNRS is gratefully acknowledged
文摘Ribavirin has been used in urgency to treat SARS patients recently.In order to study its antiviral mechanism by photolabeling approach,we have synthesized and characterized 5-azido-1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxiamide 1 as a photolabeling probe of ribavirin.The azidotriazole nucleoside showed rapid and clean photochemical reaction,suggesting that l is a promising probe to study the antiviral mechanism of ribarivin by photolabeling.
基金support from the National KeyProject for Basic Research 2003CB114400the Hi-Tech Research and Development Program of China No.2003AA2Z3506,Wuhan University and the CNRS is gratefully acknowledged.
文摘We synthesized and characterized photoactivatable phospholipidic probes 1-3.These probes have the perfluorinated aryl azide function at the polar head of phospholipid.They are stable in dark and become highly reactive upon photoirradiation.The preliminary results suggest that they are promising tools to study the topology of membrane proteins and protein-lipid interactions using photolabeling approach.
