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ZERO-CURRENT AND ZERO-VOLTAGE SWITCHING PWM BOOST FULL-BRIDGE CON VERTER 被引量:1
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作者 周林泉 阮新波 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2003年第1期60-66,共7页
This paper proposes a zer o current and zero voltage switching (ZCZVS) PWM Boost full bridge (FB) conve rter. With series inductors, the leading switches can realize zero current swit ching (ZCS) in a wide load ra... This paper proposes a zer o current and zero voltage switching (ZCZVS) PWM Boost full bridge (FB) conve rter. With series inductors, the leading switches can realize zero current swit ching (ZCS) in a wide load range using the energy of the output capacitor. Ma king use of parasitic capacitors of the lagging switches and parallel auxiliary i nductance with the primary winding of the transformer, the lagging switches can realize zero voltage switching (ZVS) under any load. Compared with the ZCS PWM Boost FB converter, the new converter has no current duty cycle loss. Operat ional principle and parameter design are analyzed. Experimental results verify the effectiveness of the proposed converter. 展开更多
关键词 pulse width modulation (PWM) soft switching boost converter full bridge converter zero voltage s witching zero current switching
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Broadband high-extinction-ratio nonvolatile optical switch based on phase change material
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作者 LIANG Kai YUE Wen-Cheng +4 位作者 XU Fan ZHU Qian-Nan ZHANG Jian-Min WANG Shu-Xiao CAI Yan 《红外与毫米波学报》 北大核心 2026年第1期36-41,共6页
In this paper,we present a broadband,high-extinction-ratio,nonvolatile 2×2 Mach-Zehnder interfer⁃ometer(MZI)optical switch based on the phase change material Sb_(2)Se_(3).The insertion loss(IL)is 0.84 dB and the ... In this paper,we present a broadband,high-extinction-ratio,nonvolatile 2×2 Mach-Zehnder interfer⁃ometer(MZI)optical switch based on the phase change material Sb_(2)Se_(3).The insertion loss(IL)is 0.84 dB and the extinction ratio(ER)reaches 28.8 dB at the wavelength of 1550 nm.The 3 dB bandwidth is greater than 150 nm.Within the 3 dB bandwidth,the ER is greater than 20.3 dB and 16.3 dB at bar and cross states,respectively.The power consumption for crystallization and amorphization of Sb_(2)Se_(3) is 105.86 nJ and 49 nJ,respectively.The switch holds significant promise for optical interconnects and optical computing applications. 展开更多
关键词 photonic integration optical switch phase change materials
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Comprehensive evaluation on Si/SiC hybrid switch including single-pulse avalanche and short-circuit robustness
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作者 Hang-Zhi Liu Yu-Ming Zhou 《Journal of Electronic Science and Technology》 2026年第1期86-98,共13页
In this paper,a comprehensive evaluation on the silicon/silicon carbide(Si/SiC)hybrid switch is performed through experimental tests in terms of both electrical performance and robustness under extreme stresses.Based ... In this paper,a comprehensive evaluation on the silicon/silicon carbide(Si/SiC)hybrid switch is performed through experimental tests in terms of both electrical performance and robustness under extreme stresses.Based on the optional turn-on and turn-off delay times under the efficiency control mode obtained from the double-pulse test(DPT),both nondestructive and destructive single-pulse avalanche tests are conducted on the Si/SiC hybrid switch as well as on the two discrete device branches inside the hybrid switch.In addition,the avalanche voltage,critical avalanche energy,and peak avalanche current,which intrinsically characterize the unclamped-inductive-switching(UIS)avalanche characteristics,are carefully examined.In this way,the physical factors dominating the UIS characteristics of the hybrid switch,thus limiting its single-pulse avalanche withstand capability,are specifically and comprehensively identified;the underlying physical mechanisms are analyzed and revealed in depth,and how the gate control sequence affects the UIS characteristics of the hybrid switch is extensively investigated.We additionally carry out short-circuit(SC)tests under the fault-under-load(FUL)condition and perform a parallel in-depth analysis to experimentally determine which branch dominates the SC withstand capability of the hybrid switch.Our experimental study indicates that,for both SC robustness and single-pulse avalanche capability,the limiting factor is a single device branch among the two parallel discrete devices,and the UIS behavior is sensitive to the variation of the gate turn-off delay time Toff_delay.The study conducted in this paper not only provides deep academic insights into the electrical performance and reliability of the Si/SiC hybrid switch,but also offers fundamental theoretical principles and technical evidence to support its more efficient and long-term reliable applications of the hybrid switch in the industrial fields. 展开更多
关键词 Gate switching delay Hybrid switch Si/SiC Single-pulse avalanche SHORT-CIRCUIT
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Dynamic balance and reliability of a stochastic ecosystem with Markov switching
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作者 Ya-Nan Sun Xin-Zhi Liu You-Ming Lei 《Chinese Physics B》 2026年第1期381-390,共10页
A stochastic predator-prey system with Markov switching is explored.We have developed a new chasing technique to efficiently solve the Fokker-Planck-Kolmogorov and backward Kolmogorov equations.Dynamic balance and rel... A stochastic predator-prey system with Markov switching is explored.We have developed a new chasing technique to efficiently solve the Fokker-Planck-Kolmogorov and backward Kolmogorov equations.Dynamic balance and reliability of the switching system are evaluated via stationary probability density function and first-passage failure theory,taking into account factors such as switching frequencies,noise intensities,and initial conditions.Results reveal that Markov switching leads to stochastic P-bifurcation,enhancing dynamic balance and reducing white-noise-induced oscillations.But frequent switching can heighten initial value dependence,harming reliability.Further,the influence of the subsystem on the switching system is not proportional to its action probabilities.Monte Carlo simulations validate the findings,offering an in-depth exploration of these dynamics. 展开更多
关键词 stochastic ecosystem Markov switching first-passage failure RELIABILITY
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Controllable phase-dependent optical switch in an atom-cavity system
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作者 Xu-Yang Li Yuan-Feng Lu +2 位作者 Ya-Jie Wu Ning Li Miao-Di Guo 《Chinese Physics B》 2026年第2期408-414,共7页
Coherent perfect absorption(CPA)and coherent perfect transmission(CPT)are two extreme states arising from the manipulation of optical fields.Generally,CPA and CPT occur under different input-field phases.Therefore,we ... Coherent perfect absorption(CPA)and coherent perfect transmission(CPT)are two extreme states arising from the manipulation of optical fields.Generally,CPA and CPT occur under different input-field phases.Therefore,we propose a scheme to realize an all-optical switch based on phase-dependent CPA–CPT conversion.In our proposal,the CPT state and the CPA state are treated as the on state and the off state,respectively.Consequently,the efficiency of this all-optical switch can reach the maximum value of 1.With the introduction of an incoherent pump field,the CPA state can be achieved under a weaker input probe field or can be converted into a CPT state.The results show that the optical switch can operate with weaker fields and can be further optimized by the application of an incoherent field. 展开更多
关键词 coherent perfect absorption CAVITY-QED optical switching
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Leader-following positive consensus of heterogeneous switched multi-agent systems with average dwell time switching
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作者 Kaiming Li Wei Xing +1 位作者 Haoyue Yang Junfeng Zhang 《Control Theory and Technology》 2026年第1期66-81,共16页
This paper focuses on the leader-following positive consensus problems of heterogeneous switched multi-agent systems.First,a state-feedback controller with dynamic compensation is introduced to achieve positive consen... This paper focuses on the leader-following positive consensus problems of heterogeneous switched multi-agent systems.First,a state-feedback controller with dynamic compensation is introduced to achieve positive consensus under average dwell time switching.Then sufficient conditions are derived to guarantee the positive consensus.The gain matrices of the control protocol are described using a matrix decomposition approach and the corresponding computational complexity is reduced by resorting to linear programming and co-positive Lyapunov functions.Finally,two numerical examples are provided to illustrate the results obtained. 展开更多
关键词 Heterogeneous switched multi-agent systems Positive consensus Linear programming
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Balancing switching and transient response for ion gating in field-effect nanofluidic transistors
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作者 Xiaoqing Wu Yajie Chen +3 位作者 Dagui Wang Song Pu Qiujiao Du Pengcheng Gao 《Chinese Chemical Letters》 2026年第1期385-388,共4页
Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has... Field-effect nanofluidic transistors(FENTs),biomimicking the structure and functionality of neuron,act as biological transistors with the ability to gate switching responses to external stimuli.The switching ratio has been verified to evaluate the performance of FENTs,but until recently,the response time,another crucial indicator,has been ignored.Employing finite-element method,we investigated the relationship among gate charge,switching ratio and response time by divisionally manipulating gate charge,including entrance surface and the surface of confinement space,for ion transport to optimize switching capability.The dual-split gate charge on FENTs exhibits synergistic effect on switching response.Based on the two regional gate charge on FENTs,multivalence ions in lower concentration,high aspect ratio and single channel show higher switching ratio but longer response time compared to monovalent ions.The findings highlight the necessity of balancing these two signals in FENTs and offer insights for optimizing their design and expanding applications to dual-signal-detection iontronics. 展开更多
关键词 Nanofluidic transistor Gate charge Ion transport switching ratio Response time
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A stretchable liquid metal switch for interactive and autonomous soft machines
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作者 Gangsheng Chen Biao Ma +6 位作者 Yanjie Chen Yakun Gao Heng Zhang Wuxing Zhang Duxin Chen Wenwu Yu Hong Liu 《International Journal of Extreme Manufacturing》 2026年第1期794-807,共14页
Soft machines harness material-level physical intelligence to perform adaptive tasks,enabling advancements in biomedical and human-machine interaction fields.Soft switches are the basic building blocks to achieve inte... Soft machines harness material-level physical intelligence to perform adaptive tasks,enabling advancements in biomedical and human-machine interaction fields.Soft switches are the basic building blocks to achieve intelligent functions like autonomous decisions and mechanical computation.However,current soft switches suffer from complex fabrication processes,limited performance,and a lack of multimodal control,which hinder their practical application and the realization of machine intelligence.Herein,by harnessing the unique self-pinch and self-healing effects of the gallium-based liquid metals(LMs),we describe a soft high-performance electric switch composed of an LM line encapsulated within an elastomer.Applying pressure to deform the LM switch can increase local current density,leading to the electromagnetic self-pinch effect for switching off.After releasing pressure,the LM can spontaneously heal with the elastic recovery of the elastomer for switching on.This LM switch shows comprehensive advantages,including a compact design(0.5 mm×1.5 mm×10 mm),good stretchability(100%),high on/off ratio(~10^(9)),rapid response time(<100 ms),and excellent durability(>12000 cycles).Moreover,the LM switches enable multiple control modes,including magnetic and optical stimulation,through the integration of responsive materials.We demonstrate various LM switch-enabled functional soft machines,such as an interactive flexible gripper,a self-oscillating soft crawler,and wearable logic gates.This work will open new avenues for the application of LM in intelligent soft machines and advanced wearable electronics. 展开更多
关键词 liquid metal soft switches electric breakdown liquid crystal elastomer soft machines
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300A/115V Zero-voltage Soft Switching Power Supply and RIBLL Line
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《IMP & HIRFL Annual Report》 1998年第0期58-58,共1页
关键词 switchING switch
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Dynamic improvement and reliability enhancement of a high speed on/off valve based on pre-excitation soft switching control
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作者 Qi ZHONG Weihang ZHOU +3 位作者 Enguang XU Junxian WANG Xiaohang SHAN Huayong YANG 《Chinese Journal of Aeronautics》 2026年第2期582-592,共11页
High Speed on/off Valve(HSV)is an essential component in Aerospace Digital Hydraulic Systems(ADHS),which impose stringent requirements on the dynamic performance and reliability of HSV due to the extreme application e... High Speed on/off Valve(HSV)is an essential component in Aerospace Digital Hydraulic Systems(ADHS),which impose stringent requirements on the dynamic performance and reliability of HSV due to the extreme application environments.However,the faster dynamic leads to increased impact between the spool and valve body,causing severe vibration and wear,which creates a conflict between rapid dynamic and high reliability.To address this problem,a Pre-Excitation Soft Switching Control(PESSC)with both pre-excitation and reverse deceleration functionalities is proposed.The initial current is optimized through pre-excitation to accelerate the opening time,while the application of reverse voltage hastens the decline of electromagnetic force,thereby reducing the spool velocity.The PESSC simultaneously achieves both faster dynamic performance and smaller impact velocity.Moreover,the optimal deceleration voltage parameters are obtained through multi-objective optimization.Experimental results demonstrate that the optimized PESSC shortens the opening time from 2.22 ms to 1.65 ms,reduces the impact velocity by 58.3%,and lowers wear by 55.4%.These findings underline the huge potential of PESSC in enhancing the dynamic performance and reliability of HSVs,offering promising applications in aerospace. 展开更多
关键词 Dynamic response High speed on/off valve Impact velocity Multi-objective optimization Pre-excitation Soft switching
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Adaptive Fault-Tolerant Consensus Tracking Control for Nonlinear Multi-Agent Systems With Double Semi-Markovian Switching Topologies and Unknown Control Directions
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作者 Chao Zhou Zehui Mao +1 位作者 Bin Jiang Xing-Gang Yan 《IEEE/CAA Journal of Automatica Sinica》 2026年第2期463-476,共14页
This paper is concerned with adaptive consensus tracking control of nonlinear multi-agent systems with actuator faults and unknown nonidentical control directions under double semi-Markovian switching topologies.Consi... This paper is concerned with adaptive consensus tracking control of nonlinear multi-agent systems with actuator faults and unknown nonidentical control directions under double semi-Markovian switching topologies.Considering the complex working environment and the stability differences in communication links between leaders and followers,a double semi-Markov process is first introduced to describe the random switching of communication topologies in the leader-follower structure.In order to address challenges from the unknown nonidentical control directions and partial loss of effectiveness actuator faults,a completely independent parameter is introduced into the Nussbaum function to overcome the inherent obstacle of mutual cancellation and avoid the rapid growth rate.Considering only the state information of agents is transmitted among the agents,an adaptive distributed fault-tolerant consensus tracking control is proposed based on the double semi-Markovian switching topologies using the designed Nussbaum function.Furthermore,the stability of the closed-loop nonlinear multi-agent systems is analyzed using contradiction argument and Lyapunov theorem,from which the asymptotic consensus tracking in mean square sense can be obtained.A numerical simulation example is provided to verify the effectiveness of the proposed algorithm. 展开更多
关键词 Adaptive control consensus tracking double semi-Markovian switching topologies fault-tolerant control Nussbaum function unknown nonidentical control directions
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Giant Enhancement of Perpendicular Magnetic Anisotropy and Field-Free Switching Through Interfacial Engineering in Pt/Co/Pt Heterostructures
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作者 Yulin Zhang Mingzhang Wei +8 位作者 Ziji Shao Haodong Fan Menghao Jin Zhongshu Feng Xiaofeng Han Changqiu Yu Jiahong Wen Xinyu Shu Tiejun Zhou 《Chinese Physics Letters》 2026年第3期48-61,共14页
The enhancement of perpendicular magnetic anisotropy(PMA)is critical for the continuous growth of magnetic memory density.Material systems that possess high interfacial PMA typically involve strong spin-orbit coupling... The enhancement of perpendicular magnetic anisotropy(PMA)is critical for the continuous growth of magnetic memory density.Material systems that possess high interfacial PMA typically involve strong spin-orbit coupling(SOC)or transition metal/oxide interfaces.In contrast,the role of 3d light metals in enhancing the interfacial PMA has been less investigated.This study demonstrated that the insertion of a few atomic Cr layers into Pt/Co/Pt/Ta heterostructures with Cr between the 1 atomic Pt layer and the 3 nm Ta overlayer enhanced the effective PMA energy(K_(eff))by a factor of 4.First-principles calculations revealed that the underlying mechanism originated from Cr-Pt d-orbital hybridization,leading to a corresponding orbital redistribution and significantly increasing the magnetic anisotropy energy.The progressive reduction in the spin-orbit torque(SOT)efficiency with increasing Cr thickness might stem from the enhanced orbital Rashba–Edelstein effect at the Pt/Cr interface.Furthermore,the wedging of a few atomic Cr layers caused the robust field-free SOT switching of perpendicular magnetization,which was due to the lateral PMA gradients enabled by the strong dependence of the PMA on the Cr thickness.The results provide a method for interfacial PMA enhancement by d-orbital hybridization of 3d–5d electrons and an alternative to field-free SOT switching towards low-power and high-density memory applications. 展开更多
关键词 d light metals interfacial engineering enhancement perpendicular magnetic anisotropy pma perpendicular magnetic anisotropy spin orbit coupling Pt Co Pt heterostructures field free switching nm t
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A New Zero-Voltage-Switching Push-Pull Converter
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作者 Yisheng Yuan Qunfang Wu 《Energy and Power Engineering》 2013年第4期125-131,共7页
A soft switching three-transistor push-pull(TTPP)converter is proposed in this paper. The 3rd transistor is inserted in the primary side of a traditional push-pull converter. Two primitive transistors can achieve zero... A soft switching three-transistor push-pull(TTPP)converter is proposed in this paper. The 3rd transistor is inserted in the primary side of a traditional push-pull converter. Two primitive transistors can achieve zero-voltage-switching (ZVS) easily under a wide load range, the 3rd transistor can also realize zero-voltage-switching assisted by leakage inductance. The rated voltage of the 3rd transistor is half of that of the main transistors. The operation theory is explained in detail. The soft-switching realization conditions are derived. An 800 W with 83.3 kHz switching frequency prototype has been built. The experimental result is provided to verify the analysis. 展开更多
关键词 PUSH PULL CONVERTER EXTRA TRANSISTOR zero-voltage-switchING
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基于UVM的PCIe交换芯片Switch子系统验证平台的设计 被引量:1
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作者 郑锐 沈剑良 +2 位作者 刘冬培 李智超 曹睿 《计算机应用研究》 北大核心 2025年第5期1480-1489,共10页
PCIe是一种高速串行计算机扩展总线标准,据此设计的PCIe交换芯片可将CPU提供的PCIe通道扩展出更多的PCIe接口。然而,随着PCIe交换芯片设计复杂度和验证向量剧增,传统基于Verilog搭建的验证平台难以实现对逻辑复杂的Switch子系统高效地验... PCIe是一种高速串行计算机扩展总线标准,据此设计的PCIe交换芯片可将CPU提供的PCIe通道扩展出更多的PCIe接口。然而,随着PCIe交换芯片设计复杂度和验证向量剧增,传统基于Verilog搭建的验证平台难以实现对逻辑复杂的Switch子系统高效地验证,且缺乏功能覆盖率模型。为解决上述问题,采用UVM通用验证方法学,搭建了针对PCIe交换芯片中Switch子系统的验证平台,采用层次划分设计,支持覆盖率驱动,且较于一般UVM验证平台作出效率优化。具体而言,首先,对平台组件Reference Model建立通信对象和通信方式进行优化设计;其次,对平台组件ScoreBoard的比对方式和接收报文端口进行改进;最后,依据PCIe协议及交换芯片特点,对功能点进行梳理分类后针对性地设计了测试用例,对Switch子系统进行全面验证。经信号波形及覆盖率数据的分析表明,改进后的验证平台在没有人为过滤的情况下实现了96.8%的代码覆盖率和100%的功能覆盖率,仿真时间平均减少了约10%。该平台显著提升了验证效率,高效地支撑了PCIe交换芯片的验证工作,为相关UVM验证平台的搭建提供了参考。 展开更多
关键词 PCIe交换芯片 switch子系统 UVM验证平台 reference model ScoreBoard 覆盖率
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ANALYSIS OF ZERO-VOLTAGE QUASI-RESONANT BOOST DC-DC CONVERTER
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作者 许建平 《Journal of Electronics(China)》 1992年第3期225-232,共8页
The zero-voltage quasi-resonant boost switching DC-DC converter has been inves-tigated by using the time averaging equivalent circuit approach of periodically switching linearnetworks.The DC steady state and AC small ... The zero-voltage quasi-resonant boost switching DC-DC converter has been inves-tigated by using the time averaging equivalent circuit approach of periodically switching linearnetworks.The DC steady state and AC small signal characteristics of the converter are also given. 展开更多
关键词 switchING CONVERTER zero-voltage QUASI-RESONANT switch Time AVERAGING EQUIVALENT circuit approach
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A zero-voltage transition for three-phase double-PWM voltage-fed converter
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作者 屈克庆 陈国呈 +2 位作者 孙承波 李杰 吴国祥 《Journal of Shanghai University(English Edition)》 CAS 2007年第5期496-501,共6页
In comparison with several zero-voltage transition (ZVT) inverter topologies, a double-PWM converter is presented using a simple ZVT topology. The rectifier and inverter of this double-PWM share a set of commutation... In comparison with several zero-voltage transition (ZVT) inverter topologies, a double-PWM converter is presented using a simple ZVT topology. The rectifier and inverter of this double-PWM share a set of commutation circuit which can provide soft-switching for the power devices and the diodes. The commutation circuit consists of 1 auxiliary device, 6 resonant inductors, and 12 diodes. Its topology is simpler than the conventional auxiliary resonant converter, leading to low loss and easy control. The control strategy and resonant working modes are analyzed. Experimental results show good performance of the system. 展开更多
关键词 zero-voltage transition (ZVT) double-PWM CONVERTER resonant.
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A New Zero-Voltage Transition Power Factor Corrected Single-Phase Single-Stage AC-to-DC Converter
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作者 Azizur Rahman 《Journal of Energy and Power Engineering》 2012年第3期397-403,共7页
This paper presents a new ZVT (zero-voltage transition) single-stage ac-to-dc converter using PWM (pulse width modulation) and HF (high frequency) transformer isolation with capacitive output filter. In this con... This paper presents a new ZVT (zero-voltage transition) single-stage ac-to-dc converter using PWM (pulse width modulation) and HF (high frequency) transformer isolation with capacitive output filter. In this converter a front-end power factor corrected boost stage integrates with a cascaded dc-to-dc bridge HF converter. The front-end boost converter operates in discontinuous current mode and ensures natural power factor correction with very simple control. The auxiliary circuit of this topology deals with very small power and is placed out of the main power path. As a result, the auxiliary circuit components have smaller power rating as opposed to main converter components. Also, output rectifier voltage is clamped to output voltage due to capacitive output filter. Identification and analyses of different operating modes of this converter are presented. Based on these analyses design example of a 50 kHz, 48 V, 1 kW ac-to-dc converter is presented. PSPICE simulation results of the designed converter are presented and explained to verify the performance of this converter. 展开更多
关键词 Power factor correction high frequency isolation zero-voltage transition.
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Electropolymerized dopamine-based memristors using threshold switching behaviors for artificial current-activated spiking neurons 被引量:1
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作者 Bowen Zhong Xiaokun Qin +4 位作者 Zhexin Li Yiqiang Zheng Lingchen Liu Zheng Lou Lili Wang 《Journal of Semiconductors》 2025年第2期98-103,共6页
Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely us... Memristors have a synapse-like two-terminal structure and electrical properties,which are widely used in the construc-tion of artificial synapses.However,compared to inorganic materials,organic materials are rarely used for artificial spiking synapses due to their relatively poor memrisitve performance.Here,for the first time,we present an organic memristor based on an electropolymerized dopamine-based memristive layer.This polydopamine-based memristor demonstrates the improve-ments in key performance,including a low threshold voltage of 0.3 V,a thin thickness of 16 nm,and a high parasitic capaci-tance of about 1μF·mm^(-2).By leveraging these properties in combination with its stable threshold switching behavior,we con-struct a capacitor-free and low-power artificial spiking neuron capable of outputting the oscillation voltage,whose spiking fre-quency increases with the increase of current stimulation analogous to a biological neuron.The experimental results indicate that our artificial spiking neuron holds potential for applications in neuromorphic computing and systems. 展开更多
关键词 ELECTROPOLYMERIZATION POLYDOPAMINE MEMRISTOR threshold switching spiking voltage artificial neuron
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Periodic Event-Triggered Consensus of Stochastic Multiagent Systems Under Switching Topology 被引量:1
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作者 Boqian LI Linhao ZHAO Shiping WEN 《Artificial Intelligence Science and Engineering》 2025年第2期147-156,共10页
The event-triggered mechanism serves as an effective discontinuous control strategy for addressing the consensus tracking problem in multiagent systems(MASs).This approach optimizes energy consumption by updating the ... The event-triggered mechanism serves as an effective discontinuous control strategy for addressing the consensus tracking problem in multiagent systems(MASs).This approach optimizes energy consumption by updating the controller only when some observed errors exceed a predefined threshold.Considering the influence of noise on agent dynamics in complex control environments,this study investigates an event-triggered control scheme for stochastic MASs,where noise is modeled as Brownian motion.Furthermore,the communication topology of the stochastic MASs is assumed to exhibit a Markovian switching mechanism.Analytical criteria are derived to guarantee consensus tracking in the mean square sense,and a numerical example is provided to validate the effectiveness of the proposed control methods. 展开更多
关键词 cooperative control stochastic systems event-triggered mechanism switching topology
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SIRT3-PINK1-PKM2 axis prevents osteoarthritis via mitochondrial renewal and metabolic switch 被引量:3
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作者 Yaoge Deng Mingzhuang Hou +7 位作者 Yubin Wu Yang Liu Xiaowei Xia Chenqi Yu Jianfeng Yu Huilin Yang Yijian Zhang Xuesong Zhu 《Bone Research》 2025年第3期686-701,共16页
Maintaining mitochondrial homeostasis is critical for preserving chondrocyte physiological conditions and increasing resistance against osteoarthritis(OA).However,the underlying mechanisms governing mitochondrial self... Maintaining mitochondrial homeostasis is critical for preserving chondrocyte physiological conditions and increasing resistance against osteoarthritis(OA).However,the underlying mechanisms governing mitochondrial self-renewal and energy production remain elusive.In this study,we demonstrated mitochondrial damage and aberrant mitophagy in OA chondrocytes.Genetically overexpressing PTEN-induced putative kinase 1(PINK1)protects against cartilage degeneration by removing defective mitochondria.PINK1 knockout aggravated cartilage damage due to impaired mitophagy.SIRT3 directly deacetylated PINK1 to promote mitophagy and cartilage anabolism.Specifically,PINK1 phosphorylated PKM2 at the Ser127 site,preserving its active tetrameric form.This inhibited nuclear translocation and the interaction withβ-catenin,resulting in a metabolic shift and increased energy production.Finally,a double-knockout mouse model demonstrated the role of the SIRT3-PINK1-PKM2 axis in safeguarding the structural integrity of articular joints and improving motor functions.Overall,this study provides a novel insight into the regulation of mitochondrial renewal and metabolic switches in OA. 展开更多
关键词 aberrant mitophagy mitochondrial renewal maintaining mitochondrial homeostasis mitochondrial damage cartilage degeneration SIRT removing defective mitochondriapink metabolic switch
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