The rational design of a specific platform that can address the unavoidable side effects of traditional cancer treatments is of great interest.In this sense,herein,an intelligent nanoplatform(ZnL1@MOF-199@FA)with effi...The rational design of a specific platform that can address the unavoidable side effects of traditional cancer treatments is of great interest.In this sense,herein,an intelligent nanoplatform(ZnL1@MOF-199@FA)with efficient reactive oxygen species(ROS)production ability in vitro with or without laser irradiation has been designed and fabricated.Furthermore,the loading of a two-photon active photosensitizer ZnL1 could induce^(1)O_(2)and O_(2)·-upon near-infrared light irradiation,showing a promising photodynamic therapy(PDT)outcome.Notably,in an acidic environment,the copper ions resulting from the degradation of MOF-199 could convert H_(2)O_(2)into O_(2)and·OH.Hereinto,the resulting O_(2)may mitigate the hypoxic environment and further promote PDT efficiency.This work provides a controllable strategy to construct functional materials with an enhanced PDT outcome in a hypoxic microenvironment.展开更多
A series of complexes of N-(3-imidazol-1-yl-propyl)-1,8-naphthalimide(L)with divalent ions of manganese,cobalt,zinc,cadmium and mercury are structurally characterized.The metal complexes[ML_(2)Cl_(2)]{M=Zn(1),Cd(2),Hg...A series of complexes of N-(3-imidazol-1-yl-propyl)-1,8-naphthalimide(L)with divalent ions of manganese,cobalt,zinc,cadmium and mercury are structurally characterized.The metal complexes[ML_(2)Cl_(2)]{M=Zn(1),Cd(2),Hg(3)}are isomorphous and have a distorted tetrahedral geometry with a bend conformation of L.The thiocyanate complex[ZnL_(2)(SCN)_(2)]has a distorted tetrahedral geometry with L in bent conformation but with a different geometry from that in the structure of complex 1.展开更多
基金supported by a grant from the National Natural Science Foundation of China(22171001,21701160,and 31600749)the Anhui Provincial Natural Science Foundation of China(2108085MB49)the Doctor Startup Fund(S020118002/026 and S020118002/073).
文摘The rational design of a specific platform that can address the unavoidable side effects of traditional cancer treatments is of great interest.In this sense,herein,an intelligent nanoplatform(ZnL1@MOF-199@FA)with efficient reactive oxygen species(ROS)production ability in vitro with or without laser irradiation has been designed and fabricated.Furthermore,the loading of a two-photon active photosensitizer ZnL1 could induce^(1)O_(2)and O_(2)·-upon near-infrared light irradiation,showing a promising photodynamic therapy(PDT)outcome.Notably,in an acidic environment,the copper ions resulting from the degradation of MOF-199 could convert H_(2)O_(2)into O_(2)and·OH.Hereinto,the resulting O_(2)may mitigate the hypoxic environment and further promote PDT efficiency.This work provides a controllable strategy to construct functional materials with an enhanced PDT outcome in a hypoxic microenvironment.
文摘A series of complexes of N-(3-imidazol-1-yl-propyl)-1,8-naphthalimide(L)with divalent ions of manganese,cobalt,zinc,cadmium and mercury are structurally characterized.The metal complexes[ML_(2)Cl_(2)]{M=Zn(1),Cd(2),Hg(3)}are isomorphous and have a distorted tetrahedral geometry with a bend conformation of L.The thiocyanate complex[ZnL_(2)(SCN)_(2)]has a distorted tetrahedral geometry with L in bent conformation but with a different geometry from that in the structure of complex 1.
