The influence of transforming pH values on the electrochemical performance of nano-scale Ni （OH）2 was analyzed. The measurement results of XRD indicate that the nano-scale Ni （OH） 2 prepared at different transform...The influence of transforming pH values on the electrochemical performance of nano-scale Ni （OH）2 was analyzed. The measurement results of XRD indicate that the nano-scale Ni （OH） 2 prepared at different transformations of pH value is β （ Ⅱ ）-phase with different crystal lattice parameters. Cyclic voltammograms （CV） and electrochemical impedance spectroscopy（EIS） measurement results show that transformations of pH value affect the proton diffusion coefficient （D） and charge-transfer resistance （Re,） of the material. The simulation of.cell experiment shows that the sample prepared at a pH of 10. 1 exhibits the maximum specific capacity （327.8 mAh/g） and higher discharge platform, the discharge performance of electrodes depends on both D and Rct, so the kinetics characteristics that electrodes reaction is controlled by both mass-transfer step and charge- transfer step are put forward.展开更多
The precursore Zn（en）2S （en=ethylenediamine） were prepared via a solvothermal process from elemental sulfur and zinc using ethylenediamine as a solvent. Detailed characterizations of the infrared （IR） absorption...The precursore Zn（en）2S （en=ethylenediamine） were prepared via a solvothermal process from elemental sulfur and zinc using ethylenediamine as a solvent. Detailed characterizations of the infrared （IR） absorption spectrum, powder X-ray diffraction （XRD） and thermogravimetric analysis （TG） confirmed two en coordinated with Zn2+ to form a complex cation. The morphological property was also characterized by transmission electron microscopy （TEM ） and electron diffraction analysis （ED）. Phase-pure hexagonal wurtzite ZnS products were obtained by annealing the precursor in nitrogen stream at about 900 ℃. Zn（en）2S showed a nanosize of about 30 nm, and ZnS of about 60 nm. The fluorescence spectra were also studied. PL results showed that Zn（en）2S excited a fluorescence at 452 nm.展开更多
Human epidermal growth factor receptor 2 positive(HER2+)breast cancer,as a subtype with high invasiveness and poor prognosis,faces issues of intertumoral heterogeneity and signaling pathway dysregulation leading to tr...Human epidermal growth factor receptor 2 positive(HER2+)breast cancer,as a subtype with high invasiveness and poor prognosis,faces issues of intertumoral heterogeneity and signaling pathway dysregulation leading to trastuzumab resistance in clinical treatment.Therefore,innovative therapeutic strategies are urgently needed to enhance treatment efficacy and improve patient prognosis.In this study,we proposed an antibody-targeted nanoplatform responsive to the tumor microenvironment,aiming to induce ferroptosis in HER2+breast can-cer cells and thereby enhance the sensitivity to HER2-targeted drugs.Fe-MOF@Erastin@Herceptin(FEH)was prepared by loading Erastin onto mesoporous Fe-MOF and modifying it with trastuzumab(a HER2+breast cancer cell-specific antibody).This platform gradually releases trastuzumab,Erastin,and Fe3+in the tumor microenvironment.The modification of trastuzumab enhances tumor cell targeting while reducing toxicity to non-target cells and tissues.Erastin inhibits system XCto reduce glutathione(GSH)synthesis.Fe3+consumes glutathione and reduces itself to Fe2+via a reduction reaction,which further enhances the catalytic effect of H2O2 and triggers the Fenton reaction to generate large amounts of reactive oxygen species(ROS).In the antibody-targeted cascade reaction,decreased intracellular GSH content and increased Fe2+and ROS can further promote lipid peroxidation and down-regulation of glutathione peroxidase 4(GPX4)in breast cancer cells,inducing ferroptosis.The experimental results indicate that FEH can significantly improve the tumor microen-vironment by enhancing ferroptosis effects,providing a potential new strategy for precision therapy of HER2+breast cancer cells.展开更多
基金the National Natural Science Foundation of China (Grant No.20271015)
文摘The influence of transforming pH values on the electrochemical performance of nano-scale Ni （OH）2 was analyzed. The measurement results of XRD indicate that the nano-scale Ni （OH） 2 prepared at different transformations of pH value is β （ Ⅱ ）-phase with different crystal lattice parameters. Cyclic voltammograms （CV） and electrochemical impedance spectroscopy（EIS） measurement results show that transformations of pH value affect the proton diffusion coefficient （D） and charge-transfer resistance （Re,） of the material. The simulation of.cell experiment shows that the sample prepared at a pH of 10. 1 exhibits the maximum specific capacity （327.8 mAh/g） and higher discharge platform, the discharge performance of electrodes depends on both D and Rct, so the kinetics characteristics that electrodes reaction is controlled by both mass-transfer step and charge- transfer step are put forward.
文摘The precursore Zn（en）2S （en=ethylenediamine） were prepared via a solvothermal process from elemental sulfur and zinc using ethylenediamine as a solvent. Detailed characterizations of the infrared （IR） absorption spectrum, powder X-ray diffraction （XRD） and thermogravimetric analysis （TG） confirmed two en coordinated with Zn2+ to form a complex cation. The morphological property was also characterized by transmission electron microscopy （TEM ） and electron diffraction analysis （ED）. Phase-pure hexagonal wurtzite ZnS products were obtained by annealing the precursor in nitrogen stream at about 900 ℃. Zn（en）2S showed a nanosize of about 30 nm, and ZnS of about 60 nm. The fluorescence spectra were also studied. PL results showed that Zn（en）2S excited a fluorescence at 452 nm.
基金supported by the National Natural Science Founda-tion of China(52171243 to Yu Wang and 52371256 to Yu Wang)Beijing Natural Science Foundation(2252058 to Zhiguang Fu).
文摘Human epidermal growth factor receptor 2 positive(HER2+)breast cancer,as a subtype with high invasiveness and poor prognosis,faces issues of intertumoral heterogeneity and signaling pathway dysregulation leading to trastuzumab resistance in clinical treatment.Therefore,innovative therapeutic strategies are urgently needed to enhance treatment efficacy and improve patient prognosis.In this study,we proposed an antibody-targeted nanoplatform responsive to the tumor microenvironment,aiming to induce ferroptosis in HER2+breast can-cer cells and thereby enhance the sensitivity to HER2-targeted drugs.Fe-MOF@Erastin@Herceptin(FEH)was prepared by loading Erastin onto mesoporous Fe-MOF and modifying it with trastuzumab(a HER2+breast cancer cell-specific antibody).This platform gradually releases trastuzumab,Erastin,and Fe3+in the tumor microenvironment.The modification of trastuzumab enhances tumor cell targeting while reducing toxicity to non-target cells and tissues.Erastin inhibits system XCto reduce glutathione(GSH)synthesis.Fe3+consumes glutathione and reduces itself to Fe2+via a reduction reaction,which further enhances the catalytic effect of H2O2 and triggers the Fenton reaction to generate large amounts of reactive oxygen species(ROS).In the antibody-targeted cascade reaction,decreased intracellular GSH content and increased Fe2+and ROS can further promote lipid peroxidation and down-regulation of glutathione peroxidase 4(GPX4)in breast cancer cells,inducing ferroptosis.The experimental results indicate that FEH can significantly improve the tumor microen-vironment by enhancing ferroptosis effects,providing a potential new strategy for precision therapy of HER2+breast cancer cells.
