For eliminating the zero-order image in digital holography, a new method using the differential of the hologram intensity instead of the hologram itself for numerical reconstruction is proposed. This method is based o...For eliminating the zero-order image in digital holography, a new method using the differential of the hologram intensity instead of the hologram itself for numerical reconstruction is proposed. This method is based on digital image processing. By analyzing the spatial spectrum of the off-axis digital hologram, it theoretically proves that the zero-order image can be effectively eliminated by differential before reconstruction. Then, the detected hologram is processed in the program with differential and reconstruction. Both the theoretical analysis and digital reconstruction results show that it can effectively eliminate the large bright spot in the center of the reconstructed image caused by the zero-order image, improve the image quality significantly, and render a better contrast of the reconstructed image. This method is very simple and convenient due to no superfluous optical elements and requiring only one time record.展开更多
Shell structures have increasingly widespread applications in biomedical ultrasound fields such as contrast agents and drug delivery,which requires the precise prediction of the acoustic radiation force under various ...Shell structures have increasingly widespread applications in biomedical ultrasound fields such as contrast agents and drug delivery,which requires the precise prediction of the acoustic radiation force under various circumstances to improve the system efficiency.The acoustic radiation force exerted by a zero-order quasi-Bessel-Gauss beam on an elastic spherical shell near an impedance boundary is theoretically and numerically studied in this study.By means of the finite series method and the image theory,a zero-order quasi-Bessel-Gauss beam is expanded in terms of spherical harmonic functions,and the exact solution of the acoustic radiation force is derived based on the acoustic scattering theory.The acoustic radiation force function,which represents the radiation force per unit energy density and per unit cross-sectional surface,is especially investigated.Some simulated results for a polymethyl methacrylate shell and an aluminum shell are provided to illustrate the behavior of acoustic radiation force in this case.The simulated results show the oscillatory property and the negative radiation force caused by the impedance boundary.An appropriate relative thickness of the shell can generate sharp peaks for a polymethyl methacrylate shell.Strong radiation force can be obtained at small half-cone angles and the beam waist only affects the results at high frequencies.Considering that the quasi-Bessel-Gauss beam possesses both the energy focusing property and the non-diffracting advantage,this study is expected to be useful in the development of acoustic tweezers,contrast agent micro-shells,and drug delivery applications.展开更多
In this research, we have improved a relaxation method for triangular meshes intended for finite element fluid simulations which contain discrete element particles. The triangle edges are treated as springs which rela...In this research, we have improved a relaxation method for triangular meshes intended for finite element fluid simulations which contain discrete element particles. The triangle edges are treated as springs which relax their lengths towards a “better” force equilibrium where the triangles are closer to equilateral shape. The actual kernel is an improved zero order integrator which is able to follow reconfigurations of the particles faster than earlier methods. The improved relaxation allows larger timesteps in the flow simulation and leads to more stable, faster mesh reconfigurations for fast moving particles in the flow. Additionally, this demonstrates how integrators of the same order zero can nevertheless have different convergence speeds towards展开更多
With derivative spectrophotometric method,the complexes of lanthanides with 2-(5-bromo-2-pyridylazo)-5-diethylaminophen- ol(5-Br-PADAP)in the presence of octylphenol poly(ethyleneg- lycol)ether(TX-100)were studied.It ...With derivative spectrophotometric method,the complexes of lanthanides with 2-(5-bromo-2-pyridylazo)-5-diethylaminophen- ol(5-Br-PADAP)in the presence of octylphenol poly(ethyleneg- lycol)ether(TX-100)were studied.It is found that the maximum absorption of fourth-order derivative spectra of the neodymium complex by 4f electron transitions is at 579(+)nm and 582(-)nm with molar derivative absorptivities of 5.2×10~3 1.mol^(-1).cm^(-1). The maximum absorption of the zero-order derivative spectra of the complexes for neodymium and praseodymium is at 580hm,the molar absorptivities are 1.47×10~5 l.mol^(-1).cm^(-1)for Nd and 1.26 ×10~5 l.mol^(-1).cm^(-1)for Pr.The component ratio of the complex is Nd:5-Br-PADAP=1:4.Beer's law is obeyed in the range of 0-3.75μg of Nd and Pr in 25ml of solution.The method has been used for the simultaneous determination of Nd and Pr in four synthetic samples and the results obtained are satisfactory.展开更多
In this paper,I consider the Hölder continuity of the Lyapunov exponent for a quasi-periodic Szegö cocycle with weak Liouville frequency.I extend the existing results about the regularity of the Lyapunov exp...In this paper,I consider the Hölder continuity of the Lyapunov exponent for a quasi-periodic Szegö cocycle with weak Liouville frequency.I extend the existing results about the regularity of the Lyapunov exponent from the Schrödinger cocycle in[24]to a Szegö cocycle.展开更多
Objective To provide suggestions for helping marketing authorization holders(MAHs)to develop an effective and compliant pharmacovigilance system.Methods The construction strategies of pharmacovigilance system of the m...Objective To provide suggestions for helping marketing authorization holders(MAHs)to develop an effective and compliant pharmacovigilance system.Methods The construction strategies of pharmacovigilance system of the multinational pharmaceutical companies were analyzed based on the requirements of regulations and laws.Results and Conclusion There are some gaps between local and multinational pharmaceutical companies in the construction of pharmacovigilance system.We can learn from the experience of multinational pharmaceutical companies to improve the pharmacovigilance system,which includes building a sound pharmacovigilance organizational structure,establishing a series of operational system files and cultivating professional talents.MAHs of China should improve the structure of enterprise pharmacovigilance system.Besides,members of Drug Safety Committee should be department managers with higher position so that they can fulfil the responsibilities of risk assessment.If MAHs possess a large variety and quantity of products,a Drug Safety Committee should be established to ensure the timely discovery of risks.In addition,MAHs should pay attention to the implementation of related regulations and laws on pharmacovigilance and establish compliant,effective and operatable files combing with the actual operation of pharmacovigilance system.Finally,MAHs should introduce and train pharmacovigilance talents,and hire pharmacovigilance experts as consultants to solve the problem of talent shortage.展开更多
目的探讨基于成果导向教育(outcome based education,OBE)的持镜助手培训在腹腔镜前列腺癌根治术(laparoscopic radical prostatectomy,LRP)中的应用。方法选取2022年7月—2022年12月上海交通大学医学院附属瑞金医院外科专业基地轮转的...目的探讨基于成果导向教育(outcome based education,OBE)的持镜助手培训在腹腔镜前列腺癌根治术(laparoscopic radical prostatectomy,LRP)中的应用。方法选取2022年7月—2022年12月上海交通大学医学院附属瑞金医院外科专业基地轮转的第一年住院医师60人为研究对象,随机分为观察组(30人)和对照组(30人)。观察组采取OBE模式培训,对照组采取自主训练,培训前后进行考核评分。结果培训前后比较,LRP持镜能力得分显著提高;两组比较,观察组的得分[10.0(0.0)]高于对照组[9.0(2.0)],差异有统计学意义(Z=-4.42,P<0.001),且观察组住院医师持镜能力更均衡。观察组住院医师LRP相关解剖和手术过程认识方面得分高于对照组,差异有统计学意义(均P<0.001)。结论基于OBE模式的LRP持镜助手系统培训,能显著提高外科专业基地住院医师的持镜能力和理论知识学习效果,值得推广。展开更多
基金The Natural Science Foundation of Jiangsu Province (No.BK2006102)the National Natural Science Foundation of China(No.10772086)
文摘For eliminating the zero-order image in digital holography, a new method using the differential of the hologram intensity instead of the hologram itself for numerical reconstruction is proposed. This method is based on digital image processing. By analyzing the spatial spectrum of the off-axis digital hologram, it theoretically proves that the zero-order image can be effectively eliminated by differential before reconstruction. Then, the detected hologram is processed in the program with differential and reconstruction. Both the theoretical analysis and digital reconstruction results show that it can effectively eliminate the large bright spot in the center of the reconstructed image caused by the zero-order image, improve the image quality significantly, and render a better contrast of the reconstructed image. This method is very simple and convenient due to no superfluous optical elements and requiring only one time record.
基金Project supported by the National Natural Science Foundation of China(Grant Nos.81527901,11604361,and 91630309)。
文摘Shell structures have increasingly widespread applications in biomedical ultrasound fields such as contrast agents and drug delivery,which requires the precise prediction of the acoustic radiation force under various circumstances to improve the system efficiency.The acoustic radiation force exerted by a zero-order quasi-Bessel-Gauss beam on an elastic spherical shell near an impedance boundary is theoretically and numerically studied in this study.By means of the finite series method and the image theory,a zero-order quasi-Bessel-Gauss beam is expanded in terms of spherical harmonic functions,and the exact solution of the acoustic radiation force is derived based on the acoustic scattering theory.The acoustic radiation force function,which represents the radiation force per unit energy density and per unit cross-sectional surface,is especially investigated.Some simulated results for a polymethyl methacrylate shell and an aluminum shell are provided to illustrate the behavior of acoustic radiation force in this case.The simulated results show the oscillatory property and the negative radiation force caused by the impedance boundary.An appropriate relative thickness of the shell can generate sharp peaks for a polymethyl methacrylate shell.Strong radiation force can be obtained at small half-cone angles and the beam waist only affects the results at high frequencies.Considering that the quasi-Bessel-Gauss beam possesses both the energy focusing property and the non-diffracting advantage,this study is expected to be useful in the development of acoustic tweezers,contrast agent micro-shells,and drug delivery applications.
文摘In this research, we have improved a relaxation method for triangular meshes intended for finite element fluid simulations which contain discrete element particles. The triangle edges are treated as springs which relax their lengths towards a “better” force equilibrium where the triangles are closer to equilateral shape. The actual kernel is an improved zero order integrator which is able to follow reconfigurations of the particles faster than earlier methods. The improved relaxation allows larger timesteps in the flow simulation and leads to more stable, faster mesh reconfigurations for fast moving particles in the flow. Additionally, this demonstrates how integrators of the same order zero can nevertheless have different convergence speeds towards
文摘With derivative spectrophotometric method,the complexes of lanthanides with 2-(5-bromo-2-pyridylazo)-5-diethylaminophen- ol(5-Br-PADAP)in the presence of octylphenol poly(ethyleneg- lycol)ether(TX-100)were studied.It is found that the maximum absorption of fourth-order derivative spectra of the neodymium complex by 4f electron transitions is at 579(+)nm and 582(-)nm with molar derivative absorptivities of 5.2×10~3 1.mol^(-1).cm^(-1). The maximum absorption of the zero-order derivative spectra of the complexes for neodymium and praseodymium is at 580hm,the molar absorptivities are 1.47×10~5 l.mol^(-1).cm^(-1)for Nd and 1.26 ×10~5 l.mol^(-1).cm^(-1)for Pr.The component ratio of the complex is Nd:5-Br-PADAP=1:4.Beer's law is obeyed in the range of 0-3.75μg of Nd and Pr in 25ml of solution.The method has been used for the simultaneous determination of Nd and Pr in four synthetic samples and the results obtained are satisfactory.
文摘In this paper,I consider the Hölder continuity of the Lyapunov exponent for a quasi-periodic Szegö cocycle with weak Liouville frequency.I extend the existing results about the regularity of the Lyapunov exponent from the Schrödinger cocycle in[24]to a Szegö cocycle.
基金Integration Application Status and Problems Investigation of ICH Q8,Q9,Q10 across the Product Life Cycle(No.20210605).
文摘Objective To provide suggestions for helping marketing authorization holders(MAHs)to develop an effective and compliant pharmacovigilance system.Methods The construction strategies of pharmacovigilance system of the multinational pharmaceutical companies were analyzed based on the requirements of regulations and laws.Results and Conclusion There are some gaps between local and multinational pharmaceutical companies in the construction of pharmacovigilance system.We can learn from the experience of multinational pharmaceutical companies to improve the pharmacovigilance system,which includes building a sound pharmacovigilance organizational structure,establishing a series of operational system files and cultivating professional talents.MAHs of China should improve the structure of enterprise pharmacovigilance system.Besides,members of Drug Safety Committee should be department managers with higher position so that they can fulfil the responsibilities of risk assessment.If MAHs possess a large variety and quantity of products,a Drug Safety Committee should be established to ensure the timely discovery of risks.In addition,MAHs should pay attention to the implementation of related regulations and laws on pharmacovigilance and establish compliant,effective and operatable files combing with the actual operation of pharmacovigilance system.Finally,MAHs should introduce and train pharmacovigilance talents,and hire pharmacovigilance experts as consultants to solve the problem of talent shortage.
文摘目的探讨基于成果导向教育(outcome based education,OBE)的持镜助手培训在腹腔镜前列腺癌根治术(laparoscopic radical prostatectomy,LRP)中的应用。方法选取2022年7月—2022年12月上海交通大学医学院附属瑞金医院外科专业基地轮转的第一年住院医师60人为研究对象,随机分为观察组(30人)和对照组(30人)。观察组采取OBE模式培训,对照组采取自主训练,培训前后进行考核评分。结果培训前后比较,LRP持镜能力得分显著提高;两组比较,观察组的得分[10.0(0.0)]高于对照组[9.0(2.0)],差异有统计学意义(Z=-4.42,P<0.001),且观察组住院医师持镜能力更均衡。观察组住院医师LRP相关解剖和手术过程认识方面得分高于对照组,差异有统计学意义(均P<0.001)。结论基于OBE模式的LRP持镜助手系统培训,能显著提高外科专业基地住院医师的持镜能力和理论知识学习效果,值得推广。
