Repeated games describe situations where players interact with each other in a dynamic pattern and make decisions ac- cording to outcomes of previous stage games. Very recently, Press and Dyson have revealed a new cla...Repeated games describe situations where players interact with each other in a dynamic pattern and make decisions ac- cording to outcomes of previous stage games. Very recently, Press and Dyson have revealed a new class of zero-determinant （ZD） strategies for the repeated games, which can enforce a fixed linear relationship between expected payoffs of two play- ers, indicating that a smart player can control her unwitting co-player＇s payoff in a unilateral way [Proc. Acad. Natl. Sci. USA 109, 10409 （2012）]. The theory of ZD strategies provides a novel viewpoint to depict interactions among players, and fundamentally changes the research paradigm of game theory. In this brief survey, we first introduce the mathematical framework of ZD strategies, and review the properties and constrains of two specifications of ZD strategies, called pinning strategies and extortion strategies. Then we review some representative research progresses, including robustness analysis, cooperative ZD strategy analysis, and evolutionary stability analysis. Finally, we discuss some significant extensions to ZD strategies, including the multi-player ZD strategies, and ZD strategies under noise. Challenges in related research fields are also listed.展开更多
As a representative emerging machine learning technique, federated learning(FL) has gained considerable popularity for its special feature of “making data available but not visible”. However, potential problems rema...As a representative emerging machine learning technique, federated learning(FL) has gained considerable popularity for its special feature of “making data available but not visible”. However, potential problems remain, including privacy breaches, imbalances in payment, and inequitable distribution.These shortcomings let devices reluctantly contribute relevant data to, or even refuse to participate in FL. Therefore, in the application of FL, an important but also challenging issue is to motivate as many participants as possible to provide high-quality data to FL. In this paper, we propose an incentive mechanism for FL based on the continuous zero-determinant(CZD) strategies from the perspective of game theory. We first model the interaction between the server and the devices during the FL process as a continuous iterative game. We then apply the CZD strategies for two players and then multiple players to optimize the social welfare of FL, for which we prove that the server can keep social welfare at a high and stable level. Subsequently, we design an incentive mechanism based on the CZD strategies to attract devices to contribute all of their high-accuracy data to FL.Finally, we perform simulations to demonstrate that our proposed CZD-based incentive mechanism can indeed generate high and stable social welfare in FL.展开更多
Self-serving,rational agents sometimes cooperate to their mutual benefit.The two-player iterated prisoner′s dilemma game is a model for including the emergence of cooperation.It is generally believed that there is no...Self-serving,rational agents sometimes cooperate to their mutual benefit.The two-player iterated prisoner′s dilemma game is a model for including the emergence of cooperation.It is generally believed that there is no simple ultimatum strategy which a player can control the return of the other participants.The zero-determinant strategy in the iterated prisoner′s dilemma dramatically expands our understanding of the classic game by uncovering strategies that provide a unilateral advantage to sentient players pitted against unwitting opponents.However,strategies in the prisoner′s dilemma game are only two strategies.Are there these results for general multi-strategy games?To address this question,the paper develops a theory for zero-determinant strategies for multi-strategy games,with any number of strategies.The analytical results exhibit a similar yet different scenario to the case of two-strategy games.The results are also applied to the Snowdrift game,the Hawk-Dove game and the Chicken game.展开更多
This paper focuses on the performance of equalizer zero-determinant(ZD)strategies in discounted repeated Stackelberg asymmetric games.In the leader-follower adversarial scenario,the strong Stackelberg equilibrium(SSE)...This paper focuses on the performance of equalizer zero-determinant(ZD)strategies in discounted repeated Stackelberg asymmetric games.In the leader-follower adversarial scenario,the strong Stackelberg equilibrium(SSE)deriving from the opponents’best response(BR),is technically the optimal strategy for the leader.However,computing an SSE strategy may be difficult since it needs to solve a mixed-integer program and has exponential complexity in the number of states.To this end,the authors propose an equalizer ZD strategy,which can unilaterally restrict the opponent’s expected utility.The authors first study the existence of an equalizer ZD strategy with one-to-one situations,and analyze an upper bound of its performance with the baseline SSE strategy.Then the authors turn to multi-player models,where there exists one player adopting an equalizer ZD strategy.The authors give bounds of the weighted sum of opponents’s utilities,and compare it with the SSE strategy.Finally,the authors give simulations on unmanned aerial vehicles(UAVs)and the moving target defense(MTD)to verify the effectiveness of the proposed approach.展开更多
The Internet of Things Application(IOTA) is an innovative public blockchain system tailored for the Internet of Things(IoT), focusing on challenges such as micro-payments, concurrency, and scalability. However, its di...The Internet of Things Application(IOTA) is an innovative public blockchain system tailored for the Internet of Things(IoT), focusing on challenges such as micro-payments, concurrency, and scalability. However, its distributed ledger,which utilizes a directed acyclic graph(DAG) structure, is vulnerable to double-spending attacks. To mitigate this risk,we propose a countermeasure employing zero-determinant(ZD) strategies to encourage honest transactions among nodes.First, we analyze the game-theoretic interactions between the IOTA committee and nodes, modeling them as an iterated prisoner's dilemma and deriving the conditions under which this dilemma holds. Next, we explore the conditions under which the IOTA committee can adopt ZD strategies, demonstrating the feasibility of unilaterally controlling node payoffs.Finally, theoretical analysis and experimental validation confirm the effectiveness of the proposed countermeasure, offering a novel game-theoretic solution for enhancing IOTA's security.展开更多
Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4/nuclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.展开更多
This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although ...This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.展开更多
Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,thi...Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,this study proposes a strategic digital recovery framework,including revised campaign content,transparent communication through social media,and data-driven customer segmentation based on diverse skincare needs and cultural backgrounds.A PESTLE analysis underscores the importance of digital transformation and rising social consciousness in brand management.Findings suggest that inclusive messaging,precision targeting,and omnichannel digital engagement are key to restoring brand trust and reputation in the digital landscape.展开更多
Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employe...Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employed to fabricate a multi-layer PENG based on a cellulose/polyvinylidene fluoride(PVDF)blend film matrix,incorporating multi-phase BCZT(0.1BaZr_(0.2)Ti_(0.8)O_(3)-0.9Ba_(0.7)Ca_(0.3)TiO_(3))ceramic fillers.Structural characterization via SEM and TEM revealed that an intricate hydrogen-bond network facilitated the uniform dispersion of ceramic fillers within the composite film’s sub-layers.In order to study the effect of filler distribution on piezoelectric performance,the single-and double-layer composite films with varying BCZT configurations were produced and evaluated.The results demonstrated that double-layer PENGs exhibit significantly enhanced electrical output compared to their single-layer counterparts,with the D-L_(3)H_(7) configuration achieving an open circuit voltage(V_(OC))of 23.13 V and a short circuit current(I_(SC))of 8.32μA.This enhancement is attributed to increased inter-layer interfaces,which effectively suppressed charge injection and migration,leading to improved charge density.Additionally,the presence of sharp tipped hexagonal tetragonal phase nanoparticles induced an electric field enhancement effect,further optimizing performance.展开更多
Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practic...Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.展开更多
Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2...Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2)O(1)was synthesized as a 2D structure using Coas the metal source,methanol‑water(4∶6,V/V)as the solvent,and specific concentrations of 2,5‑furandicarboxylic acid(H_(2)FDCA)and 1,3,5‑triimidazole benzene(L).Adjusting to pure water and lowering the concentration of L yielded the 1D chain structure of[Co(HL)2(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(2).Using Cu(Ⅱ)as the metal source,methanol/water(9∶1,V/V)as the solvent,and specific concentrations of L and H2FDCA,the 1D chain structure of[Cu(L)(FDCA)(H_(2)O)]·2H_(2)O(3)was synthesized.Upon increasing the concentrations of L and H2FDCA,and switching the solvent to pure water,the 1D chain structure of[Cu(HL)_(2)(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(4)was obtained.This shows that changing the solvent and ligand concentrations can affect the structural changes of CPs.In addition,the solid‑state photoluminescence of CPs 1‑4 at room temperature was studied,and their morphological changes were observed via scanning electron microscopy.Density functional theory calculations revealed that the negative charge concentrates on the O and N atoms of the ligand,facilitating ligand‑metal ion coordination.CCDC:2403934,1;2403935,2;2403936,3;2403938,4.展开更多
Rice production is increasingly challenged by flooding stress because of global warming and rising sea levels.As the world’s most important staple crop,rice is highly vulnerable to anaerobic and submergence condition...Rice production is increasingly challenged by flooding stress because of global warming and rising sea levels.As the world’s most important staple crop,rice is highly vulnerable to anaerobic and submergence conditions that occur during flooding,particularly at the germination and vegetative stages.Anaerobic environments hinder seedling establishment during germination,while prolonged submergence during the vegetative stage impairs growth,ultimately reducing yield and grain quality.These stresses,driven by extended inundation,trigger a cascade of detrimental physiological responses and represent a major barrier to stable rice production and global food security.In this review,we examine the effects of flooding on rice growth at both the germination and vegetative stages.We further summarize recent advances in the identification of flooding-tolerant germplasm,QTL mapping,genome-wide association study,transcriptomic and proteomic analyses,and other molecular studies.Subsequently,we highlight potential cultivation and regulatory strategies,including genetic,morphological,physiological,and endogenous hormone-related approaches,aimed at enhancing tolerance to anaerobic and submergence stress.Together,these approaches underscore the promise of integrating molecular insights with agronomic practices to mitigate flooding damage and support sustainable rice production.展开更多
The cosmetics industry operates on a global scale,making the accurate translation of ingredient terminology crucial for international trade and consumer comprehension.Cosmetic ingredient terms are characterized by the...The cosmetics industry operates on a global scale,making the accurate translation of ingredient terminology crucial for international trade and consumer comprehension.Cosmetic ingredient terms are characterized by their interdisciplinary nature,regulatory constraints,and function-oriented definitions.Based on real-world translation examples,this paper analyzes the challenges in translating cosmetics ingredient terminology for international trade and proposes targeted translation strategies.The study aims to facilitate the global marketing of cosmetic products while ensuring consumers can accurately understand product ingredient information.展开更多
The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitroge...The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitrogenous and iso-lipidic diets were formulated.The control diet was made with 62%fish meal(FM).The other two experimental diets were formulated by replacing 45%FM with 22.5%mealworm(TM)and 22.5%cottonseed protein concentrate(CPC),or with 22.5%TM and 22.5%Clostridium autoethanogenum protein(CAP),respectively.The three kinds of diet were named as A1,A2 and A3,respectively.Five groups of large yellow croaker were fed with two different strategies:the first three groups were continuously fed with A1,A2 and A3 diets,respectively.The fourth group was alternately fed with A1 and A2 diet every 5 days.The fifth group was alternately fed with A1 and A3diet every 5 days.The five groups were named D1,D2,D3,D1-2 and D1-3,respectively.Results showed that D2 and D3 groups exhibited significantly lower weight gain rate(WGR)and higher feed conversion ratios(FCR)compared to the D1 group.The D1-2 and D1-3 groups exhibited improved WGR and significantly reduced FCR compared to the D2 and D3 groups.The A2 and A3 diets significantly suppressed digestive enzymes'activities compared to A1,whereas alternate-feeding groups significantly enhanced the enzyme activities.Compared to the D1 group,D2 and D3 groups significantly downregulated mRNA expression levels of intestinal antiinflammatory cytokines and upregulated the expression of pro-inflammatory mediators.The anti-inflammatory abilities in the D1-2and D1-3 groups were significantly higher than those in the D2 and D3 groups.Additionally,diets containing TM+CAP and TM+CPC protein sources enhanced ventral redness and yellowness indices.Considering the growth,digestion,immunity and organoleptic quality of large yellow croaker,it is recommended to replace up to 45%of FM with TM+CPC and use an alternate-feeding strategy.展开更多
The structural principles of traditional Chinese mortise-and-tenon joints have inspired breakthroughs in supramolecular engineering.Nevertheless,substantial challenges remain in constructing nanoscale supramolecular a...The structural principles of traditional Chinese mortise-and-tenon joints have inspired breakthroughs in supramolecular engineering.Nevertheless,substantial challenges remain in constructing nanoscale supramolecular architectures with precisely controlled giant dimensions.Herein,we report a precision-guided synthetic strategy for constructing giant 2D and 3D supramolecular architectures with rhomboidal motifs,which was achieved through a dovetail joint strategy.Initial assembly of bis-mortise ligand L1 with dovetail tenon ligand L2 in the presence of Cd^(2+)ions yielded the fundamental bis-rhombic supramolecule R1.Subsequent structural elaboration of the dovetail tenon motif enabled the development of multitopic ligands L3 and L4,which facilitated the construction of expanded architectures of the giant bis-propeller supramolecule R2 and tris-propeller supramolecule R3.The synthesized supramolecules R1-R3 were fully characterized multidimensional NMR spectroscopy,electrospray ionization mass spectrometry(ESI-MS),traveling wave ion mobility mass spectrometry(TWIM-MS),transmission electron microscopy(TEM),and atomic force microscopy(AFM).This work develops an innovative dovetail-joint assembly strategy for constructing rigid giant supramolecular architectures,establishing a new paradigm for precision engineering of complex 3D molecular systems.展开更多
Background:Self-esteem,life satisfaction,resilience,and coping strategies are closely linked to depression;however,their interrelationships and relative contributions to depressive outcomes remain insufficiently under...Background:Self-esteem,life satisfaction,resilience,and coping strategies are closely linked to depression;however,their interrelationships and relative contributions to depressive outcomes remain insufficiently understood.This study aimed to examine these associations in individuals with major depressive disorder(MDD)and healthy controls and to evaluate their predictive and mediating roles in depression.Methods:This analytical cross-sectional study included 311 participants(158 patients with MDD and 153 healthy controls)recruited from the Psychiatry Outpatient Clinics of Mugla Training and Research Hospital.Psychiatric diagnoses were confirmed using the Structured Clinical Interview for DSM-5(SCID-5).Groups were balanced for age,sex,and education using propensity score matching(PSM).Participants completed the Rosenberg Self-Esteem Scale,Satisfaction with Life Scale,Brief Resilience Scale,Brief COPE Inventory,and Beck Depression Inventory.Results:Compared with healthy controls,individuals with MDD reported significantly lower life satisfaction and resilience and higher depressive symptom severity,whereas self-esteem did not differ significantly between groups.Emotion-focused coping decreased with increasing depression severity,while avoidant coping showed a modest but significant increase in severe depression.Logistic regression analyses identified life satisfaction(OR=0.95,p=0.004)and resilience(OR=0.92,p=0.002)as significant protective predictors of depression.Mediation analyses demonstrated that life satisfaction partially mediated the relationship between self-esteem and depression,whereas resilience exerted a predominantly direct effect.Conclusion:Life satisfaction and resilience emerge as key protective factors against depression.Self-esteem appears to influence depressive outcomes indirectly through life satisfaction rather than through a direct effect.These findings underscore the importance of interventions that enhance resilience and promote positive evaluations of life in individuals at risk for depression.展开更多
With the intensification of population aging in China,the problem of cognitive impairment in the elderly has become increasingly prominent,attracting widespread attention from all sectors of society.Geriatric cognitiv...With the intensification of population aging in China,the problem of cognitive impairment in the elderly has become increasingly prominent,attracting widespread attention from all sectors of society.Geriatric cognitive impairment is characterized by chronicity,which not only seriously threatens the health of the elderly and reduces their quality of life,but also imposes a heavy burden on families and society due to its long course.Attaching importance to and strengthening the chronic disease management of elderly cognitive impairment has profound significance for delaying disease progression,improving patients’quality of life,and reducing the burden of family care.Therefore,this paper first comprehensively understands elderly cognitive impairment by briefly elaborating on its definition and characteristics;on this basis,it focuses on exploring effective strategies for the chronic disease management of elderly cognitive impairment,hoping to provide new ideas and methods for the management of this condition and offer useful references for relevant clinical research and practice.展开更多
Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomed...Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.展开更多
Reaction-diffusion systems are widely used to describe pattern formation,and various control strategies have been applied to reaction-diffusion systems to achieve control objectives such as boundary control,output fee...Reaction-diffusion systems are widely used to describe pattern formation,and various control strategies have been applied to reaction-diffusion systems to achieve control objectives such as boundary control,output feedback stabilization,and synchronization.However,controlling pattern dynamics in reaction-diffusion systems with fractional-order diffusion remains an unresolved problem.This paper presents a proportional-derivative(PD)control strategy for the Schnakenberg system with fractional-order diffusion and cross-diffusion.Theoretical analysis explores the amplitude equation near the Turing bifurcation threshold,determining the selection and stability of pattern formations.Numerical simulations demonstrate that the PD controller accomplishes the modification of pattern structures and suppression of Turing instability by adjusting only two control parameters.Additionally,it is found that for smaller fractional diffusion order,the region can accommodate more hexagonal and stripe patterns in space.This work contributes to the control of complex pattern dynamics and offers a new approach to enhancing stability in fractional reaction-diffusion systems.展开更多
Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create...Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create a firefly campsite-a natural attraction where visitors can observe these glowing insects in a preserved habitat.The site quickly drew waves of tourists,who shared their experience online,recouping its initial investment in just two years.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.61004098 and 11222543)the Program for New Century Excellent Talentsin Universities of China(Grant No.NCET-11-0070)+2 种基金the Special Project of Youth Science and Technology Innovation Research Team of Sichuan ProvinceChina(Grant No.2013TD0006)the Research Foundation of UESTC and Scholars Program of Hong Kong(Grant No.G-YZ4D)
文摘Repeated games describe situations where players interact with each other in a dynamic pattern and make decisions ac- cording to outcomes of previous stage games. Very recently, Press and Dyson have revealed a new class of zero-determinant （ZD） strategies for the repeated games, which can enforce a fixed linear relationship between expected payoffs of two play- ers, indicating that a smart player can control her unwitting co-player＇s payoff in a unilateral way [Proc. Acad. Natl. Sci. USA 109, 10409 （2012）]. The theory of ZD strategies provides a novel viewpoint to depict interactions among players, and fundamentally changes the research paradigm of game theory. In this brief survey, we first introduce the mathematical framework of ZD strategies, and review the properties and constrains of two specifications of ZD strategies, called pinning strategies and extortion strategies. Then we review some representative research progresses, including robustness analysis, cooperative ZD strategy analysis, and evolutionary stability analysis. Finally, we discuss some significant extensions to ZD strategies, including the multi-player ZD strategies, and ZD strategies under noise. Challenges in related research fields are also listed.
基金partially supported by the National Natural Science Foundation of China (62173308)the Natural Science Foundation of Zhejiang Province of China (LR20F030001)the Jinhua Science and Technology Project (2022-1-042)。
文摘As a representative emerging machine learning technique, federated learning(FL) has gained considerable popularity for its special feature of “making data available but not visible”. However, potential problems remain, including privacy breaches, imbalances in payment, and inequitable distribution.These shortcomings let devices reluctantly contribute relevant data to, or even refuse to participate in FL. Therefore, in the application of FL, an important but also challenging issue is to motivate as many participants as possible to provide high-quality data to FL. In this paper, we propose an incentive mechanism for FL based on the continuous zero-determinant(CZD) strategies from the perspective of game theory. We first model the interaction between the server and the devices during the FL process as a continuous iterative game. We then apply the CZD strategies for two players and then multiple players to optimize the social welfare of FL, for which we prove that the server can keep social welfare at a high and stable level. Subsequently, we design an incentive mechanism based on the CZD strategies to attract devices to contribute all of their high-accuracy data to FL.Finally, we perform simulations to demonstrate that our proposed CZD-based incentive mechanism can indeed generate high and stable social welfare in FL.
文摘Self-serving,rational agents sometimes cooperate to their mutual benefit.The two-player iterated prisoner′s dilemma game is a model for including the emergence of cooperation.It is generally believed that there is no simple ultimatum strategy which a player can control the return of the other participants.The zero-determinant strategy in the iterated prisoner′s dilemma dramatically expands our understanding of the classic game by uncovering strategies that provide a unilateral advantage to sentient players pitted against unwitting opponents.However,strategies in the prisoner′s dilemma game are only two strategies.Are there these results for general multi-strategy games?To address this question,the paper develops a theory for zero-determinant strategies for multi-strategy games,with any number of strategies.The analytical results exhibit a similar yet different scenario to the case of two-strategy games.The results are also applied to the Snowdrift game,the Hawk-Dove game and the Chicken game.
基金supported by the National Key Research and Development Program of China under Grant No.2022YFA1004700the National Natural Science Foundation of China under Grant No.62173250Shanghai Municipal Science and Technology Major Project under Grant No.2021SHZDZX0100.
文摘This paper focuses on the performance of equalizer zero-determinant(ZD)strategies in discounted repeated Stackelberg asymmetric games.In the leader-follower adversarial scenario,the strong Stackelberg equilibrium(SSE)deriving from the opponents’best response(BR),is technically the optimal strategy for the leader.However,computing an SSE strategy may be difficult since it needs to solve a mixed-integer program and has exponential complexity in the number of states.To this end,the authors propose an equalizer ZD strategy,which can unilaterally restrict the opponent’s expected utility.The authors first study the existence of an equalizer ZD strategy with one-to-one situations,and analyze an upper bound of its performance with the baseline SSE strategy.Then the authors turn to multi-player models,where there exists one player adopting an equalizer ZD strategy.The authors give bounds of the weighted sum of opponents’s utilities,and compare it with the SSE strategy.Finally,the authors give simulations on unmanned aerial vehicles(UAVs)and the moving target defense(MTD)to verify the effectiveness of the proposed approach.
基金Project supported by the Natural Science Foundation of Inner Mongolia, China (Grant No. 2024LHMS06013)Basic Research Funds for Inner Mongolia Autonomous Region’s Directly Affiliated Universities in 2025 (Grant No. NCYWS25019)+2 种基金the Regional Digital Economy and Digital Governance Research Center (Grant No. szzl202401)the Research Project on Education and Teaching Reform at Inner Mongolia University of Finance and Economics (Grant No. JXZD2405)the 2025 High-Quality Research Achievement Cultivation Fund Project of Inner Mongolia University of Finance and Economics (Grant No. GZCG2529)。
文摘The Internet of Things Application(IOTA) is an innovative public blockchain system tailored for the Internet of Things(IoT), focusing on challenges such as micro-payments, concurrency, and scalability. However, its distributed ledger,which utilizes a directed acyclic graph(DAG) structure, is vulnerable to double-spending attacks. To mitigate this risk,we propose a countermeasure employing zero-determinant(ZD) strategies to encourage honest transactions among nodes.First, we analyze the game-theoretic interactions between the IOTA committee and nodes, modeling them as an iterated prisoner's dilemma and deriving the conditions under which this dilemma holds. Next, we explore the conditions under which the IOTA committee can adopt ZD strategies, demonstrating the feasibility of unilaterally controlling node payoffs.Finally, theoretical analysis and experimental validation confirm the effectiveness of the proposed countermeasure, offering a novel game-theoretic solution for enhancing IOTA's security.
基金supported by the National Natural Science Foundation of China,82471345(to LC)the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
文摘Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4/nuclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.
文摘This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.
文摘Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,this study proposes a strategic digital recovery framework,including revised campaign content,transparent communication through social media,and data-driven customer segmentation based on diverse skincare needs and cultural backgrounds.A PESTLE analysis underscores the importance of digital transformation and rising social consciousness in brand management.Findings suggest that inclusive messaging,precision targeting,and omnichannel digital engagement are key to restoring brand trust and reputation in the digital landscape.
基金National Natural Science Foundation of China(52472132)Opening Project of Engineering Research Center of Eco-friendly Polymeric Materials,Ministry of Education(EFP-KF2403)Innovation Service Capability Support Plan of Xianyang(Science and Technology Innovation Talents)。
文摘Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employed to fabricate a multi-layer PENG based on a cellulose/polyvinylidene fluoride(PVDF)blend film matrix,incorporating multi-phase BCZT(0.1BaZr_(0.2)Ti_(0.8)O_(3)-0.9Ba_(0.7)Ca_(0.3)TiO_(3))ceramic fillers.Structural characterization via SEM and TEM revealed that an intricate hydrogen-bond network facilitated the uniform dispersion of ceramic fillers within the composite film’s sub-layers.In order to study the effect of filler distribution on piezoelectric performance,the single-and double-layer composite films with varying BCZT configurations were produced and evaluated.The results demonstrated that double-layer PENGs exhibit significantly enhanced electrical output compared to their single-layer counterparts,with the D-L_(3)H_(7) configuration achieving an open circuit voltage(V_(OC))of 23.13 V and a short circuit current(I_(SC))of 8.32μA.This enhancement is attributed to increased inter-layer interfaces,which effectively suppressed charge injection and migration,leading to improved charge density.Additionally,the presence of sharp tipped hexagonal tetragonal phase nanoparticles induced an electric field enhancement effect,further optimizing performance.
基金the support from Base for Interdisciplinary Innovative Talent Training,Shanghai Jiao Tong UniversityYouth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine。
文摘Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.
文摘Four distinct coordination polymers(CPs)were successfully synthesized by altering solvent types and adjusting ligand concentrations,and their crystal structures were investigated.[Co(L)(FDCA)(H_(2)O)_(2)]·0.5H_(2)O(1)was synthesized as a 2D structure using Coas the metal source,methanol‑water(4∶6,V/V)as the solvent,and specific concentrations of 2,5‑furandicarboxylic acid(H_(2)FDCA)and 1,3,5‑triimidazole benzene(L).Adjusting to pure water and lowering the concentration of L yielded the 1D chain structure of[Co(HL)2(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(2).Using Cu(Ⅱ)as the metal source,methanol/water(9∶1,V/V)as the solvent,and specific concentrations of L and H2FDCA,the 1D chain structure of[Cu(L)(FDCA)(H_(2)O)]·2H_(2)O(3)was synthesized.Upon increasing the concentrations of L and H2FDCA,and switching the solvent to pure water,the 1D chain structure of[Cu(HL)_(2)(H_(2)O)_(2)](FDCA)_(2)·6H_(2)O(4)was obtained.This shows that changing the solvent and ligand concentrations can affect the structural changes of CPs.In addition,the solid‑state photoluminescence of CPs 1‑4 at room temperature was studied,and their morphological changes were observed via scanning electron microscopy.Density functional theory calculations revealed that the negative charge concentrates on the O and N atoms of the ligand,facilitating ligand‑metal ion coordination.CCDC:2403934,1;2403935,2;2403936,3;2403938,4.
基金supported by the National Natural Science Foundation of China(Grant Nos.32160501 and 32201901)the Accelerated Breeding Initiative of the Consultative Group on International Agricultural Research(Grant No.INIT-01)+2 种基金the Natural Science Foundation of Guangxi,China(Grant No.2021GXNSFAA220026)the Program on National Modern Agricultural Technology System Guangxi Innovation Team,China(Grant No.nycytxgxcxtd-2021-01-04)the Advantage Team Project of Guangxi Academy of Agricultural Sciences,China(Grant No.2026YT070).
文摘Rice production is increasingly challenged by flooding stress because of global warming and rising sea levels.As the world’s most important staple crop,rice is highly vulnerable to anaerobic and submergence conditions that occur during flooding,particularly at the germination and vegetative stages.Anaerobic environments hinder seedling establishment during germination,while prolonged submergence during the vegetative stage impairs growth,ultimately reducing yield and grain quality.These stresses,driven by extended inundation,trigger a cascade of detrimental physiological responses and represent a major barrier to stable rice production and global food security.In this review,we examine the effects of flooding on rice growth at both the germination and vegetative stages.We further summarize recent advances in the identification of flooding-tolerant germplasm,QTL mapping,genome-wide association study,transcriptomic and proteomic analyses,and other molecular studies.Subsequently,we highlight potential cultivation and regulatory strategies,including genetic,morphological,physiological,and endogenous hormone-related approaches,aimed at enhancing tolerance to anaerobic and submergence stress.Together,these approaches underscore the promise of integrating molecular insights with agronomic practices to mitigate flooding damage and support sustainable rice production.
基金funded by 2025 Graduate Teaching Construction Project of USST.
文摘The cosmetics industry operates on a global scale,making the accurate translation of ingredient terminology crucial for international trade and consumer comprehension.Cosmetic ingredient terms are characterized by their interdisciplinary nature,regulatory constraints,and function-oriented definitions.Based on real-world translation examples,this paper analyzes the challenges in translating cosmetics ingredient terminology for international trade and proposes targeted translation strategies.The study aims to facilitate the global marketing of cosmetic products while ensuring consumers can accurately understand product ingredient information.
基金financially supported by the Key Research and Development Program of Shandong,China(No.2021SFGC0701)。
文摘The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitrogenous and iso-lipidic diets were formulated.The control diet was made with 62%fish meal(FM).The other two experimental diets were formulated by replacing 45%FM with 22.5%mealworm(TM)and 22.5%cottonseed protein concentrate(CPC),or with 22.5%TM and 22.5%Clostridium autoethanogenum protein(CAP),respectively.The three kinds of diet were named as A1,A2 and A3,respectively.Five groups of large yellow croaker were fed with two different strategies:the first three groups were continuously fed with A1,A2 and A3 diets,respectively.The fourth group was alternately fed with A1 and A2 diet every 5 days.The fifth group was alternately fed with A1 and A3diet every 5 days.The five groups were named D1,D2,D3,D1-2 and D1-3,respectively.Results showed that D2 and D3 groups exhibited significantly lower weight gain rate(WGR)and higher feed conversion ratios(FCR)compared to the D1 group.The D1-2 and D1-3 groups exhibited improved WGR and significantly reduced FCR compared to the D2 and D3 groups.The A2 and A3 diets significantly suppressed digestive enzymes'activities compared to A1,whereas alternate-feeding groups significantly enhanced the enzyme activities.Compared to the D1 group,D2 and D3 groups significantly downregulated mRNA expression levels of intestinal antiinflammatory cytokines and upregulated the expression of pro-inflammatory mediators.The anti-inflammatory abilities in the D1-2and D1-3 groups were significantly higher than those in the D2 and D3 groups.Additionally,diets containing TM+CAP and TM+CPC protein sources enhanced ventral redness and yellowness indices.Considering the growth,digestion,immunity and organoleptic quality of large yellow croaker,it is recommended to replace up to 45%of FM with TM+CPC and use an alternate-feeding strategy.
基金supported by the Hunan Science and Technology Innovation Plan(No.2024RC3015)the National Natural Science Foundation of China(No.22501053)+1 种基金National Key Research and Development Program(Nos.2022YFC3900902 and 2024YFC3907900)Major Science and Technology Projects of Yunnan Province(No.202302AB080016).
文摘The structural principles of traditional Chinese mortise-and-tenon joints have inspired breakthroughs in supramolecular engineering.Nevertheless,substantial challenges remain in constructing nanoscale supramolecular architectures with precisely controlled giant dimensions.Herein,we report a precision-guided synthetic strategy for constructing giant 2D and 3D supramolecular architectures with rhomboidal motifs,which was achieved through a dovetail joint strategy.Initial assembly of bis-mortise ligand L1 with dovetail tenon ligand L2 in the presence of Cd^(2+)ions yielded the fundamental bis-rhombic supramolecule R1.Subsequent structural elaboration of the dovetail tenon motif enabled the development of multitopic ligands L3 and L4,which facilitated the construction of expanded architectures of the giant bis-propeller supramolecule R2 and tris-propeller supramolecule R3.The synthesized supramolecules R1-R3 were fully characterized multidimensional NMR spectroscopy,electrospray ionization mass spectrometry(ESI-MS),traveling wave ion mobility mass spectrometry(TWIM-MS),transmission electron microscopy(TEM),and atomic force microscopy(AFM).This work develops an innovative dovetail-joint assembly strategy for constructing rigid giant supramolecular architectures,establishing a new paradigm for precision engineering of complex 3D molecular systems.
文摘Background:Self-esteem,life satisfaction,resilience,and coping strategies are closely linked to depression;however,their interrelationships and relative contributions to depressive outcomes remain insufficiently understood.This study aimed to examine these associations in individuals with major depressive disorder(MDD)and healthy controls and to evaluate their predictive and mediating roles in depression.Methods:This analytical cross-sectional study included 311 participants(158 patients with MDD and 153 healthy controls)recruited from the Psychiatry Outpatient Clinics of Mugla Training and Research Hospital.Psychiatric diagnoses were confirmed using the Structured Clinical Interview for DSM-5(SCID-5).Groups were balanced for age,sex,and education using propensity score matching(PSM).Participants completed the Rosenberg Self-Esteem Scale,Satisfaction with Life Scale,Brief Resilience Scale,Brief COPE Inventory,and Beck Depression Inventory.Results:Compared with healthy controls,individuals with MDD reported significantly lower life satisfaction and resilience and higher depressive symptom severity,whereas self-esteem did not differ significantly between groups.Emotion-focused coping decreased with increasing depression severity,while avoidant coping showed a modest but significant increase in severe depression.Logistic regression analyses identified life satisfaction(OR=0.95,p=0.004)and resilience(OR=0.92,p=0.002)as significant protective predictors of depression.Mediation analyses demonstrated that life satisfaction partially mediated the relationship between self-esteem and depression,whereas resilience exerted a predominantly direct effect.Conclusion:Life satisfaction and resilience emerge as key protective factors against depression.Self-esteem appears to influence depressive outcomes indirectly through life satisfaction rather than through a direct effect.These findings underscore the importance of interventions that enhance resilience and promote positive evaluations of life in individuals at risk for depression.
文摘With the intensification of population aging in China,the problem of cognitive impairment in the elderly has become increasingly prominent,attracting widespread attention from all sectors of society.Geriatric cognitive impairment is characterized by chronicity,which not only seriously threatens the health of the elderly and reduces their quality of life,but also imposes a heavy burden on families and society due to its long course.Attaching importance to and strengthening the chronic disease management of elderly cognitive impairment has profound significance for delaying disease progression,improving patients’quality of life,and reducing the burden of family care.Therefore,this paper first comprehensively understands elderly cognitive impairment by briefly elaborating on its definition and characteristics;on this basis,it focuses on exploring effective strategies for the chronic disease management of elderly cognitive impairment,hoping to provide new ideas and methods for the management of this condition and offer useful references for relevant clinical research and practice.
基金supported by the National Natural Science Foundation of China[82003956]the National Key Research and Development Program of China[No.2022YFA1205802]+2 种基金financially supported by Henan Province Health Science and Technology Innovation Youth Talent Project(YQRC2023013 and YQRC2024013)the Key Project of Medical Science and Technology of Henan Province(SBGJ202302072)the Science and Technology Research Project of Henan Province(252102311236).
文摘Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.
基金supported by the National Natural Science Foundation of China(62073172)the Natural Science Foundation of Jiangsu Province of China(BK20221329)。
文摘Reaction-diffusion systems are widely used to describe pattern formation,and various control strategies have been applied to reaction-diffusion systems to achieve control objectives such as boundary control,output feedback stabilization,and synchronization.However,controlling pattern dynamics in reaction-diffusion systems with fractional-order diffusion remains an unresolved problem.This paper presents a proportional-derivative(PD)control strategy for the Schnakenberg system with fractional-order diffusion and cross-diffusion.Theoretical analysis explores the amplitude equation near the Turing bifurcation threshold,determining the selection and stability of pattern formations.Numerical simulations demonstrate that the PD controller accomplishes the modification of pattern structures and suppression of Turing instability by adjusting only two control parameters.Additionally,it is found that for smaller fractional diffusion order,the region can accommodate more hexagonal and stripe patterns in space.This work contributes to the control of complex pattern dynamics and offers a new approach to enhancing stability in fractional reaction-diffusion systems.
文摘Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create a firefly campsite-a natural attraction where visitors can observe these glowing insects in a preserved habitat.The site quickly drew waves of tourists,who shared their experience online,recouping its initial investment in just two years.
