With the rapid development of science and technology,the minimally invasive surgery(MIS)has become a reality.MIS is associated with less pain,a shorter hospital stay and fewer complications.The higher-quality minimall...With the rapid development of science and technology,the minimally invasive surgery(MIS)has become a reality.MIS is associated with less pain,a shorter hospital stay and fewer complications.The higher-quality minimally invasive instruments allow the surgeons to perform the surgical interventions efficiently without sacrificing patient safety.Therefore,the academic research,technology development,achievement transformation as well as clinical application of minimally invasive devices is extremely important。展开更多
Worldwide interest has increasingly focused on the sustainable utilization of landscape as a resource in urban areas,emphasizing its ecological,cultural and social significance.This study examines Guilin City,China,as...Worldwide interest has increasingly focused on the sustainable utilization of landscape as a resource in urban areas,emphasizing its ecological,cultural and social significance.This study examines Guilin City,China,as a representative case study due to its rich landscape resources and status as a national innovation demonstration zone for implementing the 2030 Agenda for Sustainable Development.This study uses bibliometric visualization tools like CiteSpace and VOSviewer to analyze research trends from 1980 to 2021 in the Chinese Academic Journal Network Publishing Database(CNKI).The results show increasing academic interest over three stages:initiation(1982-1997),exploration(1998-2004),and diversified development(2005-2021).Contributions are predominantly from local academic and tourism sectors,indicating a strong regional influence;however,relatively weak interinstitutional collaboration occurs,suggesting potential for more integrated research efforts.Primary research is also concentrated within economic disciplines,particularly tourism-related ones.The evolution of research frontiers reveals three main paths:urban development strategies,industrial economic theories and empirical validation,and ecosystem analysis and evaluation.A multidisciplinary approach and stronger collaborative efforts are crucial to enhance research on ecological values and empirical models while supporting evidence-based urban development strategies in Guilin City and comparable cities globally.展开更多
Concurrent Engineering (CE) is an effective way for enterprises to reengineer the product development processes and to improve the product development abilities. In this paper, the existing status of product developme...Concurrent Engineering (CE) is an effective way for enterprises to reengineer the product development processes and to improve the product development abilities. In this paper, the existing status of product development in Chinese manufacturing industry is analyzed, and the requirements of manufacturing technology for them are investigated. An overview of our CE R&D work is introduced, including product modeling, DFA, DFM, QFD, PDM, and other enabling technologies. A case study of the CE pilot project is discussed. The industrial implementation and application in Chinese enterprises are summarized.展开更多
Magnesium(Mg)and its alloys have been identified as one of the most promising structural,energy and biomaterials owing to their exceptional combination of properties.These include low density,high specific strength,go...Magnesium(Mg)and its alloys have been identified as one of the most promising structural,energy and biomaterials owing to their exceptional combination of properties.These include low density,high specific strength,good damping,high castability,high capacity of hydrogen storage。展开更多
Research on magnesium(Mg) alloys still remains a prominent and expanding field in recent years. The Web of Science Core Collection database documented 4898 published articles on the topic, highlighting a sustained and...Research on magnesium(Mg) alloys still remains a prominent and expanding field in recent years. The Web of Science Core Collection database documented 4898 published articles on the topic, highlighting a sustained and growing interest. Statistical analysis of the literature reveals a consistent focus on microstructures, mechanical and corrosion properties. Significant progress has also been made in the manufacture of large-scale Mg alloy components. Meanwhile, steady advancements have been achieved in functional magnesium materials, magnesiumbased hydrogen storage, and magnesium-ion batteries, with magnesium-based Energy Storage Mater. moving closer to commercial applications.Notably, the year 2024 marks a breakthrough in artificial intelligence, and the integration of big data and artificial intelligence is expected to significantly accelerate the research and development of magnesium alloy materials. Furthermore, the decline in primary magnesium prices in 2024 has triggered a new wave of research and large-scale commercial applications. Concurrently, there is growing interest in their use in emerging industries such as unmanned aerial vehicles and robotics. With continuous improvements and diversification in performance, the applications of magnesium alloys have expanded significantly in 2024, encompassing satellite components, integrated automotive structures,magnesium alloy formwork, and biomedical materials. This paper provides a comprehensive review of the current state of development and key research challenges in the field of Mg alloys as of 2024, and also outlines potential future directions for research and application.展开更多
The development of chemical technologies,which involves a multistage process covering laboratory research,scale‐up to industrial deployment,and necessitates interdisciplinary collaboration,is often accompanied by sub...The development of chemical technologies,which involves a multistage process covering laboratory research,scale‐up to industrial deployment,and necessitates interdisciplinary collaboration,is often accompanied by substantial time and economic costs.To address these challenges,in this work,we report ChemELLM,a domain‐specific large language model(LLM)with 70 billion parameters for chemical engineering.ChemELLM demonstrates state‐of‐the‐art performance across critical tasks ranging from foundational understanding to professional problem‐solving.It outperforms mainstream LLMs(e.g.,O1‐Preview,GPT‐4o,and DeepSeek‐R1)on ChemEBench,the first multidimensional benchmark for chemical engineering,which encompasses 15 dimensions across 101 distinct essential tasks.To support robust model development,we curated ChemEData,a purpose‐built dataset containing 19 billion tokens for pre‐training and 1 billion tokens for fine‐tuning.This work establishes a new paradigm for artificial intelligence‐driven innovation,bridging the gap between laboratory‐scale innovation and industrial‐scale implementation,thus accelerating technological advancement in chemical engineering.ChemELLM is publicly available at https://chemindustry.iflytek.com/chat.展开更多
Carbon dioxide(CO_(2))can be efficiently converted and utilized through the CO_(2) methanation reaction,which has significant potential benefits for the environment and the economy.The contradiction between the thermo...Carbon dioxide(CO_(2))can be efficiently converted and utilized through the CO_(2) methanation reaction,which has significant potential benefits for the environment and the economy.The contradiction between the thermodynamics and kinetics of the CO_(2) methanation reaction process leads to low CO_(2) conversion at 200-350℃and low methane selectivity at 350-500℃.The utilization of catalysts can solve the contradiction between kinetics and thermodynamics,achieving high CO_(2) methanation efficiency at low temperatures.However,the poor thermal conductivity of powder catalysts leads to the rapid accumulation of heat,resulting in the formation of hot spots,which can cause the sintering or even deactivation of active species.To solve this problem,researchers have focused on monolithic catalysts with integrated reaction systems.This review categorizes the monolithic catalysts into two main groups based on their unique characteristics,namely structured catalysts and catalytic membrane reactors.The characteristics of these monolithic catalysts,commonly used support materials,preparation techniques,and their applications in the CO_(2) methanation reaction are discussed in depth.These studies provide theoretical basis and practical guidance for the design and optimization of structured catalysts and catalytic membrane reactors.Finally,challenges and prospects in the application of monolithic catalysts for the CO_(2) methanation reaction are proposed for the future development.展开更多
In multi-component oil and gas exploration using ocean bottom nodes,converted wave data is rich in lithological and fracture information.One of the urgent problems to be solved is how to construct an accurate shear wa...In multi-component oil and gas exploration using ocean bottom nodes,converted wave data is rich in lithological and fracture information.One of the urgent problems to be solved is how to construct an accurate shear wave velocity model of the shallow sea bottom by leveraging the seismic wave information at the fluid-solid interface in the ocean,and improve the lateral resolution of marine converted wave data.Given that the dispersion characteristics of surface waves are sensitive to the S-wave velocity of subsurface media,and that Scholte surface waves,which propagate at the interface between liquid and solid media,exist in the data of marine oil and gas exploration,this paper proposes a Scholte wave inversion and modeling method based on oil and gas exploration using ocean bottom nodes.By using the method for calculating the Scholte wave dispersion spectrum based on the Bessel kernel function,the accuracy of dispersion spectrum analysis is improved,and more accurate dispersion curves are picked up.Through the adaptive weighted least squares Scholte wave dispersion inversion algorithm,the Scholte wave dispersion equation for liquid-solid media is solved,and the shear wave velocity model of the shallow sea bottom is calculated.Theoretical tests and applications of realdata have proven that this method can significantly improve the lateral resolution of converted wave data,provide high-quality data for subsequent inversion of marine multi-component oil and gas exploration data and reservoir reflection information,and contribute to the development of marine oil and gas exploration technology.展开更多
Chiral N-substituted amino amides and esters are ubiquitous scaffolds in pesticides and pharmaceutical chemicals,but their asymmetric synthesis remains challenging especially for those with multiple chiral centers.In ...Chiral N-substituted amino amides and esters are ubiquitous scaffolds in pesticides and pharmaceutical chemicals,but their asymmetric synthesis remains challenging especially for those with multiple chiral centers.In this study,IR104 from Streptomyces aureocirculatus was identified from 157 wild-type imine reductases for the synthesis of(S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide(antiepileptic drug Brivaracetam)via dynamic kinetic resolution reductive amination from ethyl 3-formylhexanoate and(S)-2-aminobutylamide with high diastereoselectivity.To further improve the catalytic efficiency of IR104,its mutant D191E/L195I/E253S/M258A(M3)was identified by saturation mutagenesis and iterative combinatorial mutagenesis,which exhibited a 102-fold increase in the catalytic efficiency relative to that of wild-type enzyme and high diastereoselectivity(98:2 d.r.).Crystal structural analysis and molecular dynamics simulations provided some insights into the molecular basis for the improved activity of the mutant enzyme.The imine reductase identified in this study could accept chiral amino amides/esters as amino donors for the dynamic kinetic resolution reductive amination of racemicα-substituted aldehydo-esters,expanding the substrate scope of imine reductases in the dynamic kinetic resolution-reductive amination.Finally,IR104-M3 was successfully used for the preparation of Brivaracetam at gram scale.Using this mutant,various N-substituted amino amides/esters with two chiral centers were also synthesized with up to 99:1 d.r.and 96%yields and subsequently converted intoγ-andδ-lactams,providing an efficient protocol for the synthesis of these important compounds via enzymatic dynamic kinetic resolution-reductive amination from simple building blocks.展开更多
For a large-scale dynamic system,the efficiency of computation becomes a vital work sometimes in engineering practices.As a layered structural system,ballastless track and substructure occupy most part of the degrees ...For a large-scale dynamic system,the efficiency of computation becomes a vital work sometimes in engineering practices.As a layered structural system,ballastless track and substructure occupy most part of the degrees of freedom of the whole system.It is,therefore,rather important to optimize the structural models in dynamic equation formulations.In this work,a three-dimensional and coupled model for multi-rigid-body of train and finite elements of track and substructures is pre-sented by multi-scale assemble and matrix reassemble method.The matrix reassembling tactic is based on the multi-scale assemble method,through which the finite element matrix bandwidth is greatly narrowed,and the Cholesky factorization,iterative and multi-time-step solution have been introduced to efficiently obtain the train,track and substructure responses.The subgrade and its subsoil works as a typical substructural system,and comparisons with the previous model without matrix reassembling,SIMPACK and ABAQUS have been conducted to fully validate the efficiency and accuracy of this train-track-subgrade dynamic interaction model.展开更多
Silicon-based anode is a promising candidate for all-solid-state batteries(ASSBs).However,it must be further improved because of its tremendous volume change.In this study,various interface treatment strategies for Si...Silicon-based anode is a promising candidate for all-solid-state batteries(ASSBs).However,it must be further improved because of its tremendous volume change.In this study,various interface treatment strategies for SiO/carbon composite anodes in ASSBs were investigated using a multiphysics modeling framework.By evaluating the effects of active(carbon)and inactive coating materials,as well as the geometric and mechanical parameters,this research provides critical insights into optimizing their electrochemical performance and mechanical stability.Computational results indicate that carbon coatings can greatly enhance lithiation kinetics by regulating the interfacial electrochemical potential gradients,reducing the residual lithium concentration,and homogenizing the lithium-ion distribution compared with uncoated or inactive-coated configurations.In addition,thinner carbon coatings further improve capacity retention and stress management by balancing shorter lithium diffusion pathways with mitigated interfacial stress accumulation.Despite their ability to mechanically stabilize the anode,inactive coatings exhibit tradeoffs between lithium transport kinetics and stress modulation,with optimal performance achieved at lower Young’s moduli.Mechanical analyses highlight distinct failure mechanisms at the anode–electrolyte(shear driven)and particle-coating(tension driven)interfaces,emphasizing the need for tailored adhesion strategies.These findings provide actionable guidelines for designing robust SiO-based anodes,emphasizing the interplay among electrochemical efficiency,stress regulation,and interfacial durability in ASSBs.展开更多
While early transition metal-based materials,such as MXene,has emerged as an efficient catalyst for the Mg-based hydrogen storage materials,their strong interaction with hydrogen resulted in the high hydrogen diffusio...While early transition metal-based materials,such as MXene,has emerged as an efficient catalyst for the Mg-based hydrogen storage materials,their strong interaction with hydrogen resulted in the high hydrogen diffusion barrier,hindering further improvement of catalytic activity.A MXene is characterized by rich anionic groups on its surface,significantly affecting electronic and catalytic functionalities.Using Nb_(2)CT_(x)as an example,we herein illustrate the critical role of anionic T_(x)defects on controlling hydrogen dissociation and diffusion processes in Mg-based hydrogen storage materials.The hydrogen desorption properties of MgH_(2)can be significantly enhanced by utilizing T_(x)controllable Nb_(2)CT_(x),and it can release 3.57 wt.%hydrogen within 10 min under 240℃with the reduced dehydrogenation activation barrier.It also realized stable de/hydrogenation reactions for at least 50 cycles.DFT studies combined with kinetic analysis revealed that the catalyst‒hydrogen interaction could be systematically controlled by optimizing surface T_(x)defect density,accelerating the hydrogen dissociation and diffusion processes at the same time.These results demonstrate that the T_(x)defects serve as the effective catalytically active centers of Nb_(2)CT_(x),offering a flexible catalyst design guideline.展开更多
Fish swimming hydrodynamics serves as a critical foundation for aquatic ecological conservation,with recent research extending from 2D to 3D perspectives.This study employs 3D high-fidelity modeling with dynamic mesh ...Fish swimming hydrodynamics serves as a critical foundation for aquatic ecological conservation,with recent research extending from 2D to 3D perspectives.This study employs 3D high-fidelity modeling with dynamic mesh technology to investigate how cylindrical obstacles at varying positions affect Carassius auratus locomotion.Analysis of nine configurations reveals bidirectional flow interactions between fish and cylinders,with cylinder wake influence persisting at 1-2 times the total length intervals but diminishing at 3times.Compared with swimming in uniform flow,the mechanical benefit of C.auratus located 2 times the total length directly behind the cylinder is the largest,and its value reaches 4.19 times.Wavelet analysis of 30-cycle mechanical data demonstrates closer intervals enhance benefit magnitude,whereas greater distances accelerate benefit realization.These 3D computational findings corroborate 2D studies while providing new spatial interaction insights,offering theoretical foundations for fish conservation strategies related to hydraulic structures.展开更多
Casing deformation is a widespread problem in a certain block of Jiaoshiba Shale Gas Field in Sichuan Basin,China,and it severely limits the development benefits of shale gas in that block.Based on the spatiotemporal ...Casing deformation is a widespread problem in a certain block of Jiaoshiba Shale Gas Field in Sichuan Basin,China,and it severely limits the development benefits of shale gas in that block.Based on the spatiotemporal characteristics of block formation,fracture development,and casing deformation occurrence,this paper employs an integrated geological—engineering research approach to identify the primary mechanisms governing casing deformation within the block and proposes countermeasures to prevent such deformation.The present research indicates the following findings:(1)The block has undergone multiple phases of tectonic superposition,with fracture development serving as the geological factor causing casing deformation.(2)Fracturing activation constitutes the engineering factor causing casing deformation,with 4 mm of formation slip inducing deformation.(3)The fracture activation risk map shows that Class Ⅰ and Class Ⅱ fractures account for 73.36%of the total recorded in the block.Within the most susceptible Class I risk zone,the critical activation pressure increment for fracturing operations ranges from 13.43 MPa to 13.99 MPa.Based on the distribution of casing failure risk zones identified in the fracture activation risk map,this paper proposes relevant technical countermeasures for preventing casing failure from three perspectives:shale gas well location deployment,drilling techniques,and fracturing techniques.These measures provide robust support for safeguarding the integrity of casing systems within the studied block.展开更多
Lead zirconate titanate(PbZr_(x)Ti_(1-x)O_(3),PZT)ferroelectric films possess remarkable characteristics such as high residual polarization,high dielectric constant,and high piezoelectric coefficient and have great ap...Lead zirconate titanate(PbZr_(x)Ti_(1-x)O_(3),PZT)ferroelectric films possess remarkable characteristics such as high residual polarization,high dielectric constant,and high piezoelectric coefficient and have great application prospects in modern electronics,communications,medical care,and military fields.At present,the microstructure changes of PZT ferroelectric thin films have a significant impact on their electrical properties.Therefore,this work summarizes the influences of geometric structure(thickness,porosity),composition structure(Zr/Ti ratio,doping),and grain structure(grain size,grain boundaries,orientation)on the electrical properties of PZT ferroelectric thin films.The results show that the changes in thickness and porosity have a significant impact on the electrical properties of PZT ferroelectric films.Especially,the actual application scenarios and preparation processes determine the required geometric dimensions and structures of PZT ferroelectric films.The Zr/Ti ratio and doping mainly affect the electrical properties by influencing the phase composition of PZT ferroelectric films.The changes in grain size,boundary structure,and orientation dependence mainly have a certain degree of influence on the domain response and domain switching behavior of PZT ferroelectric thin films.In conclusion,different structures have different influence effects on the dielectric,ferroelectric,and piezoelectric properties of PZT ferroelectric films.The way the tiny structure affects how PZT thin films work was shown,helping to guide the design of ferroelectric thin film devices.In order to further study and apply piezoelectric ceramic devices,it is crucial to have an in-depth understanding of the relationship between the structure and performance of piezoelectric ceramic devices.展开更多
Despite the promising potential of organic nanoscintillator-mediated radiodynamic therapy(RDT)in enhancing the effectiveness of immunotherapy,their cutaneous phototoxicity exacerbates the risk for immune-related adver...Despite the promising potential of organic nanoscintillator-mediated radiodynamic therapy(RDT)in enhancing the effectiveness of immunotherapy,their cutaneous phototoxicity exacerbates the risk for immune-related adverse events(irAEs).Herein,we demonstrate that organic nanoscintillators,when combined with checkpoint blockade immunotherapy and exposed to X-ray-induced RDT,can trigger cutaneous irAEs.To address this challenge,we engineered diselenide-bridged silicon coatings on organic nanoscintillators,fine-tuning the steric hindrance of the protective layer by varying its thickness.This strategy enables radiation-triggered reactive oxygen species(ROS)generation while mitigating off-target phototoxicity through neutralizing ROS.By optimizing the steric hindrance to precisely control energy transfer between the organic nanoscintillators and surrounding oxygen molecules,we effectively reduce phototoxicity and mitigate off-tumor effects through engineered surface protection.Under X-ray irradiation exposure,the steric hindrance is rapidly deactivated through the dissociation of the silicon coating,activating RDT and inducing abundant ROS generation within tumor cells.In an orthotopic 4T1 breast cancer model,intravenous administration of these surface-engineered nanoscintillators,combined with anti-programmed death-1(anti-PD-1)antibodies,results in robust anti-tumor immune responses,while minimizing cutaneous irAEs.This work offers valuable insights into how surface engineering can modulate the delicate balance between anti-tumor efficacy and off-tumor toxicity in nanoscintillator-mediated RDT.展开更多
Devising S-scheme heterostructure is considered as a cutting-edge strategy for advanced photocatalysts with effectively segregated photo-carriers and prominent redox potential for emerging organic pollutants control.H...Devising S-scheme heterostructure is considered as a cutting-edge strategy for advanced photocatalysts with effectively segregated photo-carriers and prominent redox potential for emerging organic pollutants control.Herein,an S-scheme Ag_(2)CO_(3)/C_(3)N_(5) heterojunction photocatalyst was developed via a simple in situ chemical deposition procedure,and further photoreduction operation made metallic Ag(size:3.5–12.5 nm)being in situ formed on Ag_(2)CO_(3)/C_(3)N_(5) for a plasmonic S-scheme Ag/Ag_(2)CO_(3)/C_(3)N_(5) heterojunction photocatalyst.Consequently,Ag/Ag_(2)CO_(3)/C_(3)N_(5) manifests pronouncedly upgraded photocatalytic performance toward oxytetracycline degradation with a superior photoreaction rate constant of 0.0475 min‒1,which is 13.2,3.9 and 2.2 folds that of C_(3)N_(5),Ag_(2)CO_(3),and Ag_(2)CO_(3)/C_(3)N_(5),respectively.As evidenced by comprehensive characterizations and density functional theory calculations,the localized surface plasmon resonance effect of metallic Ag and the unique S-scheme charge transfer mechanism in 0D/0D/2D Ag/Ag_(2)CO_(3)/C_(3)N_(5) collaboratively strengthen the visible-light absorption,and facilitate the effective separation of powerful charge carriers,thereby significantly promoting the generation of reactive species like·OH^(-),h^(+)and·O_(2)^(-)for efficient oxytetracycline destruction.Moreover,four consecutive cycles demonstrate the reusability of Ag/Ag_(2)CO_(3)/C_(3)N_(5).Furthermore,the authentic water purification tests affirm its practical application potential.This work not only provides a candidate strategy for advancing S-scheme heterojunction photocatalysts but also makes a certain contribution to water decontamination.展开更多
Heparin,a glycosaminoglycan,is a stable source of carbon that supports the growth of microorganisms in the human intestine.It is also a commonly used anticoagulant drug in clinical practice,with significant therapeuti...Heparin,a glycosaminoglycan,is a stable source of carbon that supports the growth of microorganisms in the human intestine.It is also a commonly used anticoagulant drug in clinical practice,with significant therapeutic effects.Low molecular weight heparin(LMWH)is a highly active low molecular weight fragment obtained via enzymatic reaction or the chemical degradation of heparin.LMWH has been applied globally in the prevention and treatment of venous thromboembolism in thrombosis patients.Simultaneously,as a potential prebiotic,because of its low molecular weight,LMWH can be well degraded by the gut microbiota to maintain intestinal balance.Enzymatic heparin degradation has recently emerged as a viable disposal method for LMWH preparation;however,only very few benchmark enzymes have been thoroughly described and subjected to protein engineering to improve their properties over the past few years.The commercialization of enzymes will require the development of robustly engineered enzymes that meet the demands of industrial processes.Herein,we report a rational protein engineering strategy that includes molecular dynamic simulations of flexible amino acid mutations and disulfide bond screening.Several Bacteroides thetaiotaomicron heparanase I(Bt-HepI)mutants were obtained and screened for high thermal stability.We obtained the Bt-HepI^(D204C/K208C/H189W/Q198R)variant,which features a stabilized protein surface structure,with a 1.3-fold increase in catalytic constant/michaelis-menten constant(k_(cat)/K_(m)),a 2.44-fold increase in thermal stability at 50℃,and a 1.8-fold decrease in the average molecular weight of LMWH produced at 40℃compared with that seen with Bt-HepI^(WT).Our study establishes a strategy to engineer thermostable HepI to underpin its industrial applications.展开更多
Up-conversion(UC)luminescent materials doped with Ln^(3+)ions possess excellent optical properties and extensive applications in the formulation of multifunctional fluorescence ink.Printing technology offers various m...Up-conversion(UC)luminescent materials doped with Ln^(3+)ions possess excellent optical properties and extensive applications in the formulation of multifunctional fluorescence ink.Printing technology offers various methods for the preparation of UC fluorescent inks.This study introduced the optical properties of luminescent materials doped with Ln^(3+)ions,including luminescence characteristics and spectral characteristics,which provide a basis for the subsequent printing process.We also reviewed different printing techniques,including direct writing,screen printing,laser printing,inkjet printing,and aerosol jet printing(AJP),developed so far in the literature and explored the printing process of ink characteristics.However,the printing process of inks was explored and their potential for various applications was maximized.Therefore,the printing technology of UC fluorescent inks still faces challenges in different aspects.This review also points out the direction for future in-depth research,which is expected to promote further development and innovation in the field.展开更多
The uplift resistance of the soil overlying shield tunnels significantly impacts their anti-floating stability.However,research on uplift resistance concerning special-shaped shield tunnels is limited.This study combi...The uplift resistance of the soil overlying shield tunnels significantly impacts their anti-floating stability.However,research on uplift resistance concerning special-shaped shield tunnels is limited.This study combines numerical simulation with machine learning techniques to explore this issue.It presents a summary of special-shaped tunnel geometries and introduces a shape coefficient.Through the finite element software,Plaxis3D,the study simulates six key parameters—shape coefficient,burial depth ratio,tunnel’s longest horizontal length,internal friction angle,cohesion,and soil submerged bulk density—that impact uplift resistance across different conditions.Employing XGBoost and ANN methods,the feature importance of each parameter was analyzed based on the numerical simulation results.The findings demonstrate that a tunnel shape more closely resembling a circle leads to reduced uplift resistance in the overlying soil,whereas other parameters exhibit the contrary effects.Furthermore,the study reveals a diminishing trend in the feature importance of buried depth ratio,internal friction angle,tunnel longest horizontal length,cohesion,soil submerged bulk density,and shape coefficient in influencing uplift resistance.展开更多
文摘With the rapid development of science and technology,the minimally invasive surgery(MIS)has become a reality.MIS is associated with less pain,a shorter hospital stay and fewer complications.The higher-quality minimally invasive instruments allow the surgeons to perform the surgical interventions efficiently without sacrificing patient safety.Therefore,the academic research,technology development,achievement transformation as well as clinical application of minimally invasive devices is extremely important。
基金supported by the National Key Research and Development Program of China under the theme“Research on urban sustainable development interactive decision-making and management technologies”[Grant No.2022YFC3802904].
文摘Worldwide interest has increasingly focused on the sustainable utilization of landscape as a resource in urban areas,emphasizing its ecological,cultural and social significance.This study examines Guilin City,China,as a representative case study due to its rich landscape resources and status as a national innovation demonstration zone for implementing the 2030 Agenda for Sustainable Development.This study uses bibliometric visualization tools like CiteSpace and VOSviewer to analyze research trends from 1980 to 2021 in the Chinese Academic Journal Network Publishing Database(CNKI).The results show increasing academic interest over three stages:initiation(1982-1997),exploration(1998-2004),and diversified development(2005-2021).Contributions are predominantly from local academic and tourism sectors,indicating a strong regional influence;however,relatively weak interinstitutional collaboration occurs,suggesting potential for more integrated research efforts.Primary research is also concentrated within economic disciplines,particularly tourism-related ones.The evolution of research frontiers reveals three main paths:urban development strategies,industrial economic theories and empirical validation,and ecosystem analysis and evaluation.A multidisciplinary approach and stronger collaborative efforts are crucial to enhance research on ecological values and empirical models while supporting evidence-based urban development strategies in Guilin City and comparable cities globally.
文摘Concurrent Engineering (CE) is an effective way for enterprises to reengineer the product development processes and to improve the product development abilities. In this paper, the existing status of product development in Chinese manufacturing industry is analyzed, and the requirements of manufacturing technology for them are investigated. An overview of our CE R&D work is introduced, including product modeling, DFA, DFM, QFD, PDM, and other enabling technologies. A case study of the CE pilot project is discussed. The industrial implementation and application in Chinese enterprises are summarized.
文摘Magnesium(Mg)and its alloys have been identified as one of the most promising structural,energy and biomaterials owing to their exceptional combination of properties.These include low density,high specific strength,good damping,high castability,high capacity of hydrogen storage。
基金supported by Advanced Materials-National Science and Technology Major Project(No.:2025ZD0619700)National Natural Science Foundation of China(No.:52225101&U24A2035).
文摘Research on magnesium(Mg) alloys still remains a prominent and expanding field in recent years. The Web of Science Core Collection database documented 4898 published articles on the topic, highlighting a sustained and growing interest. Statistical analysis of the literature reveals a consistent focus on microstructures, mechanical and corrosion properties. Significant progress has also been made in the manufacture of large-scale Mg alloy components. Meanwhile, steady advancements have been achieved in functional magnesium materials, magnesiumbased hydrogen storage, and magnesium-ion batteries, with magnesium-based Energy Storage Mater. moving closer to commercial applications.Notably, the year 2024 marks a breakthrough in artificial intelligence, and the integration of big data and artificial intelligence is expected to significantly accelerate the research and development of magnesium alloy materials. Furthermore, the decline in primary magnesium prices in 2024 has triggered a new wave of research and large-scale commercial applications. Concurrently, there is growing interest in their use in emerging industries such as unmanned aerial vehicles and robotics. With continuous improvements and diversification in performance, the applications of magnesium alloys have expanded significantly in 2024, encompassing satellite components, integrated automotive structures,magnesium alloy formwork, and biomedical materials. This paper provides a comprehensive review of the current state of development and key research challenges in the field of Mg alloys as of 2024, and also outlines potential future directions for research and application.
文摘The development of chemical technologies,which involves a multistage process covering laboratory research,scale‐up to industrial deployment,and necessitates interdisciplinary collaboration,is often accompanied by substantial time and economic costs.To address these challenges,in this work,we report ChemELLM,a domain‐specific large language model(LLM)with 70 billion parameters for chemical engineering.ChemELLM demonstrates state‐of‐the‐art performance across critical tasks ranging from foundational understanding to professional problem‐solving.It outperforms mainstream LLMs(e.g.,O1‐Preview,GPT‐4o,and DeepSeek‐R1)on ChemEBench,the first multidimensional benchmark for chemical engineering,which encompasses 15 dimensions across 101 distinct essential tasks.To support robust model development,we curated ChemEData,a purpose‐built dataset containing 19 billion tokens for pre‐training and 1 billion tokens for fine‐tuning.This work establishes a new paradigm for artificial intelligence‐driven innovation,bridging the gap between laboratory‐scale innovation and industrial‐scale implementation,thus accelerating technological advancement in chemical engineering.ChemELLM is publicly available at https://chemindustry.iflytek.com/chat.
基金the National Natural Science Foundation of China(22325804 and 22308148)the Natural Science Foundation of Jiangsu Province(BK20230344)+1 种基金the Natural Science Research Project of Jiangsu University(22KJB610001)the Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB505)。
文摘Carbon dioxide(CO_(2))can be efficiently converted and utilized through the CO_(2) methanation reaction,which has significant potential benefits for the environment and the economy.The contradiction between the thermodynamics and kinetics of the CO_(2) methanation reaction process leads to low CO_(2) conversion at 200-350℃and low methane selectivity at 350-500℃.The utilization of catalysts can solve the contradiction between kinetics and thermodynamics,achieving high CO_(2) methanation efficiency at low temperatures.However,the poor thermal conductivity of powder catalysts leads to the rapid accumulation of heat,resulting in the formation of hot spots,which can cause the sintering or even deactivation of active species.To solve this problem,researchers have focused on monolithic catalysts with integrated reaction systems.This review categorizes the monolithic catalysts into two main groups based on their unique characteristics,namely structured catalysts and catalytic membrane reactors.The characteristics of these monolithic catalysts,commonly used support materials,preparation techniques,and their applications in the CO_(2) methanation reaction are discussed in depth.These studies provide theoretical basis and practical guidance for the design and optimization of structured catalysts and catalytic membrane reactors.Finally,challenges and prospects in the application of monolithic catalysts for the CO_(2) methanation reaction are proposed for the future development.
基金financially supported by the Scientific Research and Technology Development Project of China National Petroleum Corporation(No.2021ZG02)titled"Development of Seismic Data Processing Software for Ocean Nodes(OBN)"。
文摘In multi-component oil and gas exploration using ocean bottom nodes,converted wave data is rich in lithological and fracture information.One of the urgent problems to be solved is how to construct an accurate shear wave velocity model of the shallow sea bottom by leveraging the seismic wave information at the fluid-solid interface in the ocean,and improve the lateral resolution of marine converted wave data.Given that the dispersion characteristics of surface waves are sensitive to the S-wave velocity of subsurface media,and that Scholte surface waves,which propagate at the interface between liquid and solid media,exist in the data of marine oil and gas exploration,this paper proposes a Scholte wave inversion and modeling method based on oil and gas exploration using ocean bottom nodes.By using the method for calculating the Scholte wave dispersion spectrum based on the Bessel kernel function,the accuracy of dispersion spectrum analysis is improved,and more accurate dispersion curves are picked up.Through the adaptive weighted least squares Scholte wave dispersion inversion algorithm,the Scholte wave dispersion equation for liquid-solid media is solved,and the shear wave velocity model of the shallow sea bottom is calculated.Theoretical tests and applications of realdata have proven that this method can significantly improve the lateral resolution of converted wave data,provide high-quality data for subsequent inversion of marine multi-component oil and gas exploration data and reservoir reflection information,and contribute to the development of marine oil and gas exploration technology.
文摘Chiral N-substituted amino amides and esters are ubiquitous scaffolds in pesticides and pharmaceutical chemicals,but their asymmetric synthesis remains challenging especially for those with multiple chiral centers.In this study,IR104 from Streptomyces aureocirculatus was identified from 157 wild-type imine reductases for the synthesis of(S)-2-((R)-2-oxo-4-propylpyrrolidin-1-yl)butanamide(antiepileptic drug Brivaracetam)via dynamic kinetic resolution reductive amination from ethyl 3-formylhexanoate and(S)-2-aminobutylamide with high diastereoselectivity.To further improve the catalytic efficiency of IR104,its mutant D191E/L195I/E253S/M258A(M3)was identified by saturation mutagenesis and iterative combinatorial mutagenesis,which exhibited a 102-fold increase in the catalytic efficiency relative to that of wild-type enzyme and high diastereoselectivity(98:2 d.r.).Crystal structural analysis and molecular dynamics simulations provided some insights into the molecular basis for the improved activity of the mutant enzyme.The imine reductase identified in this study could accept chiral amino amides/esters as amino donors for the dynamic kinetic resolution reductive amination of racemicα-substituted aldehydo-esters,expanding the substrate scope of imine reductases in the dynamic kinetic resolution-reductive amination.Finally,IR104-M3 was successfully used for the preparation of Brivaracetam at gram scale.Using this mutant,various N-substituted amino amides/esters with two chiral centers were also synthesized with up to 99:1 d.r.and 96%yields and subsequently converted intoγ-andδ-lactams,providing an efficient protocol for the synthesis of these important compounds via enzymatic dynamic kinetic resolution-reductive amination from simple building blocks.
基金supported by the National Natural Science Foundation of China(Grant Nos.52378468)Science and Technology Research and Development Program Project of China railway group limited(Major Special Project,No.2022-Major-14,2021-Special-08,2021-Major-02)+3 种基金Young Elite Scientists Sponsorship Program by CAST(2020-2022QNRC002)Central South University Innovation-Driven Research Programme(2023CXQD073)the National Natural Science Foundation of Hunan Province(Grant Nos.2022JJ20071 and 2021JJ30850)National Key R&D Program‘Transportation Infrastructure’‘Reveal the list and take command’project(2022YFB2603301).
文摘For a large-scale dynamic system,the efficiency of computation becomes a vital work sometimes in engineering practices.As a layered structural system,ballastless track and substructure occupy most part of the degrees of freedom of the whole system.It is,therefore,rather important to optimize the structural models in dynamic equation formulations.In this work,a three-dimensional and coupled model for multi-rigid-body of train and finite elements of track and substructures is pre-sented by multi-scale assemble and matrix reassemble method.The matrix reassembling tactic is based on the multi-scale assemble method,through which the finite element matrix bandwidth is greatly narrowed,and the Cholesky factorization,iterative and multi-time-step solution have been introduced to efficiently obtain the train,track and substructure responses.The subgrade and its subsoil works as a typical substructural system,and comparisons with the previous model without matrix reassembling,SIMPACK and ABAQUS have been conducted to fully validate the efficiency and accuracy of this train-track-subgrade dynamic interaction model.
基金supported by the startup funding from Shanghai Jiao Tong University(Grant No.WH220402052).
文摘Silicon-based anode is a promising candidate for all-solid-state batteries(ASSBs).However,it must be further improved because of its tremendous volume change.In this study,various interface treatment strategies for SiO/carbon composite anodes in ASSBs were investigated using a multiphysics modeling framework.By evaluating the effects of active(carbon)and inactive coating materials,as well as the geometric and mechanical parameters,this research provides critical insights into optimizing their electrochemical performance and mechanical stability.Computational results indicate that carbon coatings can greatly enhance lithiation kinetics by regulating the interfacial electrochemical potential gradients,reducing the residual lithium concentration,and homogenizing the lithium-ion distribution compared with uncoated or inactive-coated configurations.In addition,thinner carbon coatings further improve capacity retention and stress management by balancing shorter lithium diffusion pathways with mitigated interfacial stress accumulation.Despite their ability to mechanically stabilize the anode,inactive coatings exhibit tradeoffs between lithium transport kinetics and stress modulation,with optimal performance achieved at lower Young’s moduli.Mechanical analyses highlight distinct failure mechanisms at the anode–electrolyte(shear driven)and particle-coating(tension driven)interfaces,emphasizing the need for tailored adhesion strategies.These findings provide actionable guidelines for designing robust SiO-based anodes,emphasizing the interplay among electrochemical efficiency,stress regulation,and interfacial durability in ASSBs.
基金supported by Liuchuang Program of Chongqing Municipality(cx2022038)the Fundamental Research Funds for the Central Universities(2022CDJQY-013)the Graduate Research and Innovation Foundation of Chongqing,China(CYB22005).
文摘While early transition metal-based materials,such as MXene,has emerged as an efficient catalyst for the Mg-based hydrogen storage materials,their strong interaction with hydrogen resulted in the high hydrogen diffusion barrier,hindering further improvement of catalytic activity.A MXene is characterized by rich anionic groups on its surface,significantly affecting electronic and catalytic functionalities.Using Nb_(2)CT_(x)as an example,we herein illustrate the critical role of anionic T_(x)defects on controlling hydrogen dissociation and diffusion processes in Mg-based hydrogen storage materials.The hydrogen desorption properties of MgH_(2)can be significantly enhanced by utilizing T_(x)controllable Nb_(2)CT_(x),and it can release 3.57 wt.%hydrogen within 10 min under 240℃with the reduced dehydrogenation activation barrier.It also realized stable de/hydrogenation reactions for at least 50 cycles.DFT studies combined with kinetic analysis revealed that the catalyst‒hydrogen interaction could be systematically controlled by optimizing surface T_(x)defect density,accelerating the hydrogen dissociation and diffusion processes at the same time.These results demonstrate that the T_(x)defects serve as the effective catalytically active centers of Nb_(2)CT_(x),offering a flexible catalyst design guideline.
基金National Key Research and Development Program of China,Grant/Award Number:2022YFC3204202National Natural Science Foundation of China,Grant/Award Number:52122904Ministry of Water Resources,Grant/Award Number:SKS-2022121。
文摘Fish swimming hydrodynamics serves as a critical foundation for aquatic ecological conservation,with recent research extending from 2D to 3D perspectives.This study employs 3D high-fidelity modeling with dynamic mesh technology to investigate how cylindrical obstacles at varying positions affect Carassius auratus locomotion.Analysis of nine configurations reveals bidirectional flow interactions between fish and cylinders,with cylinder wake influence persisting at 1-2 times the total length intervals but diminishing at 3times.Compared with swimming in uniform flow,the mechanical benefit of C.auratus located 2 times the total length directly behind the cylinder is the largest,and its value reaches 4.19 times.Wavelet analysis of 30-cycle mechanical data demonstrates closer intervals enhance benefit magnitude,whereas greater distances accelerate benefit realization.These 3D computational findings corroborate 2D studies while providing new spatial interaction insights,offering theoretical foundations for fish conservation strategies related to hydraulic structures.
文摘Casing deformation is a widespread problem in a certain block of Jiaoshiba Shale Gas Field in Sichuan Basin,China,and it severely limits the development benefits of shale gas in that block.Based on the spatiotemporal characteristics of block formation,fracture development,and casing deformation occurrence,this paper employs an integrated geological—engineering research approach to identify the primary mechanisms governing casing deformation within the block and proposes countermeasures to prevent such deformation.The present research indicates the following findings:(1)The block has undergone multiple phases of tectonic superposition,with fracture development serving as the geological factor causing casing deformation.(2)Fracturing activation constitutes the engineering factor causing casing deformation,with 4 mm of formation slip inducing deformation.(3)The fracture activation risk map shows that Class Ⅰ and Class Ⅱ fractures account for 73.36%of the total recorded in the block.Within the most susceptible Class I risk zone,the critical activation pressure increment for fracturing operations ranges from 13.43 MPa to 13.99 MPa.Based on the distribution of casing failure risk zones identified in the fracture activation risk map,this paper proposes relevant technical countermeasures for preventing casing failure from three perspectives:shale gas well location deployment,drilling techniques,and fracturing techniques.These measures provide robust support for safeguarding the integrity of casing systems within the studied block.
基金Supported by National Natural Science Foundation of China(Grant No.55275227)。
文摘Lead zirconate titanate(PbZr_(x)Ti_(1-x)O_(3),PZT)ferroelectric films possess remarkable characteristics such as high residual polarization,high dielectric constant,and high piezoelectric coefficient and have great application prospects in modern electronics,communications,medical care,and military fields.At present,the microstructure changes of PZT ferroelectric thin films have a significant impact on their electrical properties.Therefore,this work summarizes the influences of geometric structure(thickness,porosity),composition structure(Zr/Ti ratio,doping),and grain structure(grain size,grain boundaries,orientation)on the electrical properties of PZT ferroelectric thin films.The results show that the changes in thickness and porosity have a significant impact on the electrical properties of PZT ferroelectric films.Especially,the actual application scenarios and preparation processes determine the required geometric dimensions and structures of PZT ferroelectric films.The Zr/Ti ratio and doping mainly affect the electrical properties by influencing the phase composition of PZT ferroelectric films.The changes in grain size,boundary structure,and orientation dependence mainly have a certain degree of influence on the domain response and domain switching behavior of PZT ferroelectric thin films.In conclusion,different structures have different influence effects on the dielectric,ferroelectric,and piezoelectric properties of PZT ferroelectric films.The way the tiny structure affects how PZT thin films work was shown,helping to guide the design of ferroelectric thin film devices.In order to further study and apply piezoelectric ceramic devices,it is crucial to have an in-depth understanding of the relationship between the structure and performance of piezoelectric ceramic devices.
基金supported by the Science and Technology Program of Guangzhou(No.2023A03J0218)。
文摘Despite the promising potential of organic nanoscintillator-mediated radiodynamic therapy(RDT)in enhancing the effectiveness of immunotherapy,their cutaneous phototoxicity exacerbates the risk for immune-related adverse events(irAEs).Herein,we demonstrate that organic nanoscintillators,when combined with checkpoint blockade immunotherapy and exposed to X-ray-induced RDT,can trigger cutaneous irAEs.To address this challenge,we engineered diselenide-bridged silicon coatings on organic nanoscintillators,fine-tuning the steric hindrance of the protective layer by varying its thickness.This strategy enables radiation-triggered reactive oxygen species(ROS)generation while mitigating off-target phototoxicity through neutralizing ROS.By optimizing the steric hindrance to precisely control energy transfer between the organic nanoscintillators and surrounding oxygen molecules,we effectively reduce phototoxicity and mitigate off-tumor effects through engineered surface protection.Under X-ray irradiation exposure,the steric hindrance is rapidly deactivated through the dissociation of the silicon coating,activating RDT and inducing abundant ROS generation within tumor cells.In an orthotopic 4T1 breast cancer model,intravenous administration of these surface-engineered nanoscintillators,combined with anti-programmed death-1(anti-PD-1)antibodies,results in robust anti-tumor immune responses,while minimizing cutaneous irAEs.This work offers valuable insights into how surface engineering can modulate the delicate balance between anti-tumor efficacy and off-tumor toxicity in nanoscintillator-mediated RDT.
文摘Devising S-scheme heterostructure is considered as a cutting-edge strategy for advanced photocatalysts with effectively segregated photo-carriers and prominent redox potential for emerging organic pollutants control.Herein,an S-scheme Ag_(2)CO_(3)/C_(3)N_(5) heterojunction photocatalyst was developed via a simple in situ chemical deposition procedure,and further photoreduction operation made metallic Ag(size:3.5–12.5 nm)being in situ formed on Ag_(2)CO_(3)/C_(3)N_(5) for a plasmonic S-scheme Ag/Ag_(2)CO_(3)/C_(3)N_(5) heterojunction photocatalyst.Consequently,Ag/Ag_(2)CO_(3)/C_(3)N_(5) manifests pronouncedly upgraded photocatalytic performance toward oxytetracycline degradation with a superior photoreaction rate constant of 0.0475 min‒1,which is 13.2,3.9 and 2.2 folds that of C_(3)N_(5),Ag_(2)CO_(3),and Ag_(2)CO_(3)/C_(3)N_(5),respectively.As evidenced by comprehensive characterizations and density functional theory calculations,the localized surface plasmon resonance effect of metallic Ag and the unique S-scheme charge transfer mechanism in 0D/0D/2D Ag/Ag_(2)CO_(3)/C_(3)N_(5) collaboratively strengthen the visible-light absorption,and facilitate the effective separation of powerful charge carriers,thereby significantly promoting the generation of reactive species like·OH^(-),h^(+)and·O_(2)^(-)for efficient oxytetracycline destruction.Moreover,four consecutive cycles demonstrate the reusability of Ag/Ag_(2)CO_(3)/C_(3)N_(5).Furthermore,the authentic water purification tests affirm its practical application potential.This work not only provides a candidate strategy for advancing S-scheme heterojunction photocatalysts but also makes a certain contribution to water decontamination.
基金supported by the Natural Science Foundation of Jiangsu Province(BE2021623,BK20220155)Natural Science Foundation of Jiangsu Province(BE2021623)+4 种基金National Natural Science Foundation of China(32001665,U1903205,32021005)the National Key Research and Development Program of China(2017YF0400303)the Key Scientific and Technological Research Projects in the Key Areas of the Xinjiang Production and Construction Corps(2018AB010)the Key Research and Development 303 Program of Ningxia(2020BFG02012)Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province。
文摘Heparin,a glycosaminoglycan,is a stable source of carbon that supports the growth of microorganisms in the human intestine.It is also a commonly used anticoagulant drug in clinical practice,with significant therapeutic effects.Low molecular weight heparin(LMWH)is a highly active low molecular weight fragment obtained via enzymatic reaction or the chemical degradation of heparin.LMWH has been applied globally in the prevention and treatment of venous thromboembolism in thrombosis patients.Simultaneously,as a potential prebiotic,because of its low molecular weight,LMWH can be well degraded by the gut microbiota to maintain intestinal balance.Enzymatic heparin degradation has recently emerged as a viable disposal method for LMWH preparation;however,only very few benchmark enzymes have been thoroughly described and subjected to protein engineering to improve their properties over the past few years.The commercialization of enzymes will require the development of robustly engineered enzymes that meet the demands of industrial processes.Herein,we report a rational protein engineering strategy that includes molecular dynamic simulations of flexible amino acid mutations and disulfide bond screening.Several Bacteroides thetaiotaomicron heparanase I(Bt-HepI)mutants were obtained and screened for high thermal stability.We obtained the Bt-HepI^(D204C/K208C/H189W/Q198R)variant,which features a stabilized protein surface structure,with a 1.3-fold increase in catalytic constant/michaelis-menten constant(k_(cat)/K_(m)),a 2.44-fold increase in thermal stability at 50℃,and a 1.8-fold decrease in the average molecular weight of LMWH produced at 40℃compared with that seen with Bt-HepI^(WT).Our study establishes a strategy to engineer thermostable HepI to underpin its industrial applications.
基金Project supported by National Natural Science Foundation of China(51962006)the High-level Talents Research Initiation Project of JXUST(205200100545)+1 种基金the Young Elite Scientists Sponsorship Program by CAST(2022QNRC001)Jiangxi Natural Science Foundation of China(20224BAB214029,20232BAB204021)。
文摘Up-conversion(UC)luminescent materials doped with Ln^(3+)ions possess excellent optical properties and extensive applications in the formulation of multifunctional fluorescence ink.Printing technology offers various methods for the preparation of UC fluorescent inks.This study introduced the optical properties of luminescent materials doped with Ln^(3+)ions,including luminescence characteristics and spectral characteristics,which provide a basis for the subsequent printing process.We also reviewed different printing techniques,including direct writing,screen printing,laser printing,inkjet printing,and aerosol jet printing(AJP),developed so far in the literature and explored the printing process of ink characteristics.However,the printing process of inks was explored and their potential for various applications was maximized.Therefore,the printing technology of UC fluorescent inks still faces challenges in different aspects.This review also points out the direction for future in-depth research,which is expected to promote further development and innovation in the field.
基金Guangzhou Metro Scientific Research Project(No.JT204-100111-23001)Chongqing Municipal Special Project for Technological Innovation and Application Development(No.CSTB2022TIAD-KPX0101)Science and Technology Research and Development Program of China State Railway Group Co.,Ltd.(No.N2023G045)。
文摘The uplift resistance of the soil overlying shield tunnels significantly impacts their anti-floating stability.However,research on uplift resistance concerning special-shaped shield tunnels is limited.This study combines numerical simulation with machine learning techniques to explore this issue.It presents a summary of special-shaped tunnel geometries and introduces a shape coefficient.Through the finite element software,Plaxis3D,the study simulates six key parameters—shape coefficient,burial depth ratio,tunnel’s longest horizontal length,internal friction angle,cohesion,and soil submerged bulk density—that impact uplift resistance across different conditions.Employing XGBoost and ANN methods,the feature importance of each parameter was analyzed based on the numerical simulation results.The findings demonstrate that a tunnel shape more closely resembling a circle leads to reduced uplift resistance in the overlying soil,whereas other parameters exhibit the contrary effects.Furthermore,the study reveals a diminishing trend in the feature importance of buried depth ratio,internal friction angle,tunnel longest horizontal length,cohesion,soil submerged bulk density,and shape coefficient in influencing uplift resistance.
